Research Topics
| J A SpertusSummaryAffiliation: Saint Luke's Hospital Country: USA Publications
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Detail Information
Publications
Assessing response bias from missing quality of life data: the Heckman methodAnne E Sales
HSR and D Center of Excellence, VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA
Health Qual Life Outcomes 2:49. 2004..The objective of this study was to demonstrate the use of the Heckman two-step method to assess and correct for bias due to missing health related quality of life (HRQL) surveys in a clinical study of acute coronary syndrome (ACS) patients...
Association between depression and worse disease-specific functional status in outpatients with coronary artery diseaseJ A Spertus
Mid America Heart Institute and Section of Cardiology, Department of Medicine, University of Missouri Kansas City, USA
Am Heart J 140:105-10. 2000..The study was designed as a cross-sectional survey and 3-month longitudinal cohort...
Blood omega-3 and trans fatty acids in middle-aged acute coronary syndrome patientsWilliam S Harris
Sanford Research and School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
Am J Cardiol 99:154-8. 2007..In conclusion, low blood EPA + DHA content is an independent predictor of increased risk for ACS, but higher blood trans FA content is not. Blood EPA + DHA may serve as a new, modifiable risk factor for ACS...
The impact of age on outcomes after coronary artery bypass surgery versus stent-assisted percutaneous coronary intervention: one-year results from the Stent or Surgery (SoS) trialZefeng Zhang
Christiana Care Center for Outcomes Research, Christiana Care Health System, Newark, DE 19713, USA
Am Heart J 152:1153-60. 2006..Relative outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) may differ between younger and older patients. There are no data comparing the age-related CABG versus PCI outcomes in the stent era...
Assessment of and physician response to glycemic control in diabetic patients presenting with an acute coronary syndromeDarcy L Green Conaway
Mid America Heart Institute of Saint Luke s Hospital, Kansas City, MO 64111, USA
Am Heart J 152:1022-7. 2006..The frequency with which physicians assess diabetic patients' glycemic control during an ACS hospitalization is not known and may represent an opportunity for quality improvement...
The impact of diabetes on one-year health status outcomes following acute coronary syndromesPamela N Peterson
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
BMC Cardiovasc Disord 6:41. 2006..The objective of this study was to examine the association between diabetes and patients' health status outcomes one year after an acute coronary syndrome (ACS)...
Time course of depression and outcome of myocardial infarctionSusmita Parashar
Divisions of General Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Arch Intern Med 166:2035-43. 2006..Our objective was to evaluate the prognostic importance of transient, new, or persistent depression on outcomes at 6 months after MI...
Impact of medication therapy discontinuation on mortality after myocardial infarctionP Michael Ho
Denver Veterans Affairs Medical Center, CO, USA
Arch Intern Med 166:1842-7. 2006....
Suspected acute coronary syndrome patients with diabetes and normal troponin-I levels are at risk for early and late death: Identification of a new high-risk acute coronary syndrome populationSteven P Marso
Mid America Heart Institute, University of Missouri-Kansas City, 64111, USA
Diabetes Care 29:1931-2. 2006
Prevalence and predictors of angina pectoris one month after myocardial infarctionJohn A Spertus
Mid America Heart Institute and University of Missouri Kansas City, Kansas City, Missouri, USA
Am J Cardiol 98:282-8. 2006..86, 95% CI 1.45 to 2.41), weekly (OR 4.24, 95% CI 3.09 to 5.82), and daily (OR 6.12, 95% CI 3.62 to 10.3) were more likely to have AP 1 month later. In conclusion, > 1 in 4 patients reported AP 1 month after an MI...
Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registryJohn A Spertus
MPH, Mid America Heart Institute, 4401 Wornall Rd, Kansas City, MO 64111
Circulation 113:2803-9. 2006..The rate and consequences of prematurely discontinuing thienopyridine therapy after DES placement for acute myocardial infarction (MI) are unknown...
The Prospective Registry Evaluating Myocardial Infarction: Events and Recovery (PREMIER)--evaluating the impact of myocardial infarction on patient outcomesJohn A Spertus
Mid America Heart Institute, Kansas City, MO 64111, USA
Am Heart J 151:589-97. 2006..More information on the longitudinal care and outcomes of patients after myocardial infarction (MI) is needed to further improve the quality of MI care. The PREMIER study was designed to meet this need...
The evolving pattern of symptomatic coronary artery disease in the United States and Canada: baseline characteristics of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trialWilliam E Boden
VA Connecticut Healthcare System, West Haven, Connecticut, USA
Am J Cardiol 99:208-12. 2007....
