Adrian M Di Bisceglie

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint Epidemiology and clinical presentation of hepatocellular carcinoma
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3634 Vista Avenue, St Louis, MO 63110, USA
    J Vasc Interv Radiol 13:S169-71. 2002
  2. ncbi request reprint Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C
    Alan Lee Rothman
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 41:617-25. 2005
  3. ncbi request reprint A 32-year-old man with hepatitis C who developed progressive liver failure after a bone marrow transplant
    Andre C Lyra
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 22:103-8. 2002
  4. ncbi request reprint Early virologic response after peginterferon alpha-2a plus ribavirin or peginterferon alpha-2b plus ribavirin treatment in patients with chronic hepatitis C
    A M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    J Viral Hepat 14:721-9. 2007
  5. pmc Comparative analysis of nearly full-length hepatitis C virus quasispecies from patients experiencing viral breakthrough during antiviral therapy: clustered mutations in three functional genes, E2, NS2, and NS5a
    Zekuan Xu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Virol 82:9417-24. 2008
  6. ncbi request reprint The history of the Department of Internal Medicine at Saint Louis University
    Adrian M Di Bisceglie
    Department of Internal Medicine, Saint Louis University Liver Center, USA
    Mo Med 109:115-8. 2012
  7. pmc Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis
    Stephen J Polyak
    Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Virol J 2:41. 2005
  8. ncbi request reprint Long term follow up of bone mineral density in patients with primary biliary cirrhosis
    A M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University, Saint Louis, MO 63110, USA
    Minerva Med 95:529-34. 2004
  9. ncbi request reprint Issues in screening and surveillance for hepatocellular carcinoma
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, Missouri 63110, USA
    Gastroenterology 127:S104-7. 2004
  10. pmc Hepatitis B and hepatocellular carcinoma
    Adrian M Di Bisceglie
    Saint Louis University Liver Center, Saint Louis University, St Louis, MO 63110, USA
    Hepatology 49:S56-60. 2009

Research Grants

  1. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 1999
  2. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2000
  3. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2001
  4. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2001
  5. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2002
  6. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2003

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Epidemiology and clinical presentation of hepatocellular carcinoma
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3634 Vista Avenue, St Louis, MO 63110, USA
    J Vasc Interv Radiol 13:S169-71. 2002
    ..Early detection of HCC is a key factor in improving outcomes of therapies. There is growing evidence that HCC may be prevented with strategies aimed at preventing or treating viral hepatitis...
  2. ncbi request reprint Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C
    Alan Lee Rothman
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 41:617-25. 2005
    ....
  3. ncbi request reprint A 32-year-old man with hepatitis C who developed progressive liver failure after a bone marrow transplant
    Andre C Lyra
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 22:103-8. 2002
  4. ncbi request reprint Early virologic response after peginterferon alpha-2a plus ribavirin or peginterferon alpha-2b plus ribavirin treatment in patients with chronic hepatitis C
    A M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    J Viral Hepat 14:721-9. 2007
    ....
  5. pmc Comparative analysis of nearly full-length hepatitis C virus quasispecies from patients experiencing viral breakthrough during antiviral therapy: clustered mutations in three functional genes, E2, NS2, and NS5a
    Zekuan Xu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Virol 82:9417-24. 2008
    ..Furthermore, the pattern for mutation clustering indicated potential mutation linkage among E2, NS2, and NS5a due to structural or functional relatedness in HCV replication...
  6. ncbi request reprint The history of the Department of Internal Medicine at Saint Louis University
    Adrian M Di Bisceglie
    Department of Internal Medicine, Saint Louis University Liver Center, USA
    Mo Med 109:115-8. 2012
    ..The department has played a key role in several medical discoveries and innovations over the last 100 years and continues to make an impact on those in its community...
  7. pmc Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis
    Stephen J Polyak
    Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Virol J 2:41. 2005
    ..QS diversity and complexity were quantified using heteroduplex mobility assays (HMA)...
  8. ncbi request reprint Long term follow up of bone mineral density in patients with primary biliary cirrhosis
    A M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University, Saint Louis, MO 63110, USA
    Minerva Med 95:529-34. 2004
    ....
