DANIEL HOFT

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. doi request reprint A recombinant adenovirus expressing immunodominant TB antigens can significantly enhance BCG-induced human immunity
    Daniel F Hoft
    Division of Infectious Diseases, Allergy and Immunology, Departments of Internal Medicine and Molecular Microbiology, Saint Louis University Medical Center and Center for Vaccine Development, Saint Louis, MO 63104, USA
    Vaccine 30:2098-108. 2012
  2. ncbi request reprint Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic trypanosoma cruzi immunity involving CD8+ CTL and B cell-mediated cross-priming
    Daniel F Hoft
    Department of Internal Medicine, Saint Louis University Health Sciences Center, Saint Louis, MO 63110, USA
    J Immunol 179:6889-900. 2007
  3. pmc Type 1 immunity provides optimal protection against both mucosal and systemic Trypanosoma cruzi challenges
    D F Hoft
    Department of Internal Medicine, Saint Louis University Health Sciences Center, Missouri 63110, USA
    Infect Immun 70:6715-25. 2002
  4. ncbi request reprint Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity
    Daniel F Hoft
    Division of Infectious Diseases and Immunology and Vaccine and Treatment Evaluation Unit, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    J Infect Dis 186:1448-57. 2002
  5. doi request reprint Tuberculosis vaccine development: goals, immunological design, and evaluation
    Daniel F Hoft
    Division of Immunobiology, Department of Internal Medicine, Saint Louis University Health Sciences Center, St Louis, MO, USA
    Lancet 372:164-75. 2008
  6. pmc A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers
    Daniel F Hoft
    Department of Internal Medicine and Molecular Biology, Saint Louis University Medical Center, and Center for Vaccine Development, Saint Louis, MO 63104, USA
    J Infect Dis 198:1491-501. 2008
  7. doi request reprint Optimizing vaccine development
    Daniel F Hoft
    Division of Infectious Diseases, Allergy and Immunology, Saint Louis University School of Medicine, St Louis, MO, USA
    Cell Microbiol 13:934-42. 2011
  8. pmc Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children
    Daniel F Hoft
    Department of Internal Medicine, Saint Louis University Vaccine and Treatment Evaluation Unit, Missouri, USA
    J Infect Dis 204:845-53. 2011
  9. ncbi request reprint Mucosal bacille calmette-Guérin vaccination of humans inhibits delayed-type hypersensitivity to purified protein derivative but induces mycobacteria-specific interferon-gamma responses
    D F Hoft
    Saint Louis University Vaccine and Treatment Evaluation Unit, Department of Internal Medicine, Saint Louis University Health Sciences Center, St Louis, MO 63110, USA
    Clin Infect Dis 30:S217-22. 2000
  10. ncbi request reprint Clinical reactogenicity of intradermal bacille Calmette-Guérin vaccination
    D F Hoft
    Department of Internal Medicine, Saint Louis University Health Sciences Center, Missouri, USA
    Clin Infect Dis 28:785-90. 1999

