J E Morley

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint Anorexia, body composition, and ageing
    J E Morley
    GRECC, VA Medical Center, St Louis, Missouri, USA
    Curr Opin Clin Nutr Metab Care 4:9-13. 2001
  2. ncbi request reprint Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice
    V B Kumar
    Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, St Louis, MO, USA
    Peptides 21:1769-75. 2000
  3. ncbi request reprint Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding
    J E Morley
    Geriatric Research, Education and Clinical Center, VA Medical Center, St Louis, MO 63125, USA
    Peptides 20:595-600. 1999
  4. ncbi request reprint Regional transport of TNF-alpha across the blood-brain barrier in young ICR and young and aged SAMP8 mice
    W A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Division of Geriatrics, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63106, USA
    Neurobiol Aging 22:671-6. 2001
  5. ncbi request reprint The pharmacology of post-trial memory processing in septum
    J F Flood
    Geriatric Research Education and Clinical Center, St Louis, MO 63106, USA
    Eur J Pharmacol 350:31-8. 1998
  6. ncbi request reprint Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory
    J E Morley
    Geriatric Research, Education and Clinical Center, St Louis Department of Veterans Affairs Medical Center, 63104, St Louis, MO, USA
    Peptides 21:1761-7. 2000
  7. ncbi request reprint Estradiol potentiates acetylcholine and glutamate-mediated post-trial memory processing in the hippocampus
    S A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO, USA
    Brain Res 864:263-9. 2000
  8. ncbi request reprint Anorexia, sarcopenia, and aging
    J E Morley
    Geriatric Research, Education, and Clinical Center, St. Louis VAMC, and the Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, Missouri, USA
    Nutrition 17:660-3. 2001
  9. ncbi request reprint Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally administered dehydroepiandrosterone sulfate but not pregnenolone sulfate
    J F Flood
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO 63106, USA
    Psychoneuroendocrinology 24:799-811. 1999
  10. ncbi request reprint Effects of wheatgerm agglutinin and aging on the regional brain uptake of HIV-1GP120
    W A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Department of Internal Medicine, MO, USA
    Life Sci 65:81-9. 1999

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Anorexia, body composition, and ageing
    J E Morley
    GRECC, VA Medical Center, St Louis, Missouri, USA
    Curr Opin Clin Nutr Metab Care 4:9-13. 2001
    ..Depression is the most common cause of weight loss in older individuals. Dieting in older individuals is associated with a loss of skeletal tissue as well as fat mass. This can place older individuals at risk of becoming the 'fat frail'...
  2. ncbi request reprint Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice
    V B Kumar
    Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, St Louis, MO, USA
    Peptides 21:1769-75. 2000
    ..These results show that AO directed at the Abeta region of APP can reduce APP levels in the brain and reverse deficits in learning and memory...
  3. ncbi request reprint Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding
    J E Morley
    Geriatric Research, Education and Clinical Center, VA Medical Center, St Louis, MO 63125, USA
    Peptides 20:595-600. 1999
    ..The alterations of NOS in brown adipose tissue following leptin administration could result in changes in blood flow or metabolism in the brown fat...
  4. ncbi request reprint Regional transport of TNF-alpha across the blood-brain barrier in young ICR and young and aged SAMP8 mice
    W A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Division of Geriatrics, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63106, USA
    Neurobiol Aging 22:671-6. 2001
    ..These results show blood-borne TNF enters some regions of the brain much more readily than others and TNF transport is increased into some brain regions of the SAMP8 mice at an age when learning and memory are impaired...
  5. ncbi request reprint The pharmacology of post-trial memory processing in septum
    J F Flood
    Geriatric Research Education and Clinical Center, St Louis, MO 63106, USA
    Eur J Pharmacol 350:31-8. 1998
    ..Receptor agonists of serotonin, gamma-amino butyric acid (GABA) and opioids impaired retention, while antagonists improved retention...