  9. ncbi request reprint Issues in screening and surveillance for hepatocellular carcinoma
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, Missouri 63110, USA
    Gastroenterology 127:S104-7. 2004
    ..Clearly, better methods are needed for early diagnosis of HCC. Improved technology will ultimately have to be tested for improved patient outcome before becoming widely recommended...
  10. pmc Hepatitis B and hepatocellular carcinoma
    Adrian M Di Bisceglie
    Saint Louis University Liver Center, Saint Louis University, St Louis, MO 63110, USA
    Hepatology 49:S56-60. 2009
    ..There are emerging data showing that prolonged antiviral therapy may reduce the risk of hepatocellular carcinoma among certain patients with chronic hepatitis B...
  11. pmc HIV-HBV coinfection among South African patients receiving antiretroviral therapy
    Adrian M Di Bisceglie
    Department of Internal Medicine, Saint Louis University, St Louis, MO, USA
    Antivir Ther 15:499-503. 2010
    ..Additional information is needed on the prevalence of HIV-HBV coinfection and treatment response to ART. We present a summary of the information available from South Africa to date...
  12. ncbi request reprint Chemoprevention of hepatocellular carcinoma: use of tamoxifen in an animal model of hepatocarcinogenesis
    Adrian M Di Bisceglie
    Saint Louis University Liver Center, Department of Medicine, Saint Louis University, 3635 Vista Ave at Grand Blvd, MO 63110, USA
    J Lab Clin Med 145:134-8. 2005
    ....
  13. ncbi request reprint The AASLD and public policy: coming in out of the cold
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, University Liver Center, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    Hepatology 45:1335-6. 2007
  14. ncbi request reprint Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Hepatol 43:434-41. 2005
    ..We assessed serum AFP among patients with chronic hepatitis C and advanced fibrosis to establish predictors of AFP elevations and changes with antiviral therapy...
  15. ncbi request reprint Pretransplant treatments for hepatocellular carcinoma: do they improve outcomes?
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Liver Transpl . 2005
    ..3. Prospective, randomized controlled trials are clearly needed to determine if pre-transplant therapy of HCC is of value...
  16. ncbi request reprint Pharmacokinetics, pharmacodynamics, and hepatitis C viral kinetics during antiviral therapy: the null responder
    Adrian M Di Bisceglie
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Med Virol 78:446-51. 2006
    ....
  17. ncbi request reprint Spontaneous retroperitoneal and rectus muscle hemorrhage as a potentially lethal complication of cirrhosis
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Liver Int 26:1291-3. 2006
    ..Cirrhosis may be complicated by bleeding from varices at sites of porto-systemic anastomosis and may be exacerbated by coagulopathy...
  18. pmc Excess mortality in patients with advanced chronic hepatitis C treated with long-term peginterferon
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA
    Hepatology 53:1100-8. 2011
    ..No specific cause of death accounted for the excess mortality and only one death was suspected to be a direct complication of peginterferon...
  19. pmc Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    N Engl J Med 359:2429-41. 2008
    ..Whether long-term antiviral therapy can prevent progressive liver disease in such patients remains uncertain...
  20. ncbi request reprint Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: a multicenter, prospective, randomized, controlled trial
    A M Di Bisceglie
    Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Hepatology 32:135-8. 2000
    ....
  21. ncbi request reprint Optimal therapy of hepatitis C
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology and the Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis University, St Louis, MO 63110, USA
    Hepatology 36:S121-7. 2002
    ....
  22. pmc Combination therapy for hepatitis B
    A M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Gut 50:443-5. 2002
    ..New drugs acting by different antiviral mechanisms may be particularly potent in combination...
  23. pmc Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e9032. 2010
    ..African American patients respond to interferon alpha-based therapy at about half the rate of Caucasian Americans. The effect of HCV's genetic variation on treatment outcome in both racial groups is poorly understood...
  24. ncbi request reprint Impact of disease severity on outcome of antiviral therapy for chronic hepatitis C: Lessons from the HALT-C trial
    Gregory T Everson
    Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, CO, USA
    Hepatology 44:1675-84. 2006
    ..In conclusion, disease severity is a major independent determinant of rate of SVR in patients with advanced chronic hepatitis C. New strategies are needed to optimize antiviral therapy in these "difficult-to-cure" patients...
