DALE L DORSETT

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint Checks and balances between cohesin and polycomb in gene silencing and transcription
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA Electronic address
    Curr Biol 24:R535-9. 2014
  2. pmc Regulation of the Drosophila Enhancer of split and invected-engrailed gene complexes by sister chromatid cohesion proteins
    Cheri A Schaaf
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    PLoS ONE 4:e6202. 2009
  3. pmc The Drosophila enhancer of split gene complex: architecture and coordinate regulation by notch, cohesin, and polycomb group proteins
    Cheri A Schaaf
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104
    G3 (Bethesda) 3:1785-94. 2013
  4. pmc Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes
    Cheri A Schaaf
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    PLoS Genet 9:e1003560. 2013
  5. pmc Genome-wide control of RNA polymerase II activity by cohesin
    Cheri A Schaaf
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS Genet 9:e1003382. 2013
  6. ncbi request reprint What fruit flies can tell us about human birth defects
    Dale Dorsett
    Edward A Doisy Biochemistry and Molecular Biology Department, Saint Louis University School of Medicine, USA
    Mo Med 110:309-13. 2013
  7. pmc Cohesin at active genes: a unifying theme for cohesin and gene expression from model organisms to humans
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Curr Opin Cell Biol 25:327-33. 2013
  8. pmc The ancient and evolving roles of cohesin in gene expression and DNA repair
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Curr Biol 22:R240-50. 2012
  9. pmc Cohesin: genomic insights into controlling gene transcription and development
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, United States
    Curr Opin Genet Dev 21:199-206. 2011
  10. pmc Cohesin, gene expression and development: lessons from Drosophila
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, Saint Louis, MO 63104, USA
    Chromosome Res 17:185-200. 2009

Research Grants

  1. An Animal Model for Cornelia de Lange Syndrome
    Dale Dorsett; Fiscal Year: 2009
  2. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2000
  3. An Animal Model for Cornelia de Lange Syndrome
    Dale Dorsett; Fiscal Year: 2009
  4. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2006
  5. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2005
  6. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2004
  7. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2004
  8. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2003
  9. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2002
  10. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2003