  6. ncbi request reprint Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory
    J E Morley
    Geriatric Research, Education and Clinical Center, St Louis Department of Veterans Affairs Medical Center, 63104, St Louis, MO, USA
    Peptides 21:1761-7. 2000
    ..This reversal of cognitive deficits provides a link between increased expression of both APP and Abeta protein and learning and memory loss in these mice...
  7. ncbi request reprint Estradiol potentiates acetylcholine and glutamate-mediated post-trial memory processing in the hippocampus
    S A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO, USA
    Brain Res 864:263-9. 2000
    ..These findings support the concept that estrogen improves memory by potentiating the activity of the cholinergic and glutamatergic systems...
  8. ncbi request reprint Anorexia, sarcopenia, and aging
    J E Morley
    Geriatric Research, Education, and Clinical Center, St. Louis VAMC, and the Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, Missouri, USA
    Nutrition 17:660-3. 2001
    ..Numerous treatable causes of anorexia and weight loss exist. Depression is the most commonly diagnosed cause of pathologic weight loss in older persons...
  9. ncbi request reprint Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally administered dehydroepiandrosterone sulfate but not pregnenolone sulfate
    J F Flood
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO 63106, USA
    Psychoneuroendocrinology 24:799-811. 1999
    ..It was concluded that EMATE, acting peripherally, increased plasma levels of DHEAS which entered the brain and added to the effect of centrally administered DHEAS. The failure of EMATE to potentiate PREGS is discussed...
  10. ncbi request reprint Effects of wheatgerm agglutinin and aging on the regional brain uptake of HIV-1GP120
    W A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Department of Internal Medicine, MO, USA
    Life Sci 65:81-9. 1999
    ....
  11. ncbi request reprint Septo-hippocampal drug interactions in post-trial memory processing
    S A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO 63109, USA
    Brain Res 847:221-30. 1999
    ..The results of this study are compatible with models that propose that serotonin innervation from the median raphe drives GABA interneurons in the medial septum that synapse on cholinergic neurons projecting to the hippocampus...
  12. ncbi request reprint Testosterone replacement in older men and women
    J E Morley
    GRECC, VA Medical Center, St. Louis, MO, USA
    J Gend Specif Med 4:49-53. 2001
    ..Less information is available concerning the role of testosterone in postmenopausal women, but testosterone replacement may have a role to play in treating disorders of libido and the sarcopenia that occurs at menopause...
  13. ncbi request reprint The cortical neuropeptide, cortistatin-14, impairs post-training memory processing
    J F Flood
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO 63106, USA
    Brain Res 775:250-2. 1997
    ..After 1 week, training was resumed to determine the effect of cortistatin-14 on retention. Cortistatin-14 was found to impair retention relative to the control group at doses of 0.5-5.0 micrograms...
  14. ncbi request reprint Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum
    W A Banks
    Veterans Affair Meical Center, St Louis, Missouri 63106, USA
    J Pharmacol Exp Ther 299:536-41. 2001
    ..In conclusion, these results show that exogenous, blood-borne hIL-1alpha affects memory by releasing mIL-1alpha from endogenous stores and by crossing the BBB to act at sites within the PDS...
  15. ncbi request reprint Frailty and the aging male
    J E Morley
    GRECC, VA Medical Center, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    Aging Male 8:135-40. 2005
    ..Sarcopenia occurs predominantly because of hormone deficiency and cytokine excess. Pain and anorexia are also associated with frailty. Stem cell research represents a potential promise for the treatment of frailty...
  16. ncbi request reprint Testosterone, aging and quality of life
    J E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Endocrinol Invest 28:76-80. 2005
    ..This is particularly important in view of the substantial placebo effect on aging symptomatology...
  17. ncbi request reprint Hormone replacement therapy and fractures in older adults
    H K Kamel
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
    J Am Geriatr Soc 49:179-87. 2001
    ..In men, there is early evidence that testosterone replacement therapy may enhance bone mass in hypogonadal men...