  25. pmc Clinical, virologic, histologic, and biochemical outcomes after successful HCV therapy: a 5-year follow-up of 150 patients
    Sarah L George
    Department of Internal Medicine, Division of Gastroenterology, Saint Louis University Liver Center, St Louis, MO, USA
    Hepatology 49:729-38. 2009
    ..No patient had conclusive evidence of virologic relapse. Three patients had persistently elevated alanine aminotransferase levels; two of these had new liver disease...
  26. pmc Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C
    Richard W Lambrecht
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 140:1490-500.e3. 2011
    ..Our aim was to assess the relationship of iron and HFE genetic variations to progression and outcomes in the HALT-C Trial and whether PegIFN therapy influenced iron variables...
  27. ncbi request reprint Liver transplantation with hepatitis C virus-infected graft: interaction between donor and recipient viral strains
    Xiaofeng Fan
    Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO, USA
    Hepatology 38:25-33. 2003
    ..In conclusion, in all 6 cases studied, there was no genetic recombination detected among HCV quasispecies or between donor and recipient HCV strains...
  28. ncbi request reprint Effect of significant histologic steatosis or steatohepatitis on response to antiviral therapy in patients with chronic hepatitis C
    Stephen A Harrison
    Saint Louis University Liver Center, Saint Louis University, St Louis, MS, USA
    Clin Gastroenterol Hepatol 3:604-9. 2005
    ..A control group (group 2) of 231 CHC patients was identified by using a 2-year database (January 2000-June 2001) of patients without evidence of greater than 33% steatosis or SH...
  29. pmc Up-regulation of circulating miR-20a is correlated with hepatitis C virus-mediated liver disease progression
    Shubham Shrivastava
    Department of Pathology, Saint Louis University, St Louis, MO, USA
    Hepatology 58:863-71. 2013
    ..These data provide evidence that plasma/serum levels of miR-20a and miR-92a have potential as sensitive and cost-effective biomarkers for early detection of HCV infection...
  30. pmc A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma
    Barham K Abu Dayyeh
    Gastrointestinal Unit, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 141:141-9. 2011
    ..We tested associations between demographic, clinical, and genetic data and development of HCC, and developed a simple predictive model in a cohort of patients with chronic hepatitis C and advanced fibrosis...
  31. ncbi request reprint Infection with hepatitis C virus genotype 4 in the United States
    Andre C Lyra
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Clin Gastroenterol 38:68-71. 2004
    ..HCV genotype 4 is rare in the United States and there are few published data regarding response to therapy in patients with HCV genotype 4 infection...
  32. ncbi request reprint Evolution of hepatitis C viral quasispecies after liver transplantation
    Andre C Lyra
    Division of Gastroenterology and Hepatology, Department of Internal Medicine and Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 123:1485-93. 2002
    ..To determine whether HCV quasispecies diversity correlated positively with liver disease progression after orthotopic liver transplantation (OLT)...
  33. pmc Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO 63104, USA
    J Virol 81:8211-24. 2007
    ..No evidence was found for novel HCV strains in the AA population, implying that AA patients may be infected with a higher proportion of the same resistant strains that are found in CA patients...
  34. doi request reprint Lack of association between genotypes and subtypes of HCV and occurrence of hepatocellular carcinoma in Egypt
    Soo Hyung Ryu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    J Med Virol 81:844-7. 2009
    ..08). In conclusion, HCV genotype 4 predominates in Egypt. There was no association between subtypes of genotype 4 and the development of HCC...
  35. pmc Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles
    Budhaditya Mazumdar
    Department of Internal Medicine, St Louis University, St Louis, Missouri, USA
    J Virol 87:7902-10. 2013
    ..Collectively, these results suggest that HCV induces and associates with a negative regulator of the complement pathway, a likely mechanism for immune evasion. ..
  36. pmc Hepatitis C virus-mediated inhibition of cathepsin S increases invariant-chain expression on hepatocyte surface
    Hangeun Kim
    Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri, USA
    J Virol 86:9919-28. 2012
    ....
