W S Harris

Summary

Affiliation: Saint Luke's Hospital
Country: USA

Publications

  1. ncbi request reprint Extending the cardiovascular benefits of omega-3 Fatty acids
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute, Saint Luke s Health System, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 7:375-80. 2005
  2. ncbi request reprint Cardiovascular disease and long-chain omega-3 fatty acids
    William S Harris
    Lipid and Diabetes Research Center, Saint Luke s Hospital, University of Missouri Kansas City School of Medicine, 64111, USA
    Curr Opin Lipidol 14:9-14. 2003
  3. ncbi request reprint Fish oil supplementation: evidence for health benefits
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke s Hospital, Kansas City, MO, USA
    Cleve Clin J Med 71:208-10, 212, 215-8 passim. 2004
  4. ncbi request reprint Clinical trial evidence for the cardioprotective effects of omega-3 fatty acids
    W S Harris
    Mid America Heart Institute of Saint Luke s Hospital and Department of Medicine, University of Missouri Kansas City, 4320 Wornall Road, Suite 128, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 3:174-9. 2001
  5. ncbi request reprint Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation
    William S Harris
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, MO, USA
    Circulation 110:1645-9. 2004
  6. ncbi request reprint Are omega-3 fatty acids the most important nutritional modulators of coronary heart disease risk?
    William S Harris
    St Luke s Mid America Heart Institute and Department of Medicine, University of Missouri Kansas City School of Medicine, 4320 Wornall Road, Suite 128, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 6:447-52. 2004
  7. ncbi request reprint Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases
    W S Harris
    St Luke s Hospital, University of Missouri Kansas City 64111, USA
    Am J Clin Nutr 66:254-60. 1997
  8. ncbi request reprint n-3 fatty acids and serum lipoproteins: human studies
    W S Harris
    Metabolism and Vascular Research Laboratory, Mid America Heart Institute, St Luke s Hospital, Kansas City, MO 64111, USA
    Am J Clin Nutr 65:1645S-1654S. 1997
  9. ncbi request reprint n-3 fatty acids and serum lipoproteins: animal studies
    W S Harris
    Metabolism and Vascular Research Laboratory, Mid America Heart Institute, St Luke s Hospital, Kansas City, MO 64111, USA
    Am J Clin Nutr 65:1611S-1616S. 1997
  10. ncbi request reprint n-3 fatty acids and urinary excretion of nitric oxide metabolites in humans
    W S Harris
    Department of Medicine, University of Kansas Medical Center, Kansas City, MO, USA
    Am J Clin Nutr 65:459-64. 1997

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Extending the cardiovascular benefits of omega-3 Fatty acids
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute, Saint Luke s Health System, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 7:375-80. 2005
    ..If intakes of the latter are adequate (perhaps over 250 mg/d), then there appears to be little need to consume more ALA or less LA...
  2. ncbi request reprint Cardiovascular disease and long-chain omega-3 fatty acids
    William S Harris
    Lipid and Diabetes Research Center, Saint Luke s Hospital, University of Missouri Kansas City School of Medicine, 64111, USA
    Curr Opin Lipidol 14:9-14. 2003
    ..Of all known dietary factors, long-chain omega-3 fatty acids may be the most protective against death from coronary heart disease. New evidence has confirmed and refined the cardioprotective role of these fatty acids...
  3. ncbi request reprint Fish oil supplementation: evidence for health benefits
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke s Hospital, Kansas City, MO, USA
    Cleve Clin J Med 71:208-10, 212, 215-8 passim. 2004
    ..This article answers a series of questions that health care professionals often ask regarding fish oil, such as what are proper dosages, and are there risks of ingesting pollutants by eating more fish or using supplements?..
  4. ncbi request reprint Clinical trial evidence for the cardioprotective effects of omega-3 fatty acids
    W S Harris
    Mid America Heart Institute of Saint Luke s Hospital and Department of Medicine, University of Missouri Kansas City, 4320 Wornall Road, Suite 128, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 3:174-9. 2001
    ..These findings support the view that relatively small intakes of w-3 fatty acids are indeed cardioprotective, and suggest that they may operate by stabilizing the myocardium itself...
