P J Hauptman

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. doi request reprint Clinical trial design in contemporary device studies in heart failure: is there a gold standard?
    Paul J Hauptman
    Department of Medicine, Saint Louis University School of Medicine, St Louis, Missouri Electronic address
    J Card Fail 20:223-8. 2014
  2. doi request reprint Patient perceptions, physician communication, and the implantable cardioverter-defibrillator
    Paul J Hauptman
    Departments of Medicine, Saint Louis University School ofMedicine, St Louis, MO 63110, USA
    JAMA Intern Med 173:571-7. 2013
  3. doi request reprint Clinical challenge of hyponatremia in heart failure
    Paul J Hauptman
    Division of Cardiology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Hosp Med 7:S6-10. 2012
  4. ncbi request reprint It is time to stop ignoring malignancy in heart transplantation: a call to arms
    Paul J Hauptman
    St Louis University Health Sciences Center, MO 63110, USA
    J Heart Lung Transplant 24:1111-3. 2005
  5. ncbi request reprint Comparison of two doses and dosing regimens of tolvaptan in congestive heart failure
    Paul J Hauptman
    Saint Louis University Health Sciences Center, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Cardiovasc Pharmacol 46:609-14. 2005
  6. ncbi request reprint Quality of life in advanced heart failure: role of mitral regurgitation
    Paul J Hauptman
    Division of Cardiology, Department of Medicine, Saint Louis University Health Sciences Center, St Louis, MO, USA
    Am Heart J 151:213-8. 2006
  7. pmc Chronic inotropic therapy in end-stage heart failure
    Paul J Hauptman
    Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Am Heart J 152:1096.e1-8. 2006
  8. pmc Use of nesiritide before and after publications suggesting drug-related risks in patients with acute decompensated heart failure
    Paul J Hauptman
    Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    JAMA 296:1877-84. 2006
  9. ncbi request reprint Medication adherence in heart failure
    Paul J Hauptman
    Division of Cardiology, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Heart Fail Rev 13:99-106. 2008
  10. ncbi request reprint Characteristics of patients hospitalized with acute decompensated heart failure who are referred for hospice care
    Paul J Hauptman
    Division of Cardiology, Saint Louis University Hospital, 3635 Vista Avenue, St Louis, MO 63110, USA
    Arch Intern Med 167:1990-7. 2007

