WILLIS SAMSON

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint A novel action of the newly described prolactin-releasing peptides: cardiovascular regulation
    W K Samson
    Department of Pharmacological and Physiological Sciences, St Louis University School of Medicine, St Louis, MO 63104 1028, USA
    Brain Res 858:19-25. 2000
  2. ncbi request reprint Central neuropeptide B administration activates stress hormone secretion and stimulates feeding in male rats
    W K Samson
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
    J Neuroendocrinol 16:842-9. 2004
  3. ncbi request reprint Non-sleep effects of hypocretin/orexin
    Willis K Samson
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Sleep Med Rev 9:243-52. 2005
  4. ncbi request reprint Prolactin releasing peptide (PrRP): an endogenous regulator of cell growth
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Peptides 27:1099-103. 2006
  5. ncbi request reprint Putting the brakes on lactotrope hyperplasia
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63131, USA
    Trends Endocrinol Metab 17:2-3. 2006
  6. ncbi request reprint Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 292:R382-7. 2007
  7. ncbi request reprint Obestatin acts in brain to inhibit thirst
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 292:R637-43. 2007
  8. doi request reprint Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    J Endocrinol 196:559-64. 2008
  9. ncbi request reprint Hypothalamic localization of steroidogenic acute regulatory protein: the missing piece of the puzzle is found
    Willis K Samson
    Pharmacological and Physiological Sciences, St Louis University, 1402 South Grand Boulevard, MO 63131, USA
    Trends Endocrinol Metab 14:99-100. 2003
  10. ncbi request reprint Prolactin-releasing peptide and its homolog RFRP-1 act in hypothalamus but not in anterior pituitary gland to stimulate stress hormone secretion
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Endocrine 20:59-66. 2003

Research Grants

  1. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    WILLIS SAMSON; Fiscal Year: 2009
  2. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    WILLIS SAMSON; Fiscal Year: 2007
  3. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
  4. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    WILLIS SAMSON; Fiscal Year: 2003
  5. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010