  5. ncbi request reprint Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation
    William S Harris
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, MO, USA
    Circulation 110:1645-9. 2004
    ..The extent of incorporation has not been determined in humans...
  6. ncbi request reprint Are omega-3 fatty acids the most important nutritional modulators of coronary heart disease risk?
    William S Harris
    St Luke s Mid America Heart Institute and Department of Medicine, University of Missouri Kansas City School of Medicine, 4320 Wornall Road, Suite 128, Kansas City, MO 64111, USA
    Curr Atheroscler Rep 6:447-52. 2004
    ..The strength of the n-3 story has now led to a proposal that blood levels of EPA plus DHA be considered a new, modifiable, and clinically relevant risk factor for death from CHD...
  7. ncbi request reprint Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases
    W S Harris
    St Luke s Hospital, University of Missouri Kansas City 64111, USA
    Am J Clin Nutr 66:254-60. 1997
    ....
  8. ncbi request reprint n-3 fatty acids and serum lipoproteins: human studies
    W S Harris
    Metabolism and Vascular Research Laboratory, Mid America Heart Institute, St Luke s Hospital, Kansas City, MO 64111, USA
    Am J Clin Nutr 65:1645S-1654S. 1997
    ..These effects of marine n-3 fatty acids are now well-established; what remains is to determine the mechanisms behind these effects and, more importantly, their health consequences...
  9. ncbi request reprint n-3 fatty acids and serum lipoproteins: animal studies
    W S Harris
    Metabolism and Vascular Research Laboratory, Mid America Heart Institute, St Luke s Hospital, Kansas City, MO 64111, USA
    Am J Clin Nutr 65:1611S-1616S. 1997
    ..Failure to properly address these issues will make it difficult to uncover the biochemical basis for the hypolipidemic effect of fish oils in humans through use of experimental animals...
  10. ncbi request reprint n-3 fatty acids and urinary excretion of nitric oxide metabolites in humans
    W S Harris
    Department of Medicine, University of Kansas Medical Center, Kansas City, MO, USA
    Am J Clin Nutr 65:459-64. 1997
    ..The lack of effect with EPA supplementation suggests that this component of the FOC is not likely to be an active component. If confirmed, these observations suggest another mechanism whereby n-3 fatty acids may be antiatherogenic...
  11. ncbi request reprint Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids
    Yongsoon Park
    Lipid and Diabetes Research Center, Saint Luke s Hospital, and The University of Missouri Kansas City School of Medicine, 64111, USA
    Am J Clin Nutr 80:45-50. 2004
    ..Margination occurs when blood borne particles attach to the vessel wall. Triacylglycerol-rich lipoprotein (TRL) particles marginate when they bind to endothelial lipoprotein lipase (LpL)...
  12. ncbi request reprint Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs
    William S Harris
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, MO, USA
    Lipids 42:325-33. 2007
    ..Compared to dietary EPA, SDA was 20-23% as efficient in raising tissue EPA levels. In conclusion, SDA supplementation increased the EPA content of RBC and heart and may have utility as a plant-based source of omega-3 FA...
  13. ncbi request reprint Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids
    William S Harris
    Lipid and Diabetes Research Center, Saint Luke s Mid America Heart Institute, Kansas City, MO, USA
    Am J Clin Nutr 86:1621-5. 2007
    ..n-3 Fatty acids (FAs) have been shown to be beneficial for cardiovascular health. Whether n-3 FAs from oily fish consumed weekly or from fish-oil capsules taken daily are equally bioavailable is not clear...
  14. ncbi request reprint Measurement of human chylomicron triglyceride clearance with a labeled commercial lipid emulsion
    Y Park
    University of Missouri Kansas City, Department of Medicine and Cardiovascular Research Department, Mid America Heart Institute, Saint Luke s Hospital, 64111, USA
    Lipids 36:115-20. 2001
    ..The results indicate that a radiolabeled commercial lipid emulsion is metabolized in a fashion similar to native chylomicron TG, and thus can be used to study chylomicron TG kinetics...