  18. ncbi request reprint Age-related changes in septal serotonergic, GABAergic and glutamatergic facilitation of retention in SAMP8 mice
    J F Flood
    Geriatric Research Education and Clinical Center, VA Medical Center, St Louis University School of Medicine, MO 63106, USA
    Mech Ageing Dev 105:173-88. 1998
    ..SAMP8 mice may show an age-related impairment of septohippocampal functioning...
  19. ncbi request reprint The effect of cholinergic, GABAergic, serotonergic, and glutamatergic receptor modulation on posttrial memory processing in the hippocampus
    S A Farr
    Geriatric Research Education and Clinical Center, VA Medical Center, St Louis, MO 63106, USA
    Neurobiol Learn Mem 73:150-67. 2000
    ..Receptor agonists of serotonin and GABA impaired retention, while antagonists improved retention. Drugs acting on 5-HT-1 and 5-HT-2 as well as GABA(A) and GABA(B) receptor subtypes did not differentially effect retention...
  20. ncbi request reprint Permeability of the blood-brain barrier to albumin and insulin in the young and aged SAMP8 mouse
    W A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Department of Internal Medicine, Missouri, USA
    J Gerontol A Biol Sci Med Sci 55:B601-6. 2000
    ..We conclude that alterations in BBB integrity or the activity of the BBB insulin transporter do not underlie the deficits in learning and memory seen in the aged SAMP8 mouse...
  21. ncbi request reprint Rapid assay for nitric oxide synthase using thin-layer chromatography
    V B Kumar
    Geriatric Research Education and Clinical Center, St Louis VA Medical Center, St Louis, Missouri 63125, USA
    Anal Biochem 269:17-20. 1999
    ..This method is versatile and allows rapid simultaneous assay of several samples in a short period of time. Therefore, this assay is very useful for both qualitative and quantitative estimation of NOS activity...
  22. ncbi request reprint Effect of age on calcium-dependent proteins in hippocampus of senescence-accelerated mice
    H J Armbrecht
    Geriatric Research, Education, and Clinical Center, St Louis VA Medical Center, St Louis, MO 63125, USA
    Brain Res 842:287-93. 1999
    ..These studies demonstrate a decrease in the amount and distribution of hippocampal PKC-gamma in the SAMP8 between 4 and 12 months that is associated with decreased retention...
  23. ncbi request reprint Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention
    S A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center 151 JC 915 N Grand Blvd, St Louis, MO 63109, USA
    Brain Res 872:242-9. 2000
    ..The current findings indicate that the hippocampus plays an important role in learning and memory processing in the aversive T-maze paradigm...
  24. ncbi request reprint Cachexia and aging: an update based on the Fourth International Cachexia Meeting
    J E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine and GRECC, VA Medical Center, St Louis, MO 63104, USA
    J Nutr Health Aging 13:47-55. 2009
    ..It stresses the importance of these conditions in older persons...
  25. ncbi request reprint The hormonal fountains of youth: myth or reality?
    M J Kim
    Division of Geriatric Medicine, Saint Louis University School of Medicine and Geriatrics Research, Education and Clinical Care Center, VA Medical Center, Missouri 63104, USA
    J Endocrinol Invest 28:5-14. 2005
    ..Modern research has, however, demonstrated that the concept of a "hormonal fountain of youth" is predominantly mythological...
  26. doi request reprint Testosterone modulates gene expression pathways regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle
    M T Haren
    Geriatric Research, Education and Clinical Center GRECC, St Louis Veterans Affairs Medical Center, St Louis, MO 63125, USA
    Int J Androl 34:55-68. 2011
    ..These findings identify specific mechanisms by which testosterone may regulate skeletal muscle glucose and protein metabolism...
  27. ncbi request reprint Serum leptin levels in wild and captive populations of baboons (papio): implications for the ancestral role of leptin
    W A Banks
    Geriatric Research, Educational and Clinical Center, Veterans Affairs Medical Center St Louis, St Louis, Missouri 63106, USA
    J Clin Endocrinol Metab 86:4315-20. 2001
    ..In comparison, captive baboons had levels about three times higher than wild baboons, with a clear inverse relation between age and leptin levels. These results support the view that leptin evolved to be effective at low levels...