Collaborators

Detail Information

Publications41

  1. ncbi request reprint A novel action of the newly described prolactin-releasing peptides: cardiovascular regulation
    W K Samson
    Department of Pharmacological and Physiological Sciences, St Louis University School of Medicine, St Louis, MO 63104 1028, USA
    Brain Res 858:19-25. 2000
    ....
  2. ncbi request reprint Central neuropeptide B administration activates stress hormone secretion and stimulates feeding in male rats
    W K Samson
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
    J Neuroendocrinol 16:842-9. 2004
    ....
  3. ncbi request reprint Non-sleep effects of hypocretin/orexin
    Willis K Samson
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Sleep Med Rev 9:243-52. 2005
    ....
  4. ncbi request reprint Prolactin releasing peptide (PrRP): an endogenous regulator of cell growth
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Peptides 27:1099-103. 2006
    ....
  5. ncbi request reprint Putting the brakes on lactotrope hyperplasia
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63131, USA
    Trends Endocrinol Metab 17:2-3. 2006
    ..These novel findings promise increased knowledge of the genesis and potential therapeutic control of human prolactinomas...
  6. ncbi request reprint Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 292:R382-7. 2007
    ..These data suggest receptor subtype-selective responses to hypocretin/orexin and provide further evidence for the importance of endogenously produced peptide in the physiological control of stress hormone secretion...
  7. ncbi request reprint Obestatin acts in brain to inhibit thirst
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 292:R637-43. 2007
    ..Importantly, in rats the effects of obestatin on food intake may be secondary to an action of the peptide to inhibit water drinking...
  8. doi request reprint Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    J Endocrinol 196:559-64. 2008
    ..We conclude that this product of post-translational processing of the ghrelin prohormone may be an important contributor to the physiologic regulation of fluid and electrolyte homeostasis...
  9. ncbi request reprint Hypothalamic localization of steroidogenic acute regulatory protein: the missing piece of the puzzle is found
    Willis K Samson
    Pharmacological and Physiological Sciences, St Louis University, 1402 South Grand Boulevard, MO 63131, USA
    Trends Endocrinol Metab 14:99-100. 2003
    ....
  10. ncbi request reprint Prolactin-releasing peptide and its homolog RFRP-1 act in hypothalamus but not in anterior pituitary gland to stimulate stress hormone secretion
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Endocrine 20:59-66. 2003
    ....
  11. ncbi request reprint The hypocretin/orexin story
    W K Samson
    Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63131, USA
    Trends Endocrinol Metab 11:257-62. 2000
    ..Neuroendocrine and metabolic effects of these peptides, some related to sleep-wakefulness and arousal state, are just now being discovered...
  12. ncbi request reprint Hypocretin/orexin suppresses corticotroph responsiveness in vitro
    W K Samson
    Pharmacological and Physiological Sciences, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1140-5. 2001
    ..Our data suggest a direct, pituitary action of the Hcrts/ORXs to modulate the endocrine response to stress and identify the potential cellular mechanism of a unique biological action of the peptides in the anterior pituitary gland...
  13. ncbi request reprint Orexin actions in hypothalamic paraventricular nucleus: physiological consequences and cellular correlates
    Willis K Samson
    Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Regul Pept 104:97-103. 2002
    ..0+/-0.6 mV), accompanied by increases in spike frequency in identified magno- and parvocellular neurons in the PVN. Our data suggest a potential role for endogenous orexin in the hypothalamic regulation of stress hormone secretion...
  14. pmc Orexin receptor subtype activation and locomotor behaviour in the rat
    W K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63131, USA
    Acta Physiol (Oxf) 198:313-24. 2010
    ..We describe here the ability of orexin to increase locomotor behaviours and identify the importance of both receptor subtypes in these actions...
  15. ncbi request reprint Prolactin-releasing peptides
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Regul Pept 114:1-5. 2003
    ....
  16. pmc Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 283:31949-59. 2008
    ..Our findings demonstrate diverse neuronal, neuroendocrine, and cardiovascular actions of a somatostatin gene-encoded hormone and provide the basis to investigate the physiological roles of this endogenously produced brain/gut peptide...
  17. ncbi request reprint Knockout knockouts
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Trends Endocrinol Metab 16:1-2. 2005
    ....
  18. ncbi request reprint The other side of the orexins: endocrine and metabolic actions
    Meghan M Taylor
    Pharmacological and Physiological Science, St Louis University School of Medicine, Missouri 63104, USA
    Am J Physiol Endocrinol Metab 284:E13-7. 2003
    ..Thus these pluripotent peptides hold great potential not only for the treatment of human narcolepsy but also to provide insight into the coordinated regulation of multiple physiological systems...
  19. ncbi request reprint Neuropeptide W acts in brain to control prolactin, corticosterone, and growth hormone release
    Jennifer R Baker
    Pharmacological and Physiological Sciences, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Endocrinology 144:2816-21. 2003
    ....
  20. ncbi request reprint Actions of neuropeptide W in paraventricular hypothalamus: implications for the control of stress hormone secretion
    Meghan M Taylor
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 288:R270-5. 2005
    ..Our data suggest that endogenous NPW, produced in brain, may play a physiologically relevant role in the neuroendocrine response to stress...
  21. ncbi request reprint Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake
    Meghan M Taylor
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 288:R919-27. 2005
    ..Our data indicate that IMD has potent actions within the CNS that may be a result of the combined activation of both AM and CGRP receptors...
  22. pmc The melanocortins, not oxytocin, mediate the anorexigenic and antidipsogenic effects of neuronostatin
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, Saint Louis, MO 63104, USA
    Peptides 31:1711-4. 2010
    ..Neuronostatin-induced anorexia was not reversed by pretreatment with the oxytocin receptor antagonist, OVT, suggesting that neuronostatin acts through a unique subset of POMC neurons that do not signal via central oxytocin receptors...
  23. pmc The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist
    Gina L C Yosten
    Department of Pharmacological and Physiological Science, Saint Louis University, Saint Louis, Missouri 63104, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1642-7. 2010
    ....
