J E Morley

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. doi request reprint Undernutrition in older adults
    John E Morley
    Department of Internal Medicine, Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Fam Pract 29:i89-i93. 2012
  2. doi request reprint Frailty consensus: a call to action
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Am Med Dir Assoc 14:392-7. 2013
  3. doi request reprint Scientific overview of hormone treatment used for rejuvenation
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Fertil Steril 99:1807-13. 2013
  4. doi request reprint Frailty, sarcopenia, and hormones
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Endocrinol Metab Clin North Am 42:391-405. 2013
  5. doi request reprint Pathophysiology of the anorexia of aging
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Curr Opin Clin Nutr Metab Care 16:27-32. 2013
  6. doi request reprint Behavioral management in the person with dementia
    J E Morley
    J E Morley, Division of Geriatric Medicine, St Louis University School of Medicine, 1402 S Grand Blvd, M238, St Louis, MO 63104, Email
    J Nutr Health Aging 17:35-8. 2013
  7. doi request reprint The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Biochim Biophys Acta 1822:650-6. 2012
  8. ncbi request reprint A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans
    J E Morley
    Division of Geriatrics, Department of Internal Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    J Nutr Health Aging 16:601-8. 2012
  9. doi request reprint Hormesis and amyloid-β protein: physiology or pathology?
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    J Alzheimers Dis 29:487-92. 2012
  10. doi request reprint Sarcopenia in the elderly
    John E Morley
    Geriatric Research, Education and Clinical Center GRECC, Veterans Affairs Medical Center and Department of Internal Medicine, Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Fam Pract 29:i44-i48. 2012

Collaborators

Detail Information

Publications150 found, 100 shown here

  1. doi request reprint Undernutrition in older adults
    John E Morley
    Department of Internal Medicine, Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Fam Pract 29:i89-i93. 2012
    ..The major causes are anorexia, cachexia, sarcopenia, dehydration, malabsorption and hypermetabolism. This article also provides an overview of the use of nutritional supplements and an approach to managing protein energy wasting...
  2. doi request reprint Frailty consensus: a call to action
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Am Med Dir Assoc 14:392-7. 2013
    ..4. For the purposes of optimally managing individuals with physical frailty, all persons older than 70 years and all individuals with significant weight loss (>5%) due to chronic disease should be screened for frailty...
  3. doi request reprint Scientific overview of hormone treatment used for rejuvenation
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Fertil Steril 99:1807-13. 2013
    ..Overall, exercise, adequate exposure to sunlight, and adequate dietary protein appear to have at least as positive an effect as any of the hormones being used to rejuvenate older persons...
  4. doi request reprint Frailty, sarcopenia, and hormones
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Endocrinol Metab Clin North Am 42:391-405. 2013
    ..Exercise (resistance and aerobic), vitamin D and protein supplementation, and reduction of polypharmacy are keys to the treatment of frailty...
  5. doi request reprint Pathophysiology of the anorexia of aging
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Curr Opin Clin Nutr Metab Care 16:27-32. 2013
    ..Anorexia represents a major problem for older persons leading to weight loss, sarcopenia, functional decline, and mortality. There is increasing information on the pathophysiological mechanisms that lead to anorexia...
  6. doi request reprint Behavioral management in the person with dementia
    J E Morley
    J E Morley, Division of Geriatric Medicine, St Louis University School of Medicine, 1402 S Grand Blvd, M238, St Louis, MO 63104, Email
    J Nutr Health Aging 17:35-8. 2013
    ..As proposed by the IAGG/WHO position paper on nursing homes there is a high need for research and education on behavioral interventions for agitated behavior...
  7. doi request reprint The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Biochim Biophys Acta 1822:650-6. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
  8. ncbi request reprint A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans
    J E Morley
    Division of Geriatrics, Department of Internal Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    J Nutr Health Aging 16:601-8. 2012
    ..To validate the FRAIL scale...
  9. doi request reprint Hormesis and amyloid-β protein: physiology or pathology?
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    J Alzheimers Dis 29:487-92. 2012
    ..It is postulated that both over- and underproduction of amyloid-β can lead to memory deficits. This is similar to a number of hormonal diseases, e.g., thyroid, where both low and high levels produce disease...
  10. doi request reprint Sarcopenia in the elderly
    John E Morley
    Geriatric Research, Education and Clinical Center GRECC, Veterans Affairs Medical Center and Department of Internal Medicine, Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Fam Pract 29:i44-i48. 2012
    ..There is an emerging role for testosterone and other anabolic steroids. An activin II receptor soluble fusion protein is showing great potential to increase muscle mass and bone mineral density...