  15. ncbi request reprint A new method for the study of chylomicron kinetics in vivo
    Y Park
    Department of Medicine, University of Missouri Kansas City, St Luke s Hospital, Kansas City, Missouri 64111, USA
    Am J Physiol Endocrinol Metab 279:E1258-63. 2000
    ..kg(-1). h(-1), equal to the presumed ingestion rate. In summary, a radiolabeled intravenous lipid emulsion is able to accurately estimate chylomicron TG R(a) and therefore can be used to measure in vivo fat absorption rates...
  16. ncbi request reprint Metabolic syndrome-mediated inflammation following elective percutaneous coronary intervention
    Steven P Marso
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri 64111, USA
    Diab Vasc Dis Res 2:31-6. 2005
    ..In this patient population, the metabolic syndrome correlates with a heightened inflammatory response following elective PCI...
  17. ncbi request reprint Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions
    James H O'Keefe
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri, USA
    Am J Cardiol 97:1127-30. 2006
    ..These changes are consistent with an increase in vagal activity and may in part explain the observed decrease in risk for sudden cardiac death seen with omega-3 fatty acid supplementation...
  18. doi request reprint Omega-3 fatty acids: cardiovascular benefits, sources and sustainability
    John H Lee
    Mid America Heart Institute and University of Missouri Kansas City, 64111, USA
    Nat Rev Cardiol 6:753-8. 2009
    ..Sustainable sources of omega-3 fatty acids will need to be identified if long-term cardiovascular risk reduction is to be achieved at the population level...
  19. ncbi request reprint The Omega-3 Index: a new risk factor for death from coronary heart disease?
    William S Harris
    Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke s Hospital, University of Missouri KC School of Medicine, Kansas City, MO 64111, USA
    Prev Med 39:212-20. 2004
    ..Red blood cell (RBC) fatty acid (FA) composition reflects long-term intake of EPA + DHA. We propose that the RBC EPA + DHA (hereafter called the Omega-3 Index) be considered a new risk factor for death from CHD...
  20. pmc Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels
    Alpesh A Amin
    Department of Cardiology, Mid America Heart Institute, Saint Luke Hospital, Kansas City, Missouri, USA
    Psychosom Med 70:856-62. 2008
    ..Reduced levels of blood cell membrane omega-3 (n-3) fatty acids (FAs), an emerging risk factor for both CV disease and depression, may help to explain the link between depression and adverse CV outcomes...
  21. ncbi request reprint Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
    Yongsoon Park
    Department of Medicine, University of Missouri, Kansas City, MO 64108, USA
    J Lipid Res 44:455-63. 2003
    ..The results suggest that omega-3 FA supplementation accelerates chylomicron TG clearance by increasing LPL activity, and that EPA and DHA are equally effective...
  22. ncbi request reprint The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes
    Scott A Sands
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri 64111, USA
    Lipids 40:343-7. 2005
    ..Given the importance of n-3 FA in influencing risk for death from CHD, further studies are warranted to delineate the nondietary factors that influence RBC EPA + DHA content...
  23. pmc Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction
    Monika K Duda
    Division of Cardiology, Department of Medicine, University of Maryland Baltimore, 20 Penn Street, HSF2, Room S022, Baltimore, MD 21201, USA
    Cardiovasc Res 81:319-27. 2009
    ....
  24. ncbi request reprint Effects of omega-3 fatty acids on heart rate in cardiac transplant recipients
    William S Harris
    University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA
    Am J Cardiol 98:1393-5. 2006
    ..These findings suggest that n-3 FAs may modify electrophysiologic properties of the myocardium itself...
  25. pmc Red blood cell ω-3 fatty acid levels and markers of accelerated brain aging
    Z S Tan
    Department of Medicine, Division of Geriatric Medicine, Easton Center for Alzheimer s Disease Research, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, USA
    Neurology 78:658-64. 2012
    ..We examined the cross-sectional relation of red blood cell (RBC) fatty acid levels to subclinical imaging and cognitive markers of dementia risk in a middle-aged to elderly community-based cohort...