  24. ncbi request reprint Adrenomedullin and the integrative physiology of fluid and electrolyte balance
    Meghan M Taylor
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Microsc Res Tech 57:105-9. 2002
    ..Development of molecular tools to determine the physiologic role of endogenous AM will greatly enhance our understanding of AM and its regulation of fluid and electrolyte homeostasis...
  25. pmc Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system
    Gina L C Yosten
    Saint Louis Univ, Dept of Pharmacological and Physiological Science, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 297:R330-6. 2009
    ..Thus we have identified a novel action of nesfatin-1, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity...
  26. ncbi request reprint Involvement of the central adrenomedullin peptides in the baroreflex
    Meghan M Taylor
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Regul Pept 112:87-93. 2003
    ..These findings suggest that endogenous, brain-derived AM and PAMP participate in the regulation of autonomic activity in response to baroreceptor activation and inactivation...
  27. ncbi request reprint Ribozyme compromise of adrenomedullin mRNA reveals a physiological role in the regulation of water intake
    Meghan M Taylor
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1739-45. 2002
    ....
  28. ncbi request reprint Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary
    Meghan M White
    Saint Louis University, School of Medicine, Department of Pharmacological and Physiological Science, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Peptides 28:2171-8. 2007
    ..c.v. administration, cause increased water drinking in male rats. This tool may provide a better method than the use of the IMD17-47 compound to study the role of endogenous IMD within the CNS and pituitary...
  29. pmc Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptors
    Gina L C Yosten
    Dept of Pharmacological and Physiological Science, Saint Louis University, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1194-9. 2011
    ....
  30. ncbi request reprint Stress hormone secretion is altered by central administration of intermedin/adrenomedullin-2
    Meghan M Taylor
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
    Brain Res 1045:199-205. 2005
    ..These results suggest that multiple members of the AM family of peptides may be involved in the cardiovascular, behavioral and neuroendocrine responses to stress...
  31. ncbi request reprint Intermedin/Adrenomedullin-2 inhibits growth hormone release from cultured, primary anterior pituitary cells
    Meghan M Taylor
    Saint Louis University, Pharmacological and Physiological Science, Missouri 63104, USA
    Endocrinology 147:859-64. 2006
    ....
  32. ncbi request reprint A possible mechanism for the action of adrenomedullin in brain to stimulate stress hormone secretion
    Meghan M Taylor
    Saint Louis University, Department of Pharmacological and Physiological Science, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    Endocrinology 145:4890-6. 2004
    ..In addition, AM given intracerebroventricularly stimulated the release of prolactin but did not alter the secretion of GH. We propose that AM produced in the brain may be an important neuromodulator of the hormonal stress response...
  33. ncbi request reprint Brain-derived adrenomedullin controls blood volume through the regulation of arginine vasopressin production and release
    Meghan M Taylor
    Dept of Pharmacological and Physiological Science, Saint Louis Univ, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1203-10. 2005
    ..These data suggest that brain-derived AM is a physiological regulator of vasopressin secretion and, thereby, fluid homeostasis...
  34. doi request reprint A possible relationship between brain-derived adrenomedullin and oxytocin in the regulation of sodium balance
    Meghan M White
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Endocrinol 203:253-62. 2009
    ....
  35. ncbi request reprint Closing the link in short-loop prolactin feedback
    Meghan M White
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Trends Endocrinol Metab 17:217-8. 2006
    ..Short-loop negative feedback actions of prolactin in hypothalamus have been recognized for some time. Two recent papers demonstrate the multiple sites of this feedback action and the signaling mechanisms involved...
  36. ncbi request reprint Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1
    Tulin O Price
    Geriatric Research, Education, and Clinical Center GRECC, Veteran Affairs Medical Center, St Louis, MO 63106, USA
    Peptides 28:2372-81. 2007
    ..Efflux of labeled nesfatin-1 from brain back into blood was by way of bulk flow. These findings demonstrate that nesfatin-1 crosses the BBB in both the blood-to-brain and brain-to-blood directions by nonsaturable mechanisms...
  37. ncbi request reprint Antisense inhibition: oligonucleotides, ribozymes, and siRNAs
    Y Clare Zhang
    Department of Pediatrics, University of South Florida, St Petersburg, FL, USA
    Methods Mol Med 106:11-34. 2005
  38. ncbi request reprint Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C
    Bo Yang
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Neurosci 23:6215-22. 2003
    ..These results therefore show that the excitatory effects of ORX-A on NTS neurons are mediated through activation of the PLC-PKC-NSCC and -IK signaling pathways, which probably result from OXR-coupled activation of Gq...
  39. ncbi request reprint The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function
    Alastair V Ferguson
    Department of Physiology, Queen s University, Kingston, ON, Canada
    Front Neuroendocrinol 24:141-50. 2003
    ..This review focuses upon evidence for potential physiologic roles for the peptides in these sites...
  40. pmc The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction
    Alastair V Ferguson
    Queen s University, Department of Physiology, Kingston, Ontario, K7L 3N6, Canada
    Expert Opin Ther Targets 12:717-27. 2008
    ....
  41. ncbi request reprint Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes
    Feng Dong
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071 3375, USA
    J Appl Physiol 101:778-84. 2006
    ..Our data suggest that IMD acutely augments cardiomyocyte contractile function through, at least in part, a protein kinase C- and protein kinase A-dependent mechanism...

Research Grants11

  1. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    WILLIS SAMSON; Fiscal Year: 2009
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  2. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    WILLIS SAMSON; Fiscal Year: 2007
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  3. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
    ..abstract_text> ..
  4. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    WILLIS SAMSON; Fiscal Year: 2003
    ..These studies will also begin to examine a potentially novel confluence of endocrine and autonomic responses to stress and thereby provide insight into the coordinated responses of multiple organ systems to stress. ..
  5. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..