Impact of chronic obstructive pulmonary disease on post-myocardial infarction outcomesAdam C Salisbury
Mayo Graduate School of Medicine, Rochester, Minnesota, USA
Am J Cardiol 99:636-41. 2007..Although additional research is needed, clinicians should recognize that patients with COPD are at high risk for poor outcomes after MI...
Effect of PCI on quality of life in patients with stable coronary diseaseWilliam S Weintraub
Christiana Care Health System, Newark, DE 19718, USA
N Engl J Med 359:677-87. 2008..It has not been clearly established whether percutaneous coronary intervention (PCI) can provide an incremental benefit in quality of life over that provided by optimal medical therapy among patients with chronic coronary artery disease...
The influence of age on health status outcomes after acute myocardial infarctionP Michael Ho
Medical Service, Denver VA Medical Center, Denver, CO, USA
Am Heart J 155:855-61. 2008..Older age is a risk factor for higher mortality after acute myocardial infarction (AMI), but the association with health status outcomes is largely unexplored...
Association of early follow-up after acute myocardial infarction with higher rates of medication useStacie L Daugherty
Department of Medicine, Division of Cardiology, University of Colorado Denver Health Sciences Center, Denver, CO, USA
Arch Intern Med 168:485-91; discussion 492. 2008..Early outpatient follow-up after acute myocardial infarction (AMI) is recommended in guidelines, but its relationship with the use of evidence-based therapies is unknown...
Acute myocardial infarction patients' information needs over the course of treatment and recoveryCarole Decker
Mid America Heart Institute at Saint Luke s Hospital, 4401 Wornall Road, Kansas City, MO 64111, USA
J Cardiovasc Nurs 22:459-65. 2007..The current study focuses on describing cardiac patients' preferences for involvement in decision making in the context of the myocardial infarction event continuum...
One-year health status outcomes of unstable angina versus myocardial infarction: a prospective, observational cohort study of ACS survivorsThomas M Maddox
Denver VAMC University of Colorado Health Science Center, Denver, CO, USA
BMC Cardiovasc Disord 7:28. 2007..Little is known, however, about the health status outcomes (angina, physical function, and quality of life) of UA versus MI patients among survivors of an ACS hospitalization...
Connexin37 (GJA4) genotype predicts survival after an acute coronary syndromeDavid E Lanfear
Henry Ford Heart and Vascular Institute and Wayne State University, Detroit, MI, USA
Am Heart J 154:561-6. 2007..We tested the hypothesis that these genotypes would predict long-term mortality after an acute coronary syndrome (ACS)...
Impact of the Food and Drug Administration's Public Health Notification on the adoption of drug-eluting stentsJeptha P Curtis
Yale University, New Haven, Connecticut, USA
Am J Cardiol 99:1227-9. 2007..By January 2004, DES use had returned to the prenotification rate and continued to increase thereafter. In conclusion, the Food and Drug Administration's notification had a modest but temporary effect on clinical practice...
Self-reported use of complementary and alternative medicine in patients with previous acute coronary syndromeCarole Decker
Mid America Heart Institute of Saint Lukes Hospital, and School of Nursing, University of Missouri Kansas City, Kansas City, Missouri, USA
Am J Cardiol 99:930-3. 2007..05, 95% CI 0.87 to 1.28 for using statins). In conclusion, although CAM users with established CAD have worse socioeconomic status than nonusers, we found no evidence that they were less compliant with evidence-based therapies...
Optimal medical therapy with or without PCI for stable coronary diseaseWilliam E Boden
Western New York Veterans Affairs Healthcare Network and Buffalo General Hospital SUNY, Buffalo, NY 14203, USA
N Engl J Med 356:1503-16. 2007....
Financial barriers to health care and outcomes after acute myocardial infarctionAli R Rahimi
Department of Medicine, Yale University School of Medicine, New Haven, Conn 06520 8088, USA
JAMA 297:1063-72. 2007..The prevalence and consequences of financial barriers to health care services and medications are not well documented for patients with an acute myocardial infarction (AMI)...
Does health status differ between men and women in early recovery after myocardial infarction?Linda S Garavalia
Mid America Heart Institute of Saint Luke s Hospital, Kansas City, Missouri, University of Missouri Kansas City, Kansas City, Missouri
J Womens Health (Larchmt) 16:93-101. 2007....