  37. pmc Hepatitis C virus proteins inhibit C3 complement production
    Budhaditya Mazumdar
    Departments of Internal Medicine, Saint Louis University, Saint Louis, Missouri, USA
    J Virol 86:2221-8. 2012
    ..Together, these results underscore the role of HCV NS5A protein in impairing innate immune function...
  38. pmc The Core/E1 domain of hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma
    Xiaoan Zhang
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Clin Virol 52:333-8. 2011
    ..As HCV shows remarkable genetic diversity, an interesting and important issue is whether such a high viral genetic diversity plays a role in the incidence of HCC. Prior data on this subject are conflicting...
  39. pmc Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C
    Robert J Fontana
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0362, USA
    Gastroenterology 138:2321-31, 2331.e1-2. 2010
    ..We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis...
  40. pmc Occult and previous hepatitis B virus infection are not associated with hepatocellular carcinoma in United States patients with chronic hepatitis C
    Anna S Lok
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 54:434-42. 2011
    ..7% of controls. HBV DNA was detected in the serum of only one control subject and no patients with HCC. HBV DNA (as a marker of occult HBV infection) was detected in the livers of 10.7% of HCC cases and 23.6% of controls (P=0.18)...
  41. ncbi request reprint Separation of near full-length hepatitis C virus quasispecies variants from a complex population
    Donghui Zhou
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Virol Methods 141:220-4. 2007
    ..These observations emphasize the significance of the use of near full-length genomic sequences for HCV genetic studies and for reverse genetic analysis using authentic quasispecies variants...
  42. ncbi request reprint Hepatocyte senescence in end-stage chronic liver disease: a study of cyclin-dependent kinase inhibitor p21 in liver biopsies as a marker for progression to hepatocellular carcinoma
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Liver Int 27:662-71. 2007
    ..Histologic markers to predict hepatocellular carcinoma (HCC) include small cell change and dysplastic nodules. Hepatocyte senescence is noted in chronic liver disease and may or may not be important in progression to HCC...
  43. pmc Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytes
    Sandip K Bose
    Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, Missouri, USA
    J Virol 86:13621-8. 2012
    ..This observation may have implications for liver disease progression and therapeutic intervention strategies using inhibitory molecules...
  44. pmc Divergent quasispecies evolution in de novo hepatitis C virus infection associated with bone marrow transplantation
    Weihua Wang
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Biochem Biophys Res Commun 414:148-52. 2011
    ..Instead, our data suggested an essential role of the fitness adaptation of founder viral population in driving such an evolutionary pattern...
  45. ncbi request reprint Diversification of hypervariable region 1 of hepatitis C virus after liver transplantation
    Xiaofeng Fan
    Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63110 0250, USA
    J Med Virol 70:212-8. 2003
    ..However, the dramatic diversification of HVR1 sequence over time is mainly due to the adaptation of new replicative site, the donor liver, indicating that HCV may obtain the higher replication fitness by mutating HVR1 domain...
  46. pmc High diversity of hepatitis C viral quasispecies is associated with early virological response in patients undergoing antiviral therapy
    Xiaofeng Fan
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St Louis University School of Medicine, St Louis, MO, USA
    Hepatology 50:1765-72. 2009
    ..5%), which contributed substantially to the overall association between EVR and increased baseline QS diversity. In addition, EVR was linked to a clustered evolutionary pattern in terms of QS dynamic changes...
  47. ncbi request reprint CD81 binding regions of hepatitis C virus remain conserved after liver transplantation
    Andre C Lyra
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Braz J Infect Dis 8:126-32. 2004
    ..This may favor HCV re-infection of the allograft after liver transplantation...
  48. ncbi request reprint The progression of hepatitis B- and C-infections to chronic liver disease and hepatocellular carcinoma: epidemiology and pathogenesis
    Paul H Hayashi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University Liver Center, 3635 Vista Avenue, St Louis, Mo 63110 0250, USA
    Med Clin North Am 89:371-89. 2005
    ..Understanding of this epidemiology and pathophysiology provides the basis for the clinical evaluation, diagnosis, screening, and treatment of HCC...
