DANIEL ZAHM

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint Synaptologic and fine structural features distinguishing a subset of basal forebrain cholinergic neurons embedded in the dense intrinsic fiber network of the caudal extended amygdala
    Louise D Loopuijt
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Comp Neurol 498:93-111. 2006
  2. pmc Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO, 63104, USA
    Brain Struct Funct 219:511-26. 2014
  3. pmc On lateral septum-like characteristics of outputs from the accumbal hedonic "hotspot" of Peciña and Berridge with commentary on the transitional nature of basal forebrain "boundaries"
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Comp Neurol 521:50-68. 2013
  4. pmc Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulant-elicited Fos expression and collateralization
    Heather N Lavezzi
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, MO 63104, USA
    Brain Struct Funct 217:719-34. 2012
  5. pmc The dopaminergic projection system, basal forebrain macrosystems, and conditioned stimuli
    Daniel S Zahm
    Saint Louis University School of Medicine, Department of Pharmacological and Physiological Science, St Louis, MO 63104, USA
    CNS Spectr 13:32-40. 2008
  6. pmc Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the Basal forebrain and recalibration of expression
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Neuropsychopharmacology 35:445-63. 2010
  7. pmc Pharmacotherapeutic approach to the treatment of addiction: persistent challenges
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA
    Mo Med 107:276-80. 2010
  8. ncbi request reprint The evolving theory of basal forebrain functional-anatomical 'macrosystems'
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Neurosci Biobehav Rev 30:148-72. 2006
  9. ncbi request reprint Discrimination of striatopallidum and extended amygdala in the rat: a role for parvalbumin immunoreactive neurons?
    Daniel S Zahm
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Brain Res 978:141-54. 2003
  10. ncbi request reprint Neurons of origin of the neurotensinergic plexus enmeshing the ventral tegmental area in rat: retrograde labeling and in situ hybridization combined
    D S Zahm
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO 63104, USA
    Neuroscience 104:841-51. 2001

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Synaptologic and fine structural features distinguishing a subset of basal forebrain cholinergic neurons embedded in the dense intrinsic fiber network of the caudal extended amygdala
    Louise D Loopuijt
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Comp Neurol 498:93-111. 2006
    ..The implications of these findings for interaction of fear, anxiety, and attention are considered...
  2. pmc Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO, 63104, USA
    Brain Struct Funct 219:511-26. 2014
    ..In contrast, slight activation of locomotion and no effect on rearing accompanied unilateral and bilateral ventral pallidal infusions. Implications of these findings for forebrain processing of reward are discussed. ..
  3. pmc On lateral septum-like characteristics of outputs from the accumbal hedonic "hotspot" of Peciña and Berridge with commentary on the transitional nature of basal forebrain "boundaries"
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Comp Neurol 521:50-68. 2013
    ....
  4. pmc Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulant-elicited Fos expression and collateralization
    Heather N Lavezzi
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, MO 63104, USA
    Brain Struct Funct 217:719-34. 2012
    ..The findings suggest that the RMTg is an integrative modulator of multiple rostrally projecting structures...
  5. pmc The dopaminergic projection system, basal forebrain macrosystems, and conditioned stimuli
    Daniel S Zahm
    Saint Louis University School of Medicine, Department of Pharmacological and Physiological Science, St Louis, MO 63104, USA
    CNS Spectr 13:32-40. 2008
    ....
  6. pmc Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the Basal forebrain and recalibration of expression
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Neuropsychopharmacology 35:445-63. 2010
    ....
  7. pmc Pharmacotherapeutic approach to the treatment of addiction: persistent challenges
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA
    Mo Med 107:276-80. 2010
    ..It is noted further that relapse remains the most persistent challenge in the treatment of addictions...
  8. ncbi request reprint The evolving theory of basal forebrain functional-anatomical 'macrosystems'
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Neurosci Biobehav Rev 30:148-72. 2006
    ..The relative merits of the theory of functional-anatomical macrosystems are discussed in relation to Swanson's model of cerebral hemisphere control of motivated behavior...
  9. ncbi request reprint Discrimination of striatopallidum and extended amygdala in the rat: a role for parvalbumin immunoreactive neurons?
    Daniel S Zahm
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Brain Res 978:141-54. 2003
    ..The paucity of PVs may be a characteristic feature distinguishing extended amygdala and its projection areas from striatopallidum, as well as the general character of neural processing that occurs in each...
  10. ncbi request reprint Neurons of origin of the neurotensinergic plexus enmeshing the ventral tegmental area in rat: retrograde labeling and in situ hybridization combined
    D S Zahm
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO 63104, USA
    Neuroscience 104:841-51. 2001
    ..These results identify a novel brain substrate for control of midbrain dopamine levels, which affect reward mechanisms and motivation...
  11. pmc Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors
    Daniel S Zahm
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Comp Neurol 519:3159-88. 2011
    ....
  12. ncbi request reprint Ventral mesopontine projections of the caudomedial shell of the nucleus accumbens and extended amygdala in the rat: double dissociation by organization and development
    D S Zahm
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    J Comp Neurol 436:111-25. 2001
    ....
