Jeffrey Teckman

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint Fasting in alpha1-antitrypsin deficient liver: constitutive [correction of consultative] activation of autophagy
    Jeffrey H Teckman
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1156-65. 2002
  2. ncbi request reprint In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA
    Pedro E Cruz
    Department of Pediatrics, University of Florida, Gainesville, FL, USA
    Lab Invest 87:893-902. 2007
  3. ncbi request reprint Alpha1-antitrypsin deficiency in childhood
    Jeffrey H Teckman
    Department of Pediatrics, St Louis University, Cardinal Glennon Children s Medical Center, St Louis, Missouri 63104, USA
    Semin Liver Dis 27:274-81. 2007
  4. doi request reprint Liver disease in alpha-1 antitrypsin deficiency: current understanding and future therapy
    Jeffrey H Teckman
    St Louis University School of Medicine, Cardinal Glennon Children s Medical Center, St Louis, MO 63104, USA
    COPD 10:35-43. 2013
  5. ncbi request reprint Alpha-1-antitrypsin deficiency: diagnosis, pathophysiology, and management
    Jeffrey H Teckman
    Gastroenterology and Hepatology, Department of Pediatrics, Saint Louis University School of Medicine, Cardinal Glennon Children s Hospital, 1465 South Grand Boulevard, St Louis, MO 63104, USA
    Curr Gastroenterol Rep 8:14-20. 2006
  6. pmc Characteristics of hepatocellular carcinoma in a murine model of alpha-1-antitrypsin deficiency
    Nancy Y Marcus
    Department of Pediatrics, Doisy Research Center, St Louis University School of Medicine, 1100 S, Grand Avenue, St Louis, MO 63104, USA Email
    Hepatol Res 40:641-53. 2010
  7. pmc Hepatic progenitor cell proliferation and liver injury in α-1-antitrypsin deficiency
    Elizabeth M Brunt
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    J Pediatr Gastroenterol Nutr 51:626-30. 2010
  8. ncbi request reprint Alpha-1-antitrypsin mutant Z protein content in individual hepatocytes correlates with cell death in a mouse model
    Douglas Lindblad
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63104, USA
    Hepatology 46:1228-35. 2007
  9. ncbi request reprint Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Hepatology 44:976-82. 2006
  10. ncbi request reprint Lack of effect of oral 4-phenylbutyrate on serum alpha-1-antitrypsin in patients with alpha-1-antitrypsin deficiency: a preliminary study
    Jeffrey H Teckman
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri, USA
    J Pediatr Gastroenterol Nutr 39:34-7. 2004

Research Grants

  1. Therapy for Alpha-1AT Deficiency Liver Disease
    Jeffrey Teckman; Fiscal Year: 2009

Collaborators

  • DAVID RUDNICK
  • David Perlmutter
  • Elizabeth M Brunt
  • Keith Blomenkamp
  • Douglas Lindblad
  • Nancy Y Marcus
  • Pedro E Cruz
  • Jae Koo An
  • Faiza Ali
  • Muneeb Ahmad
  • Martha Campbell-Thompson
  • Christian Mueller
  • Travis L Cossette
  • Qiushi Tang
  • Alexandra Golant
  • Keith S Blomenkamp
  • Stuart G Beattie
  • Terence R Flotte
  • Mark Brantly