  11. ncbi request reprint The SAMP8 mouse: a model to develop therapeutic interventions for Alzheimer's disease
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Curr Pharm Des 18:1123-30. 2012
    ..An antisense to APP has been developed that reverses the cognitive deficits and oxidative damage. This antisense represents a potential treatment for Alzheimer's disease...
  12. ncbi request reprint Pathophysiology of anorexia
    John E Morley
    Division of Geriatric Medicine, St Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA
    Clin Geriatr Med 18:661-73, v. 2002
    ..This article first reviews the physiologic factors responsible for anorexia in older persons. It then reviews the major pathologic processes responsible for producing protein-energy malnutrition in older persons...
  13. doi request reprint Diabetes, sarcopenia, and frailty
    John E Morley
    Geriatric Research Education and Clinical Center, St Louis VA Medical Center, 1 Jefferson Barracks Drive, 11E, St Louis, MO 63125, USA
    Clin Geriatr Med 24:455-69, vi. 2008
    ..Diabetics develop the conditions necessary for frailty earlier than other aging individuals. Appropriate treatment of diabetes mellitus and frailty precursors can result in a slowing of the aging process...
  14. ncbi request reprint Orexigenic and anabolic agents
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard M238, Saint Louis, MO 63104, USA
    Clin Geriatr Med 18:853-66. 2002
    ..An approach to the management of anorexia and weight loss in older persons is given in Fig. 1. Thomas et al have provided a more complex algorithm the management of weight loss in nursing home residents...
  15. doi request reprint Cachexia and neuropeptide Y
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Nutrition 24:815-9. 2008
    ..Activation of neuronal nitric oxide synthase results in increased adenosine monophosphate kinase and a decrease in malonyl coenzyme A, leading to increased food intake...
  16. ncbi request reprint Cachexia and aging: an update based on the Fourth International Cachexia Meeting
    J E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine and GRECC, VA Medical Center, St Louis, MO 63104, USA
    J Nutr Health Aging 13:47-55. 2009
    ..It stresses the importance of these conditions in older persons...
  17. ncbi request reprint Frailty and hormones
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine and GRECC, VA Medical Center, St Louis, Missouri 63104, USA
    Rev Endocr Metab Disord 6:101-8. 2005
  18. doi request reprint Calories and cachexia
    John E Morley
    GRECC, VA Medical Center and Division of Geriatric Medicine, Saint Louis University, School of Medicine, 1402 S Grand Blvd, M238, St Louis, MO 63104, USA
    Curr Opin Clin Nutr Metab Care 12:607-10. 2009
    ..Anorexia and weight loss are associated with increased mortality in cachectic patients. The role of caloric supplementation is controversial. The purpose of this review is to examine the role of calorie supplementation in cachexia...
  19. ncbi request reprint Frailty
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, MO 63104, USA
    Med Clin North Am 90:837-47. 2006
    ..In people who have frailty aggressive health promotion and disease prevention techniques can lead to an inhibition of the downward spiral to disability...
  20. doi request reprint Antiaging, longevity and calorie restriction
    John E Morley
    GRECC, VA Medical Center, St Louis, Missouri, USA
    Curr Opin Clin Nutr Metab Care 13:40-5. 2010
    ..The role of calorie restriction in humans is controversial. Recently, new data in monkeys and humans have provided new insights into the potential role of calorie restriction in longevity...
  21. ncbi request reprint The SAMP8 mouse: a model of Alzheimer disease?
    John E Morley
    Division of Geriatric Medicine, Saint Louis University, Missouri, USA
    Biogerontology 3:57-60. 2002
    ..The SAMP8 mouse appears to be an excellent model to examine the pathophysiology of early defects seen in Alzheimer disease...
  22. ncbi request reprint Developing novel therapeutic approaches to frailty
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine and GRECC, VA Medical Center, St Louis, Missouri 63104, USA
    Curr Pharm Des 15:3384-95. 2009
    ..While, at present, exercise is the primary therapy, it is expected over the next decade that numerous drugs will be available to treat components of the frailty syndrome...
  23. ncbi request reprint Validation of salivary testosterone as a screening test for male hypogonadism
    John E Morley
    Division of Geriatric Medicine, Saint Louis University, Missouri 63104, USA
    Aging Male 9:165-9. 2006
    ..Saliva collection is an easy, non-invasive method to measure hormones...
  24. ncbi request reprint Nutrition and cognition in older persons
    John E Morley
    GRECC, St Louis VA Medical Center, MO, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 6:121-30; discussion 130-4. 2002
  25. ncbi request reprint Hormones and the aging process
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine and Geriatrics Research, Education and Clinical Care Center, VA Medical Center, St Louis, Missouri 63104, USA
    J Am Geriatr Soc 51:S333-7. 2003
    ..The best evidence for hormonal replacement is vitamin D and estrogen replacement to prevent hip fractures. Other than that, treatment should be limited to hormone replacement in persons who have endocrine disease...
