Affiliation: Saint Louis University
Country: USA


  1. Dorsett D. What fruit flies can tell us about human birth defects. Mo Med. 2013;110:309-13 pubmed
    ..Such information can often be obtained in animal models, such as the fruit fly. Here we describe how understanding a gene's function in fruit flies has illuminated the etiology of Cornelia de Lange syndrome. ..
  2. Dorsett D. Running rings around chromosomes to trim axons and target dendrites. Dev Cell. 2008;14:156-8 pubmed publisher
    ..Other recent studies argue that these roles involve regulation of gene transcription. ..
  3. Dorsett D, Merkenschlager M. Cohesin at active genes: a unifying theme for cohesin and gene expression from model organisms to humans. Curr Opin Cell Biol. 2013;25:327-33 pubmed publisher
    ..In all organisms examined, however, cohesin marks a subset of active genes. This review focuses on the roles of cohesin at active genes, and to what extent these roles are conserved between organisms. ..
  4. Dorsett D. Cohesin: genomic insights into controlling gene transcription and development. Curr Opin Genet Dev. 2011;21:199-206 pubmed publisher
    ..These mechanisms are poorly understood, but involve both partial gene repression in concert with Polycomb group proteins, and facilitating long-range looping, both between enhancers and promoters, and between CTCF protein binding sites. ..
  5. Dorsett D, Ström L. The ancient and evolving roles of cohesin in gene expression and DNA repair. Curr Biol. 2012;22:R240-50 pubmed publisher
    ..Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man. ..
  6. Dorsett D, Misulovin Z. Measuring Sister Chromatid Cohesion Protein Genome Occupancy in Drosophila melanogaster by ChIP-seq. Methods Mol Biol. 2017;1515:125-139 pubmed
    ..The locations of enrichment peaks, however, can differ between ChIP-chip and ChIP-seq, and low sequencing depth can splinter broad regions of occupancy into distinct peaks. ..
  7. Dorsett D, Eissenberg J, Misulovin Z, Martens A, Redding B, McKim K. Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila. Development. 2005;132:4743-53 pubmed
    ..Such effects of cohesin on gene expression could be responsible for many of the developmental deficits that occur in Cornelia de Lange syndrome, which is caused by mutations in the human homolog of Nipped-B...
  8. Dorsett D. Roles of the sister chromatid cohesion apparatus in gene expression, development, and human syndromes. Chromosoma. 2007;116:1-13 pubmed
    ..Effects on chromatid cohesion are apparent in RBS/SC syndrome, but data from yeast and Drosophila point to the likelihood that changes in expression of genes located in heterochromatin could contribute to the developmental deficits...
  9. Dorsett D, Krantz I. On the molecular etiology of Cornelia de Lange syndrome. Ann N Y Acad Sci. 2009;1151:22-37 pubmed publisher
    ..The mechanisms by which cohesion factors regulate gene expression remain to be elucidated, but current data suggest that they likely regulate transcription in multiple ways. ..

More Information


  1. Dorsett D. Cohesin, gene expression and development: lessons from Drosophila. Chromosome Res. 2009;17:185-200 pubmed publisher
  2. Dorsett D, Kassis J. Checks and balances between cohesin and polycomb in gene silencing and transcription. Curr Biol. 2014;24:R535-9 pubmed publisher