J C Eissenberg

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi Divided loyalties: transdetermination and the genetics of tissue regeneration
    Joel C Eissenberg
    Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, Missouri 63104, USA
    Bioessays 28:574-7. 2006
  2. pmc Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells
    Maria Gause
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Chromosoma 117:51-66. 2008
  3. pmc The unique GGA clathrin adaptor of Drosophila melanogaster is not essential
    Shan Luan
    Department of Biology, Macelwane Hall, Saint Louis University, St Louis, Missouri, USA
    PLoS ONE 7:e45163. 2012
  4. pmc Heterochromatin protein 1 is involved in control of telomere elongation in Drosophila melanogaster
    Mikhail Savitsky
    Department of Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 117334 Moscow, Russia
    Mol Cell Biol 22:3204-18. 2002
  5. ncbi Telomeres, cancer & aging: live long & prosper?
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, USA
    Mo Med 110:11-6. 2013
  6. doi Structural biology of the chromodomain: form and function
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, St Louis, MO 63104 1079, USA
    Gene 496:69-78. 2012
  7. ncbi Decisive factors: a transcription activator can overcome heterochromatin silencing
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Bioessays 23:767-71. 2001
  8. ncbi Molecular biology of the chromo domain: an ancient chromatin module comes of age
    J C Eissenberg
    Edward A Doisy Department of Biochemistry, and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104 1079, USA
    Gene 275:19-29. 2001
  9. ncbi The HP1 protein family: getting a grip on chromatin
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Curr Opin Genet Dev 10:204-10. 2000
  10. ncbi Functional genomics of histone modification and non-histone chromosomal proteins using the polytene chromosomes of Drosophila
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Methods 40:360-4. 2006

Collaborators

Detail Information

Publications51

  1. ncbi Divided loyalties: transdetermination and the genetics of tissue regeneration
    Joel C Eissenberg
    Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, Missouri 63104, USA
    Bioessays 28:574-7. 2006
    ..The data identify key mechanisms that control developmental homeostasis and cell fate restriction that could be manipulated to make somatic stem-cell engineering possible...
  2. pmc Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells
    Maria Gause
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Chromosoma 117:51-66. 2008
    ..These results support the idea that direct regulation of cohesin function underlies the diverse functions of Nipped-B and its orthologs...
  3. pmc The unique GGA clathrin adaptor of Drosophila melanogaster is not essential
    Shan Luan
    Department of Biology, Macelwane Hall, Saint Louis University, St Louis, Missouri, USA
    PLoS ONE 7:e45163. 2012
    ..However, GGA null flies are hypersensitive to dietary chloroquine and to starvation, implicating GGA in lysosomal function and autophagy...
  4. pmc Heterochromatin protein 1 is involved in control of telomere elongation in Drosophila melanogaster
    Mikhail Savitsky
    Department of Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 117334 Moscow, Russia
    Mol Cell Biol 22:3204-18. 2002
    ..The Drosophila lines bearing the Su(var)2-5 mutations maintain extremely long telomeres consisting of HeT-A and TART for many generations. Thus, HP1 plays an important role in the control of telomere elongation in D. melanogaster...
  5. ncbi Telomeres, cancer & aging: live long & prosper?
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, USA
    Mo Med 110:11-6. 2013
    ..Drugs that selectively fray the ends of cancer cell chromosomes would be potent and general anti-cancer therapies. Here, I summarize data on the role of chromosome ends in cellular and organismal aging...
  6. doi Structural biology of the chromodomain: form and function
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, St Louis, MO 63104 1079, USA
    Gene 496:69-78. 2012
    ..In this review, our current knowledge of chromodomain structure and function is summarized...
  7. ncbi Decisive factors: a transcription activator can overcome heterochromatin silencing
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Bioessays 23:767-71. 2001
    ..This competition, together with developmental change in the stability of heterochromatin itself, decides the transcriptional state for a gene subject to heterochromatin repression...