  26. ncbi request reprint The medical director, JAMDA, and the twenty-first century
    John E Morley
    Division of Geriatrics Medicine, Saint Louis University Medical Center, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    J Am Med Dir Assoc 8:65-7. 2007
  27. ncbi request reprint The aging gut: physiology
    John E Morley
    Division of Geriatric Medicine, Saint Louis University Medical Center, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA
    Clin Geriatr Med 23:757-67, v-vi. 2007
    ..Nevertheless, physiologic changes play a role in the anorexia of aging, postprandial hypotension, aspiration pneumonia, increased Clostridium difficile infections, fecal incontinence, gallstones, and altered drug metabolism...
  28. ncbi request reprint Constipation and irritable bowel syndrome in the elderly
    John E Morley
    Division of Geriatric Medicine, Saint Louis University Medical Center, Saint Louis University School of Medicine, 1402 S Grand Blvd, M238, St Louis, MO 63104, USA
    Clin Geriatr Med 23:823-32, vi-vii. 2007
    ..Irritable bowel syndrome should be considered in the differential diagnosis of abdominal pain, diarrhea and constipation in older persons...
  29. ncbi request reprint The diagnosis of late life hypogonadism
    John E Morley
    Division of Geriatric Medicine, Saint Louis University Medical Center, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
    Aging Male 10:217-20. 2007
    ..While this may appear to be a radical proposal, we believe it represents the most rigorous scientific approach to the diagnosis of late life hypogonadism at the present time...
  30. ncbi request reprint Female sexuality
    John E Morley
    Division of Geriatric Medicine, St Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA
    Med Clin North Am 87:1077-90. 2003
    ..Overall, there is a need for the development of well-organized, randomized, controlled studies on appropriate assessment and intervention for sexual dysfunction in women...
  31. ncbi request reprint Testosterone and behavior
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, GRECC VA Medical Center, St Louis, MO, USA
    Clin Geriatr Med 19:605-16. 2003
    ..Table 2 summarizes the putative behavioral effects of testosterone. [Table: see text] There is a clear need for better designed large-scale behavioral studies to determine the effects of testosterone in older men and women...
  32. ncbi request reprint Urinary incontinence and the community-dwelling elder: a practical approach to diagnosis and management for the primary care geriatrician
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Clin Geriatr Med 20:427-35, v-vi. 2004
    ..Patients need to be asked regularly if they are incontinent and, after the diagnosis is made, should be given a rational treatment plan. Urodynamics should not be performed until mainstream treatments have failed...
  33. ncbi request reprint Andropause: an old concept in new clothing
    John E Morley
    GRECC, VA Medical Center, Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Clin Geriatr Med 19:507-28. 2003
    ..There is a need for a men's health study to determine the long-term efficacy and safety of testosterone replacement in older persons...
  34. ncbi request reprint Androgen treatment of male hypogonadism in older males
    John E Morley
    GRECC, VA Medical Center, School of Medicine, Saint Louis University, 1402 S Grand Blvd, M238, St Louis, MO 63104, USA
    J Steroid Biochem Mol Biol 85:367-73. 2003
    ..There is a desperate need for well designed, large controlled trials to establish the value or otherwise of testosterone treatment in older males...
  35. ncbi request reprint Publication productivity in geriatrics: 1995-2006
    John E Morley
    Division of Geriatric Medicine, Saint Louis University Medical Center, 1402 S Grand Blvd, M238, St Louis, MO 63104, USA
    J Gerontol A Biol Sci Med Sci 63:584-5. 2008
  36. doi request reprint Diabetes. Preface
    John E Morley
    Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA
    Clin Geriatr Med 24:xi-xiii. 2008
  37. ncbi request reprint Decreased food intake with aging
    J E Morley
    Geriatric Research, Education and Clinical Center, Saint Louis VA Medical Center, Missouri 63104, USA
    J Gerontol A Biol Sci Med Sci 56:81-8. 2001
    ..Cytokines are potent anorectic agents. Many older persons have mild inflammatory disorders that lead to anorexia. Exercise may increase food intake in older persons...
  38. ncbi request reprint Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding
    J E Morley
    Geriatric Research, Education and Clinical Center, VA Medical Center, St Louis, MO 63125, USA
    Peptides 20:595-600. 1999
    ..The alterations of NOS in brown adipose tissue following leptin administration could result in changes in blood flow or metabolism in the brown fat...