Research Grants

  1. Decision Making in End-Stage Heart Failure
    Paul Hauptman; Fiscal Year: 2006

Detail Information

Publications45

  1. doi request reprint Clinical trial design in contemporary device studies in heart failure: is there a gold standard?
    Paul J Hauptman
    Department of Medicine, Saint Louis University School of Medicine, St Louis, Missouri Electronic address
    J Card Fail 20:223-8. 2014
    ..Until rules for and assessment of blinding are developed or surrogate measures are considered to be acceptable from a regulatory standpoint, an open-label design with objective end points is an unavoidable default standard. ..
  2. doi request reprint Patient perceptions, physician communication, and the implantable cardioverter-defibrillator
    Paul J Hauptman
    Departments of Medicine, Saint Louis University School ofMedicine, St Louis, MO 63110, USA
    JAMA Intern Med 173:571-7. 2013
    ..Implantable cardioverter-defibrillators (ICDs) have changed the way in which patients with chronic ventricular dysfunction are evaluated and treated...
  3. doi request reprint Clinical challenge of hyponatremia in heart failure
    Paul J Hauptman
    Division of Cardiology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Hosp Med 7:S6-10. 2012
    ..Even modest degrees of hyponatremia are associated with a poorer prognosis. Treatment options include fluid restriction and the vaptan class ("aquaretics") in select patients...
  4. ncbi request reprint It is time to stop ignoring malignancy in heart transplantation: a call to arms
    Paul J Hauptman
    St Louis University Health Sciences Center, MO 63110, USA
    J Heart Lung Transplant 24:1111-3. 2005
    ..Recommendations on malignancy screening are provided as well as an outline of areas of ongoing uncertainty...
  5. ncbi request reprint Comparison of two doses and dosing regimens of tolvaptan in congestive heart failure
    Paul J Hauptman
    Saint Louis University Health Sciences Center, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Cardiovasc Pharmacol 46:609-14. 2005
    ..Based on these findings, tolvaptan 30 mg was chosen as the comparator for placebo in a large phase 3 survival trial...
  6. ncbi request reprint Quality of life in advanced heart failure: role of mitral regurgitation
    Paul J Hauptman
    Division of Cardiology, Department of Medicine, Saint Louis University Health Sciences Center, St Louis, MO, USA
    Am Heart J 151:213-8. 2006
    ....
  7. pmc Chronic inotropic therapy in end-stage heart failure
    Paul J Hauptman
    Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Am Heart J 152:1096.e1-8. 2006
    ..However, little is known about associated mortality and cost. Therefore, we sought to describe the impact of chronic infusions on resource use and survival...
  8. pmc Use of nesiritide before and after publications suggesting drug-related risks in patients with acute decompensated heart failure
    Paul J Hauptman
    Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    JAMA 296:1877-84. 2006
    ....
  9. ncbi request reprint Medication adherence in heart failure
    Paul J Hauptman
    Division of Cardiology, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Heart Fail Rev 13:99-106. 2008
    ....
  10. ncbi request reprint Characteristics of patients hospitalized with acute decompensated heart failure who are referred for hospice care
    Paul J Hauptman
    Division of Cardiology, Saint Louis University Hospital, 3635 Vista Avenue, St Louis, MO 63110, USA
    Arch Intern Med 167:1990-7. 2007
    ..However, little is known about hospice referral practices when patients are admitted because of acute decompensated heart failure...
  11. doi request reprint Physician attitudes toward end-stage heart failure: a national survey
    Paul J Hauptman
    Division of Cardiology, Saint Louis University School of Medicine, St Louis, MO, USA
    Am J Med 121:127-35. 2008
    ..However, there is a paucity of data published describing physician beliefs about heart failure management, especially in its advanced stages...
  12. doi request reprint Resource utilization in patients hospitalized with heart failure: insights from a contemporary national hospital database
    Paul J Hauptman
    Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Am Heart J 155:978-985.e1. 2008
    ..However, little is known about the variability in and contributors to costs associated with HF hospitalizations. We examined the distribution of costs associated with a HF diagnosis in a large contemporary hospital database...
  13. doi request reprint Underutilization of beta-blockers in patients undergoing implantable cardioverter-defibrillator and cardiac resynchronization procedures
    Paul J Hauptman
    Department of Medicine, Division of Cardiology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Circ Cardiovasc Qual Outcomes 3:204-11. 2010
    ..Our objective was to evaluate use of beta-blockers (BB) among patients with heart failure undergoing a cardiac device procedure...
  14. ncbi request reprint Integrating palliative care into heart failure care
    Paul J Hauptman
    Division of Cardiology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 165:374-8. 2005
    ..Failure to respond to the need for palliative care puts at risk the mandate to treat the patient with heart failure during the entire course of illness...
  15. ncbi request reprint The business concept of leader pricing as applied to heart failure disease management
    Paul J Hauptman
    School of Medicine and Public Health, Saint Louis University, St Louis, Missouri, USA
    Dis Manag 7:226-34. 2004
    ..The actual magnitude of this benefit and the degree to which it mitigates overall administration costs requires further study...
  16. ncbi request reprint Measurement of end points in heart failure trials: jousting at windmills?