Collaborators

Detail Information

Publications29

  1. doi request reprint A recombinant adenovirus expressing immunodominant TB antigens can significantly enhance BCG-induced human immunity
    Daniel F Hoft
    Division of Infectious Diseases, Allergy and Immunology, Departments of Internal Medicine and Molecular Microbiology, Saint Louis University Medical Center and Center for Vaccine Development, Saint Louis, MO 63104, USA
    Vaccine 30:2098-108. 2012
    ..Despite the availability of Bacille Calmette Guérin (BCG) vaccines, Mycobacterium tuberculosis currently infects billions of people and millions die annually from tuberculosis (TB) disease. New TB vaccines are urgently needed...
  2. ncbi request reprint Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic trypanosoma cruzi immunity involving CD8+ CTL and B cell-mediated cross-priming
    Daniel F Hoft
    Department of Internal Medicine, Saint Louis University Health Sciences Center, Saint Louis, MO 63110, USA
    J Immunol 179:6889-900. 2007
    ....
  3. pmc Type 1 immunity provides optimal protection against both mucosal and systemic Trypanosoma cruzi challenges
    D F Hoft
    Department of Internal Medicine, Saint Louis University Health Sciences Center, Missouri 63110, USA
    Infect Immun 70:6715-25. 2002
    ..We conclude that future vaccines for T. cruzi and possibly other mucosally invasive, intracellular pathogens should induce both mucosal and systemic type 1 immunity...
  4. ncbi request reprint Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity
    Daniel F Hoft
    Division of Infectious Diseases and Immunology and Vaccine and Treatment Evaluation Unit, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    J Infect Dis 186:1448-57. 2002
    ..Despite previous evidence that type 1 immune responses are essential for TB immunity, interferon-gamma production did not correlate with mycobacterial inhibition. These results have important implications for TB vaccine development...
  5. doi request reprint Tuberculosis vaccine development: goals, immunological design, and evaluation
    Daniel F Hoft
    Division of Immunobiology, Department of Internal Medicine, Saint Louis University Health Sciences Center, St Louis, MO, USA
    Lancet 372:164-75. 2008
    ....
  6. pmc A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers
    Daniel F Hoft
    Department of Internal Medicine and Molecular Biology, Saint Louis University Medical Center, and Center for Vaccine Development, Saint Louis, MO 63104, USA
    J Infect Dis 198:1491-501. 2008
    ..rBCG30, which overexpresses the Mycobacterium tuberculosis secreted antigen Ag85b, was the first rBCG shown to induce significantly greater protection against TB in animals than parental BCG...
  7. doi request reprint Optimizing vaccine development
    Daniel F Hoft
    Division of Infectious Diseases, Allergy and Immunology, Saint Louis University School of Medicine, St Louis, MO, USA
    Cell Microbiol 13:934-42. 2011
    ..This review presents general concepts relevant for the design and development of ideal vaccines protective against diverse pathogens...
  8. pmc Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children
    Daniel F Hoft
    Department of Internal Medicine, Saint Louis University Vaccine and Treatment Evaluation Unit, Missouri, USA
    J Infect Dis 204:845-53. 2011
    ..However, whether combinations of LAIV and TIV are safe and equally immunogenic is unknown. Furthermore, LAIV is more protective than TIV in children for unclear reasons...
  9. ncbi request reprint Mucosal bacille calmette-Guérin vaccination of humans inhibits delayed-type hypersensitivity to purified protein derivative but induces mycobacteria-specific interferon-gamma responses
    D F Hoft
    Saint Louis University Vaccine and Treatment Evaluation Unit, Department of Internal Medicine, Saint Louis University Health Sciences Center, St Louis, MO 63110, USA
    Clin Infect Dis 30:S217-22. 2000
    ..More detailed studies of cytokine and homing molecule expression indicated that differential mucosal versus cutaneous trafficking may explain the dissociation between IFN-gamma and DTH responses...
  10. ncbi request reprint Clinical reactogenicity of intradermal bacille Calmette-Guérin vaccination
    D F Hoft
    Department of Internal Medicine, Saint Louis University Health Sciences Center, Missouri, USA
    Clin Infect Dis 28:785-90. 1999
    ..These results demonstrate the clinical reactogenicity of BCG and the potential risk of contact spread of the vaccine strain and suggest that clinical reactogenicity is a trade-off for the induction of protective mycobacterial immunity...
  11. pmc Involvement of CD4(+) Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma cruzi
    D F Hoft
    Departments of Internal Medicine, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    Infect Immun 68:197-204. 2000
    ..cruzi systemic immunity may be to provide helper activity for the development of other effector functions protective in vivo...
  12. ncbi request reprint Persistence and boosting of bacille Calmette-Guérin-induced delayed-type hypersensitivity
    D F Hoft
    Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, Missouri 63110, USA
    Ann Intern Med 131:32-6. 1999
    ..Bacille Calmette-Guérin (BCG) vaccination may induce persistent and booster purified protein derivative (PPD) responses that complicate tuberculosis screening efforts...
  13. ncbi request reprint Bacille Calmette-Guérin vaccination enhances human gamma delta T cell responsiveness to mycobacteria suggestive of a memory-like phenotype
    D F Hoft
    St Louis University Vaccine Treatment and Evaluation Unit, Department of Internal Medicine, St Louis University Health Sciences Center, MO 63110, USA
    J Immunol 161:1045-54. 1998
    ..Our results suggest that gamma delta T cells may be capable of developing a memory immune-like phenotype, and therefore might be important targets for new vaccines...
  14. pmc Type 1 immunity provides both optimal mucosal and systemic protection against a mucosally invasive, intracellular pathogen
    Daniel F Hoft
    Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, 3635 Vista Avenue, St Louis, MO 63110, USA
    Infect Immun 73:4934-40. 2005
    ..These results strongly confirm our earlier conclusion from studies with polarizing vaccination protocols that type 1 immunity provides optimal mucosal and systemic protection against a mucosally invasive, intracellular pathogen...
  15. pmc Intranasal vaccinations with the trans-sialidase antigen plus CpG Adjuvant induce mucosal immunity protective against conjunctival Trypanosoma cruzi challenges