  39. ncbi request reprint Testosterone, aging and quality of life
    J E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Endocrinol Invest 28:76-80. 2005
    ..This is particularly important in view of the substantial placebo effect on aging symptomatology...
  40. ncbi request reprint Comparison of screening questionnaires for the diagnosis of hypogonadism
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 S Grand Blvd, M238, St Louis, MO 63104, USA
    Maturitas 53:424-9. 2006
    ..Total testosterone correlated poorly with most of the questions. In conclusion, the ADAM and AMS may be useful screening tools for hypogonadism across the adult lifespan, but both are relatively nonspecific...
  41. ncbi request reprint Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory
    J E Morley
    Geriatric Research, Education and Clinical Center, St Louis Department of Veterans Affairs Medical Center, 63104, St Louis, MO, USA
    Peptides 21:1761-7. 2000
    ..This reversal of cognitive deficits provides a link between increased expression of both APP and Abeta protein and learning and memory loss in these mice...
  42. ncbi request reprint Cachexia: pathophysiology and clinical relevance
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1042 South Grand Boulevard M238, St Louis, MO 63104, USA
    Am J Clin Nutr 83:735-43. 2006
    ..Numerous diseases can result in cachexia, each by a slightly different mechanism. Both nutritional support and orexigenic agents play a role in the management of cachexia...
  43. ncbi request reprint Antibody to amyloid beta protein alleviates impaired acquisition, retention, and memory processing in SAMP8 mice
    John E Morley
    Geriatric Research, Education, and Clinical Center, VA Medical Center, St Louis, Missouri 63106, USA
    Neurobiol Learn Mem 78:125-38. 2002
    ..Antibody to beta-amyloid restores the retention response to neurotransmitter manipulation to that seen in 4-month-old mice. beta-amyloid appears to play a key role in the loss of acquisition and retention seen in SAMP8/TaJF mice...
  44. doi request reprint Sarcopenia with limited mobility: an international consensus
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine and GRECC, VA Medical Center, St Louis, MO 63104, USA
    J Am Med Dir Assoc 12:403-9. 2011
    ..Clinically significant interventions are defined as an increase in the 6-minute walk of at least 50 meters or an increase of walking speed of at least 0.1 m/s...
  45. doi request reprint Nitric oxide is a central component in neuropeptide regulation of appetite
    John E Morley
    Geriatric Research Educational and Clinical Center, VA Medical Center, St Louis, MO 63104, USA
    Peptides 32:776-80. 2011
    ..The heterozygous mice showed partial food inhibition after the CCK. The current results add further support to the theory that NO is a central mediator in food intake...
  46. ncbi request reprint Sexuality and disease
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, GRECC, VA Medical Center, St Louis, MO, USA
    Clin Geriatr Med 19:563-73. 2003
    ..Health professionals need to give education, support, and counseling on sexuality for patients with disease...
  47. ncbi request reprint Frailty and the aging male
    J E Morley
    GRECC, VA Medical Center, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    Aging Male 8:135-40. 2005
    ..Sarcopenia occurs predominantly because of hormone deficiency and cytokine excess. Pain and anorexia are also associated with frailty. Stem cell research represents a potential promise for the treatment of frailty...
  48. ncbi request reprint Critique of the requirement for vitamin E
    M K Horwitt
    Division of Geriatric Medicine, St Louis University School of Medicine, MO 63104, USA
    Am J Clin Nutr 73:1003-5. 2001
    ..Vitamin E plus aspirin may increase the tendency to hemorrhage, which makes a lower upper intake level worth consideration...
  49. ncbi request reprint Clinical practice in nursing homes as a key for progress
    J E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Nutr Health Aging 14:586-93. 2010
    ..Key medical issues include moving to a restraint free environment, subsyndromal delirium, behavioral disturbances, weight loss, pain management, pressure ulcers, falls, hip fractures, polypharmacy, depression and frailty...
  50. ncbi request reprint Anorexia of aging: physiologic and pathologic
    J E Morley
    Division of Geriatrics, St Louis University Medical School, MO 63104, USA
    Am J Clin Nutr 66:760-73. 1997
    ..Approaches to the management of anorexia and weight loss in older persons are reviewed. Although many drugs exist that can enhance appetite, none of these are ideal for use in older persons currently...
  51. doi request reprint Diabetes and aging: epidemiologic overview
    John E Morley
    Geriatric Research Education and Clinical Center, St Louis VA Medical Center, 1 Jefferson Barracks Drive, 11G, St Louis, MO 63125, USA
    Clin Geriatr Med 24:395-405, v. 2008
    ..This article explores the increasing prevalence of diabetes mellitus with aging and how insulin resistance leads to accelerated frailty, disability, hospitalization, institutionalization, and death...