Health status identifies heart failure outpatients at risk for hospitalization or deathPaul A Heidenreich
VA Palo Alto Health Care System, Palo Alto, California 94304, USA
J Am Coll Cardiol 47:752-6. 2006..We tested the hypothesis that one health status measure, the Kansas City Cardiomyopathy Questionnaire (KCCQ), provides prognostic information independent of other clinical data in outpatients with heart failure (HF)...
Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndromeDavid E Lanfear
Departments of Medicine, Genetics, and Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO
JAMA 294:1526-33. 2005..However, no associations between these polymorphisms and mortality have been demonstrated...
Relation of anemia at discharge to survival after acute coronary syndromesJoseph Vaglio
Mid America Heart Institute of Saint Luke's Hospital, Missouri, USA
Am J Cardiol 96:496-9. 2005..5%, p < 0.001). In multivariable analyses, adjusted hazard ratios for all-cause mortality were 1.57 (95% confidence interval 0.82 to 2.96) for mild anemia and 2.46 (95% confidence interval 1.25 to 4.85) for moderate/severe anemia...
Health status and social risk correlates of extended length of stay following coronary artery bypass surgeryGilbert Johnston
St Joseph Medical Center, Tacoma, Washington, USA
Ann Thorac Surg 77:557-62. 2004..Our hypothesis was that poorer self-reported health and greater social risk, as measured by standardized instruments, are significantly associated with extended SLOS defined as greater than or equal to 7 days...
Expanding the outcomes in clinical trials of heart failure: the quality of life and economic components of EPHESUS (EPlerenone's neuroHormonal Efficacy and SUrvival Study)John A Spertus
Mid America Heart Institute and the University of Missouri, Kansas City, MO, USA
Am Heart J 143:636-42. 2002....
Impact of angina burden and other factors on treatment satisfaction after acute coronary syndromesSean C Beinart
Cardiovascular Outcomes Research Center, VA Puget Sound Health Care System, Seattle, Wash, USA
Am Heart J 146:646-52. 2003..These results suggest that treatment satisfaction may be improved through better communication and better control of angina symptoms...
The elderly: health status benefits and recovery of function one year after coronary artery bypass surgeryDarcy Green Conaway
Mid America Heart Institute of Saint Luke's Hospital and the University of Missouri-Kansas City, Kansas City, Missouri, USA
J Am Coll Cardiol 42:1421-6. 2003..These data should assist physicians in counseling elderly patients and suggest that age alone should not be a deterrent for recommending bypass surgery...
Disease-specific health status after stent-assisted percutaneous coronary intervention and coronary artery bypass surgery: one-year results from the Stent or Surgery trialZefeng Zhang
Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30306, USA
Circulation 108:1694-700. 2003..During the first postprocedure year, patients' angina burden and physical limitations were alleviated to a greater extent with CABG...
History of depression, angina, and quality of life after acute coronary syndromesJohn S Rumsfeld
Cardiology, Denver VA Medical Center, Denver, Colo 80206, USA
Am Heart J 145:493-9. 2003..These findings further support the importance of depression as a risk marker for adverse outcomes after ACS...
A comparison of the recovery of health status after percutaneous coronary intervention and coronary artery bypassA Michael Borkon
Mid America Heart Institute, Kansas City, Missouri, USA
Ann Thorac Surg 74:1526-30; discussion 1530. 2002..Selection of the optimum mode of coronary revascularization should not only be directed by technical outcomes, but should also consider patients' postprocedural health status, including symptoms, functionality, and quality of life...
Resource utilization, cost, and health status impacts of coronary stent versus "optimal" percutaneous coronary angioplasty: results from the OPUS-I trialNancy Neil
Virginia Mason Medical Center, University of Washington School of Public Health, Seattle, Washington
J Interv Cardiol 15:249-55. 2002....
Health status predicts long-term outcome in outpatients with coronary diseaseJohn A Spertus
Mid America Heart Institute and University of Missouri Kansas City, Kansas City, MO 64111, USA
Circulation 106:43-9. 2002..Demonstrating that they independently predict mortality and hospitalizations among outpatients with coronary disease could emphasize their clinical value...
Relative benefit of coronary artery bypass grafting versus stent-assisted percutaneous coronary intervention for angina pectoris and multivessel coronary disease in women versus men (one-year results from the Stent or Surgery trial)Zefeng Zhang
Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30306, USA
Am J Cardiol 93:404-9. 2004..049 for the interaction among treatment, gender, and follow-up for the quality of life domain). Although CABG may be superior to PCI in men, in women, at 1 year after intervention, both procedures appear equally effective...