  8. ncbi Molecular biology of the chromo domain: an ancient chromatin module comes of age
    J C Eissenberg
    Edward A Doisy Department of Biochemistry, and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104 1079, USA
    Gene 275:19-29. 2001
    ..In this review, our current knowledge of chromo domain properties is summarized and a variety of contexts in which chromo domains participate in aspects of chromatin metabolism are discussed...
  9. ncbi The HP1 protein family: getting a grip on chromatin
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Curr Opin Genet Dev 10:204-10. 2000
    ..A number of intriguing interactions between HP1 and other proteins have been described, implicating HP1 in gene regulation, DNA replication, and nuclear architecture...
  10. ncbi Functional genomics of histone modification and non-histone chromosomal proteins using the polytene chromosomes of Drosophila
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Methods 40:360-4. 2006
    ..Immunofluorescence localization of chromosomal proteins and specific post-translational modifications of histones is a simple and rapid tool for the functional genomics of chromosomal proteins...
  11. pmc dELL is an essential RNA polymerase II elongation factor with a general role in development
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 99:9894-9. 2002
    ..These data show that an ELL family elongation factor is essential, acts broadly in development, and is not functionally redundant to other elongation factors in vivo...
  12. ncbi Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Genet Genomics 277:101-14. 2007
    ..Binding of the RNA Polymerase II elongation factor ELL was reduced in knockdown chromosomes, suggesting that ELL is recruited to active polymerase via CTD phosphorylation...
  13. pmc Histone H3 lysine 4 (H3K4) methylation in development and differentiation
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St Louis, MO 63104, USA
    Dev Biol 339:240-9. 2010
    ..Since their discovery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mechanistic insight into the role of H3K4 methylation in HOX gene regulation during development...
  14. pmc Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway
    Joel C Eissenberg
    Saint Louis University School of Medicine, Edward A Doisy Dept of Biochemistry and Molecular Biology, 221 N Grand Blvd, St Louis, MO 63101, USA
    Mol Cell Biol 25:6559-69. 2005
    ..We show that SRCAP potentiates Notch-dependent gene activation in HeLa cells. Taken together, these data implicate SRCAP and DOM in developmental gene activation...
  15. pmc Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo
    M Gerber
    The Edward Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Blvd, Saint Louis, MO 63104, USA
    EMBO J 20:6104-14. 2001
    ..We also demonstrate that dELL physically interacts with Pol II. Our results strongly suggest that dELL functions with elongating RNA polymerase II in vivo...
  16. pmc Functional analysis of the chromo domain of HP1
    J S Platero
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Medical School, MO 63104 1079, USA
    EMBO J 14:3977-86. 1995
    ....
  17. ncbi Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A
    Mark Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Health Sciences Center, Saint Louis, Missouri 63104, USA
    J Biol Chem 280:4017-20. 2005
    ..Our data represent the first demonstration of an essential role for an RNA polymerase II elongation factor in the regulation of heat shock gene expression in an animal model...
  18. ncbi Developmental regulation of heterochromatin-mediated gene silencing in Drosophila
    B Y Lu
    Cell and Molecular Biology Program and Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, St Louis, MO 63104, USA
    Development 125:2223-34. 1998
    ..These data suggest that the silencing activity of heterochromatin is developmentally programmed...
  19. pmc Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling
    Kristen Tenney
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 103:11970-4. 2006
    ..Here we demonstrate that the dRtf1 component of the Paf1 complex functions in Notch signaling...
  20. pmc Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding
    J A Powers
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, Missouri 63104
    J Cell Biol 120:291-9. 1993
    ..Both of these functional domains overlap an evolutionarily conserved COOH-terminal region...
  21. ncbi Phosphorylation site mutations in heterochromatin protein 1 (HP1) reduce or eliminate silencing activity
    T Zhao
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 276:9512-8. 2001
    ..These results suggest that dynamic phosphorylation/dephosphorylation regulates HP1 activity in heterochromatic silencing...
