D Salvemini

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. pmc Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism
    Amanda Finley
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e55255. 2013
  2. doi request reprint Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 304:R473-87. 2013
  3. doi request reprint Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain
    Daniela Salvemini
    Department of Pharmacological and Physiological Sciences, St Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Trends Pharmacol Sci 34:110-8. 2013
  4. pmc Controlling murine and rat chronic pain through A3 adenosine receptor activation
    Zhoumou Chen
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    FASEB J 26:1855-65. 2012
  5. ncbi request reprint Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Life Sci 86:604-14. 2010
  6. ncbi request reprint Searching for new strategies for the pharmacological treatment of chronic pain
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA
    Mo Med 107:262-4. 2010
  7. pmc Roles of reactive oxygen and nitrogen species in pain
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Free Radic Biol Med 51:951-66. 2011
  8. doi request reprint Peroxynitrite: a strategic linchpin of opioid analgesic tolerance
    Daniela Salvemini
    Department of Internal Medicine, Saint Louis University, St Louis, MO 63110, USA
    Trends Pharmacol Sci 30:194-202. 2009
  9. ncbi request reprint Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation
    D Salvemini
    Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, Mo 63110 0250, USA
    Biochem Soc Trans 34:965-70. 2006
  10. ncbi request reprint A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats
    D Salvemini
    MetaPhore Pharmaceuticals, 1910 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Science 286:304-6. 1999