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Checks and balances between cohesin and polycomb in gene silencing and transcription
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA Electronic address
    Curr Biol 24:R535-9. 2014
    ....
  2. pmc Regulation of the Drosophila Enhancer of split and invected-engrailed gene complexes by sister chromatid cohesion proteins
    Cheri A Schaaf
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    PLoS ONE 4:e6202. 2009
    ..We propose that cohesin helps restrain transcription of these gene complexes, and that deregulation of similarly cohesin-hypersensitive genes may underlie developmental deficits in Cornelia de Lange syndrome...
  3. pmc The Drosophila enhancer of split gene complex: architecture and coordinate regulation by notch, cohesin, and polycomb group proteins
    Cheri A Schaaf
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104
    G3 (Bethesda) 3:1785-94. 2013
    ..We posit that the E(spl)-C architecture dictates where cohesin and PcG complexes bind and act when they are recruited by as yet unidentified factors, thereby controlling the E(spl)-C as a coordinated domain. ..
  4. pmc Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes
    Cheri A Schaaf
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    PLoS Genet 9:e1003560. 2013
    ..These studies reveal a previously unrecognized role for PRC1 in facilitating productive gene transcription and provide new insights into how cohesin and PRC1 control development. ..
  5. pmc Genome-wide control of RNA polymerase II activity by cohesin
    Cheri A Schaaf
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS Genet 9:e1003382. 2013
    ..The multiple transcriptional roles of cohesin revealed by these studies likely underlie the growth and developmental deficits caused by minor changes in cohesin activity...
  6. ncbi request reprint What fruit flies can tell us about human birth defects
    Dale Dorsett
    Edward A Doisy Biochemistry and Molecular Biology Department, Saint Louis University School of Medicine, USA
    Mo Med 110:309-13. 2013
    ..Such information can often be obtained in animal models, such as the fruit fly. Here we describe how understanding a gene's function in fruit flies has illuminated the etiology of Cornelia de Lange syndrome...
  7. pmc Cohesin at active genes: a unifying theme for cohesin and gene expression from model organisms to humans
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Curr Opin Cell Biol 25:327-33. 2013
    ..In all organisms examined, however, cohesin marks a subset of active genes. This review focuses on the roles of cohesin at active genes, and to what extent these roles are conserved between organisms. ..
  8. pmc The ancient and evolving roles of cohesin in gene expression and DNA repair
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Curr Biol 22:R240-50. 2012
    ..Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man...
  9. pmc Cohesin: genomic insights into controlling gene transcription and development
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, United States
    Curr Opin Genet Dev 21:199-206. 2011
    ..These mechanisms are poorly understood, but involve both partial gene repression in concert with Polycomb group proteins, and facilitating long-range looping, both between enhancers and promoters, and between CTCF protein binding sites...
  10. pmc Cohesin, gene expression and development: lessons from Drosophila
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, Saint Louis, MO 63104, USA
    Chromosome Res 17:185-200. 2009
    ....
  11. pmc On the molecular etiology of Cornelia de Lange syndrome
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, Saint Louis, MO 63104, USA
    Ann N Y Acad Sci 1151:22-37. 2009
    ..The mechanisms by which cohesion factors regulate gene expression remain to be elucidated, but current data suggest that they likely regulate transcription in multiple ways...
  12. pmc Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Development 132:4743-53. 2005
    ..Such effects of cohesin on gene expression could be responsible for many of the developmental deficits that occur in Cornelia de Lange syndrome, which is caused by mutations in the human homolog of Nipped-B...
  13. pmc Roles of the sister chromatid cohesion apparatus in gene expression, development, and human syndromes
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Chromosoma 116:1-13. 2007
    ..Effects on chromatid cohesion are apparent in RBS/SC syndrome, but data from yeast and Drosophila point to the likelihood that changes in expression of genes located in heterochromatin could contribute to the developmental deficits...
  14. doi request reprint Running rings around chromosomes to trim axons and target dendrites
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, Saint Louis, MO 63104, USA
    Dev Cell 14:156-8. 2008
    ..Other recent studies argue that these roles involve regulation of gene transcription...
  15. pmc Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells
    Maria Gause
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Chromosoma 117:51-66. 2008
    ..These results support the idea that direct regulation of cohesin function underlies the diverse functions of Nipped-B and its orthologs...
  16. pmc Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome
    Ziva Misulovin
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Chromosoma 117:89-102. 2008
    ..These mechanisms are likely involved in the etiology of Cornelia de Lange syndrome, in which mutation of one copy of the NIPBL gene encoding the human Nipped-B ortholog causes diverse structural and mental birth defects...
  17. pmc Dosage-sensitive regulation of cohesin chromosome binding and dynamics by Nipped-B, Pds5, and Wapl
    Maria Gause
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Mol Cell Biol 30:4940-51. 2010
    ..We also found that Nipped-B, Pds5, and the Wapl protein that interacts with Pds5 all play unique roles in cohesin chromosome binding...
  18. ncbi request reprint Adherin: key to the cohesin ring and cornelia de Lange syndrome
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    Curr Biol 14:R834-6. 2004
    ..New studies indicate that adherin activity is coordinated with DNA replication and chromosome segregation, and that its dosage is critical for gene expression and human development...
  19. pmc Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development
    Maria Gause
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, USA
    Mol Cell Biol 26:2347-59. 2006
    ..Based on these results, we propose that Nipped-A, through the action of the SAGA and Tip60 complexes, facilitates assembly of the Notch activator complex and target gene transcription...
  20. doi request reprint Cohesin and CTCF: cooperating to control chromosome conformation?
    Maria Gause
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Missouri 63104, USA
    Bioessays 30:715-8. 2008
    ..Thus, these studies demonstrate at least one mechanism by which cohesin can control gene expression...
  21. pmc Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling
    Kristen Tenney
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 103:11970-4. 2006
    ..Here we demonstrate that the dRtf1 component of the Paf1 complex functions in Notch signaling...

Research Grants15

  1. An Animal Model for Cornelia de Lange Syndrome
    Dale Dorsett; Fiscal Year: 2009
    ....
  2. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2000
    ..These experiments will help define the roles of CHIP in potentiating enhancer activity, and increase understanding of how remote enhancers regulate transcription. ..
  3. An Animal Model for Cornelia de Lange Syndrome
    Dale Dorsett; Fiscal Year: 2009
    ....
  4. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2006
    ..These studies will increase understanding of long-range gene activation and illuminate fundamental mechanisms underlying some human genetic diseases. ..
  5. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2005
    ..These studies will increase understanding of long-range gene activation and illuminate fundamental mechanisms underlying some human genetic diseases. ..
  6. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2004
    ..These studies will increase understanding of long-range gene activation and illuminate fundamental mechanisms underlying some human genetic diseases. ..
  7. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2004
    ..This will help illuminate the basic mechanisms underlying gene expression defects that occur in some human diseases. ..
  8. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2003
    ..This will help illuminate the basic mechanisms underlying gene expression defects that occur in some human diseases. ..
  9. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2002
    ..These experiments will help define the roles of CHIP in potentiating enhancer activity, and increase understanding of how remote enhancers regulate transcription. ..
  10. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2003
    ..These studies will increase understanding of long-range gene activation and illuminate fundamental mechanisms underlying some human genetic diseases. ..
  11. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2002
    ..This will help illuminate the basic mechanisms underlying gene expression defects that occur in some human diseases. ..
  12. LONG DISTANCE ENHANCER-PROMOTER INTERACTIONS
    Dale Dorsett; Fiscal Year: 2001
    ..These experiments will help define the roles of CHIP in potentiating enhancer activity, and increase understanding of how remote enhancers regulate transcription. ..
  13. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2001
    ..This will help illuminate the basic mechanisms underlying gene expression defects that occur in some human diseases. ..
  14. An Animal Model for Cornelia de Lange Syndrome
    DALE L DORSETT; Fiscal Year: 2010
    ....