Robert Fleming

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint Pathogenesis of hereditary hemochromatosis: genetics and beyond
    Robert S Britton
    Department of Internal Medicine, Saint Louis University School of Medicine, Mo 63110 0250, USA
    Semin Gastrointest Dis 13:68-79. 2002
  2. pmc Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice
    Qi Feng
    Department of Pediatrics, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1397-404. 2012
  3. pmc Expression of iron-related genes in human brain and brain tumors
    Milla M Hänninen
    Institute of Medical Technology and School of Medicine, University of Tampere, Tampere University Hospital, Tampere, Finland
    BMC Neurosci 10:36. 2009
  4. doi request reprint Knockout mouse models of iron homeostasis
    Robert E Fleming
    Departments of Pediatrics and Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Annu Rev Nutr 31:117-37. 2011
  5. doi request reprint Iron sensing as a partnership: HFE and transferrin receptor 2
    Robert E Fleming
    Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Cell Metab 9:211-2. 2009
  6. doi request reprint Iron and inflammation: cross-talk between pathways regulating hepcidin
    Robert E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, 1465 South Grand Ave, St Louis, MO 63104, USA
    J Mol Med (Berl) 86:491-4. 2008
  7. ncbi request reprint Iron Imports. VI. HFE and regulation of intestinal iron absorption
    Robert E Fleming
    Department of Pediatrics, Saint Louis University Liver Center, Saint Louis University School of Medicine, MO 63104, USA
    Am J Physiol Gastrointest Liver Physiol 290:G590-4. 2006
  8. pmc Pathophysiology of hereditary hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Semin Liver Dis 25:411-9. 2005
  9. ncbi request reprint Mechanisms of iron accumulation in hereditary hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    Annu Rev Physiol 64:663-80. 2002
  10. ncbi request reprint Advances in understanding the molecular basis for the regulation of dietary iron absorption
    Robert E Fleming
    Saint Louis University School of Medicine, 1465 South Grand Avenue, Saint Louis, Missouri 63104, USA
    Curr Opin Gastroenterol 21:201-6. 2005