  13. ncbi request reprint An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens
    D S Zahm
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO 63104, USA
    Neurosci Biobehav Rev 24:85-105. 2000
    ....
  14. pmc Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine
    Stefanie Geisler
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Neuropsychopharmacology 33:2688-700. 2008
    ..It is concluded that a previously unappreciated activation of pallidal and brainstem afferents may contribute to the modulation of dopaminergic neuronal activity following cocaine administration...
  15. ncbi request reprint Functional-anatomical implications of the nucleus accumbens core and shell subterritories
    D S Zahm
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, Missouri 63104, USA
    Ann N Y Acad Sci 877:113-28. 1999
    ..Whereas locomotion and oro-facial movements are elicitable from the shell, lesions and blockade of EAA transmission in the core reduce locomotion. It is hypothesized that core-shell has a feed-forward functional organization...
  16. ncbi request reprint Direct comparison of projections from the central amygdaloid region and nucleus accumbens shell
    D S Zahm
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Eur J Neurosci 11:1119-26. 1999
    ..The substantial differences in the output systems of the caudomedial shell of accumbens and central amygdala suggest that the two represent distinct functional-anatomical systems...
  17. ncbi request reprint Is the caudomedial shell of the nucleus accumbens part of the extended amygdala? A consideration of connections
    D S Zahm
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO 63104, USA
    Crit Rev Neurobiol 12:245-65. 1998
    ....
  18. ncbi request reprint Distinct and interactive effects of d-amphetamine and haloperidol on levels of neurotensin and its mRNA in subterritories in the dorsal and ventral striatum of the rat
    D S Zahm
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, Missouri 63104, USA
    J Comp Neurol 400:487-503. 1998
    ..It is suggested that some of the reported anti-dopaminergic behavioral effects of basal ganglia neurotensin may be attenuated in conditions of reduced dopamine neurotransmission...
  19. ncbi request reprint Desensitization and enhancement of neurotensin/neuromedin N mRNA responses in subsets of rat caudate-putamen neurons following multiple administrations of haloperidol
    D S Zahm
    Departments of Anatomy and Neurobiology, St Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Brain Res Mol Brain Res 59:196-204. 1998
    ..This suggests that peptide synthesis, as opposed to decreased release of peptide, has a role in the accumulation of neurotensin immunoreactivity by dorsomedial and ventrolateral striatal neurons...
  20. ncbi request reprint Altered Fos-like immunoreactivity in terminal regions of the mesotelencephalic dopamine system is associated with reappearance of tyrosine hydroxylase immunoreactivity at the sites of focal 6-hydroxydopamine lesions in the nucleus accumbens
    M A Chapman
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO 63104, USA
    Brain Res 736:270-9. 1996
    ..Further investigation is necessary to determine whether reappearance of TH-LI at the lesion site contributes to the return of Fos-LI to basal levels...
  21. ncbi request reprint Temporal dissociation of neurotensin/neuromedin N mRNA expression in topographically separate subsets of rat striatal neurons following administration of haloperidol
    D S Zahm
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO 63104, USA
    Brain Res Mol Brain Res 42:71-8. 1996
    ..The data are consistent with at least two subpopulations of caudate-putamen neurons in which neurotensin/neuromedin N mRNA expression is differentially regulated in response to haloperidol administration...
  22. ncbi request reprint Asymmetrical distribution of neurotensin immunoreactivity following unilateral injection of 6-hydroxydopamine in rat ventral tegmental area (VTA)
    D S Zahm
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO 63104
    Brain Res 483:301-11. 1989
    ..Lateral ventral pallidum, which gives rise to projections terminating in the substantia nigra and subthalamic nucleus and normally exhibits sparse NT-IR displayed intense NT-IR following the chemical lesion...
  23. ncbi request reprint Catecholamine monoamine oxidase a metabolite in adrenergic neurons is cytotoxic in vivo
    W J Burke
    Department of Neurology, Veterans Affairs Medical Center and Saint Louis University Medical School, St Louis, MO 63104, USA
    Brain Res 891:218-27. 2001
    ..Active uptake of the catecholamine-derived aldehyde into differentiated PC-12 cells is demonstrated. Implications of these findings for catecholamine neuron death in neurodegenerative diseases are discussed...
  24. ncbi request reprint Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions
    Stefanie Geisler
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Comp Neurol 490:270-94. 2005
    ..Given the importance of the VTA in basic behaviors, this organization might provide a basis for an extraordinary level of afferent integration...
  25. ncbi request reprint The caudal sublenticular region/anterior amygdaloid area is the only part of the rat forebrain and mesopontine tegmentum occupied by magnocellular cholinergic neurons that receives outputs from the central division of extended amygdala
    Myriam Gastard
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Brain Res 957:207-22. 2002
    ....
  26. ncbi request reprint Vulnerabilities of ventral mesencephalic neurons projecting to the nucleus accumbens following infusions of 6-hydroxydopamine into the medial forebrain bundle in the rat
    Andrew J Lancia
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Brain Res 997:119-27. 2004
    ....