  52. ncbi request reprint Weight loss in older persons: new therapeutic approaches
    John E Morley
    Division of Geriatric Medicine, Saint Louis University Medical Center, St Louis, MO 63104, USA
    Curr Pharm Des 13:3637-47. 2007
    ..The potential role of anabolic steroids is also discussed...
  53. doi request reprint Nutrition and the aging male
    John E Morley
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, 1 Jefferson Barracks Drive, Saint Louis, MO 63125, USA
    Clin Geriatr Med 26:287-99. 2010
    ..Women are limited to only 1 drink a day. This article examines some key nutritional factors involved in successful aging and highlights different needs between men and women...
  54. doi request reprint Nutrition and the brain
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St Louis, MO 63104, USA
    Clin Geriatr Med 26:89-98. 2010
    ..Epidemiologic and animal studies have linked several other nutrients (omega-3 fatty acids, lutein, alpha-lipoic acid, and the Mediterranean diet) to cognitive performance and the prevention of dementia...
  55. doi request reprint Nutritional recommendations for the management of sarcopenia
    John E Morley
    Saint Louis University School of Medicine, GRECC, VA Medical Center, MO, USA
    J Am Med Dir Assoc 11:391-6. 2010
    ..Adequate protein intake (leucine-enriched balanced amino acids and possibly creatine) may enhance muscle strength. Low 25(OH) vitamin D levels require vitamin D replacement...
  56. ncbi request reprint Serum leptin in elderly people: associations with sex hormones, insulin, and adipose tissue volumes
    R N Baumgartner
    Center for Population Health, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque 87131, USA
    Obes Res 7:141-9. 1999
    ..Serum leptin would not be associated with sex hormone concentrations or serum fasting insulin after adjusting for body fat and fat distribution...
  57. ncbi request reprint Effect of metformin on nitric oxide synthase in genetically obese (ob/ob) mice
    V B Kumar
    Geriatric Research, Education and Clinical Center, VA Medical Center, St. Louis, MO 63125, USA
    Life Sci 69:2789-99. 2001
    ..No effect of metformin was observed in white adipose tissue of control or obese mice. Thus, metformin may produce anorectic effects through modulation of NOS...
  58. ncbi request reprint Reported and measured physical functioning in older inner-city diabetic African Americans
    D K Miller
    Division of Geriatric Medicine, St Louis University, Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, Missouri 63104, USA
    J Gerontol A Biol Sci Med Sci 54:M230-6. 1999
    ..The impact of diabetes on disability and physical functioning in older African Americans and potential causes of the excessive disability associated with diabetes in other studies have been inadequately investigated...
  59. ncbi request reprint Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice
    V B Kumar
    Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, St Louis, MO, USA
    Peptides 21:1769-75. 2000
    ..These results show that AO directed at the Abeta region of APP can reduce APP levels in the brain and reverse deficits in learning and memory...
  60. ncbi request reprint Testosterone replacement in older men and women
    J E Morley
    GRECC, VA Medical Center, St. Louis, MO, USA
    J Gend Specif Med 4:49-53. 2001
    ..Less information is available concerning the role of testosterone in postmenopausal women, but testosterone replacement may have a role to play in treating disorders of libido and the sarcopenia that occurs at menopause...
  61. ncbi request reprint Andropause: is the emperor wearing any clothes?
    S H Tariq
    GRECC, VA Medical Center and Division of Geriatric Medicine, Saint Louis University, St Louis, Missouri, USA
    Rev Endocr Metab Disord 6:77-84. 2005
  62. ncbi request reprint Anorexia, sarcopenia, and aging
    J E Morley
    Geriatric Research, Education, and Clinical Center, St. Louis VAMC, and the Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, Missouri, USA
    Nutrition 17:660-3. 2001
    ..Numerous treatable causes of anorexia and weight loss exist. Depression is the most commonly diagnosed cause of pathologic weight loss in older persons...
  63. ncbi request reprint Anorexia of aging in long term care: is dronabinol an effective appetite stimulant?--a pilot study
    M M G Wilson
    Division of Geriatric Medicine, Saint Louis University, 1402, S Grand Blvd, Rm M238, St Louis, MO 63104, USA
    J Nutr Health Aging 11:195-8. 2007
    ..In patients who fail to respond to nutritional intervention, orexigenic drugs are sometimes prescribed. There is limited data regarding the safety and efficacy of these drugs in older adults...
  64. ncbi request reprint Regional transport of TNF-alpha across the blood-brain barrier in young ICR and young and aged SAMP8 mice
    W A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Division of Geriatrics, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63106, USA
    Neurobiol Aging 22:671-6. 2001
    ..These results show blood-borne TNF enters some regions of the brain much more readily than others and TNF transport is increased into some brain regions of the SAMP8 mice at an age when learning and memory are impaired...