  26. ncbi request reprint LCAT inhibitors interfere with the enzymatic determination of cholesterol and triglycerides
    W S Harris
    Department of Medicine, University of Kansas Medical Center, Kansas City 66103
    Lipids 25:341-3. 1990
    ..Thus, these inhibitors should be avoided when plasma samples are to be enzymatically analyzed for cholesterol or triglycerides...
  27. ncbi request reprint Why do omega-3 fatty acids lower serum triglycerides?
    William S Harris
    Mid America Heart Institute, Saint Luke s Health System, USA
    Curr Opin Lipidol 17:387-93. 2006
    ....
  28. doi request reprint Omega-3 fatty acids for cardioprotection
    John H Lee
    Mid America Heart Institute and University of Missouri Kansas City, 4330 Wornall Road, Kansas City, MO 64111, USA
    Mayo Clin Proc 83:324-32. 2008
    ..Blood DHA and EPA levels could one day be used to identify patients with deficient levels and to individualize therapeutic recommendations...
  29. ncbi request reprint Atorvastatin reduces remnant lipoproteins and small, dense low-density lipoproteins regardless of the baseline lipid pattern
    James H O'Keefe
    Mid America Heart Institute, St Luke s Hospital, 4401 Wornall Road, Suite 2000, Kansas City, MO 64111
    Prev Cardiol 7:154-60. 2004
    ..Increased attention should be paid to absolute concentrations of LDL subfraction cholesterol, which may be a more sensitive indicator of coronary heart disease risk than total LDL or an LDL pattern...
  30. ncbi request reprint Effect of atorvastatin on hemorheologic-hemostatic parameters and serum fibrinogen levels in hyperlipidemic patients
    C A Dujovne
    Lipid, Arteriosclerosis and Metabolic Clinic, University of Kansas Medical Center, Kansas City, USA
    Am J Cardiol 85:350-3. 2000
    ....
  31. ncbi request reprint Tissue omega-6/omega-3 fatty acid ratio and risk for coronary artery disease
    William S Harris
    Department of Medicine, Mid America Heart Institute of Saint Luke s Health System, Kansas City, Missouri, USA
    Am J Cardiol 98:19i-26i. 2006
    ..Tissue EPA + DHA appears to be the best fatty acid metric for evaluating for CAD risk...
  32. ncbi request reprint Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy
    John M Miles
    Mid America Heart Institute of Saint Luke s Hospital, University of Missouri Kansas City, Kansas City, MO, USA
    Diabetes 52:675-81. 2003
    ..In summary, nocturnal and postprandial FFA R(a) is increased in type 2 diabetes. Postprandial lipolysis appears to be preferentially improved by thiazolidinediones compared with nocturnal lipolysis...
  33. ncbi request reprint New evidence for the cardiovascular benefits of long chain omega-3 fatty acids
    Susan N Hansen
    Nutrition and Metabolic Disease Research Institute, Sanford Research University of South Dakota, 1400 West 22nd Street, L 07, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 9:434-40. 2007
    ..Finally, a supplementation study in cardiac surgery patients has demonstrated both the time course and extent of incorporation of LC n-3 FAs into the human heart...
  34. ncbi request reprint Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association
    Penny M Kris-Etherton
    Arterioscler Thromb Vasc Biol 23:151-2. 2003
  35. ncbi request reprint Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives
    William S Harris
    Nutrition and Metabolic Disease Research, Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA
    Atherosclerosis 197:12-24. 2008
    ..Our focus is to review the potential mechanisms by which these fatty acids reduce cardiovascular disease risk...
  36. ncbi request reprint Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Arterioscler Thromb Vasc Biol 23:e20-30. 2003
  37. pmc UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health
    John C Stanley
    Trinity College and St Hugh s College, Oxford, UK
    Br J Nutr 98:1305-10. 2007
    ..Other markers of fatty acid intake, that more closely relate to physiological function, may be more useful...
  38. ncbi request reprint Effects of moderate variations in the macronutrient content of the diet on cardiovascular disease risk factors in obese patients with the metabolic syndrome
    Fulvio Muzio
    Clinical Nutrition Unit, G Salvini Hospital, Garbagnate Milanese, Milan, Italy
    Am J Clin Nutr 86:946-51. 2007
    ..Even if there is full agreement that lifestyle changes to induce weight loss are the first-line approach, the ideal diet for the treatment of the metabolic syndrome remains uncertain...