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Pathogenesis of hereditary hemochromatosis: genetics and beyond
    Robert S Britton
    Department of Internal Medicine, Saint Louis University School of Medicine, Mo 63110 0250, USA
    Semin Gastrointest Dis 13:68-79. 2002
    ..Future investigations will refine our knowledge of the mechanisms of action of HFE protein, the phenotypic variability observed in persons homozygous for the C282Y mutation, and the mechanisms responsible for non-HFE-related HH...
  2. pmc Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice
    Qi Feng
    Department of Pediatrics, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1397-404. 2012
    ..We conclude that exogenous iron-containing ferritin upregulates hepatic Bmp6 expression, and we speculate that liver ferritin contributes to regulation of Bmp6 and, thus, Hamp1 genes...
  3. pmc Expression of iron-related genes in human brain and brain tumors
    Milla M Hänninen
    Institute of Medical Technology and School of Medicine, University of Tampere, Tampere University Hospital, Tampere, Finland
    BMC Neurosci 10:36. 2009
    ..The specimens included 5 normal brain tissue samples, 4 meningiomas, one medulloblastoma, 3 oligodendrocytic gliomas, 2 oligoastrocytic gliomas, 8 astrocytic gliomas, and 3 astrocytoma cell lines...
  4. doi request reprint Knockout mouse models of iron homeostasis
    Robert E Fleming
    Departments of Pediatrics and Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Annu Rev Nutr 31:117-37. 2011
    ..The availability of mice with floxed iron-related genes allows the study of the in vivo consequences of cell-selective deletion of these genes...
  5. doi request reprint Iron sensing as a partnership: HFE and transferrin receptor 2
    Robert E Fleming
    Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Cell Metab 9:211-2. 2009
    ..Gao et al. (2009) make the key discovery that the regulation of hepcidin in response to holotransferrin requires the interaction between HFE and transferrin receptor 2 (TfR2)...
  6. doi request reprint Iron and inflammation: cross-talk between pathways regulating hepcidin
    Robert E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, 1465 South Grand Ave, St Louis, MO 63104, USA
    J Mol Med (Berl) 86:491-4. 2008
  7. ncbi request reprint Iron Imports. VI. HFE and regulation of intestinal iron absorption
    Robert E Fleming
    Department of Pediatrics, Saint Louis University Liver Center, Saint Louis University School of Medicine, MO 63104, USA
    Am J Physiol Gastrointest Liver Physiol 290:G590-4. 2006
    ..These models are not mutually exclusive, and it is possible that HFE influences the iron status in each of these cell populations, leading to cell type-specific downstream effects on intestinal iron absorption and body iron distribution...
  8. pmc Pathophysiology of hereditary hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Semin Liver Dis 25:411-9. 2005
    ..The mechanism by which HFE influences hepcidin expression is an area of current investigation and may offer insights into the phenotypic variability observed in persons with mutations in HFE...
  9. ncbi request reprint Mechanisms of iron accumulation in hereditary hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    Annu Rev Physiol 64:663-80. 2002
    ..This review summarizes our current understanding of the relationship between iron stores and absorption and presents models to explain the dysregulated iron homeostasis in HH...
  10. ncbi request reprint Advances in understanding the molecular basis for the regulation of dietary iron absorption
    Robert E Fleming
    Saint Louis University School of Medicine, 1465 South Grand Avenue, Saint Louis, Missouri 63104, USA
    Curr Opin Gastroenterol 21:201-6. 2005
    ....
  11. ncbi request reprint Pathogenesis of hereditary hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, Cardinal Glennon Childrens Hospital, 1465 S Grand Blvd, St Louis, MO 63104, USA
    Clin Liver Dis 8:755-73, vii. 2004
    ..Two major hypotheses have been proposed to explain the pathogenesis of HFE-related hereditary hemochromatosis: the hepcidin hypothesis and the duodenal crypt cell programming hypothesis...
  12. ncbi request reprint Orchestration of iron homeostasis
    Robert E Fleming
    Saint Louis University School of Medicine, St Louis, USA
    N Engl J Med 352:1741-4. 2005
  13. pmc Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis
    Shunji Tomatsu
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 100:15788-93. 2003
    ..These observations indicate that the H67D mutation leads to partial loss of Hfe function and can contribute to murine HH...
  14. pmc Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis
    Abdul Waheed
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 99:3117-22. 2002
    ....
  15. pmc Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, MO 63104, USA
    Proc Natl Acad Sci U S A 99:10653-8. 2002
    ..This study confirms the important role for TFR2 in iron homeostasis and provides a tool for investigating the excess iron absorption and abnormal iron distribution in iron-overload disorders...
  16. ncbi request reprint Decreased liver hepcidin expression in the Hfe knockout mouse
    Kaashif A Ahmad
    Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Avenue, St Louis, MO 63130, USA
    Blood Cells Mol Dis 29:361-6. 2002
    ..We speculate that decreased hepcidin expression relative to body iron stores contributes to the iron homeostasis abnormalities characteristic of HH...
  17. doi request reprint HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron
    Abdul Waheed
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Arch Biochem Biophys 474:193-7. 2008
    ..These observations indicate that HFE influences the functional properties of TfR2, and suggests a model in which the interaction of these proteins might influence signal transduction to hepcidin...
  18. ncbi request reprint Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
    Hiroshi Kawabata
    Division of Hematology Immunology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Blood 105:376-81. 2005
    ..These results suggest that up-regulation of hepcidin expression by inflammatory stimuli is independent of TfR2 and that TfR2 is upstream of hepcidin in the regulatory pathway of body iron homeostasis...
  19. ncbi request reprint Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2
    Jokke Hannuksela
    Department of Clinical Chemistry, University of Oulu, Oulu, Finland
    Eur J Haematol 70:201-6. 2003
    ..HFE, the protein defective in hereditary hemochromatosis, and transferrin receptor 2 (TfR2) are two novel protein candidates that could be involved in mechanisms of iron transport across the platelet plasma membrane...
  20. ncbi request reprint Hepcidin activation during inflammation: make it STAT
    Robert E Fleming
    Gastroenterology 132:447-9. 2007
  21. pmc Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2
    Vladimir Lesnikov
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D1 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Apoptosis 13:1005-12. 2008
    ..Both apoptotic Fas responses and cytoprotective effects of Tf were associated with significant shifts in plasma iron levels, which quantitatively differed between male and female mice...

Research Grants9

  1. IRON TRANSPORT IN A MURINE MODEL OF HEMOCHROMATOSIS
    Robert Fleming; Fiscal Year: 2004
    ..We hope the findings suggest novel approaches to prevent iron loading in HH and other diseases with excess dietary iron absorption. ..
  2. Role of Transferrin Receptor 2 in Iron Homeostasis
    Robert Fleming; Fiscal Year: 2007
    ..This knowledge will increase our understanding of iron homeostasis, and may suggest new approaches to the management of diseases of iron overload and maldistribution. ..