Comparison of quality of life after repeat versus initial coronary artery bypass graftingDavid M Safley
Mid America Heart Institute of Saint Luke s Hospital, 4401 Wornall Road, Kansas City, MO 64111, USA
Am J Cardiol 94:494-7. 2004..30], Quality of Life score [SAQ-QoL: 34 +/- 24 vs 35 +/- 5; p = 0.87], and Angina Frequency score (SAQ-AF: 35 +/- 40 vs 25 +/- 24; p = 0.03])...
Influence of racial disparities in procedure use on functional status outcomes among patients with coronary artery diseasePadma Kaul
University of Alberta, Edmonton, Alberta, Canada
Circulation 111:1284-90. 2005..Differential use of coronary revascularization may contribute to the poorer functional outcomes observed among black patients with documented coronary disease...
Risk of restenosis and health status outcomes for patients undergoing percutaneous coronary intervention versus coronary artery bypass graft surgeryJohn A Spertus
Mid America Heart Institute of Saint Luke s Hospital and the University of Missouri, 4401 Wornall Rd, Kansas City, MO 64111, USA
Circulation 111:768-73. 2005..No previous studies comparing the health status outcomes of PCI and CABG have examined differences in these outcomes as a function of patients' preprocedural risk for restenosis...
The impact of acute coronary syndrome on clinical, economic, and cardiac-specific health status after coronary artery bypass surgery versus stent-assisted percutaneous coronary intervention: 1-year results from the stent or surgery (SoS) trialZefeng Zhang
Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30306, USA
Am Heart J 150:175-81. 2005..Data are limited regarding the impact of acute coronary syndromes (ACSs) on the relative benefits of coronary artery bypass grafting (CABG) versus stent-assisted percutaneous coronary intervention (PCI)...
Low-to-moderate alcohol intake and health status in heart failure patientsAdam C Salisbury
University of Missouri-Kansas City, Missouri, USA
J Card Fail 11:323-8. 2005..These data do not support the need for complete alcohol abstinence for all HF patients among those who drink in moderation...
Predictors of quality-of-life benefit after percutaneous coronary interventionJohn A Spertus
University of Missouri Kansas City, and Mid America Heart Institute of Saint Luke s Hospital, USA
Circulation 110:3789-94. 2004..This study was conducted to identify patient characteristics associated with quality-of-life benefit after PCI...
Predictors of weight change in overweight patients with myocardial infarctionYazid Y Fadl
Washington University in St Louis, St Louis, MO, USA
Am Heart J 154:711-7. 2007..Weight loss is recommended among overweight survivors of myocardial infarction (MI). This study describes patterns of weight change among overweight patients with MI and identifies factors associated with weight change...
Association between angina and treatment satisfaction after myocardial infarctionMary E Plomondon
Cardiovascular Outcomes Research, Eastern Colorado Health Care System, Denver VA Medical Center, Denver, CO, USA
J Gen Intern Med 23:1-6. 2008..Patient satisfaction is increasingly recognized as a quality indicator and important outcome of care. Little is known about the clinical factors associated with satisfaction after myocardial infarction (MI)...
Hospital quality for acute myocardial infarction: correlation among process measures and relationship with short-term mortalityElizabeth H Bradley
Department of Epidemiology and Public Health, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn 06520-8088, USA
JAMA 296:72-8. 2006..Multiple measures that reflect a variety of processes and also outcomes, such as risk-standardized mortality rates, are needed to more fully characterize hospital performance...
Validity, reliability, and responsiveness of the Kansas City Cardiomyopathy Questionnaire in anemic heart failure patientsJohn A Spertus
Mid America Heart Institute, 4401 Wornall Road, Kansas City, MO 64111, USA
Qual Life Res 17:291-8. 2008....
The relationship between anemia, change in hematocrit over time and change in health status in patients with heart failure after myocardial infarctionMikhail Kosiborod
Mid America Heart Institute and University of Missouri Kansas City, Kansas City, Missouri, USA
J Card Fail 14:27-34. 2008..However, whether changes in hematocrit are associated with changes in health status is unknown...
Glucometrics in patients hospitalized with acute myocardial infarction: defining the optimal outcomes-based measure of riskMikhail Kosiborod
Mid America Heart Institute of Saint Luke s Hospital, 4401 Wornall Rd, Kansas City, MO 64111, USA
Circulation 117:1018-27. 2008..Whether metrics that incorporate multiple glucose assessments during acute myocardial infarction hospitalization are better predictors of mortality than admission glucose alone is not well defined...