    Paul J Hauptman
    Division of Cardiology and Department of Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA
    Mt Sinai J Med 71:298-304. 2004
    ....
  17. ncbi request reprint Angiography of potential cardiac donors
    P J Hauptman
    Department of Medicine, St Louis University School of Medicine, Missouri, USA
    J Am Coll Cardiol 37:1252-8. 2001
    ....
  18. ncbi request reprint Novel use of a short-acting intravenous beta blocker in combination with inotropic therapy as a bridge to chronic oral beta blockade in patients with advanced heart failure
    Paul J Hauptman
    Saint Louis University School of Medicine, St Louis, Missouri, USA
    Clin Cardiol 25:247-9. 2002
    ..We conclude that some patients with advanced heart failure can be offered oral beta-blocker therapy by bridging with a combination of intravenous inotrope and short-acting intravenous beta blocker...
  19. doi request reprint The heart failure clinic: a consensus statement of the Heart Failure Society of America
    Paul J Hauptman
    Division of Cardiology, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Card Fail 14:801-15. 2008
    ..Outpatient care accounts for a significant proportion of total heart failure (HF) expenditures. This observation, plus an expanding list of treatment options, has led to the development of the disease-specific HF clinic...
  20. ncbi request reprint Rationale and design of CASPER: compliance and quality of life study comparing once-daily carvedilol CR and twice-daily carvedilol IR in patients with heart failure
    Paul J Hauptman
    Division of Cardiology, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Am J Cardiol 98:60L-66L. 2006
    ..The background, methods, and statistical approaches used in this trial are reviewed in this article...
  21. doi request reprint Implantable cardiac device procedures in older patients: use and in-hospital outcomes
    Jason P Swindle
    Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 170:631-7. 2010
    ..We sought to characterize age-specific practices and outcomes among patients with heart failure undergoing device implantation using a large nationally representative administrative database...
  22. pmc Short-term mortality and cost associated with cardiac device implantation in patients hospitalized with heart failure
    Jason Swindle
    Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Am Heart J 156:322-8. 2008
    ..Therefore, we evaluated the inhospital mortality and costs associated with patients with heart failure who received an implantable cardioverter defibrillator, cardiac resynchronization device, or device lead...
  23. doi request reprint Adherence with once daily versus twice daily carvedilol in patients with heart failure: the Compliance And Quality of Life Study Comparing Once-Daily Controlled-Release Carvedilol CR and Twice-Daily Immediate-Release Carvedilol IR in Patients with Heart F
    James E Udelson
    Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Card Fail 15:385-93. 2009
    ....
  24. ncbi request reprint The natural history of renal function following orthotopic heart transplant
    Ziyad Al Aly
    Division of Nephrology, Saint Louis University, Saint Louis, MO 63110, USA
    Clin Transplant 19:683-9. 2005
    ..The natural history of kidney function following orthotopic heart transplant is not well defined and long-term follow up studies are scant...
  25. ncbi request reprint Digoxin use and digoxin toxicity in the post-DIG trial era
    Zainal Hussain
    Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
    J Card Fail 12:343-6. 2006
    ..This issue appears to have been heightened after the publication of the results of the Digitalis Investigation Group (DIG) Trial in 1997 that did not demonstrate a statistically significant impact of digoxin on mortality...
  26. pmc Cardiovascular risk assessment among potential kidney transplant candidates: approaches and controversies
    Krista L Lentine
    Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Am J Kidney Dis 55:152-67. 2010
    ..Biomarkers, such as cardiac troponin, have prognostic value in end-stage renal disease, but require further study to determine clinical applications in directing more expensive and invasive cardiac evaluation...
  27. doi request reprint Implantable defibrillators and cardiac resynchronization therapy in heart transplant recipients: results of a national survey
    Deryk L McDowell
    Division of Cardiology, Saint Louis University School of Medicine, St Louis, MO, USA
    J Heart Lung Transplant 28:847-50. 2009
    ..A device was implanted in 44 recipients (38 with defibrillator alone), and 6 had an appropriate discharge during follow-up. There was an interest in establishing a registry to enable further study and analysis...
  28. pmc Cardiac evaluation before kidney transplantation: a practice patterns analysis in Medicare-insured dialysis patients
    Krista L Lentine
    St Louis University Center for Outcomes Research, Salus Center, 2nd Floor, 3545 Lafayette Avenue, St Louis, MO 63104, USA
    Clin J Am Soc Nephrol 3:1115-24. 2008
    ..Evaluation for ischemic heart disease (IHD) is a nonstandardized practice before kidney transplantation. We retrospectively studied pretransplant cardiac evaluation (CE) practices in a national sample of renal allograft recipients...
  29. ncbi request reprint Mode of death from congestive heart failure: implications for clinical management
    Mary Clare Derfler
    Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, MO 63110, USA
    Am J Geriatr Cardiol 13:299-304; quiz 305-6. 2004
    ..The numbers of these patients is likely to increase in an era of implantable cardioverter-defibrillators. Intervention studies designed to evaluate and improve strategies that emphasize symptom control should target this group...