    O K Giddings
    Department of Molecular Microbiology and Immunology, Saint Louis University Medical Center, St Louis, Missouri 63104, USA
    Infect Immun 78:1333-8. 2010
    ..We also provide the first direct evidence that mucosal antibodies induced by intranasal TS vaccination can inhibit parasite invasion...
  16. pmc Differential effects of control and antigen-specific T cells on intracellular mycobacterial growth
    S Worku
    Department of Internal Medicine, Saint Louis University Center for Vaccine Development, St Louis, MO 63110, USA
    Infect Immun 71:1763-73. 2003
    ..These culture systems provide in vitro models for studying the opposing T-cell mechanisms involved in mycobacterial survival and protective host immunity...
  17. pmc Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies
    S de Valliere
    Department of Internal Medicine, Saint Louis University Health Science Center, MO 63110, USA
    Infect Immun 73:6711-20. 2005
    ..We conclude that mycobacterium-specific antibodies are capable of enhancing both innate and cell-mediated immune responses to mycobacteria...
  18. pmc Gastric invasion by Trypanosoma cruzi and induction of protective mucosal immune responses
    D F Hoft
    Department of Internal Medicine, Saint Louis University Health Sciences Center, Missouri 63110, USA
    Infect Immun 64:3800-10. 1996
    ..Our results document the first example of systemic microbial invasion through gastric mucosa and suggest the feasibility of a mucosal vaccine designed to prevent infection with this important human pathogen...
  19. ncbi request reprint Immunoregulatory role of secreted glycoprotein G from respiratory syncytial virus
    R Ray
    Division of Infectious Diseases and Immunology, Saint Louis University, 3635 Vista Avenue, St Louis, MO 63110, USA
    Virus Res 75:147-54. 2001
    ..However, Gs did not inhibit live RSV specific T cell responses. These results suggest that Gs may suppress immune response to unrelated antigens, but should not interfere with the overall development of RSV specific immunity...
  20. pmc Anatomical route of invasion and protective mucosal immunity in Trypanosoma cruzi conjunctival infection
    O K Giddings
    Department of Molecular Microbiology and Immunology, St Louis University Health Science Center, 3635 Vista Ave, FDT 8N, St Louis, MO 63110, USA
    Infect Immun 74:5549-60. 2006
    ..05), demonstrating that mucosal antibodies can play a role in T. cruzi immunity. This model provides an important tool for detailed studies of mucosal immunity necessary for the development of mucosal vaccines...
  21. ncbi request reprint Canarypox vaccines induce antigen-specific human gammadelta T cells capable of interferon-gamma production
    S Worku
    Division of Infectious Diseases and Immunology, Department of Internal Medicine, Saint Louis University Health Sciences Center, St Louis, Missouri, USA
    J Infect Dis 184:525-32. 2001
    ..02). Increased IFN-gamma production by gammadelta T and NK cells could enhance the induction of protective type 1 memory immunity. Thus, stimulation of gammadelta T cells might be an important feature of live vaccines...
  22. pmc Differential interleukin-8 and nitric oxide production in epithelial cells induced by mucosally invasive and noninvasive Trypanosoma cruzi trypomastigotes
    C S Eickhoff
    Department of Internal Medicine, Saint Louis University Health Sciences Center, St Louis, Missouri, USA
    Infect Immun 71:5394-7. 2003
    ..MT may avoid induction of inflammation as an important biological mechanism facilitating mucosal invasion...
  23. ncbi request reprint Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection
    Anita R Schnapp
    Division of Infectious Diseases and Immunology, Department of Internal Medicine, St Louis University Health Sciences Center, 3635 Vista Avenue, St Louis, MO 63110, USA
    Microbes Infect 4:805-13. 2002
    ..cruzi-infected cells. The induction of serum antibody, mucosal IgA, Th1 cytokine and CTL responses by cruzipain in mice supports the use of this parasite protein for further efforts in T. cruzi vaccine development...
  24. pmc Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice
    Anita R Schnapp
    Department of Internal Medicine, St Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    Infect Immun 70:5065-74. 2002
    ..cruzi mucosal infection. Overall, these data indicate that cruzipain is an important T. cruzi vaccine candidate and that protective T. cruzi vaccines will need to induce more than CD4(+) Th1 cells alone...
  25. pmc Bactericidal activity in whole blood as a potential surrogate marker of immunity after vaccination against tuberculosis
    Seon Hee Cheon
    Case Western Reserve University, Cleveland, Ohio, USA
    Clin Diagn Lab Immunol 9:901-7. 2002
    ..These experiments indicate that whole blood culture may be used to measure immunity to M. tuberculosis and that further studies of repeated BCG vaccination are warranted...
  26. ncbi request reprint Flow-cytometric detection of vaccinia-induced memory effector CD4(+), CD8(+), and gamma delta TCR(+) T cells capable of antigen-specific expansion and effector functions
    Getahun Abate
    Department of Internal Medicine, Saint Louis University, St Louis, Missouri 63110, USA
    J Infect Dis 192:1362-71. 2005
    ..CFSE-based flow-cytometric assays will be useful in evaluating cell-mediated immune responses induced by new smallpox vaccines...
  27. pmc CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2
    Adriano F S Araújo
    CINTERGEN, UNIFESP Escola Paulista de Medicina, Rua Mirassol, 207, São Paulo SP 04044 010, Brazil
    Infect Immun 73:6017-25. 2005
    ..cruzi infection...
  28. pmc Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production
    Kousuke Saito
    Departments of Internal Medicine, Saint Louis University, St Louis, Missouri, USA
    J Virol 82:3320-8. 2008
    ..These effects may account for or contribute to the low overall level of immunogenicity of HCV observed in chronically infected patients...
  29. ncbi request reprint Lipoarabinomannan-reactive human secretory immunoglobulin A responses induced by mucosal bacille Calmette-Guérin vaccination
    Robin M Brown
    Saint Louis University Vaccine and Treatment Evaluation Unit, Division of Infectious Diseases and Immunology, Department of Internal Medicine, Saint Louis University, St Louis, Missouri 63110, USA
    J Infect Dis 187:513-7. 2003
    ..05). LAM-reactive antibody assays can serve as markers of humoral and mucosal immunity in future trials of BCG and newer attenuated mycobacterial vaccines...