  28. ncbi request reprint Androgens and aging
    J E Morley
    Division of Geriatric Medicine, Room M238, Saint Louis University Medical School, 1402 South Grand Blvd, St Louis, MO 63104 1028, USA
    Maturitas 38:61-71; discussion 71-3. 2001
    ..Less data is available to support the use of DHEA or its sulfate or pregnenolone. Further studies are clearly necessary in all these areas. However, it may be tentatively concluded that we are at the dawning of the age of androgens...
  29. ncbi request reprint Anorexia of aging in long term care: is dronabinol an effective appetite stimulant?--a pilot study
    M M G Wilson
    Division of Geriatric Medicine, Saint Louis University, 1402, S Grand Blvd, Rm M238, St Louis, MO 63104, USA
    J Nutr Health Aging 11:195-8. 2007
    ..In patients who fail to respond to nutritional intervention, orexigenic drugs are sometimes prescribed. There is limited data regarding the safety and efficacy of these drugs in older adults...
  30. ncbi request reprint A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans
    J E Morley
    Division of Geriatrics, Department of Internal Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    J Nutr Health Aging 16:601-8. 2012
    ..To validate the FRAIL scale...
  31. ncbi request reprint Delivery across the blood-brain barrier of antisense directed against amyloid beta: reversal of learning and memory deficits in mice overexpressing amyloid precursor protein
    W A Banks
    Geriatric Research, Education and Clinical Center, St. Louis Veterans Affairs Medical Center and Department of Internal Medicine, Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA
    J Pharmacol Exp Ther 297:1113-21. 2001
    ..c.v. dose reversed the learning and memory deficits of aged SAMP8 mice. These studies show for the first time that phosphorothiolate oligonucleotides can be delivered to the brain in effective doses by intravenous administration...
  32. ncbi request reprint Andropause: is the emperor wearing any clothes?
    S H Tariq
    GRECC, VA Medical Center and Division of Geriatric Medicine, Saint Louis University, St Louis, Missouri, USA
    Rev Endocr Metab Disord 6:77-84. 2005
  33. ncbi request reprint Effect of metformin on nitric oxide synthase in genetically obese (ob/ob) mice
    V B Kumar
    Geriatric Research, Education and Clinical Center, VA Medical Center, St. Louis, MO 63125, USA
    Life Sci 69:2789-99. 2001
    ..No effect of metformin was observed in white adipose tissue of control or obese mice. Thus, metformin may produce anorectic effects through modulation of NOS...
  34. ncbi request reprint Overview of the MNA--Its history and challenges
    B Vellas
    INSERM U 558, Department of Geriatrics, Toulouse University Hospital, Toulouse, France
    J Nutr Health Aging 10:456-63; discussion 463-5. 2006
    ..A short screening version (MNA-SF) has been developed, which, if positive, indicates the need to complete the full MNA. It takes less than 4 minutes to administer the MNA-SF and between 10 and 15 minutes for the full MNA...
  35. ncbi request reprint The I.A.N.A Task Force on frailty assessment of older people in clinical practice
    G Abellan Van Kan
    Department of Geriatric Medicine, Pavillon J P Junod, CHU Toulouse, 170 avenue de Casselardit, TSA40031, 31059 Toulouse Cedex 9, France
    J Nutr Health Aging 12:29-37. 2008
    ....
  36. ncbi request reprint A prospective, randomized clinical study of adjunctive peripheral parenteral nutrition in adult subacute care patients
    D R Thomas
    Division of Geriatric Medicine and The GRECC, Jefferson Barracks VA Medical Center, Saint Louis, MO 63104, USA
    J Nutr Health Aging 9:321-5. 2005
    ..However, no data exists for the use of peripheral parenteral nutrition longer than two weeks and overall there are remarkably few studies on the efficacy of peripheral parenteral nutrition...
