Brent A Neuschwander-Tetri

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. doi request reprint Carbohydrate intake and nonalcoholic fatty liver disease
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, Missouri 63105, USA
    Curr Opin Clin Nutr Metab Care 16:446-52. 2013
  2. pmc Dietary trans-fatty acid induced NASH is normalized following loss of trans-fatty acids from hepatic lipid pools
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University, Saint Louis, USA
    Lipids 47:941-50. 2012
  3. ncbi request reprint Nonalcoholic steatohepatitis and the metabolic syndrome
    Brent A Neuschwander-Tetri
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, St Louis, Missouri 63110, USA
    Am J Med Sci 330:326-35. 2005
  4. ncbi request reprint Fatty liver and the metabolic syndrome
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, St Louis, Missouri 63110, USA
    Curr Opin Gastroenterol 23:193-8. 2007
  5. doi request reprint Farnesoid x receptor agonists: what they are and how they might be used in treating liver disease
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Curr Gastroenterol Rep 14:55-62. 2012
  6. doi request reprint Lifestyle modification as the primary treatment of NASH
    Brent A Neuschwander-Tetri
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    Clin Liver Dis 13:649-65. 2009
  7. doi request reprint Nontriglyceride hepatic lipotoxicity: the new paradigm for the pathogenesis of NASH
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Curr Gastroenterol Rep 12:49-56. 2010
  8. pmc Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease
    Brent A Neuschwander-Tetri
    Saint Louis University School of Medicine, St Louis, MO, USA
    Hepatology 52:913-24. 2010
  9. doi request reprint Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO 63110, USA
    Hepatology 52:774-88. 2010
  10. ncbi request reprint Induced thrombospondin expression in the mouse pancreas during pancreatic injury
    Brent A Neuschwander-Tetri
    Saint Louis University Liver Center and Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA
    Int J Biochem Cell Biol 38:102-9. 2006

Research Grants

  1. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2004
  2. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2005
  3. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2006
  4. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2007
  5. Hyperinsulinemia and the pathogenesis of NASH
    Brent Neuschwander Tetri; Fiscal Year: 2007