Detail Information

Publications13

  1. ncbi request reprint Fasting in alpha1-antitrypsin deficient liver: constitutive [correction of consultative] activation of autophagy
    Jeffrey H Teckman
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1156-65. 2002
    ....
  2. ncbi request reprint In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA
    Pedro E Cruz
    Department of Pediatrics, University of Florida, Gainesville, FL, USA
    Lab Invest 87:893-902. 2007
    ..The rAAV8-3X-siRNA vector may hold promise as a potential therapy for patients with AAT liver disease...
  3. ncbi request reprint Alpha1-antitrypsin deficiency in childhood
    Jeffrey H Teckman
    Department of Pediatrics, St Louis University, Cardinal Glennon Children s Medical Center, St Louis, Missouri 63104, USA
    Semin Liver Dis 27:274-81. 2007
    ..The heterozygous carrier state for the mutant Z gene, present in 1.5% to 3% of the population, is not itself a common cause of liver injury but may be a modifier gene for other liver diseases...
  4. doi request reprint Liver disease in alpha-1 antitrypsin deficiency: current understanding and future therapy
    Jeffrey H Teckman
    St Louis University School of Medicine, Cardinal Glennon Children s Medical Center, St Louis, MO 63104, USA
    COPD 10:35-43. 2013
    ..Studies of the processes of intracellular injury have led to a new era of rational therapeutic development...
  5. ncbi request reprint Alpha-1-antitrypsin deficiency: diagnosis, pathophysiology, and management
    Jeffrey H Teckman
    Gastroenterology and Hepatology, Department of Pediatrics, Saint Louis University School of Medicine, Cardinal Glennon Children s Hospital, 1465 South Grand Boulevard, St Louis, MO 63104, USA
    Curr Gastroenterol Rep 8:14-20. 2006
    ..The heterozygous carrier state for the mutant Z gene, found in 1.5% to 3% of the population, is not itself a common cause of liver injury but may be a modifier gene for other liver diseases...
  6. pmc Characteristics of hepatocellular carcinoma in a murine model of alpha-1-antitrypsin deficiency
    Nancy Y Marcus
    Department of Pediatrics, Doisy Research Center, St Louis University School of Medicine, 1100 S, Grand Avenue, St Louis, MO 63104, USA Email
    Hepatol Res 40:641-53. 2010
    ..The accumulation of mutant Z protein altered the regulation of several genes driving proliferation and tumorigenesis...
  7. pmc Hepatic progenitor cell proliferation and liver injury in α-1-antitrypsin deficiency
    Elizabeth M Brunt
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    J Pediatr Gastroenterol Nutr 51:626-30. 2010
    ..However, the mechanisms linking hepatocellular injury to these responses are poorly understood. In this study, we examined liver injury and response in human liver and in transgenic mice for involvement of hepatic progenitor cells...
  8. ncbi request reprint Alpha-1-antitrypsin mutant Z protein content in individual hepatocytes correlates with cell death in a mouse model
    Douglas Lindblad
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63104, USA
    Hepatology 46:1228-35. 2007
    ..Further development of this hypothetical cascade will focus future research on this and other metabolic liver diseases...
  9. ncbi request reprint Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Hepatology 44:976-82. 2006
    ....
  10. ncbi request reprint Lack of effect of oral 4-phenylbutyrate on serum alpha-1-antitrypsin in patients with alpha-1-antitrypsin deficiency: a preliminary study
    Jeffrey H Teckman
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri, USA
    J Pediatr Gastroenterol Nutr 39:34-7. 2004
    ..The authors hypothesized that 4-PBA could be used to treat both the liver and lung disease of humans with alpha1AT deficiency...
  11. ncbi request reprint Quantitative isolation of alphalAT mutant Z protein polymers from human and mouse livers and the effect of heat
    Jae Koo An
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO, USA
    Hepatology 41:160-7. 2005
    ....
  12. ncbi request reprint Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hepatology 39:1048-55. 2004
    ..This selective proliferation suggests that hepatocellular transplantation may be applicable for treatment of this and other slowly progressive metabolic liver diseases...
  13. ncbi request reprint Mitochondrial autophagy and injury in the liver in alpha 1-antitrypsin deficiency
    Jeffrey H Teckman
    Dept of Pediatrics, Washington Univ School of Medicine, 660 South Euclid Ave, Box 8208, St Louis, MO 63110, USA
    Am J Physiol Gastrointest Liver Physiol 286:G851-62. 2004
    ....

Research Grants5

  1. Therapy for Alpha-1AT Deficiency Liver Disease
    Jeffrey Teckman; Fiscal Year: 2009
    ..of these therapeutic strategies for future human trials, examine the mechanisms involved in inhibiting liver cell injury, and add to the understanding of the basic mechanisms of cellular injury in liver disease ..