  37. ncbi request reprint Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations
    E Nieschlag
    Institute of Reproductive Medicine, University of Munster, Germany
    J Androl 27:135-7. 2006
  38. ncbi request reprint Lipid peroxidation in brain during aging in the senescence-accelerated mouse (SAM)
    A L Petursdottir
    Department of Physiology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, IS 101 Reykjavik, Iceland
    Neurobiol Aging 28:1170-8. 2007
    ..The oldest age group contained the highest concentration of alpha-tocopherol, indicating a protection against oxidative damage of PUFA in brain membrane phospholipids...
  39. ncbi request reprint Investigation, treatment and monitoring of late-onset hypogonadism in males
    E Nieschlag
    Institute of Reproductive Medicine, University of Munster, Germany
    Aging Male 8:56-8. 2005
  40. ncbi request reprint Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain
    H F Poon
    Department of Chemistry, University of Kentucky, Lexington, KY 40506 0055, USA
    Neuroscience 126:915-26. 2004
    ....
  41. ncbi request reprint Impaired cognitive function and mental performance in mild dehydration
    M M G Wilson
    Division of Geriatric Medicine, St Louis University Health Sciences Center, and GRECC, Veteran s Administration Medical Center, MO 63104, USA
    Eur J Clin Nutr 57:S24-9. 2003
    ..Intervention models directed toward improving outcomes in dehydration must incorporate strategies to enhance prompt recognition of cognitive dysfunction...
  42. ncbi request reprint Examining the effect of intervention to nutritional problems of the elderly living in an inner city area: a pilot project
    Y Suda
    Department of Sociology, St. Louis University, MO 63103, USA
    J Nutr Health Aging 5:118-23. 2001
    ..CONCLUSION: A combination of interventions by medical professionals and by trained neighborhood residents seemed to be an effective strategy to approach nutritional problems of seniors living in inner city areas...
  43. ncbi request reprint Sarcopenia
    J E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, MO 63104, USA
    J Lab Clin Med 137:231-43. 2001
    ..Decreased physical activity with aging appears to be the key factor involved in producing sarcopenia. An increased research emphasis on the factors involved in the pathogenesis of sarcopenia is needed...
  44. ncbi request reprint Defining 'relative' androgen deficiency in aging men: how should testosterone be measured and what are the relationships between androgen levels and physical, sexual and emotional health?
    M T Haren
    Department of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia
    Climacteric 5:15-25. 2002
    ..The maximum benefit occurs in those men with the lowest testosterone levels...
  45. ncbi request reprint Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8)
    V B Kumar
    Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, MO 63125, USA
    Biochem Cell Biol 79:57-67. 2001
    ..The expression could be regulated in a time- and concentration-dependent manner by using an antisense oligonucleotide specific to APP mRNA. Such regulation of APP expression may have a therapeutic application in vivo...
  46. ncbi request reprint The GAIN (Geriatric Anorexia Nutrition) registry: the impact of appetite and weight on mortality in a long-term care population
    D H Sullivan
    GRECC, Central Arkansas Veterans Healthcare System, and Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Nutr Health Aging 6:275-81. 2002
    ....
  47. pmc Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease
    W A Banks
    Geriatrics Research Educational and Clinical Center, Veterans Affairs Medical Center St Louis and Division of Geriatrics, Department of Internal Medicine, St Louis University School of Medicine, St Louis, MO 63106, USA
    Neuroscience 121:487-92. 2003
    ..These differences in the efflux of the various forms of AbetaP among the three groups of mice supports the hypothesis that impaired efflux is an important factor in the accumulation of AbetaP in the CNS...
  48. ncbi request reprint Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men
    C G MacIntosh
    Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Australia
    Am J Gastroenterol 96:997-1007. 2001
    ..d. nutrients. An enhanced satiating effect of small intestinal carbohydrates may potentially contribute to the anorexia of aging...
