Ali Shilatifard

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. pmc Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8
    Karl W Henry
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 17:2648-63. 2003
  2. ncbi request reprint Transcriptional elongation control by RNA polymerase II: a new frontier
    Ali Shilatifard
    Department of Biochemistry and the Cancer Center, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Biochim Biophys Acta 1677:79-86. 2004
  3. ncbi request reprint Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression
    Ali Shilatifard
    Saint Louis University School of Medicine and the Saint Louis University Cancer Center, St Louis, Missouri 63104, USA
    Annu Rev Biochem 75:243-69. 2006
  4. ncbi request reprint The RNA polymerase II elongation complex
    Ali Shilatifard
    Edward A Doisey Department of Biochemistry, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Annu Rev Biochem 72:693-715. 2003
  5. ncbi request reprint Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Genet Genomics 277:101-14. 2007
  6. ncbi request reprint The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p
    Adam Wood
    Department of Biochemistry, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 278:34739-42. 2003
  7. pmc Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling
    Kristen Tenney
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 103:11970-4. 2006
  8. ncbi request reprint Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter
    Adam Wood
    Department of Biochemistry, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Mol Cell 11:267-74. 2003
  9. pmc Ctk complex-mediated regulation of histone methylation by COMPASS
    Adam Wood
    Saint Louis University School of Medicine, Department of Biochemistry, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 27:709-20. 2007
  10. ncbi request reprint The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, Missouri 63104, USA
    Nat Struct Mol Biol 14:344-6. 2007

Collaborators

Detail Information

Publications56

  1. pmc Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8
    Karl W Henry
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 17:2648-63. 2003
    ..These results suggest that the histone H2B ubiquitylation state is dynamic during transcription, and that the sequence of histone modifications helps to control transcription...
  2. ncbi request reprint Transcriptional elongation control by RNA polymerase II: a new frontier
    Ali Shilatifard
    Department of Biochemistry and the Cancer Center, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Biochim Biophys Acta 1677:79-86. 2004
    ..Recent studies on the role of RNA polymerase II elongation factors in regulating of the overall rate of transcription both in vitro and in vivo, histone modification by methylation and organismal development will be reviewed here...
  3. ncbi request reprint Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression
    Ali Shilatifard
    Saint Louis University School of Medicine and the Saint Louis University Cancer Center, St Louis, Missouri 63104, USA
    Annu Rev Biochem 75:243-69. 2006
    ....
  4. ncbi request reprint The RNA polymerase II elongation complex
    Ali Shilatifard
    Edward A Doisey Department of Biochemistry, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Annu Rev Biochem 72:693-715. 2003
    ..Below we describe these recent advances, which highlight the important role of the RNA polymerase II elongation complex in regulation of eukaryotic gene expression...
  5. ncbi request reprint Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Genet Genomics 277:101-14. 2007
    ..Binding of the RNA Polymerase II elongation factor ELL was reduced in knockdown chromosomes, suggesting that ELL is recruited to active polymerase via CTD phosphorylation...
  6. ncbi request reprint The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p
    Adam Wood
    Department of Biochemistry, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 278:34739-42. 2003
    ..Thus, in addition to its role during the elongation phase of transcription, the Paf1 complex appears to activate the function but not the placement of the Rad6-Bre1 ubiquitin-protein ligase at the promoters of active genes...
  7. pmc Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling
    Kristen Tenney
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 103:11970-4. 2006
    ..Here we demonstrate that the dRtf1 component of the Paf1 complex functions in Notch signaling...
  8. ncbi request reprint Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter
    Adam Wood
    Department of Biochemistry, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Mol Cell 11:267-74. 2003
    ..These results suggest that Bre1 is the likely E3 enzyme that directs Rad6 to modify chromatin and ultimately to affect gene expression...
  9. pmc Ctk complex-mediated regulation of histone methylation by COMPASS
    Adam Wood
    Saint Louis University School of Medicine, Department of Biochemistry, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 27:709-20. 2007
    ..Our study suggests a role for the Ctk complex in the regulation of the pattern of H3K4 mono-, di-, and trimethylation via COMPASS...
