JOHN TAVIS

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. pmc Hepatitis C virus diversity and evolution in the full open-reading frame during antiviral therapy
    Nathan A Cannon
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 3:e2123. 2008
  2. pmc Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e9032. 2010
  3. pmc The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    PLoS Pathog 9:e1003125. 2013
  4. pmc Genome-wide networks of amino acid covariances are common among viruses
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis, University School of Medicine, St Louis, Missouri, USA
    J Virol 86:3050-63. 2012
  5. pmc A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame
    Ermei Yao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    Virol J 2:88. 2005
  6. pmc Evidence that the RNAseH activity of the duck hepatitis B virus is unable to act on exogenous substrates
    Y Gong
    Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    BMC Microbiol 1:12. 2001
  7. pmc Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Genome Med 3:8. 2011
  8. pmc Substrate specificity of the herpes simplex virus type 2 UL13 protein kinase
    Gina L Cano-Monreal
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Virology 374:1-10. 2008
  9. ncbi request reprint Suppression of mRNA accumulation by the duck hepatitis B virus reverse transcriptase
    Feng Cao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Virology 350:475-83. 2006
  10. pmc Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Clin Invest 119:225-36. 2009

Collaborators

Detail Information

Publications23

  1. pmc Hepatitis C virus diversity and evolution in the full open-reading frame during antiviral therapy
    Nathan A Cannon
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 3:e2123. 2008
    ..To determine if viral genetic differences contribute to the difference between response and relapse, we examined the inter-patient genetic diversity and mutation pattern in the full open reading frame HCV genotype 1a consensus sequences...
  2. pmc Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e9032. 2010
    ..African American patients respond to interferon alpha-based therapy at about half the rate of Caucasian Americans. The effect of HCV's genetic variation on treatment outcome in both racial groups is poorly understood...
  3. pmc The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    PLoS Pathog 9:e1003125. 2013
    ..Finally, differential inhibition of HBV genotype D and H RNAseHs indicates that viral genetic variability will be a factor during drug development...
  4. pmc Genome-wide networks of amino acid covariances are common among viruses
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis, University School of Medicine, St Louis, Missouri, USA
    J Virol 86:3050-63. 2012
    ..Five examples with hepatitis B virus and poliovirus are presented to illustrate how covariance network analysis can lead to inferences about viral biology...
  5. pmc A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame
    Ermei Yao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    Virol J 2:88. 2005
    ..This places divergent demands of the amplification conditions that can be very difficult to reconcile...
  6. pmc Evidence that the RNAseH activity of the duck hepatitis B virus is unable to act on exogenous substrates
    Y Gong
    Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    BMC Microbiol 1:12. 2001
    ..The mechanism of this template commitment is unknown. Here we provide evidence that the RNAseH activity of duck hepatitis B virus reverse transcriptase may also be unable to act on exogenous substrates...
  7. pmc Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Genome Med 3:8. 2011
    ..Direct-acting inhibitors of HCV that will be used in combination with IFN╬▒ are nearing approval, so genetic prediction for anti-HCV therapy will soon need to incorporate viral genetic markers of viral resistance to the new drugs...
  8. pmc Substrate specificity of the herpes simplex virus type 2 UL13 protein kinase
    Gina L Cano-Monreal
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Virology 374:1-10. 2008
    ..This motif's simplicity indicates that distal sequence or protein structure contributes to HSV-2 UL13 substrate specificity...
  9. ncbi request reprint Suppression of mRNA accumulation by the duck hepatitis B virus reverse transcriptase
    Feng Cao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Virology 350:475-83. 2006
    ..Therefore, suppression of the pregenomic RNA by DHBV P creates a negative feedback loop to limit viral antigen accumulation and replication, possibly contributing to maintenance of chronic infection...
  10. pmc Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Clin Invest 119:225-36. 2009
    ..Finally, covariance network analysis could be applicable to any virus with sufficient genetic variation, including most human RNA viruses...
  11. pmc RNA elements directing translation of the duck hepatitis B Virus polymerase via ribosomal shunting
    Feng Cao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S Grand Blvd, St Louis, MO 63104, USA
    J Virol 85:6343-52. 2011
    ..Together, these data indicate that DHBV employs either a novel shunting mechanism or a major variation on one of the characterized mechanisms...
  12. ncbi request reprint The duck hepatitis B virus polymerase and core proteins accumulate in different patterns from their common mRNA
    Ermei Yao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Virology 311:81-8. 2003
    ..These data provide a framework for comparing replication studies performed in LMH cells, PDHs and ducks...
  13. ncbi request reprint Localization of duck hepatitis B virus polymerase within cells
    Ermei Yao
    Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, MO, USA
    Methods Mol Med 95:281-93. 2004
  14. ncbi request reprint The duck hepatitis B virus reverse transcriptase functions as a full-length monomer
    Zhian Zhang
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 281:35794-801. 2006
    ..Therefore, non-nucleoside compounds that interfere with this change may be novel antiviral agents...
  15. ncbi request reprint Separation of near full-length hepatitis C virus quasispecies variants from a complex population
    Donghui Zhou
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Virol Methods 141:220-4. 2007
    ..These observations emphasize the significance of the use of near full-length genomic sequences for HCV genetic studies and for reverse genetic analysis using authentic quasispecies variants...
  16. pmc Translation of duck hepatitis B virus reverse transcriptase by ribosomal shunting
    Nandini Sen
    Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    J Virol 78:11751-7. 2004
    ..Therefore, the majority of the ribosomes that translate P are shunted from a donor region near the 5' end of the pgRNA to an acceptor site at or near the P AUG, and the shunt acceptor sequences may augment initiation at the P AUG...
  17. ncbi request reprint Herpes simplex virus 2 VP22 phosphorylation induced by cellular and viral kinases does not influence intracellular localization
    Brian J Geiss
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104 1083, USA
    Virology 330:74-81. 2004
    ....
  18. pmc Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO 63104, USA
    J Virol 81:8211-24. 2007
    ..No evidence was found for novel HCV strains in the AA population, implying that AA patients may be infected with a higher proportion of the same resistant strains that are found in CA patients...
  19. ncbi request reprint Detection and characterization of cytoplasmic hepatitis B virus reverse transcriptase
    Feng Cao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO 63104, USA
    J Gen Virol 85:3353-60. 2004
    ..Furthermore, conservation of the cytoplasmic form of the polymerase suggests that it might have function(s) in virus replication or pathology beyond copying the viral genome...
  20. pmc Identification of an essential molecular contact point on the duck hepatitis B virus reverse transcriptase
    Feng Cao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    J Virol 79:10164-70. 2005
    ..Therefore, small-molecule ligands that compete for binding to T3 with its natural ligand could form a novel class of antiviral drugs...
  21. ncbi request reprint Kinetics of synthesis and turnover of the duck hepatitis B virus reverse transcriptase
    Ermei Yao
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Missouri 63104, USA
    J Biol Chem 278:1201-5. 2003
    ..These data support the hypothesis that polymerase may have functions beyond copying the viral genome by demonstrating that the polymerase is a cytoplasmic protein that is only rarely encapsidated...
  22. pmc Immune evasion versus recovery after acute hepatitis C virus infection from a shared source
    Ian Tester
    Department of Medicine, Portland Veterans Administration Medical Center, Oregon Health Science University, Portland, OR 97239, USA
    J Exp Med 201:1725-31. 2005
    ..Statistical evidence for positive Darwinian selective pressure against an immunodominant epitope is presented. Wild-type cytotoxic T lymphocytes persisted even after the cognate antigen was no longer present...