  49. ncbi request reprint Systemic inflammatory markers in older persons: the effect of oral nutritional supplementation with prebiotics
    E J Schiffrin
    Nestlé Nutrition, Nestec Ltd Avenue Reller 22, CH 1800 Vevey, Switzerland
    J Nutr Health Aging 11:475-9. 2007
    ..To evaluate the effect of oral nutritional supplementation with and without oligosaccharides on gut bacteriology, in particular the bifidogenic flora, and on immunology and inflammatory parameters in older persons at risk of malnutrition...
  50. ncbi request reprint Effect of competitive antagonism of NO synthetase on weight and food intake in obese and diabetic mice
    J E Morley
    Geriatric Research Educational and Clinical Center, Veterans Affairs Medical Center, St Louis 63106
    Am J Physiol 266:R164-8. 1994
    ..01). A small decrease in body weight and food intake was seen in db/db and db/c mice receiving L-NAME. These studies provide further evidence for a role of nitric oxide in the modulation of food intake and weight gain...
  51. ncbi request reprint Measurement of nitric oxide synthase and its mRNA in genetically obese (ob/ob) mice
    J E Morley
    Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, MO, USA
    Life Sci 57:1327-31. 1995
    ..01) and NOS mRNA was 32.0 +/- 5.0 pg NOS mRNA/mg total RNA in ob/ob compared to 12.4 +/- 4.0 in ob/c (p < 0.05). These studies further support the possibility of a role for nitric oxide in the regulation of food intake...
  52. ncbi request reprint Is weight loss harmful to older men?
    J E Morley
    Aging Male 9:135-7. 2006
  53. ncbi request reprint Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging
    C G MacIntosh
    Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia 5000
    J Clin Endocrinol Metab 86:5830-7. 2001
    ..Because older people retain their sensitivity to the satiating effects of exogenous CCK and plasma endogenous CCK concentrations are higher in older people, increased CCK activity may contribute to the anorexia of aging...
  54. ncbi request reprint Effects of aging on the opioid modulation of feeding in humans
    C G MacIntosh
    University of Adelaide, Department of Medicine, Royal Adelaide Hospital, Australia
    J Am Geriatr Soc 49:1518-24. 2001
    ..Possible gender differences in this sensitivity warrant further investigation. A decline in opioid activity is unlikely to contribute substantially to the physiological anorexia of aging observed in older people...
  55. ncbi request reprint Treating malnutrition with megestrol acetate: literature review and review of our experience
    E Karcic
    Division of Geriatrics, Saint Louis University, GRECC, Saint Louis Veteran s Administration Medical Center
    J Nutr Health Aging 6:191-200. 2002
    ....
  56. ncbi request reprint The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics
    A Lee
    Department of Medicine, St Louis University Medical Center, and GRECC, St Louis VA Medical Center, St Louis, MO, USA
    Diabetes Obes Metab 4:329-35. 2002
    ..GLP-1 plays a role to mediate satiety. Any agent that substantially elevates GLP-1 levels may theoretically reduce hunger, increase satiation and limit food intake...
  57. ncbi request reprint Longitudinal study of fasting serum glucose concentrations in healthy elderly. The New Mexico Aging Process Study
    R D Lindeman
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
    J Nutr Health Aging 7:172-7. 2003
    ..The American Diabetes Association s Expert Committee on the Diagnosis and Classification of Diabetes Mellitus has made the recommendation that all individuals over the age of 45 years should be screened for diabetes every 3 years...
  58. ncbi request reprint Investigation, treatment and monitoring of late-onset hypogonadism in males. ISA, ISSAM, and EAU recommendations
    E Nieschlag
    Institute of Reproductive Medicine, University of Munster, Germany
    Eur Urol 48:1-4. 2005
  59. ncbi request reprint Geriatric future history
    J E Morley
    Division of Geriatric Medicine, Saint Louis University Medical Center And Geriatric Research, Education and Clinical Center St Louis Veterans Administration, USA
    J Nutr Health Aging 10:431. 2006