  65. ncbi request reprint Delivery across the blood-brain barrier of antisense directed against amyloid beta: reversal of learning and memory deficits in mice overexpressing amyloid precursor protein
    W A Banks
    Geriatric Research, Education and Clinical Center, St. Louis Veterans Affairs Medical Center and Department of Internal Medicine, Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA
    J Pharmacol Exp Ther 297:1113-21. 2001
    ..c.v. dose reversed the learning and memory deficits of aged SAMP8 mice. These studies show for the first time that phosphorothiolate oligonucleotides can be delivered to the brain in effective doses by intravenous administration...
  66. ncbi request reprint Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally administered dehydroepiandrosterone sulfate but not pregnenolone sulfate
    J F Flood
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO 63106, USA
    Psychoneuroendocrinology 24:799-811. 1999
    ..It was concluded that EMATE, acting peripherally, increased plasma levels of DHEAS which entered the brain and added to the effect of centrally administered DHEAS. The failure of EMATE to potentiate PREGS is discussed...
  67. ncbi request reprint Permeability of the blood-brain barrier to albumin and insulin in the young and aged SAMP8 mouse
    W A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Department of Internal Medicine, Missouri, USA
    J Gerontol A Biol Sci Med Sci 55:B601-6. 2000
    ..We conclude that alterations in BBB integrity or the activity of the BBB insulin transporter do not underlie the deficits in learning and memory seen in the aged SAMP8 mouse...
  68. ncbi request reprint The pharmacology of post-trial memory processing in septum
    J F Flood
    Geriatric Research Education and Clinical Center, St Louis, MO 63106, USA
    Eur J Pharmacol 350:31-8. 1998
    ..Receptor agonists of serotonin, gamma-amino butyric acid (GABA) and opioids impaired retention, while antagonists improved retention...
  69. ncbi request reprint The GAIN (Geriatric Anorexia Nutrition) registry: the impact of appetite and weight on mortality in a long-term care population
    D H Sullivan
    GRECC, Central Arkansas Veterans Healthcare System, and Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Nutr Health Aging 6:275-81. 2002
    ....
  70. ncbi request reprint Estradiol potentiates acetylcholine and glutamate-mediated post-trial memory processing in the hippocampus
    S A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO, USA
    Brain Res 864:263-9. 2000
    ..These findings support the concept that estrogen improves memory by potentiating the activity of the cholinergic and glutamatergic systems...
  71. ncbi request reprint The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
    Susan A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center 151 JC, 915 N Grand Boulevard, St Louis, MO 63109, USA
    J Neurochem 84:1173-83. 2003
    ..These results support the hypothesis that oxidative stress can lead to cognitive dysfunction and provide evidence for a therapeutic role for antioxidants...
  72. ncbi request reprint DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice
    Susan A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO, USA
    Life Sci 75:2775-85. 2004
    ..These findings suggest that DHEAS is more effective in reversing the cognitive impairments associated with overexpression of Abeta than with diabetes...
  73. doi request reprint Testosterone modulates gene expression pathways regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle
    M T Haren
    Geriatric Research, Education and Clinical Center GRECC, St Louis Veterans Affairs Medical Center, St Louis, MO 63125, USA
    Int J Androl 34:55-68. 2011
    ..These findings identify specific mechanisms by which testosterone may regulate skeletal muscle glucose and protein metabolism...
  74. ncbi request reprint Anorexia, body composition, and ageing
    J E Morley
    GRECC, VA Medical Center, St Louis, Missouri, USA
    Curr Opin Clin Nutr Metab Care 4:9-13. 2001
    ..Depression is the most common cause of weight loss in older individuals. Dieting in older individuals is associated with a loss of skeletal tissue as well as fat mass. This can place older individuals at risk of becoming the 'fat frail'...
  75. ncbi request reprint Effects of wheatgerm agglutinin and aging on the regional brain uptake of HIV-1GP120
    W A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Department of Internal Medicine, MO, USA
    Life Sci 65:81-9. 1999
    ....
  76. ncbi request reprint Hormone replacement therapy and fractures in older adults
    H K Kamel
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
    J Am Geriatr Soc 49:179-87. 2001
    ..In men, there is early evidence that testosterone replacement therapy may enhance bone mass in hypogonadal men...
  77. ncbi request reprint The cortical neuropeptide, cortistatin-14, impairs post-training memory processing
    J F Flood
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO 63106, USA
    Brain Res 775:250-2. 1997
    ..After 1 week, training was resumed to determine the effect of cortistatin-14 on retention. Cortistatin-14 was found to impair retention relative to the control group at doses of 0.5-5.0 micrograms...