Research Grants20

  1. Role of HCV Sequence Variation in Pathology
    John E Tavis; Fiscal Year: 2010
    ..This will yield insight into the mechanism of pathology by identifying viral genes associated with differences in disease progression. Finally, these studies may identify viral motifs predictive of rapid disease advancement. ..
  2. Role of HCV Sequence Variation in Pathology
    JOHN TAVIS; Fiscal Year: 2007
    ..This will yield insight into the mechanism of pathology by identifying viral genes associated with differences in disease progression. Finally, these studies may identify viral motifs predictive of rapid disease advancement. ..
  3. Variation in NTP use by the HCV polymerase and response to therapy
    JOHN TAVIS; Fiscal Year: 2007
    ..abstract_text> ..
  4. Analysis of the hepadnaviral reverse transcriptase
    JOHN TAVIS; Fiscal Year: 2006
    ..The proposed studies will fill basic gaps in our knowledge of hepadnaviral replication and will guide design of antiviral therapies. ..
  5. Analysis of the hepadnaviral reverse transcriptase
    JOHN TAVIS; Fiscal Year: 2004
    ..The proposed studies will fill basic gaps in our knowledge of hepadnaviral replication and will guide design of antiviral therapies. ..
  6. Role of HCV Sequence Variation in Pathology
    JOHN TAVIS; Fiscal Year: 2009
    ..This will yield insight into the mechanism of pathology by identifying viral genes associated with differences in disease progression. Finally, these studies may identify viral motifs predictive of rapid disease advancement. ..
  7. HCV genetic variation and hepatocellular carcinoma
    JOHN TAVIS; Fiscal Year: 2009
    ..They may also lead to greater ability to identify patients at highest risk for development of HCC through discovery of viral motifs associated with HCC. ..
  8. HCV genetic variation and hepatocellular carcinoma
    John E Tavis; Fiscal Year: 2010
    ..They may also lead to greater ability to identify patients at highest risk for development of HCC through discovery of viral motifs associated with HCC. ..
  9. Role of HCV Sequence Variation in Pathology
    JOHN TAVIS; Fiscal Year: 2009
    ..This will yield insight into the mechanism of pathology by identifying viral genes associated with differences in disease progression. Finally, these studies may identify viral motifs predictive of rapid disease advancement. ..
  10. Variation in NTP use by the HCV polymerase and response to therapy
    JOHN TAVIS; Fiscal Year: 2007
    ....
  11. Response of HCV to Therapy in African Americans
    JOHN TAVIS; Fiscal Year: 2005
    ..This may improve treatment or guide development of new therapies for both racial groups. ..
  12. Analysis of the hepadnaviral reverse transcriptase
    JOHN TAVIS; Fiscal Year: 2005
    ..The proposed studies will fill basic gaps in our knowledge of hepadnaviral replication and will guide design of antiviral therapies. ..
  13. International Conference on the Hepatitis B Viruses
    JOHN TAVIS; Fiscal Year: 2003
    ..The 2003 HBV Meeting will be organized by Drs. Antonio Bertoletti and John Tavis. The meeting will be modeled on the successful traditions of this series: intimate interactions through small ..
  14. Analysis of the hepadnaviral reverse transcriptase
    JOHN TAVIS; Fiscal Year: 2003
    ..The proposed studies will fill basic gaps in our knowledge of hepadnaviral replication and will guide design of antiviral therapies. ..
  15. Analysis of the hepadnaviral reverse transcriptase
    JOHN TAVIS; Fiscal Year: 2002
    ..The proposed studies will fill basic gaps in our knowledge of hepadnaviral replication and will guide design of antiviral therapies. ..
  16. Nonencapsidated HBV P protein as an anticancer target
    JOHN TAVIS; Fiscal Year: 2002
    ..We will introduce the HBV polymerase into cells and determine if the polymerase inhibits interferon alpha-mediated signaling and responses. ..