  22. pmc Heterochromatin protein 1 is required for the normal expression of two heterochromatin genes in Drosophila
    B Y Lu
    Cell and Molecular Biology Program, Saint Louis University Medical School, MO 63104, USA
    Genetics 155:699-708. 2000
    ..These results also show that HP1, initially recognized as a transcriptional silencer, is required for the normal transcriptional activation of heterochromatic genes...
  23. ncbi Heterochromatin protein 1 binds to nucleosomes and DNA in vitro
    T Zhao
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 275:28332-8. 2000
    ..Together, these observations suggest that HP1 may serve as a cross-linker in chromatin, linking nucleosomal DNA and nonhistone protein complexes to form higher order chromatin structures...
  24. ncbi In vivo assay for protein-protein interactions using Drosophila chromosomes
    J S Platero
    Cell and Molecular Biology Program, Saint Louis University Health Science Center, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Chromosoma 104:393-404. 1996
    ..Ectopic binding of chimeric chromosomal proteins provides a useful tool for distinguishing specific protein-protein interactions from specific protein-DNA interactions important for complex assembly in vivo...
  25. ncbi Time out: developmental regulation of heterochromatic silencing in Drosophila
    B Y Lu
    Cell and Molecular Biology Program, Saint Louis University Health Sciences Center, Missouri 63104, USA
    Cell Mol Life Sci 54:50-9. 1998
    ....
  26. pmc Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster
    J C Eissenberg
    E A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, MO 63104
    Proc Natl Acad Sci U S A 87:9923-7. 1990
    ..This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects...
  27. ncbi The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, Missouri 63104, USA
    Nat Struct Mol Biol 14:344-6. 2007
    ....
  28. pmc In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development
    Mark Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 24:9911-9. 2004
    ..The discovery of the role of elongin A in an in vivo model system defines the novel contribution played by RNA polymerase II elongation machinery in regulation of gene expression that is required for proper development...
  29. ncbi Phosphorylation of heterochromatin protein 1 by casein kinase II is required for efficient heterochromatin binding in Drosophila
    T Zhao
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Health Sciences Center, St Louis, Missouri 63104 1079, USA
    J Biol Chem 274:15095-100. 1999
    ..We propose that phosphorylation of HP1 promotes protein-protein interaction between HP1 and target binding proteins in heterochromatin...
  30. ncbi Expression and functional analysis of three isoforms of human heterochromatin-associated protein HP1 in Drosophila
    J Ma
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Medical School, MO, USA
    Chromosoma 109:536-44. 2001
    ..Ectopic expression of two of the three human HP1 family proteins significantly enhances heterochromatic silencing in Drosophila...
  31. pmc Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster
    Mark A Gerber
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104, USA
    Mol Cell Biol 25:7803-11. 2005
    ....
  32. ncbi Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila
    T C James
    Department of Biology, Washington University, St Louis, MO 63130
    Eur J Cell Biol 50:170-80. 1989
    ..Thus, the C1A9 antibody may serve as a useful marker for both structural and functional studies of the Drosophila nucleus...
  33. pmc Developmental timing and tissue specificity of heterochromatin-mediated silencing
    B Y Lu
    Cell and Molecular Biology Program, Saint Louis University Health Sciences Center, MO 63104, USA
    EMBO J 15:1323-32. 1996
    ..Though unpredicted by prevailing models, this mechanism is evident in other analogous systems...
  34. ncbi A heat shock-activated cDNA rescues the recessive lethality of mutations in the heterochromatin-associated protein HP1 of Drosophila melanogaster
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104 1079
    Mol Gen Genet 240:333-8. 1993
    ....
  35. pmc Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development
    Maria Gause
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
    Mol Cell Biol 26:2347-59. 2006
    ..Based on these results, we propose that Nipped-A, through the action of the SAGA and Tip60 complexes, facilitates assembly of the Notch activator complex and target gene transcription...