  39. pmc Red blood cell docosahexaenoic acid and eicosapentaenoic acid concentrations are positively associated with socioeconomic status in patients with established coronary artery disease: data from the Heart and Soul Study
    Beth E Cohen
    Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Nutr 138:1135-40. 2008
    ..Our results raise the possibility that (n-3) fatty acids may be an important mediating factor in the association between low SES and CVD...
  40. ncbi request reprint The omega-3 index as a risk factor for coronary heart disease
    William S Harris
    Metabolism and Nutrition Research Center, Sanford Research USD, Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD, USA
    Am J Clin Nutr 87:1997S-2002S. 2008
    ..Before assessment of n-3 FA biostatus can be used in routine clinical evaluation of patients, standardized laboratory methods and quality control materials must become available...
  41. ncbi request reprint Conclusions and recommendations from the symposium, Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty Acids
    Richard J Deckelbaum
    Institute of Human Nutrition, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA
    Am J Clin Nutr 87:2010S-2S. 2008
    ..Additional references for these conclusions can be found in the articles included in the supplement...
  42. doi request reprint You are what you eat applies to fish, too
    William S Harris
    J Am Diet Assoc 108:1131-3. 2008
  43. doi request reprint Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker
    William S Harris
    Sanford Research USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA
    Lipids 43:805-11. 2008
    ..Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs...
  44. ncbi request reprint Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  45. ncbi request reprint Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events
    William S Harris
    Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States
    Atherosclerosis 193:1-10. 2007
    ..The purpose of this paper is to evaluate the published associations between risk for CHD events and tissue n-3 and n-6 FA composition...
  46. pmc Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor
    William S Harris
    Nutrition and Metabolic Disease Research Institute, Sanford Research USD, Sanford School of Medicine of the University of South Dakota, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Pharmacol Res 55:217-23. 2007
    ..For these and a number of other reasons, the omega-3 index compares very favourably with other risk factors for sudden cardiac death...
  47. ncbi request reprint The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus
    William L Isley
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Lipid Res 47:193-200. 2006
    ..The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus...
  48. ncbi request reprint n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
    ..The evidence for the benefits of fish oil is stronger in secondary- than in primary-prevention settings. Adverse effects appear to be minor...
  49. ncbi request reprint Cardiovascular benefits of omega-3 fatty acids
    Clemens von Schacky
    Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Ziemssenstrasse 1, D 80336 Munich, Germany
    Cardiovasc Res 73:310-5. 2007
    ..As is the case now for LDL, in the future, the cardiac societies might very well recommend treatment with EPA and DHA to become goal oriented (e.g. an omega-3 index>8%)...
  50. ncbi request reprint Hypertriglyceridemia: management of atherogenic dyslipidemia
    Thomas Bersot
    Gladstone Institute of Cardiovascular Disease, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    J Fam Pract 55:S1-8. 2006
    ..Fibrates, niacin, and omega-3 acid ethyl esters are highly effective at reducing triglycerides, while statins are considered moderately efficacious (SOR: A)...
  51. ncbi request reprint n-3 Fatty acids and cardiovascular disease
    Dennis W T Nilsen
    Am J Clin Nutr 79:166. 2004
  52. ncbi request reprint Blood omega-3 and trans fatty acids in middle-aged acute coronary syndrome patients
    William S Harris
    Sanford Research and School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA
    Am J Cardiol 99:154-8. 2007
    ..In conclusion, low blood EPA + DHA content is an independent predictor of increased risk for ACS, but higher blood trans FA content is not. Blood EPA + DHA may serve as a new, modifiable risk factor for ACS...
  53. ncbi request reprint Risks and benefits of fish intake
    Michel Lucas
    JAMA 297:585; author reply 586. 2007
  54. ncbi request reprint n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
    Sarah K Gebauer
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 83:1526S-1535S. 2006
    ..Foods enriched with EPA and DHA or fish oil supplements are a suitable alternate to achieve recommended intakes and may be necessary to achieve intakes of 1 g/d...