  49. ncbi request reprint The progression of hepatitis B- and C-infections to chronic liver disease and hepatocellular carcinoma: presentation, diagnosis, screening, prevention, and treatment of hepatocellular carcinoma
    Paul H Hayashi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University Liver Center, 3635 Vista Avenue, St Louis, Mo 63110 0250, USA
    Med Clin North Am 89:345-69. 2005
    ..It is hoped that antiviral treatment studies will lower the risk of HCC, and that these changes will occur soon enough to help the many patients at risk for or diagnosed with HCC over the next several years...
  50. ncbi request reprint A descriptive study of the relationship between mood disorders and hepatitis C treatment compliance: does nursing play a role?
    Janice M Strinko
    Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Issues Ment Health Nurs 25:715-22. 2004
    ..Eighty-one percent of sustained responders experienced psychiatric events, and it is speculated that comprehensive nursing support and intervention were key components in achieving favorable patient outcomes...
  51. ncbi request reprint The safety of intra-abdominal surgery in patients with cirrhosis: model for end-stage liver disease score is superior to Child-Turcotte-Pugh classification in predicting outcome
    Alex S Befeler
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University, St Louis, MO 63110, USA
    Arch Surg 140:650-4; discussion 655. 2005
    ..We hypothesized that the model for end-stage liver disease (MELD) score may be a better and less subjective method than the Child-Turcotte-Pugh score for stratifying patients with cirrhosis before abdominal surgery...
  52. ncbi request reprint Hepatitis C-related hepatocellular carcinoma in the United States: influence of ethnic status
    Adrian M Di Bisceglie
    Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    Am J Gastroenterol 98:2060-3. 2003
    ..The aim of this study was to evaluate the influence of racial and ethnic status in the viral etiology of HCC in the US...
  53. pmc Viral categorization and discovery in human circulation by transcriptome sequencing
    Weihua Wang
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Biochem Biophys Res Commun 436:525-9. 2013
    ..Such an integrated approach may have an immediate application in any clinical situations concerning with viral etiology. ..
  54. pmc Hepatitis C virus suppresses C9 complement synthesis and impairs membrane attack complex function
    Hangeun Kim
    Department of Internal Medicine, Saint Louis University, St Louis, Missouri, USA
    J Virol 87:5858-67. 2013
    ..Together, these results for C9 regulation by HCV core protein coupled with functional impairment of the membrane attack complex underscore HCV-mediated attenuation of immune mechanisms...
  55. pmc Hepatitis C virus infection modulates expression of interferon stimulatory gene IFITM1 by upregulating miR-130A
    Joydip Bhanja Chowdhury
    Department of Pathology, Saint Louis University, Saint Louis, Missouri, USA
    J Virol 86:10221-5. 2012
    ..Hepatocytes stably expressing IFITM1 reduced HCV replication. Together, these results suggested that HCV infection of hepatocytes upregulates miR-130a and that use of anti-miR-130a may have potential for restriction of HCV replication...
  56. ncbi request reprint Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C
    Herbert L Bonkovsky
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 131:1440-51. 2006
    ....
  57. pmc Transcriptional repression of C4 complement by hepatitis C virus proteins
    Arup Banerjee
    Department of Internal Medicine, Saint Louis University, 1100 S Grand Blvd, 8th Floor, St Louis, MO 63104, USA
    J Virol 85:4157-66. 2011
    ..These results underscore the roles of HCV proteins in innate immune regulation in establishing a chronic infection...
  58. pmc Comprehensive cloning of patient-derived 9022-bp amplicons of hepatitis C virus
    Yang Lu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Virol Methods 191:105-12. 2013
    ..These observations are not only valuable for potentially establishing an HCV 1a cell culture model but also have general implications for other RNA viruses due to concern about cloning instability...