  10. ncbi request reprint The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, Missouri 63104, USA
    Nat Struct Mol Biol 14:344-6. 2007
    ....
  11. ncbi request reprint The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS
    Adam Wood
    Department of Biochemistry, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    Mol Cell 20:589-99. 2005
    ..Our results identify in vivo substrates for Bur1/Bur2, thus linking its role to transcriptional elongation and demonstrating a potential activation mechanism for histone H2B monoubiquitination by the Rad6/Bre1 complex...
  12. ncbi request reprint Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A
    Mark Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Health Sciences Center, Saint Louis, Missouri 63104, USA
    J Biol Chem 280:4017-20. 2005
    ..Our data represent the first demonstration of an essential role for an RNA polymerase II elongation factor in the regulation of heat shock gene expression in an animal model...
  13. ncbi request reprint Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression
    Jessica Schneider
    Department of Biochemistry, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    Mol Cell 19:849-56. 2005
    ....
  14. ncbi request reprint A site to remember: H3K36 methylation a mark for histone deacetylation
    Jung Shin Lee
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Mutat Res 618:130-4. 2007
    ..These modifications provide restoration of normal chromatin structure in the wake of elongating Pol II and prevent inappropriate initiation within protein-coding regions masked by chromatin...
  15. pmc Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster
    Mark A Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104, USA
    Mol Cell Biol 25:7803-11. 2005
    ....
  16. pmc In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development
    Mark Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 24:9911-9. 2004
    ..The discovery of the role of elongin A in an in vivo model system defines the novel contribution played by RNA polymerase II elongation machinery in regulation of gene expression that is required for proper development...
  17. ncbi request reprint Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II
    Jessica Schneider
    Department of Biochemistry, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 281:37270-4. 2006
    ..This histone modification is also associated with some of the transcriptionally active puff sites in Drosophila. Our results indicate a new role for the Rtt109 protein in the proper regulation of H3K56 acetylation...
  18. ncbi request reprint Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6
    Jim Dover
    Department of Biochemistry, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 277:28368-71. 2002
    ..Ubiquitination of histone H2B on lysine 123 is the signal for the methylation of histone H3, which leads to silencing of genes located near telomeres...
  19. ncbi request reprint Leaving a mark: the many footprints of the elongating RNA polymerase II
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology and the Cancer Center, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Curr Opin Genet Dev 16:184-90. 2006
    ..These findings expand the role for RNA polymerase II elongation in targeting chromatin modifications to include a histone methyl mark more commonly associated with gene silencing...
  20. ncbi request reprint Cross-talking histones: implications for the regulation of gene expression and DNA repair
    Adam Wood
    Department of Biochemistry, Saint Louis School of Medicine, MO 63104, USA
    Biochem Cell Biol 83:460-7. 2005
    ..This review details efforts made towards understanding the regulatory mechanisms and biological significance of COMPASS and Dot1p-mediated histone methylation...
  21. ncbi request reprint Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications
    Jessica Schneider
    Saint Louis University School of Medicine, Department of Biochemistry, St Louis, Missouri 63104
    Methods Enzymol 377:227-34. 2004
  22. ncbi request reprint Transcriptional elongation by RNA polymerase II and histone methylation
    Mark Gerber
    Department of Biochemistry and the St Louis University Cancer Center, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 278:26303-6. 2003
    ..In this article, we will review the recent literature linking the key biochemical process of transcriptional elongation by RNA polymerase II to histone methylation by COMPASS, Dot1p, and Set2 methyltransferases...
  23. ncbi request reprint Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb
    Adam Wood
    Department of Biochemistry, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Cell Cycle 5:1066-8. 2006
    ..Recent findings regarding the role of these kinases in histone tail modifications and transcriptional regulation is briefly reviewed below...
  24. pmc Histone H3 lysine 4 (H3K4) methylation in development and differentiation
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St Louis, MO 63104, USA
    Dev Biol 339:240-9. 2010
    ..Since their discovery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mechanistic insight into the role of H3K4 methylation in HOX gene regulation during development...