  36. pmc Regulation of the Drosophila melanogaster protein, enhancer of rudimentary, by casein kinase II
    Mark E Gelsthorpe
    Department of Biology, Saint Louis University, St Louis, Missouri 63103, USA
    Genetics 174:265-70. 2006
    ..ER that is unphosphorylated at both T18A and S24 is inactive. CKII activates ER by phosphorylating either T18 or S24. Further phosphorylation to produce the doubly phosphorylated protein inactivates ER...
  37. pmc Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Health Sciences Center, Missouri 63104, USA
    Mol Cell Biol 17:6367-78. 1997
    ....
  38. pmc The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, Missouri 63104
    Genetics 131:345-52. 1992
    ..The implications of these observations for mechanism of heterochromatic position effects and heterochromatin function are discussed...
  39. ncbi Leaving a mark: the many footprints of the elongating RNA polymerase II
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology and the Cancer Center, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Curr Opin Genet Dev 16:184-90. 2006
    ..These findings expand the role for RNA polymerase II elongation in targeting chromatin modifications to include a histone methyl mark more commonly associated with gene silencing...
  40. pmc Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Development 132:4743-53. 2005
    ..Such effects of cohesin on gene expression could be responsible for many of the developmental deficits that occur in Cornelia de Lange syndrome, which is caused by mutations in the human homolog of Nipped-B...
  41. ncbi Boundary functions in the control of gene expression
    J C Eissenberg
    Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, MO 63104
    Trends Genet 7:335-40. 1991
    ..These studies will lead to an analysis of boundary structure, and in addition will provide clues to the mechanism(s) of gene regulation by higher order chromatin packaging...
  42. doi Cellular mechanism for targeting heterochromatin formation in Drosophila
    Joel C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Int Rev Cell Mol Biol 273:1-47. 2009
    ....
  43. ncbi Heterochromatin, position effects, and the genetic dissection of chromatin
    Joel C Eissenberg
    Department of Biochemistry and Molecular Biology, St Louis School of Medicine, St Louis, Missouri 63104, USA
    Prog Nucleic Acid Res Mol Biol 74:275-99. 2003
  44. ncbi Molecular biology: antagonizing the neighbours
    Joel C Eissenberg
    Nature 438:1090-1. 2005
  45. pmc Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL
    Edwin R Smith
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 105:8575-9. 2008
    ..Consistent with a role in elongation, dELL knockdown reduces the levels of phosphorylated Pol II at heat-shock loci. This study implicates dELL in the expression of loci regulated by Pol II elongation...
  46. pmc Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II
    Edwin R Smith
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Mol Cell Biol 28:1041-6. 2008
    ..Our data indicate that dUTX is intimately associated with actively transcribed genes and may provide a paradigm for how H3K27 demethylation is required for the activation of preinitiated Pol II on transcriptionally poised genes...
  47. ncbi Marking time
    Joel C Eissenberg
    Nat Genet 38:276-7. 2006
  48. pmc Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns
    Erin M Smith
    Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583 0806, USA
    J Nutr 137:2006-12. 2007
    ..Biotinylation of histones was barely detectable in biotin-deprived flies, suggesting that epigenetic events might have contributed to effects of biotin deprivation...
  49. pmc cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four
    Fang Lin Sun
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 24:8210-20. 2004
    ..We propose that heterochromatin formation is initiated at dispersed repetitive elements along the fourth chromosome and spreads for approximately 10 kb or until encountering competition from a euchromatic determinant...
  50. pmc Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance
    Gabriela Camporeale
    Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583 0806, USA
    J Nutr 136:2735-42. 2006
    ....
  51. pmc Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases
    Gabriela Camporeale
    Department of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE 68583 0806, USA
    J Nutr 137:885-9. 2007
    ..We conclude that gene expression patterns and phenotypes in HCS-deficient flies in previous studies are caused by decreased biotinylation of histones rather than MCC...