  78. ncbi request reprint Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum
    W A Banks
    Veterans Affair Meical Center, St Louis, Missouri 63106, USA
    J Pharmacol Exp Ther 299:536-41. 2001
    ..In conclusion, these results show that exogenous, blood-borne hIL-1alpha affects memory by releasing mIL-1alpha from endogenous stores and by crossing the BBB to act at sites within the PDS...
  79. ncbi request reprint Chronic ethanol consumption impairs learning and memory after cessation of ethanol
    Susan A Farr
    Geriatric Research Education and Clinical Center, VA Medical Center, St Louis, MO 63109, USA
    Alcohol Clin Exp Res 29:971-82. 2005
    ..The current results indicate that a duration of ethanol consumption as short as eight weeks produces deficits in learning and memory that are present 12 weeks after withdrawal...
  80. pmc Predictors of serum testosterone and DHEAS in African-American men
    Matthew T Haren
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Int J Androl 31:50-9. 2008
    ..Higher total T levels were associated with serum metabolic markers, particularly lower triglycerides, whereas higher BT was associated with better cognitive and muscle function and DHEAS with lower adiponectin and higher MMSE scores...
  81. pmc Obesity and hypertriglyceridemia produce cognitive impairment
    Susan A Farr
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Endocrinology 149:2628-36. 2008
    ....
  82. ncbi request reprint Pathophysiology of weight loss in older persons
    John E Morley
    VA Medical Center, and Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 S Grand Boulevard, St Louis, MO 63104, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 10:167-72; discussion 172-8. 2005
  83. pmc Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer's disease: effects of anti-amyloid antibody and antisense treatments
    Abbas K Ali
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center St Louis, MO 63106, USA
    J Gerontol A Biol Sci Med Sci 64:1025-30. 2009
    ..These results suggest a complex relation between Abeta and NOS in the SAMP8 that is largely mediated through posttranslational mechanisms...
  84. ncbi request reprint Antibody to beta-amyloid protein increases acetylcholine in the hippocampus of 12 month SAMP8 male mice
    Susan A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center 151 JC, 915 N Grand Boulevard, St Louis, MO 63109, USA
    Life Sci 73:555-62. 2003
    ..These results suggest that antagonism of Abeta increases acetylcholine concentrations in the hippocampus, an area important for learning and memory...
  85. ncbi request reprint Andropause: a quality-of-life issue in older males
    Matthew T Haren
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, MO 63104, USA
    Med Clin North Am 90:1005-23. 2006
    ..Testosterone replacement can reverse many of these effects. At present, no ideal form of testosterone replacement is available. Like the phosphodiesterase-5 inhibitors, testosterone replacement in older men is a quality of life issue...
  86. ncbi request reprint Effects of leptin on memory processing
    Susan A Farr
    Geriatric Research Education and Clinical Center GRECC, VA Medical Center, St Louis, MO 63106, USA
    Peptides 27:1420-5. 2006
    ....
  87. ncbi request reprint Rapid assay for nitric oxide synthase using thin-layer chromatography
    V B Kumar
    Geriatric Research Education and Clinical Center, St Louis VA Medical Center, St Louis, Missouri 63125, USA
    Anal Biochem 269:17-20. 1999
    ..This method is versatile and allows rapid simultaneous assay of several samples in a short period of time. Therefore, this assay is very useful for both qualitative and quantitative estimation of NOS activity...
  88. ncbi request reprint Impaired cognitive function and mental performance in mild dehydration
    M M G Wilson
    Division of Geriatric Medicine, St Louis University Health Sciences Center, and GRECC, Veteran s Administration Medical Center, MO 63104, USA
    Eur J Clin Nutr 57:S24-9. 2003
    ..Intervention models directed toward improving outcomes in dehydration must incorporate strategies to enhance prompt recognition of cognitive dysfunction...
  89. pmc Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease
    W A Banks
    Geriatrics Research Educational and Clinical Center, Veterans Affairs Medical Center St Louis and Division of Geriatrics, Department of Internal Medicine, St Louis University School of Medicine, St Louis, MO 63106, USA
    Neuroscience 121:487-92. 2003
    ..These differences in the efflux of the various forms of AbetaP among the three groups of mice supports the hypothesis that impaired efflux is an important factor in the accumulation of AbetaP in the CNS...
  90. ncbi request reprint Tablet-breaking ability of older persons with type 2 diabetes mellitus
    M G Wilson
    Division of Geriatric Medicine, St Louis University Health Sciences Center, GRECC, Veteran s Administration Medical Center, St Louis, Missouri, USA
    Diabetes Educ 27:530-40. 2001
    ..The purpose of this study was to assess the ability of older persons with type 2 diabetes to accurately break in half 2 different formulations of micronized glyburide tablets...