  25. ncbi request reprint Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes
    Melissa M Steward
    Department of Biochemistry, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, Missouri 63104, USA
    Nat Struct Mol Biol 13:852-4. 2006
    ..These findings offer insight into the molecular role of ASH2L, and by extension that of WDR5, in proper H3K4 trimethylation...
  26. ncbi request reprint Packing for the germy: the role of histone H4 Ser1 phosphorylation in chromatin compaction and germ cell development
    Kristy D Wendt
    Department of Biochemistry, Saint Louis University School of Medicine, Missouri 63104, USA
    Genes Dev 20:2487-91. 2006
  27. ncbi request reprint A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin
    Kristen Tenney
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Health Sciences Center, Saint Louis, MO 63104, USA
    J Cell Biochem 95:429-36. 2005
    ..In this review, we will discuss the recent findings regarding the molecular mechanism and consequences of histone modification by the MLL related protein containing complex COMPASS...
  28. ncbi request reprint COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression
    Nevan J Krogan
    Department of Biochemistry, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 277:10753-5. 2002
    ..Set1 and several other components of COMPASS are also required for histone H3 methylation in vivo and for transcriptional silencing of a gene located near a chromosome telomere...
  29. ncbi request reprint Posttranslational modifications of histones by methylation
    Adam Wood
    Department of Biochemistry, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Adv Protein Chem 67:201-22. 2004
  30. ncbi request reprint Transcriptional blackjack with p21
    Adam Wood
    Department of Biochemistry, Saint Louis University School of Medicine, St Louis, MI 63104, USA
    Genes Dev 20:643-7. 2006
  31. ncbi request reprint Histone demethylation by hydroxylation: chemistry in action
    Jessica Schneider
    Department of Biochemistry, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, Missouri 63104, USA
    ACS Chem Biol 1:75-81. 2006
    ..This study broadens our understanding of different types of reaction mechanisms and cofactor requirements for a different category of histone demethylating machinery...
  32. pmc dELL is an essential RNA polymerase II elongation factor with a general role in development
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 99:9894-9. 2002
    ..These data show that an ELL family elongation factor is essential, acts broadly in development, and is not functionally redundant to other elongation factors in vivo...
  33. ncbi request reprint The A, B, Gs of silencing
    Edwin Smith
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Genes Dev 21:1141-4. 2007
  34. pmc RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach
    Nevan J Krogan
    Banting and Best Department of Medical Research Department of Molecular and Medical Genetics, University of Toronto TYPO, Toronto Yeast Proteomics Organization, Toronto, Ontario, Canada
    Mol Cell Biol 22:6979-92. 2002
    ..Spt5, Spt6, and Iws1 are phosphorylated on consensus CKII sites in vivo, conceivably by the Chd1/CKII associated with Spt16/Pob3. All the elongation factors but Elongator copurified with RNAPII...
  35. pmc Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae
    Kristin Ingvarsdottir
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 27:7856-64. 2007
    ..Thus, analysis of lysine demethylation in yeast provides new insight into the physiological roles of jumonji demethylase enzymes...
  36. ncbi request reprint Covalent modifications of histones during development and disease pathogenesis
    Sukesh R Bhaumik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Nat Struct Mol Biol 14:1008-16. 2007
    ..We also discuss how perturbation of the activity of this enzymatic machinery can cause developmental defects and disease...
  37. ncbi request reprint New nomenclature for chromatin-modifying enzymes
    C David Allis
    Cell 131:633-6. 2007
  38. pmc Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II
    Edwin R Smith
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Mol Cell Biol 28:1041-6. 2008
    ..Our data indicate that dUTX is intimately associated with actively transcribed genes and may provide a paradigm for how H3K27 demethylation is required for the activation of preinitiated Pol II on transcriptionally poised genes...
  39. ncbi request reprint Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS
    Jung Shin Lee
    Stowers Institute for Medical Research, 1000 East 50 th Street, Kansas City, MO 64110, USA
    Cell 131:1084-96. 2007
    ..Cps35 is also required for proper H3K79 trimethylation. These findings offer insight into the molecular role of Cps35 in translating the H2B monoubiquitination signal into H3 methylation...