  59. ncbi request reprint New therapeutic strategies for hepatitis C
    Adrian M Di Bisceglie
    Saint Louis University, St Louis MO 63110, USA
    Hepatology 35:224-31. 2002
  60. pmc Enhanced protocol for determining the 3' terminus of hepatitis C virus
    Xiaoan Zhang
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    J Virol Methods 167:158-64. 2010
    ..The availability of abundant authentic sequence information for the complete HCV 3'UTR will allow full investigation of its biological role in the life cycle of HCV...
  61. ncbi request reprint Efficient amplification and cloning of near full-length hepatitis C virus genome from clinical samples
    Xiaofeng Fan
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 346:1163-72. 2006
    ..Thus, our LRP protocol could be applied for the amplification of other difficult RNA templates and may facilitate RNA virus research such as linked viral mutations and reverse genetics...
  62. ncbi request reprint Diabetic hepatosclerosis: diabetic microangiopathy of the liver
    Stephen A Harrison
    Liver Center, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Arch Pathol Lab Med 130:27-32. 2006
    ..After observing a noncirrhotic form of hepatic sinusoidal fibrosis in patients with long-standing diabetes mellitus who underwent liver biopsy, we set about to characterize this novel entity...
  63. ncbi request reprint Comparison of liver biopsy and noninvasive methods for diagnosis of hepatocellular carcinoma
    Eldad S Bialecki
    Department of Internal Medicine, Saint Louis University School of Medicine St Louis, Missouri, USA
    Clin Gastroenterol Hepatol 4:361-8. 2006
    ..We evaluated our experience of patients with liver disease and hepatic lesions suspicious for HCC who underwent both fine-needle aspiration and core biopsy and correlated the results with those from commonly used noninvasive approaches...
  64. doi request reprint RT-PCR amplification and cloning of large viral sequences
    Xiaofeng Fan
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO, USA
    Methods Mol Biol 630:139-49. 2010
    ....
  65. ncbi request reprint Expression of P-glycoprotein and C-MOAT in human hepatocellular carcinoma: detection by immunostaining
    John Richart
    Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Dig Dis Sci 47:2454-8. 2002
    ....
  66. ncbi request reprint Liver transplantation for hepatocellular carcinoma
    Alex S Befeler
    Saint Louis University Liver Center, Saint Louis University, Missouri 63110, USA
    Gastroenterology 128:1752-64. 2005
  67. ncbi request reprint Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes
    Arnab Basu
    Department of Internal Medicine, Liver Center and Cancer Center, Saint Louis University, St Louis, MO 63110, USA
    Virology 349:347-58. 2006
    ..Identification of these modulated genes with potential roles may help in the selection of targets for therapies against HCV-mediated liver disease progression...
  68. pmc Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Genome Med 3:8. 2011
    ..Direct-acting inhibitors of HCV that will be used in combination with IFN╬▒ are nearing approval, so genetic prediction for anti-HCV therapy will soon need to incorporate viral genetic markers of viral resistance to the new drugs...
  69. ncbi request reprint Benign hepatocellular tumors (adenomatosis) in nonalcoholic steatohepatitis: a case report
    Elizabeth M Brunt
    Saint Louis University Liver Center, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    Semin Liver Dis 25:230-6. 2005
  70. ncbi request reprint Hepatocellular carcinoma: diagnosis and treatment
    Alex S Befeler
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    Gastroenterology 122:1609-19. 2002
    ..Identifying hepatocellular carcinoma at an early stage is often associated with having better treatment options for patients with small, asymptomatic tumors...
  71. ncbi request reprint Genetic complexity and serum reactivity of HVR1 quasispecies of hepatitis C virus in patients with cirrhosis
    Xiaofeng Fan
    Department of Internal Medicine, Saint Louis University School of Medicine, Missouri 63110 0250, USA
    Am J Gastroenterol 97:1489-95. 2002
    ..However, the significance of this finding has not been examined extensively at genetic and serological levels...
  72. ncbi request reprint Aging liver and hepatitis
    Omer Junaidi
    Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, Saint Louis, MO 63110, USA
    Clin Geriatr Med 23:889-903, viii. 2007
    ..This article reviews the likely causes of hepatitis in elderly individuals and discusses evidence for treating this population...