Detail Information

Publications41

  1. doi request reprint Carbohydrate intake and nonalcoholic fatty liver disease
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, Missouri 63105, USA
    Curr Opin Clin Nutr Metab Care 16:446-52. 2013
    ..Reviewed here is basis for this relationship and the recent additional evidence that excessive dietary carbohydrate consumption, especially excessive fructose or sucrose consumption, is playing a role in the epidemic of NAFLD...
  2. pmc Dietary trans-fatty acid induced NASH is normalized following loss of trans-fatty acids from hepatic lipid pools
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University, Saint Louis, USA
    Lipids 47:941-50. 2012
    ..The substantial loss of trans-fats from the cholesteryl ester pool in parallel with improvement in NASH suggests that this pool of trans-fats could play a role in the pathogenesis of NASH...
  3. ncbi request reprint Nonalcoholic steatohepatitis and the metabolic syndrome
    Brent A Neuschwander-Tetri
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, St Louis, Missouri 63110, USA
    Am J Med Sci 330:326-35. 2005
    ..Treatment focuses on addressing the underlying insulin resistance with increased exercise and weight reduction...
  4. ncbi request reprint Fatty liver and the metabolic syndrome
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, St Louis, Missouri 63110, USA
    Curr Opin Gastroenterol 23:193-8. 2007
    ..This review briefly summarizes advances in our understanding of the pathogenesis of nonalcoholic fatty liver disease and its prevalence, natural history and treatment...
  5. doi request reprint Farnesoid x receptor agonists: what they are and how they might be used in treating liver disease
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Curr Gastroenterol Rep 14:55-62. 2012
    ....
  6. doi request reprint Lifestyle modification as the primary treatment of NASH
    Brent A Neuschwander-Tetri
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    Clin Liver Dis 13:649-65. 2009
    ....
  7. doi request reprint Nontriglyceride hepatic lipotoxicity: the new paradigm for the pathogenesis of NASH
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Curr Gastroenterol Rep 12:49-56. 2010
    ..This review examines the new evidence supporting the role of nontriglyceride fatty acid metabolites in causing NASH and how adipose and muscle insulin resistance contribute to hepatic lipotoxicity...
  8. pmc Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease
    Brent A Neuschwander-Tetri
    Saint Louis University School of Medicine, St Louis, MO, USA
    Hepatology 52:913-24. 2010
    ..70-0.79), and better for advanced fibrosis (AUROC 0.73-0.85)...
  9. doi request reprint Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO 63110, USA
    Hepatology 52:774-88. 2010
    ....
  10. ncbi request reprint Induced thrombospondin expression in the mouse pancreas during pancreatic injury
    Brent A Neuschwander-Tetri
    Saint Louis University Liver Center and Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA
    Int J Biochem Cell Biol 38:102-9. 2006
    ..These modulators of fibrogenesis could play a role in the development of pancreatic fibrosis that characterizes chronic pancreatitis...
  11. ncbi request reprint Nonalcoholic steatohepatitis: an evolving diagnosis
    B A Neuschwander-Tetri
    Saint Louis University, MO 63110, USA
    Can J Gastroenterol 14:321-6. 2000
    ..About 15% to 40% of NASH patients develop fibrosis; how many of these cases progress to cirrhosis is unknown, but about 1% of liver transplants are performed with a pretransplant diagnosis of NASH...
  12. ncbi request reprint Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis
    Brent A Neuschwander-Tetri
    Department of Internal Medicine, Saint Louis University Liver Center, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Hepatol 38:434-40. 2003
    ....
  13. ncbi request reprint Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, MO 63110, USA
    Hepatology 37:1202-19. 2003
    ....
  14. ncbi request reprint Differential expression of the trypsin inhibitor SPINK3 mRNA and the mouse ortholog of secretory granule protein ZG-16p mRNA in the mouse pancreas after repetitive injury
    Brent A Neuschwander-Tetri
    Liver Center, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Pancreas 28:e104-11. 2004
    ..These findings suggest that the pancreatic acinar cell may respond to injury with a program of self-preservation and loss of normal function...
  15. ncbi request reprint Evolving pathophysiologic concepts in nonalcoholic steatohepatitis
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    Curr Gastroenterol Rep 4:31-6. 2002
    ..Clinical trials will now determine whether treatment of insulin resistance is an effective therapy for NASH...
  16. ncbi request reprint Repetitive acute pancreatic injury in the mouse induces procollagen alpha1(I) expression colocalized to pancreatic stellate cells
    B A Neuschwander-Tetri
    Department of Internal Medicine, Saint Louis University School of Medicine, Missouri 63110, USA
    Lab Invest 80:143-50. 2000
    ..Additionally, focal areas of sustained pancreatic fibrogenesis persist after cessation of cerulein treatment, and these areas may contribute to sustained total organ collagen expression in the absence of ongoing injury...
  17. ncbi request reprint Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    Brent A Neuschwander-Tetri
    University Liver Center, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    Hepatology 38:1008-17. 2003
    ....
  18. ncbi request reprint Nonalcoholic steatohepatitis: histologic features and clinical correlations with 30 blinded biopsy specimens
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    Hum Pathol 35:1070-82. 2004
    ....
  19. doi request reprint Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse
    Barbara Ulmasov
    Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    Am J Physiol Gastrointest Liver Physiol 299:G70-80. 2010
    ..Our results demonstrate that AT1a and AT1b receptor pathways do not seem to be essential for the development of pancreatitis in the mouse model of pancreatitis induced by repetitive cerulein injury...
  20. doi request reprint Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
    Laura H Tetri
    Department of Internal Medicine, Saint Louis University, MO, USA
    Am J Physiol Gastrointest Liver Physiol 295:G987-95. 2008
    ..Because dietary trans fats promoted liver steatosis and injury, their role in the epidemic of NASH needs further evaluation...
  21. pmc Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
    Elizabeth M Brunt
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hepatology 49:809-20. 2009
    ..0001). In the pediatric biopsies, "more than mild" was associated with steatosis location (P = 0.0008) and fibrosis score (P < 0.0001), specifically, the portal/periportal fibrosis or greater fibrosis) (P < 0.01)...
  22. pmc Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings
    Elizabeth M Brunt
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Hepatology 53:810-20. 2011