  30. ncbi request reprint Palliation in heart failure: when less and more are more
    Paul J Hauptman
    Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Am J Hosp Palliat Care 23:150-2. 2006
  31. pmc The impact of kidney transplantation on heart failure risk varies with candidate body mass index
    Krista L Lentine
    Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Am Heart J 158:972-82. 2009
    ..The relationship of body mass index (BMI) with heart failure (HF) risk before and after kidney transplant is not well described...
  32. ncbi request reprint Variability in the clinical status of patients with advanced heart failure
    Paul J Hauptman
    Department of Medicine, Saint Louis University School of Medicine, Missouri, USA
    J Card Fail 10:397-402. 2004
    ..The frequency of such follow-up is not established and is likely to depend on the natural history and variability of patients' health status and the availability and use of appropriate treatments...
  33. ncbi request reprint Fulminant acute cellular rejection with negative findings on endomyocardial biopsy
    Rajeshkumar Bhalodolia
    Department of Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 25:989-92. 2006
    ....
  34. ncbi request reprint Progression of coronary artery disease in non-ischemic dilated cardiomyopathy
    Olaf Hedrich
    Department of Medicine, School of Medicine, Saint Louis University, Missouri, USA
    Coron Artery Dis 15:291-7. 2004
    ..Risk factor modification strategies should be applied to the non-ischemic DCM cohort, especially with continued improvements in survival rates in patients with heart failure...
  35. ncbi request reprint Effectiveness of percutaneous coronary intervention in cardiac allograft vasculopathy
    Amit A Doshi
    Saint Louis University Hospital, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    Am J Cardiol 93:90-2. 2004
    ..8 +/- 2.2 years from time of transplant. Periprocedural success was high, and there was a trend toward better outcomes in the group that underwent stent deployment compared with conventional balloon angioplasty...
  36. ncbi request reprint Malignant fibrous histiocytoma of the lung presenting as bronchial obstruction in a heart transplant recipient
    Tariq Alhadab
    Division of Pulmonary Medicine, Saint Louis University Health Sciences Center, St Louis, Missouri, USA
    J Heart Lung Transplant 21:1140-3. 2002
    ..Despite attempts at palliative endoscopic argon coagulation, the patient expired soon after presentation...
  37. ncbi request reprint beta-Adrenergic receptor blockers and heart failure risk after myocardial infarction: a critical review
    Robert H Neumayr
    Division of Cardiology, FDT 15, Saint Louis University Hospital, 3635 Vista Avenue, Saint Louis, MO 63110, USA
    Curr Heart Fail Rep 6:220-8. 2009
    ..Areas of uncertainty, such as the selection of dose and duration of therapy, current guidelines, and patterns of underuse of therapy with this important class of drugs are outlined and highlighted...
  38. ncbi request reprint Panel-reactive antibody screening practices prior to heart transplantation
    Adam S Betkowski
    Division of Cardiology, Department of Medicine, St Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 21:644-50. 2002
    ..A variety of definitions and approaches to sensitization have been described in the literature but no analyses of actual practice have been reported...
  39. ncbi request reprint Utility of impedance cardiography for the identification of short-term risk of clinical decompensation in stable patients with chronic heart failure
    Milton Packer
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8822, USA
    J Am Coll Cardiol 47:2245-52. 2006
    ..This study sought to assess the potential utility of impedance cardiography (ICG) in predicting clinical deterioration in ambulatory patients with heart failure (HF)...
  40. ncbi request reprint Consensus statement: Palliative and supportive care in advanced heart failure
    Sarah J Goodlin
    Institute for Health Care Delivery and Research, Intermountain Health Care, Salt Lake City, Utah 84111, USA
    J Card Fail 10:200-9. 2004
    ..A consensus conference was convened to define the current state and important gaps in knowledge and needed research on "Palliative and Supportive Care in Advanced Heart Failure."..
  41. ncbi request reprint Anything does not go: defining and refining interventions designed to improve quality in cardiovascular diseases
    Paul J Hauptman
    Am J Med 117:433-5. 2004
  42. ncbi request reprint Limitations of listing criteria for heart transplantation in the United States: call for a critical review
    Paul J Hauptman
    J Heart Lung Transplant 23:1123. 2004
  43. ncbi request reprint Left ventricular assist device
    Paul J Hauptman
    N Engl J Med 346:1023-5; author reply 1023-5. 2002
  44. ncbi request reprint Hospice care for heart failure patients
    Sarah J Goodlin
    Palliative Care Heart Failure Education and Research Trials, Institute for Health Care Delivery Research, Salt Lake City, UT 84111, USA
    J Pain Symptom Manage 29:525-8. 2005
  45. ncbi request reprint Understanding individual and small area variation in the underuse of coronary angiography following acute myocardial infarction
    Pushkal P Garg
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115 5899, USA
    Med Care 40:614-26. 2002
    ..Underuse of coronary angiography is common among patients with acute myocardial infarction (AMI) and the magnitude of underuse varies across geographic areas...

Research Grants4

  1. Decision Making in End-Stage Heart Failure
    Paul Hauptman; Fiscal Year: 2006
    ..These studies will form the conceptual framework for an intervention study designed to address, at physician and patient levels, the process of selection of care options for older heart failure patients near the end of life. ..