Research Grants17

  1. Role of gamma/delta T cells in Vaccine Induced Immunity
    DANIEL HOFT; Fiscal Year: 2009
    ..Dobos at Colorado State, who will pursue detailed biochemical studies designed to identify the specific components of mycobacteria and vaccinia that induce gamma/delta T cells relevant for vaccine development. ..
  2. Role of gamma/delta T cells in Vaccine Induced Immunity
    DANIEL HOFT; Fiscal Year: 2007
    ..Dobos at Colorado State, who will pursue detailed biochemical studies designed to identify the specific components of mycobacteria and vaccinia that induce gamma/delta T cells relevant for vaccine development. ..
  3. TRYPANOSOMA CRUZI MUCOSAL & SYSTEMIC PROTECTIVE IMMUNITY
    DANIEL HOFT; Fiscal Year: 2007
    ..Chemokine and/or integrin receptor expression will be studied by flow cytometry and RT-Real-Time PCR, and the in vivo effects of defective chemokine and integrin binding and/or signaling will be evaluated. ..
  4. Vaccine Induced Mucosal Protection Against TB Infection
    DANIEL HOFT; Fiscal Year: 2005
    ..Prime/boosting strategies found to prevent BCG infection after aerosol challenges will be studied for the ability to prevent infection with virulent M. tuberculosis by aerosol challenge. ..
  5. Role of gammadelta T Cells in Vaccine-Induced Immunity
    DANIEL HOFT; Fiscal Year: 2004
    ..Finally, the involvement of gd T cells in protective effector mechanisms capable of inhibiting intracellular replication of mycobacteria inside macrophages and HIV inside T cells will be examined. ..
  6. TRYPANOSOMA CRUZI MUCOSAL & SYSTEMIC PROTECTIVE IMMUNITY
    DANIEL HOFT; Fiscal Year: 2002
    ..Protective soluble protein and live recombinant vaccines will be studied in genetic knockout mice to identify the molecular and cellular requirements for immune protection. ..
  7. Role of gamma/delta T cells in Vaccine Induced Immunity
    Daniel F Hoft; Fiscal Year: 2010
    ..Dobos at Colorado State, who will pursue detailed biochemical studies designed to identify the specific components of mycobacteria and vaccinia that induce gamma/delta T cells relevant for vaccine development. ..