    ..Higher values of the NAS were associated with higher levels of alanine aminotransferase and aspartate aminotransferase, whereas the diagnosis of SH was associated with features of the metabolic syndrome...
  23. pmc Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis
    Barbara Ulmasov
    Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri, USA
    Am J Pathol 183:692-708. 2013
    ..We also identified several genes associated with development of CP in both substrains, including RIKEN cDNA 1810009J06 gene (trypsinogen 5), Ccl8, and Ccl6. ..
  24. pmc Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis
    Barbara Ulmasov
    Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Gastrointest Liver Physiol 296:G284-94. 2009
    ..We propose that the effects of AII on injury-induced pancreatic fibrosis may be determined by the balance between AT1 and AT2 receptor signaling...
  25. ncbi request reprint Effect of significant histologic steatosis or steatohepatitis on response to antiviral therapy in patients with chronic hepatitis C
    Stephen A Harrison
    Saint Louis University Liver Center, Saint Louis University, St Louis, MS, USA
    Clin Gastroenterol Hepatol 3:604-9. 2005
    ..A control group (group 2) of 231 CHC patients was identified by using a 2-year database (January 2000-June 2001) of patients without evidence of greater than 33% steatosis or SH...
  26. ncbi request reprint Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease
    Elizabeth M Brunt
    Saint Louis University Liver Center Department of Pathology, Saint Louis University Health Sciences Center, St Louis, Missouri, USA
    Mod Pathol 16:49-56. 2003
    ..Diabetes was reported in 35%, 25%, and 9%. The concurrence of clinical and histologic features of steatohepatitis with another chronic liver disease may be a reflection of the frequency of steatohepatitis in the population at large...
  27. pmc A mechanism by which dietary trans fats cause atherosclerosis
    Chun Lin Chen
    Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, St Louis, MO 63104, USA
    J Nutr Biochem 22:649-55. 2011
    ..This effect is presumably mediated by the increased deposition of cholesterol into cellular plasma membranes in vascular tissue, as in hypercholesterolemia...
  28. pmc Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease
    Amy G Shah
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:1104-12. 2009
    ..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD...
  29. doi request reprint Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol
    Helen H Wang
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Eur J Clin Invest 43:413-26. 2013
    ....
  30. doi request reprint Steatosis in the liver
    David Q H Wang
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, Missouri
    Compr Physiol 3:1493-532. 2013
    ....
  31. ncbi request reprint The hepatocellular bile acid transporter Ntcp facilitates uptake of the lethal mushroom toxin alpha-amanitin
    Sri Gundala
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    Arch Toxicol 78:68-73. 2004
    ..6-fold induction, P<0.02 compared with stimulated transfected cells without alpha-amanitin). These findings demonstrate that Ntcp may be an important mediator of alpha-amanitin uptake by the liver...
  32. ncbi request reprint Amanita bisporigera ingestion: mistaken identity, dose-related toxicity, and improvement despite severe hepatotoxicity
    Manu Madhok
    Missouri Regional Poison Center, Cardinal Glennon Children s Hospital, St Louis, MO, USA
    Pediatr Emerg Care 22:177-80. 2006
    ..The use of nasobiliary drainage as a novel approach to interrupting the enterohepatic circulation of amatoxins is illustrated. Pathophysiology and treatment of Amanita poisoning are reviewed...
  33. ncbi request reprint Acute pancreatitis after single-dose exposure to propofol: a case report and review of literature
    Qaiser Jawaid
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Missouri 63110, USA
    Dig Dis Sci 47:614-8. 2002
  34. ncbi request reprint Primary sclerosing cholangitis: summary of a workshop
    Nicholas F Larusso
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hepatology 44:746-64. 2006
    ..Thus, significant opportunities remain for basic and clinical research into the cause, natural history, and therapy of PSC...
  35. ncbi request reprint Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction
    Michelle M Richardson
    School of Medicine, Southern Clinical Division, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Gastroenterology 133:80-90. 2007
    ..We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus...
  36. ncbi request reprint The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis
    Stephen H Caldwell
    Gastrointestinal Hepatology Division, Digestive Health Center of Excellence, University of Virginia, Charlottesville, VA 22908, USA
    Hepatology 46:1101-7. 2007
    ..Macrosteatosis (P < 0.001) and Mallory bodies (P = 0.05) significantly decreased, but no change was evident in microsteatosis, cellular enlargement, dilated endoplasmic reticulum, or apoptosis...
  37. ncbi request reprint Portal hypertensive gastropathy in chronic hepatitis C patients with bridging fibrosis and compensated cirrhosis: results from the HALT-C trial
    Robert J Fontana
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Am J Gastroenterol 101:983-92. 2006
    ....
  38. ncbi request reprint Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
    Stephen A Harrison
    Department of Gastroenterology and Hepatology, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Clin Liver Dis 8:861-79, ix. 2004
    ..The article includes current thoughts on the natural history and pathogenesis of NAFLD and describes current trends in the diagnosis and treatment of this condition...
  39. ncbi request reprint Pharmacologic management of nonalcoholic fatty liver disease
    Stephen A Harrison
    Brooke Army Medical Center, Department of Gastroenterology and Hepatology, 3851 Roger Brooke Drive, Ft Sam Houston, TX 78234, USA
    Clin Liver Dis 8:715-28, xii. 2004
    ..This article focuses on the various therapeutic agents that have been evaluated in the treatment of NAFLD and their efficacy as well as their limitations...
  40. pmc Influence of local reference populations on upper limits of normal for serum alanine aminotransferase levels
    Brent A Neuschwander-Tetri
    Arch Intern Med 168:663-6. 2008
  41. doi request reprint Hepatitis C virus-induced insulin resistance: not all genotypes are the same
    Brent A Neuschwander-Tetri
    Gastroenterology 134:619-22. 2008

Research Grants6

  1. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2004
    ..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. ..
  2. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2005
    ..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. ..
  3. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2006
    ..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. ..
  4. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2007
    ..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. ..
  5. Hyperinsulinemia and the pathogenesis of NASH
    Brent Neuschwander Tetri; Fiscal Year: 2007
    ..The primary endpoint will be improvement in the liver biopsy necroinflammatory score. ..