Angina at 1 year after myocardial infarction: prevalence and associated findingsThomas M Maddox
Cardiology Section 111B, Denver Veterans Affairs MedicalCenter, 1055 Clermont St, Denver, CO 80209, USA
Arch Intern Med 168:1310-6. 2008..Eradication of angina is a primary goal of care after myocardial infarction (MI). However, the prevalence of angina 1 year after MI and factors associated with it are unknown...
Clinically important differences in health status for patients with heart disease: an expert consensus panel reportKathleen W Wyrwich
Department of Research Methodology, Saint Louis University, St Louis, MO 63103, USA
Am Heart J 147:615-22. 2004..No important difference standards for the SF-36 have been published for patients with heart disease. This development of CIDs would facilitate the use of health status measures in daily clinical decision-making...
Opportunities for improvement in the diagnosis and treatment of heart failurePeter A McCullough
Department of Basic Science, Cardiology Section, University of Missouri Kansas City School of Medicine, Truman Medical Center, Kansas City, Missouri, USA
Clin Cardiol 26:231-7. 2003..Improved treatment of congestive heart failure (CHF) can slow disease progression, promote clinical stability, and prolong survival...
Age, functional capacity, and health-related quality of life in patients with heart failureFrederick A Masoudi
Department of Medicine, Denver Health Medical Center, Colorado 80204, USA
J Card Fail 10:368-73. 2004..These results underscore the importance of treatments aimed at maintaining functional status in older persons with heart failure, including those with significant baseline functional limitations...
Socioeconomic disparities in outcomes after acute myocardial infarctionSusannah M Bernheim
Department of Medicine, Section of Geriatrics, Yale University School of Medicine, New Haven, CT 06520 8088, USA
Am Heart J 153:313-9. 2007..Patients of low socioeconomic status (SES) have higher mortality after acute myocardial infarction (AMI). Little is known about the underlying mechanisms or the relationship between SES and rehospitalization after AMI...
Quantifying improvement in symptoms, functioning, and quality of life after peripheral endovascular revascularizationDavid M Safley
Mid America Heart Institute, St Luke s Hospital, Kansas City, MO 64111, USA
Circulation 115:569-75. 2007..Patients with peripheral arterial disease often undergo peripheral endovascular revascularization (PER) to alleviate symptoms. Despite the growth of PER, little information exists quantifying the health status benefits after the procedure...
Beta2-adrenergic receptor genotype predicts survival: implications and future directionsDavid E Lanfear
Section of Advanced Heart Failure and Cardiac Transplantation, Henry Ford Heart and Vascular Institute, Detroit, MI 48202, USA
J Cardiovasc Nurs 21:474-7. 2006..Much of this work is already underway and is likely to influence the future standard of cardiovascular care...
The prevalence of unrecognized depression in patients with acute coronary syndromeAlpesh A Amin
Mid America Heart Institute of Saint Luke's Hospital, Kansas City, MO, USA
Am Heart J 152:928-34. 2006..Better interventions are warranted to increase the recognition and improve the management of depressive symptoms in patients with ACS...
Variability in the clinical status of patients with advanced heart failurePaul J Hauptman
Department of Medicine, Saint Louis University School of Medicine, Missouri, USA
J Card Fail 10:397-402. 2004....
Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failureJohn S Rumsfeld
Cardiology 111B, Denver VA Medical Center, Denver, Colorado 80220, USA
J Am Coll Cardiol 42:1811-7. 2003..The purpose of this study was to assess whether depressive symptoms are independently associated with changes in heart failure (HF)-specific health status...
Predictors of the onset of depressive symptoms in patients with heart failureEdward P Havranek
University of Colorado Health Sciences Center and Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204 4507, USA
J Am Coll Cardiol 44:2333-8. 2004..The objective of this study was to identify the factors associated with the development of depressive symptoms in outpatients with heart failure (HF)...
Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication studyThomas M Morgan
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Conn 06510, USA
JAMA 297:1551-61. 2007..Given the numerous, yet inconsistent, reports of genetic variants being associated with acute coronary syndromes (ACS), there is a need for comprehensive validation of ACS susceptibility genotypes...
Anginal symptoms consistently predict total mortality among outpatients with coronary artery diseaseDariush Mozaffarian
Health Services Research and Development Center of Excellence, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Wash, USA
Am Heart J 146:1015-22. 2003....