  27. ncbi request reprint Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and the extended amygdala
    Sheila M Reynolds
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Neurosci 25:11757-67. 2005
    ....
  28. pmc Glutamatergic afferents of the ventral tegmental area in the rat
    Stefanie Geisler
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Neurosci 27:5730-43. 2007
    ....
  29. ncbi request reprint Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages
    Somnath Mukhopadhyay
    Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    J Neuroimmunol 181:82-92. 2006
    ..Forskolin or dibutyryl cyclic AMP increased CB(2) receptor immunoreactivity, suggesting the involvement of the cyclic AMP-protein kinase A-Cyclic AMP response element pathway in the regulation of CB(2) receptor levels...
  30. ncbi request reprint Brain neurotensin, psychostimulants, and stress--emphasis on neuroanatomical substrates
    Stefanie Geisler
    Department of Pharmacological and Physiological Science, Saint Louis University, School of Medicine, St Louis, MO 63104, USA
    Peptides 27:2364-84. 2006
    ..Finally, recent data about the actions of NT in processes underlying behavioral sensitization to psychostimulant drugs and the involvement of NT in the regulation of the hypothalamo-pituitary-adrenal gland axis are considered...
  31. ncbi request reprint Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling
    Yanning Hou
    Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Brain Res Dev Brain Res 151:149-57. 2004
    ....
  32. ncbi request reprint 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis
    William J Burke
    Department of Neurology, Saint Louis University Medical Center, 3635 Vista at Grand, St Louis, MO 63110, USA
    Brain Res 989:205-13. 2003
    ..However, 20 microg of DA produced lesions in the SN and VTA. We conclude that DOPAL is the toxic DA metabolite in vivo. Implications for a unified hypothesis for PD pathogenesis are discussed...
  33. ncbi request reprint Neurotensin antagonist acutely and robustly attenuates locomotion that accompanies stimulation of a neurotensin-containing pathway from rostrobasal forebrain to the ventral tegmental area
    Sheila M Reynolds
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Eur J Neurosci 24:188-96. 2006
    ..The results demonstrate the capacity of a neurotensin-containing pathway from LPH-MPOA to VTA to modulate locomotion. This pathway may be important in linking hippocampal and mesolimbic mechanisms in normal behaviour and drug addiction...
  34. ncbi request reprint On the retention of neurotensin in the ventral tegmental area (VTA) despite destruction of the main neurotensinergic afferents of the VTA--implications for the organization of forebrain projections to the VTA
    Stefanie Geisler
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, MO 63104, USA
    Brain Res 1087:87-104. 2006
    ....
  35. ncbi request reprint BDNF heterozygous mice demonstrate age-related changes in striatal and nigral gene expression
    Alicia J Saylor
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Exp Neurol 199:362-72. 2006
    ....

Research Grants26

  1. CONVERGENT VS.PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2002
    ..abstract_text> ..
  2. LPH to VTA Neurotensin: Actions and Cocaine Effects
    DANIEL ZAHM; Fiscal Year: 2002
    ..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
  3. CONVERGENT VS.PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2003
    ..abstract_text> ..
  4. LPH to VTA Neurotensin: Actions and Cocaine Effects
    DANIEL ZAHM; Fiscal Year: 2003
    ..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
  5. CONVERGENT VS.PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2004
    ..abstract_text> ..
  6. LPH to VTA Neurotensin: Actions and Cocaine Effects
    DANIEL ZAHM; Fiscal Year: 2003
    ..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
  7. LPH to VTA Neurotensin: Actions and Cocaine Effects
    DANIEL ZAHM; Fiscal Year: 2004
    ..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
  8. CONVERGENT VS.PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2005
    ..abstract_text> ..
  9. Form/function of Extended Amygdala/Accumbens Shell:CRF
    DANIEL ZAHM; Fiscal Year: 2005
    ....
  10. Convergent Versus Parallel Striatal Afferents
    DANIEL ZAHM; Fiscal Year: 2009
    ....
  11. CONVERGENT VS PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 2000
    ..The third aim will use a complex set of pharmacologically-mediated changes in specific gene expression to distinguish among and characterize different populations of striatal NT neurons. ..
  12. CONVERGENT VS PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 1991
    ..In concert, the two components of the proposed investigation should contribute to bridging conceptual gaps separating structure and function in striatum...
  13. CONVERGENT VS PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 1999
    ..The third aim will use a complex set of pharmacologically-mediated changes in specific gene expression to distinguish among and characterize different populations of striatal NT neurons. ..
  14. CONVERGENT VS PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 1993
    ....
  15. CONVERGENT VS PARALLEL STRIATAL DOPAMINERGIC AFFERENTS
    DANIEL ZAHM; Fiscal Year: 1990
    ..In concert, the two components of the proposed investigation should contribute to bridging conceptual gaps separating structure and function in striatum...
  16. Convergent Versus Parallel Striatal Afferents
    Daniel S Zahm; Fiscal Year: 2010
    ....