Research Topics
| Sharon FreySummaryAffiliation: Saint Louis University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Safety and immune responses in children after concurrent or sequential 2009 H1N1 and 2009-2010 seasonal trivalent influenza vaccinationsSharon E Frey
Division of Infectious Diseases, Allergy and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
J Infect Dis 206:828-37. 2012....- Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adultsSharon E Frey
Saint Louis University School of Medicine, Division of Infectious Diseases and Immunology, St Louis, MO 63104, USA
Vaccine 28:6367-73. 2010..We describe the first in humans clinical trial of this prophylactic HCV vaccine... 
Comparison of the safety and immunogenicity of ACAM1000, ACAM2000 and Dryvax in healthy vaccinia-naive adultsSharon E Frey
Division of Infectious Diseases and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, 1100 S Grand Blvd DRC 8th Floor, St Louis, MO 63104, United States
Vaccine 27:1637-44. 2009..0x10(8)PFU/mL. All subjects had a primary skin reaction indicating a successful vaccination. The adverse events, 4-fold neutralizing antibody rise and T cell immune responses were similar between the groups...- Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challengeSharon E Frey
Department of Medicine, Saint Louis University School of Medicine and National Institute of Allergy and Infectious Diseases Vaccine Treatment and Evaluation Unit, 1100 S Grand Blvd DRC 8, St Louis, MO 63104, USA
Vaccine 25:8562-73. 2007..IMVAMUNE vaccination prior to Dryvax reduced virus replication at the Dryvax site, decreased the size of the primary cutaneous lesion, and decreased the time to healing but did not completely ameliorate the immune response... 
Comparison of the safety, tolerability, and immunogenicity of a MF59-adjuvanted influenza vaccine and a non-adjuvanted influenza vaccine in non-elderly adultsSharon Frey
Saint Louis University School of Medicine, Saint Louis, MO, USA
Vaccine 21:4234-7. 2003..Compared with Fluzone, FLUAD was associated with increased immunogenicity and mild post-immunization reactions in healthy adults. The magnitude of increased immunogenicity in healthy adults was less than that seen in elderly populations...- High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjectsPaul A Goepfert
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2050, USA
J Infect Dis 192:1249-59. 2005..0) TCID50 (60 participants) than when given at the regular dose, 10(7.26) TCID50 (40 participants); as a control, a placebo vaccine preparation also was administered (10 participants)... - Improved assay to detect neutralizing antibody following vaccination with diluted or undiluted vaccinia (Dryvax) vaccineFrances K Newman
Saint Louis University Vaccine Treatment and Evaluation Unit, St Louis, Missouri 63110, USA
J Clin Microbiol 41:3154-7. 2003..Therefore, the more sensitive, specific, and reproducible plaque neutralization assay for the detection of antibody to vaccinia virus is the method using a 15-h-incubation time and freshly sonicated vaccinia virus... - Dose-related effects of smallpox vaccineSharon E Frey
Department of Medicine, National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit, Saint Louis University School of Medicine, St. Louis, USA
N Engl J Med 346:1275-80. 2002..The development of vesicular skin lesions after vaccination correlates with the induction of the antibody and T-cell responses that are considered essential for clearing vaccinia virus infections... - Clinical responses to undiluted and diluted smallpox vaccineSharon E Frey
Department of Medicine, National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit, Saint Louis University School of Medicine, St. Louis, USA
N Engl J Med 346:1265-74. 2002..0) pfu per milliliter (approximately 10,000 pfu per dose) and induce local viral replication and vesicle formation in more than 97 percent of persons... - Antibody profiling by proteome microarray reveals the immunogenicity of the attenuated smallpox vaccine modified vaccinia virus ankara is comparable to that of DryvaxD Huw Davies
University of California Irvine, Department of Medicine Division of Infectious Diseases, 3501 Hewitt Hall, Irvine, CA 92697, USA
J Virol 82:652-63. 2008..The work supports other information suggesting that MVA may be a useful alternative to Dryvax... - Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adultsRobert B Belshe