  73. ncbi request reprint HCV E2 glycoprotein: mutagenesis of N-linked glycosylation sites and its effects on E2 expression and processing
    Tiffany Slater-Handshy
    Department of Molecular Microbiology and Immunology, St Louis University School of Medicine, St Louis, MO 63104, USA
    Virology 319:36-48. 2004
    ..These experiments provide direct evidence that the presence of multiple N-linked glycans is required for the proper folding of the E2 protein in the ER and secretory pathway as well as for formation of its antigenic structure...
  74. ncbi request reprint Markedly elevated serum CA 19-9 levels in association with a benign biliary stricture due to primary sclerosing cholangitis
    Mark D Murray
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    J Clin Gastroenterol 41:115-7. 2007
    ..We conclude that serum CA 19-9 levels need to be assessed in the clinical context of biliary obstruction and should ideally be measured after relief of that obstruction, as it may be falsely elevated due to benign biliary strictures...
  75. pmc Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults
    Sharon E Frey
    Saint Louis University School of Medicine, Division of Infectious Diseases and Immunology, St Louis, MO 63104, USA
    Vaccine 28:6367-73. 2010
    ..We describe the first in humans clinical trial of this prophylactic HCV vaccine...
  76. ncbi request reprint Clinical presentation and natural course of hepatocellular carcinoma
    Eldad S Bialecki
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, USA
    Eur J Gastroenterol Hepatol 17:485-9. 2005
    ..Growth and maturation of hepatocellular carcinoma is variable and involves a complex network of hepatic vasculature. Staging systems have been developed to predict disease progression and survival and continue to undergo investigation...
  77. ncbi request reprint Advances in the understanding and treatment of nonalcoholic fatty liver disease
    Stephen A Harrison
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Drugs 63:2379-94. 2003
    ....
  78. ncbi request reprint Biliary-venous fistula complicating transjugular intrahepatic portosystemic shunt presenting with recurrent bacteremia, jaundice, anemia and fever
    Qaiser Jawaid
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Saint Louis, MO, USA
    Am J Transplant 3:1604-7. 2003
    ..Liver transplantation may be the preferred treatment if TIPS becomes infected following its complete occlusion...
  79. pmc Complement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoprotein
    Keith Meyer
    Department of Internal Medicine, Saint Louis University, 3635 Vista Ave, St Louis, Missouri 63110, USA
    J Virol 76:2150-8. 2002
    ....
  80. ncbi request reprint Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease
    Elizabeth M Brunt
    Saint Louis University Liver Center Department of Pathology, Saint Louis University Health Sciences Center, St Louis, Missouri, USA
    Mod Pathol 16:49-56. 2003
    ..Diabetes was reported in 35%, 25%, and 9%. The concurrence of clinical and histologic features of steatohepatitis with another chronic liver disease may be a reflection of the frequency of steatohepatitis in the population at large...
  81. ncbi request reprint A new approach to therapy for hepatocellular carcinoma?
    Stephen A Harrison
    Saint Louis University, MO, USA
    Hepatology 37:471-3. 2003
  82. ncbi request reprint Direct evidence for GB virus C/hepatitis G virus (GBV-C/HGV) superinfection: elimination of resident viral strain by donor strain in a patient undergoing liver transplantation
    Xiaofeng Fan
    Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Med Virol 68:76-81. 2002
    ..This study, therefore, provides direct evidence for GBV-C/HGV superinfection of one strain by another with one of them predominating probably due to replication competition...
  83. doi request reprint Procarbazine-induced hepatotoxicity: case report and review of the literature
    Mark J Fesler
    Division of Hematology and Medical Oncology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri 63110, USA
    Pharmacotherapy 30:540. 2010
    ..Based on our experience with this patient, periodic assessment of hepatic function, as suggested in the package insert, is recommended in patients receiving procarbazine...
  84. ncbi request reprint Histological changes after the use of mycophenolate mofetil in autoimmune hepatitis
    Elizabeth M Brunt
    Saint Louis University Liver Center, Saint Louis University Health Sciences Center, St Louis, MO, USA
    Hum Pathol 35:509-12. 2004
    ..Both cytoplasmic features of adaptation and nuclear alterations were noted in hepatocytes. Possible mechanisms for these findings are discussed...