Research Grants

Collaborators

Detail Information

Publications22

  1. pmc Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism
    Amanda Finley
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e55255. 2013
    ..Targeting the S1P/S1PR(1) axis opens a therapeutic strategy for the development of novel non-narcotic anti-hyperalgesic agents...
  2. doi request reprint Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 304:R473-87. 2013
    ..This article provides a comprehensive state-of-the art overview in this area...
  3. doi request reprint Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain
    Daniela Salvemini
    Department of Pharmacological and Physiological Sciences, St Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Trends Pharmacol Sci 34:110-8. 2013
    ..It is therefore timely and important to critically evaluate the pharmacological basis for targeting the ceramide-to-S1P pathway as an approach to pain management...
  4. pmc Controlling murine and rat chronic pain through A3 adenosine receptor activation
    Zhoumou Chen
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    FASEB J 26:1855-65. 2012
    ..Our findings provide the scientific rationale and pharmacological basis for therapeutic development of A(3)AR agonists for chronic pain...
  5. ncbi request reprint Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Life Sci 86:604-14. 2010
    ..These concepts provide a pharmacological basis for developing inhibitors of PN biosynthesis as novel non-narcotic analgesics, thus addressing a large and currently unmet medical need with major socioeconomic consequences...
  6. ncbi request reprint Searching for new strategies for the pharmacological treatment of chronic pain
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA
    Mo Med 107:262-4. 2010
    ..Targeting PN is a novel evidence-based approach to develop novel therapeutics for managing chronic pain...
  7. pmc Roles of reactive oxygen and nitrogen species in pain
    Daniela Salvemini
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Free Radic Biol Med 51:951-66. 2011
    ..Over the past 15 years, our team has spearheaded research concerning the roles of SO and PN in pain and these results are currently leading to the development of solid therapeutic strategies in this important area...
  8. doi request reprint Peroxynitrite: a strategic linchpin of opioid analgesic tolerance
    Daniela Salvemini
    Department of Internal Medicine, Saint Louis University, St Louis, MO 63110, USA
    Trends Pharmacol Sci 30:194-202. 2009
    ....
  9. ncbi request reprint Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation
    D Salvemini
    Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, Mo 63110 0250, USA
    Biochem Soc Trans 34:965-70. 2006
    ..Given the limited space to cover this broad topic, here we will refer the reader to comprehensive review articles whenever possible...
  10. ncbi request reprint A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats
    D Salvemini
    MetaPhore Pharmaceuticals, 1910 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Science 286:304-6. 1999
    ..Injection of M40403 into rat models of inflammation and ischemia-reperfusion injury protected the animals against tissue damage. Such mimics may result in better clinical therapies for diseases mediated by superoxide radicals...
  11. pmc Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathology
    D Salvemini
    Discovery Pharmacology, G D Searle Co, St Louis, MO 63167, USA
    Proc Natl Acad Sci U S A 95:2659-63. 1998
    ..Taken together, our data provide compelling evidence supporting the therapeutic value of manipulating PN pharmacologically. Thus, PN decomposition catalysts may represent a unique class of anti-inflammatory agents...
  12. doi request reprint NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice
    T Doyle
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Neuroscience 241:1-9. 2013
    ..Thus, NOX2 may provide a potential target for adjuvant therapy to protect opioid analgesia...
  13. pmc Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403
    D Salvemini
    MetaPhore Pharmaceuticals, 1910 Innerbelt Business Center Drive, St Louis, Missouri, MO 63114, USA
    Br J Pharmacol 132:815-27. 2001
    ..Therefore, synthetic enzymes of SOD such as M40403, offers a novel therapeutic approach for the management of various inflammatory diseases where these radicals have been postulated to play a role...
  14. pmc Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance
    T Doyle
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Neuroscience 164:702-10. 2009
    ..These results support our general contention that PN-targeted therapeutics may have potential as adjuncts to opiates in pain management...
  15. pmc Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock
    H Macarthur
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, MO 63104, USA
    Proc Natl Acad Sci U S A 97:9753-8. 2000
    ..As a result, both hyporeactivity and hypotension are reversed, generation of potentially toxic adrenochromes is reduced, and survival rate is improved...
  16. ncbi request reprint A catalyst of peroxynitrite decomposition inhibits murine experimental autoimmune encephalomyelitis
    A H Cross
    Department of Neurology and Neurosurgery, Washington University School of Medicine, Box 8111, 660 S Euclid, St Louis, MO 63110, USA
    J Neuroimmunol 107:21-8. 2000
    ..PN plays an important role distinct from that of NO in the pathogenesis of EAE, a major model for MS...
  17. pmc Regulation of prostaglandin production by nitric oxide; an in vivo analysis
    D Salvemini
    G D Searle, Department of Molecular Pharmacology, St Louis, MO 63167, USA
    Br J Pharmacol 114:1171-8. 1995
    ....
  18. ncbi request reprint Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic
    D Salvemini
    MetaPhore Pharmaceuticals, St Louis, Missouri 63114, USA
    Arthritis Rheum 44:2909-21. 2001
    ..To investigate the effects of M40403, a synthetic mimetic of superoxide dismutase (SOD), on collagen-induced arthritis (CIA) in rats...
  19. pmc Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway
    Tim Doyle
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    FASEB J 25:2782-91. 2011
    ....
  20. pmc Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve
    L J Coppey
    Veterans Affairs Medical Center, Diabetes Endocrinology Research Center and Department of Internal Medicine, University of Iowa, Iowa City, IA 52246, USA
    Br J Pharmacol 134:21-9. 2001
    ..These studies provide additional evidence that diabetes-induced oxidative stress and the generation of superoxide and perhaps peroxynitrite may be partially responsible for the development of diabetic vascular and neural complications...
  21. ncbi request reprint Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis
    S Cuzzocrea
    Institute of Pharmacology, University of Messina, Messina, Italy
    Eur J Pharmacol 432:79-89. 2001
    ..The results of this study suggested that administration of a superoxide dismutase mimetic may be beneficial for treatment of inflammatory bowel disease...
  22. ncbi request reprint Superoxide: a key player in hypertension
    Salvatore Cuzzocrea
    Institute of Pharmacology, University of Messina, Italy
    FASEB J 18:94-101. 2004
    ..By removing superoxide, M40403 restores blood pressure to near-to-normal values...

Research Grants4

  1. Role of peroxynitrite in morphine hyperalgesia and tolerance
    Daniela Salvemini; Fiscal Year: 2009
    ....
  2. Role of peroxynitrite in morphine hyperalgesia and tolerance
    Daniela Salvemini; Fiscal Year: 2010
    ....