Wendi Neckameyer

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint Serotonin synthesis by two distinct enzymes in Drosophila melanogaster
    Chandra M Coleman
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Arch Insect Biochem Physiol 59:12-31. 2005
  2. ncbi request reprint Substrate regulation of serotonin and dopamine synthesis in Drosophila
    Chandra M Coleman
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Invert Neurosci 5:85-96. 2004
  3. pmc Comparative approaches to the study of physiology: Drosophila as a physiological tool
    Wendi S Neckameyer
    Dept of Pharmacological and Physiological Science, St Louis Univ School of Medicine, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 304:R177-88. 2013
  4. pmc Neurotrophic actions of dopamine on the development of a serotonergic feeding circuit in Drosophila melanogaster
    Wendi S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, Missouri 63104, USA
    BMC Neurosci 13:26. 2012
  5. doi request reprint Distinct neural circuits reflect sex, sexual maturity, and reproductive status in response to stress in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, MO 63104, USA
    Neuroscience 156:841-56. 2008
  6. ncbi request reprint Compartmentalization of neuronal and peripheral serotonin synthesis in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis, University School of Medicine, MO 63104, USA
    Genes Brain Behav 6:756-69. 2007
  7. ncbi request reprint Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates
    Wendi S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Biochem Genet 43:425-43. 2005
  8. ncbi request reprint Stress affects dopaminergic signaling pathways in Drosophila melanogaster
    Wendi S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, MO 63104, USA
    Stress 8:117-31. 2005
  9. ncbi request reprint Dopamine modulates female sexual receptivity in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, MO 63104, USA
    J Neurogenet 12:101-14. 1998
  10. ncbi request reprint GABA transporters in Drosophila melanogaster: molecular cloning, behavior, and physiology
    W S Neckameyer
    Department of Pharmacology and Physiological Sciences, St Louis University School of Medicine, MO 63104, USA
    Invert Neurosci 3:279-94. 1998

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Serotonin synthesis by two distinct enzymes in Drosophila melanogaster
    Chandra M Coleman
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Arch Insect Biochem Physiol 59:12-31. 2005
    ..These experiments suggest that the presence of distinct tryptophan hydroxylase enzymes may be evolutionarily conserved and serve as an ancient mechanism to appropriately regulate the production of serotonin in its target tissues...
  2. ncbi request reprint Substrate regulation of serotonin and dopamine synthesis in Drosophila
    Chandra M Coleman
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Invert Neurosci 5:85-96. 2004
    ..These studies suggest that regulation of DTPH enzymatic activity occurs, at least in part, through the actions of its substrate...
  3. pmc Comparative approaches to the study of physiology: Drosophila as a physiological tool
    Wendi S Neckameyer
    Dept of Pharmacological and Physiological Science, St Louis Univ School of Medicine, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 304:R177-88. 2013
    ..The broad and diverse array of contributions from Drosophila underscore its translational relevance to modeling human disease...
  4. pmc Neurotrophic actions of dopamine on the development of a serotonergic feeding circuit in Drosophila melanogaster
    Wendi S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, Missouri 63104, USA
    BMC Neurosci 13:26. 2012
    ..Since dopamine can function in central nervous system development, separate from its role as a neurotransmitter, the role of neuronal dopamine was assessed on the development, and mature function, of the 5-HT larval feeding circuit...
  5. doi request reprint Distinct neural circuits reflect sex, sexual maturity, and reproductive status in response to stress in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, MO 63104, USA
    Neuroscience 156:841-56. 2008
    ..These data also provide evidence for neural plasticity in the adult insect brain...
  6. ncbi request reprint Compartmentalization of neuronal and peripheral serotonin synthesis in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis, University School of Medicine, MO 63104, USA
    Genes Brain Behav 6:756-69. 2007
    ..We also show that DTPHu functions in vivo as a phenylalanine hydroxylase in addition to its role as the peripheral TPH in Drosophila, and is critical for non-neuronal developmental events...
  7. ncbi request reprint Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates
    Wendi S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Biochem Genet 43:425-43. 2005
    ..Drosophila thus provides a highly conserved and tractable model system in which to test the functional consequences of perturbing TH activity by acute regulatory mechanisms...
  8. ncbi request reprint Stress affects dopaminergic signaling pathways in Drosophila melanogaster
    Wendi S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, MO 63104, USA
    Stress 8:117-31. 2005
    ..Transgenic Drosophila with reduced levels of neuronal dopamine displayed an altered response to these stressors, suggesting that, as in mammals, dopamine is a key element in the stress response...
  9. ncbi request reprint Dopamine modulates female sexual receptivity in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, MO 63104, USA
    J Neurogenet 12:101-14. 1998
    ....
  10. ncbi request reprint GABA transporters in Drosophila melanogaster: molecular cloning, behavior, and physiology
    W S Neckameyer
    Department of Pharmacology and Physiological Sciences, St Louis University School of Medicine, MO 63104, USA
    Invert Neurosci 3:279-94. 1998
    ..The data suggest that, as in mammals, there are multiple GABA transporters in Drosophila whose expression is differentially regulated...
  11. ncbi request reprint Dopamine and senescence in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Neurobiol Aging 21:145-52. 2000
    ..These results suggest that the deficits seen in dopaminergic-modulated behaviors may arise as a consequence of degenerative changes within the aging brain...
  12. ncbi request reprint Dopamine and sensory tissue development in Drosophila melanogaster
    W Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63108, USA
    J Neurobiol 47:280-94. 2001
    ..The beta-galactosidase expression colocalized with tyrosine hydroxylase protein. These results are consistent with a developmental requirement for dopamine in the normal physiology of adult sensory tissues...
  13. ncbi request reprint Pharmacological evidence for GABAergic regulation of specific behaviors in Drosophila melanogaster
    Sandra M Leal
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, Missouri 63103, USA
    J Neurobiol 50:245-61. 2002
    ....
  14. doi request reprint A trophic role for serotonin in the development of a simple feeding circuit
    Wendi S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA neckamws slu edu
    Dev Neurosci 32:217-37. 2010
    ..We conclude that 5-HT is tightly regulated during CNS development to direct the normal architecture and mature function of this neural circuit...
  15. ncbi request reprint GABAergic modulation of motor-driven behaviors in juvenile Drosophila and evidence for a nonbehavioral role for GABA transport
    Sandra M Leal
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, Missouri 63103, USA
    J Neurobiol 61:189-208. 2004
    ....
  16. pmc Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila
    Danling Wang
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:13520-5. 2006
    ....
  17. ncbi request reprint Talking the talk: the role of VEGF proteins in cell signaling
    Sandra M Leal
    Trends Endocrinol Metab 13:319-20. 2002
    ....
  18. pmc Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns
    Erin M Smith
    Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583 0806, USA
    J Nutr 137:2006-12. 2007
    ..Biotinylation of histones was barely detectable in biotin-deprived flies, suggesting that epigenetic events might have contributed to effects of biotin deprivation...

Research Grants5

  1. MOLECULAR ANALYSIS OF THE DROSOPHILA GABA TRANSPORTERS
    Wendi Neckameyer; Fiscal Year: 2001
    ....
  2. Hormonal Factors and Recruitment of Neurons into the Stress Response Circuitry
    Wendi S Neckameyer; Fiscal Year: 2010
    ..This will provide a unique and innovative approach to modeling the development and organization of the stress circuitry in mammals. ..