  40. pmc Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation
    Ali Shilatifard
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Curr Opin Cell Biol 20:341-8. 2008
    ....
  41. pmc Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL
    Edwin R Smith
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 105:8575-9. 2008
    ..Consistent with a role in elongation, dELL knockdown reduces the levels of phosphorylated Pol II at heat-shock loci. This study implicates dELL in the expression of loci regulated by Pol II elongation...
  42. pmc A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation
    Shima Nakanishi
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA
    Nat Struct Mol Biol 15:881-8. 2008
    ..This library will be a valuable tool for defining the role of histone residues in processes requiring chromatin...
  43. ncbi request reprint Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein
    Min Gyu Lee
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cell 128:877-87. 2007
    ....
  44. ncbi request reprint The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation
    Nevan J Krogan
    Banting and Best Department of Medical Research, Department of Molecular and Medical Genetics, University of Toronto, Toronto, M5G 1L6, Ontario, Canada
    Mol Cell 11:721-9. 2003
    ..Collectively, our results suggest that the Paf1 complex is required for histone H3 methylation, therefore linking transcriptional elongation to chromatin methylation...
  45. ncbi request reprint Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing
    N C Tolga Emre
    Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19024, USA
    Mol Cell 17:585-94. 2005
    ..Our results suggest that these H2B-deubiquitylating enzymes have distinct genomic functions...
  46. ncbi request reprint Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation
    Christopher Wynder
    The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
    Nat Cell Biol 7:1113-7. 2005
    ..Moreover, depletion of iBRAF abrogates recruitment of MLL and enhancement of histone H3K4 trimethylation. Together, these results indicate that the HMG-domain protein iBRAF has a key role in the initiation of neuronal differentiation...
  47. ncbi request reprint Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II
    Rushad Pavri
    Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
    Cell 125:703-17. 2006
    ....
  48. pmc ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL
    Stephanie E Kong
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 102:10094-8. 2005
    ..Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription...
  49. ncbi request reprint Preparation and assay of RNA polymerase II elongation factors elongin and ELL
    Stephanie E Kong
    Stowers Institute Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Methods Enzymol 371:276-83. 2003
  50. pmc Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II
    Nevan J Krogan
    Banting and Best Department of Medical Research, Toronto Yeast Proteomics Organization, University of Toronto, Toronto, Ontario, Canada M5G 1L6
    Mol Cell Biol 23:4207-18. 2003
    ..SET2 also interacts genetically with components of the Set1 and Set3 complexes, suggesting that Set1, Set2, and Set3 similarly affect transcription by RNAPII...
  51. ncbi request reprint Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II
    David Baillat
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Cell 123:265-76. 2005
    ..The Integrator complex is evolutionarily conserved in metazoans and directly interacts with the C-terminal domain of the RNA polymerase II largest subunit...
  52. ncbi request reprint Guided by COMPASS on a journey through chromosome segregation
    Adam Wood
    Nat Struct Mol Biol 12:839-40. 2005
  53. pmc Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice
    Pengfei Wang
    Van Andel Research Institute, 333 Bostwick Avenue, N E, Grand Rapids, MI 49503, USA
    Mol Cell Biol 28:2930-40. 2008
    ..Thus, our results show that expression of Hrpt2 and parafibromin is pivotal in mammalian development and survival in adults and that these functions are likely mediated by the transcriptional regulation of growth factors...
  54. ncbi request reprint Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
    Nevan J Krogan
    Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, Ontario M5S 3E1, Canada
    Nature 440:637-43. 2006
    ..The data (all of which are available online) will help future studies on individual proteins as well as functional genomics and systems biology...
  55. pmc Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL
    Dmitri Wiederschain
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:4230-46. 2003
    ....
  56. ncbi request reprint Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage
    Dmitri Wiederschain
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 280:24315-21. 2005
    ..Our data suggest that abrogation of p53 functional activity can be a common feature of MLL fusion-mediated leukemogenesis...