  91. ncbi request reprint The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics
    A Lee
    Department of Medicine, St Louis University Medical Center, and GRECC, St Louis VA Medical Center, St Louis, MO, USA
    Diabetes Obes Metab 4:329-35. 2002
    ..GLP-1 plays a role to mediate satiety. Any agent that substantially elevates GLP-1 levels may theoretically reduce hunger, increase satiation and limit food intake...
  92. ncbi request reprint Identification of age-dependent changes in expression of senescence-accelerated mouse (SAMP8) hippocampal proteins by expression array analysis
    V B Kumar
    Geriatric Research, Education, and Clinical Center, St Louis VA Medical Center, Missouri 63125, USA
    Biochem Biophys Res Commun 272:657-61. 2000
    ....
  93. ncbi request reprint Polypharmacy and hospitalization among older home care patients
    J H Flaherty
    Division of Geriatric Medicine, Saint Louis University Medical School, Missouri 63104, USA
    J Gerontol A Biol Sci Med Sci 55:M554-9. 2000
    ..The objective of this study was to examine the relation between medication use (number, type, and inappropriateness) and hospitalization among home care patients older than 65 years...
  94. ncbi request reprint Effect of competitive antagonism of NO synthetase on weight and food intake in obese and diabetic mice
    J E Morley
    Geriatric Research Educational and Clinical Center, Veterans Affairs Medical Center, St Louis 63106
    Am J Physiol 266:R164-8. 1994
    ..01). A small decrease in body weight and food intake was seen in db/db and db/c mice receiving L-NAME. These studies provide further evidence for a role of nitric oxide in the modulation of food intake and weight gain...
  95. ncbi request reprint Serum leptin levels in wild and captive populations of baboons (papio): implications for the ancestral role of leptin
    W A Banks
    Geriatric Research, Educational and Clinical Center, Veterans Affairs Medical Center St Louis, St Louis, Missouri 63106, USA
    J Clin Endocrinol Metab 86:4315-20. 2001
    ..In comparison, captive baboons had levels about three times higher than wild baboons, with a clear inverse relation between age and leptin levels. These results support the view that leptin evolved to be effective at low levels...
  96. ncbi request reprint Androgens and aging
    J E Morley
    Division of Geriatric Medicine, Room M238, Saint Louis University Medical School, 1402 South Grand Blvd, St Louis, MO 63104 1028, USA
    Maturitas 38:61-71; discussion 71-3. 2001
    ..Less data is available to support the use of DHEA or its sulfate or pregnenolone. Further studies are clearly necessary in all these areas. However, it may be tentatively concluded that we are at the dawning of the age of androgens...
  97. ncbi request reprint Sarcopenia
    J E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, MO 63104, USA
    J Lab Clin Med 137:231-43. 2001
    ..Decreased physical activity with aging appears to be the key factor involved in producing sarcopenia. An increased research emphasis on the factors involved in the pathogenesis of sarcopenia is needed...
  98. ncbi request reprint Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8)
    V B Kumar
    Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, MO 63125, USA
    Biochem Cell Biol 79:57-67. 2001
    ..The expression could be regulated in a time- and concentration-dependent manner by using an antisense oligonucleotide specific to APP mRNA. Such regulation of APP expression may have a therapeutic application in vivo...
  99. ncbi request reprint Nutritional management in long-term care: development of a clinical guideline. Council for Nutritional Strategies in Long-Term Care
    D R Thomas
    Division of Geriatric Medicine, Saint Louis University School of Medicine, Missouri 63104, USA
    J Gerontol A Biol Sci Med Sci 55:M725-34. 2000
    ..Although body weight is easily measured, the evaluation of unintended weight loss in long-term care facilities is difficult...
  100. doi request reprint Late-life onset hypogonadism: a review
    Nazem Bassil
    Division of Geriatric Psychiatry, Department of Neurology and Psychiatry, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Clin Geriatr Med 26:197-222. 2010
    ..The physician should discuss with the patient the potential benefits and risks of TRT. This review discusses the benefits and risks of TRT...
  101. ncbi request reprint Erectile dysfunction: etiology and treatment in young and old patients
    Syed H Tariq
    Division of Geriatric Medicine, Saint Louis University School of Medicine, Room M 238, GREEC VA Medical Center, St Louis, MO 63104, USA
    Clin Geriatr Med 19:539-51. 2003
    ..Sildenafil with its ease of administration and high efficacy seems to be the logical first choice for most of the patients. If contraindications exist or treatment failures occur, other treatment options should be offered to patients...