Saint Louis University Medical Center, St Louis, MO 63110, United States
Vaccine 25:6755-63. 2007..ID route was not superior to IM vaccine at inducing antibodies. ID vaccine induced significantly more local inflammatory response than IM vaccine... - Antibody responses to vaccinia membrane proteins after smallpox vaccinationSteven J Lawrence
Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
J Infect Dis 196:220-9. 2007..Vaccinia virus (VV) membrane proteins are candidates for orthopoxvirus subunit vaccines and potential targets for therapeutic antibodies. Human antibody responses to these proteins after VV vaccination have not been well characterized... - The immunogenetics of smallpox vaccinationSamuel L Stanley
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Infect Dis 196:212-9. 2007.... - Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trialNina D Russell
Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J Acquir Immune Defic Syndr 44:203-12. 2007..We conducted a phase 2 trial to determine if a canarypox vaccine candidate (vCP1452) administered with rgp120 subunit protein would "qualify" for a trial to define a correlate of efficacy... - Lack of transmission of vaccinia virusJames H Stark
Emerg Infect Dis 12:698-700. 2006 - Stability of undiluted and diluted vaccinia-virus vaccine, DryvaxFrances K Newman
Saint Louis University, St Louis, Missouri, USA
J Infect Dis 187:1319-22. 2003.... - Immune status in a primary smallpox vaccinee who failed to develop an immunization site reactionJohn M Kelso
JAMA 293:677-8. 2005 - Induction of human T cell-mediated immune responses after primary and secondary smallpox vaccinationJeffrey S Kennedy
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Infect Dis 190:1286-94. 2004..Postvaccination cell-mediated immune (CMI) responses have not been compared by use of controlled trials in previously vaccinated (vaccinia-nonnaive) and nonvaccinated (vaccinia-naive) individuals... - Dose-dependent neutralizing-antibody responses to vacciniaRobert B Belshe
Center for Vaccine Development, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
J Infect Dis 189:493-7. 2004..Larger lesion size and fever after vaccination were associated with significantly higher neutralizing-antibody titers after vaccination... - Response to smallpox vaccine in persons immunized in the distant pastSharon E Frey
Department of Medicine, Saint Louis University School of Medicine and National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit, MO, USA
JAMA 289:3295-9. 2003..Fewer adverse reactions were observed in this study of non-naive participants when compared with events in vaccinia-naive participants, which may be due to immunologic memory... - Flow-cytometric detection of vaccinia-induced memory effector CD4(+), CD8(+), and gamma delta TCR(+) T cells capable of antigen-specific expansion and effector functionsGetahun Abate
Department of Internal Medicine, Saint Louis University, St. Louis, Missouri 63110, USA
J Infect Dis 192:1362-71. 2005..CFSE-based flow-cytometric assays will be useful in evaluating cell-mediated immune responses induced by new smallpox vaccines... - Unique risks to volunteers in HIV vaccine trialsSharon E Frey
Division of Infectious Diseases and Immunology, Saint Louis University School of Medicine, 3635 Vista Ave. (FDT-8N, St. Louis, MO 63110, USA
J Investig Med 51:S18-20. 2003..The conduct of HIV vaccine trials has forced a constant re-evaluation of the risk-to-benefit ratio related to trial participation and a challenge to the ethics surrounding vaccine research... - Safety profile of recombinant canarypox HIV vaccinesGuy de Bruyn
HIV Vaccines Trials Network Core Operations, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Vaccine 22:704-13. 2004..Reactogenicity does not appear to be related to the number or type of inserted genes, and did not vary between different ALVAC constructs... - Safety and immunogenicity of a high-titered canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Group Protocol 022AKalpana Gupta
Department of Medicine, University of Washington, Seattle, Washington, USA
J Acquir Immune Defic Syndr 29:254-61. 2002..This high-titered preparation of ALVAC-HIV vCP205 in combination with gp120 was safe and immunogenic in a diverse group of HIV-1-seronegative volunteers...