  55. ncbi request reprint Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    ..By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States...
  56. ncbi request reprint n-3 Fatty acids and health: DaVinci's code
    William S Harris
    Am J Clin Nutr 88:595-6. 2008
  57. ncbi request reprint n-3 Long-chain polyunsaturated fatty acids reduce risk of coronary heart disease death: extending the evidence to the elderly
    William S Harris
    Am J Clin Nutr 77:279-80. 2003
  58. ncbi request reprint Cardiovascular risk and alpha-linolenic acid: can Costa Rica clarify?
    William S Harris
    Circulation 118:323-4. 2008
  59. ncbi request reprint The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus
    William L Isley
    Endocrine Research Unit, Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Rochester, MN 55905, USA
    Metabolism 55:758-62. 2006
    ..These results suggest that the triglyceride-lowering effect of statins is not mediated through an effect on FFA metabolism...
  60. ncbi request reprint Alpha-linolenic acid: a gift from the land?
    William S Harris
    Circulation 111:2872-4. 2005
  61. ncbi request reprint Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acids
    John M Miles
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 53:521-7. 2004
    ..They further suggest that LPL-mediated fatty acid uptake is an inefficient process, but may be more efficient in muscle than in adipose tissue...
  62. ncbi request reprint The effect of high dose simvastatin on, platelet size in patients with, type 2 diabetes mellitus
    William L Isley
    Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Endocrine Research Unit, Rochester, MN 55905, USA
    Platelets 17:292-5. 2006
    ..6 and 1.7%, respectively (P < 0.05), during simvastatin treatment as opposed to the placebo period. We conclude that some of the effects of high dose simvastatin therapy on platelets may not necessarily be anti-atherogenic...
  63. ncbi request reprint Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006
    Alice H Lichtenstein
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:2186-91. 2006
  64. ncbi request reprint The omega-6/omega-3 ratio and cardiovascular disease risk: uses and abuses
    William S Harris
    University of South Dakota, Nutrition and Metabolic Diseases Research Institute, South Dakota Health Research Foundation, 1400 West 22nd Street, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 8:453-9. 2006
    ..Metrics that include the n-3 FAs alone, especially eicosapentaenoic and docosahexaenoic acids, appear to hold the greatest promise...
  65. ncbi request reprint International recommendations for consumption of long-chain omega-3 fatty acids
    William S Harris
    Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota 57105, USA
    J Cardiovasc Med (Hagerstown) 8:S50-2. 2007
    ..Fortification is perhaps the best long-term solution to the chronically-low intake of omega-3 fatty acids that plagues western cultures...
  66. ncbi request reprint Cardiovascular risk and the omega-3 index
    Clemens von Schacky
    Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Cardiovasc Med (Hagerstown) 8:S46-9. 2007
    ..Cardiac societies recommend EPA + DHA for prevention of SCD. The omega-3 index can assess risk for SCD and monitor therapy with EPA + DHA. Moreover, it compares very favourably with other risk factors for SCD...
  67. ncbi request reprint EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls
    Robert C Block
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, Box 644, 601 Elmwood Avenue, NY 14642, United States robert
    Atherosclerosis 197:821-8. 2008
    ....
  68. ncbi request reprint Preventive use of N-3 fatty acids
    William S Harris
    Circulation 108:e139; author reply e139. 2003
  69. ncbi request reprint Expert opinion: omega-3 fatty acids and bleeding-cause for concern?
    William S Harris
    Sanford School of Medicine of University of South Dakota, Sioux Falls, South Dakota 57105, USA
    Am J Cardiol 99:44C-46C. 2007
    ..As such, the benefits of triglyceride lowering with omega-3 fatty acids more than outweigh any theoretical risks for increased bleeding...
  70. ncbi request reprint n-3 Fatty acid fortification: opportunities and obstacles
    William S Harris
    Sanford Research USD, Nutrition and Metabolic Disease Research Institute, Internal Medicine Department, Sanford School of Medicine of The University of South Dakota and Sioux Valley Hospitals and Health Systems, Sioux Falls, USA
    Br J Nutr 97:593-5. 2007