  85. doi request reprint Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease
    W Ray Kim
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Hepatology 47:1363-70. 2008
  86. ncbi request reprint Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial
    Leonard B Seeff
    Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 47:605-12. 2008
    ..Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C...
  87. doi request reprint Design and endpoints of clinical trials in hepatocellular carcinoma
    Josep M Llovet
    HCC Translational Research Lab, Barcelona Clinic Liver Cancer Group, Liver Unit, Hospital Clinic, CIBERehd, Institute for Biomedical Investigations August Pi Sunyer, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Natl Cancer Inst 100:698-711. 2008
    ..These surrogate markers may help to enrich study populations and maximize the cost-benefit ratio of trial execution. Design and conduct of phase 3 trials should be coordinated by centers with appropriate expertise in HCC...
  88. doi request reprint Improved outcomes in patients with hepatitis C with difficult-to-treat characteristics: randomized study of higher doses of peginterferon alpha-2a and ribavirin
    Michael W Fried
    University of North Carolina, Chapel Hill, NC 27514, USA
    Hepatology 48:1033-43. 2008
    ..The arm with the higher doses of both drugs was less well-tolerated than the other regimens...
  89. ncbi request reprint What every hepatologist should know about endocrinology: obesity, diabetes, and liver disease
    Adrian M Di Bisceglie
    Gastroenterology 126:604-6. 2004
  90. ncbi request reprint HCV RNA detection by TMA during the hepatitis C antiviral long-term treatment against cirrhosis (Halt-C) trial
    Chihiro Morishima
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98104, USA
    Hepatology 44:360-7. 2006
    ..In patients with negative PCR results during treatment, a single positive TMA test did not exclude SVR, although persistently positive tests did...
  91. ncbi request reprint Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University, Richmond, 23298, USA
    Gastroenterology 126:1015-23; discussion 947. 2004
    ..This study evaluated the effectiveness of this treatment in patients who were nonresponders to previous interferon-based therapy...
  92. ncbi request reprint The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis
    Arun J Sanyal
    Division of Gastroenterology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Gastrointest Endosc 64:855-64. 2006
    ..The factors predictive of the presence or the absence of esophageal varices in hepatitis C virus (HCV) and advanced fibrosis have not been defined...
  93. pmc Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis
    Herbert L Bonkovsky
    Liver Biliary Pancreatic Center and the Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    J Hepatol 46:420-31. 2007
    ..This study assessed HRQOL and sexual health in patients with advanced fibrosis or cirrhosis in the HALT-C Trial...
  94. ncbi request reprint Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C
    Chihiro Morishima
    Department of Laboratory Medicine and Pediatrics, University of Washington, Seattle, USA
    J Infect Dis 193:931-40. 2006
    ..Thus, in patients with advanced hepatic fibrosis due to HCV infection, pretreatment HCV-specific immune responses and increased QS variability appear to hinder viral clearance by pegylated IFN- alpha 2a and ribavirin combination therapy...
  95. ncbi request reprint Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohort
    Anna S F Lok
    Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48210, USA
    Hepatology 42:282-92. 2005
    ..In conclusion, a model based on standard laboratory test results can be used to predict histological cirrhosis with a high degree of accuracy in 50% of patients with CHC...
  96. pmc Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C
    David Butera
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Ave, New York, NY 10021, USA
    Blood 106:1175-82. 2005
    ..This observation has implications for understanding the pathogenesis of HCV infection...
  97. ncbi request reprint Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Gastroenterology 132:103-12. 2007
    ..However, prior studies did not assess the impact of reducing the dose of peginterferon independent of ribavirin or differentiate between dose reduction or interrupting or prematurely discontinuing treatment...
  98. ncbi request reprint Hepatic steatosis in hepatitis C: comparison of diabetic and nondiabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Anna S F Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    Clin Gastroenterol Hepatol 5:245-54. 2007
    ....
  99. ncbi request reprint Testing for hepatitis C virus infection should be routine for persons at increased risk for infection
    Miriam J Alter
    Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 141:715-7. 2004
    ....
  100. ncbi request reprint Evolution of the HALT-C Trial: pegylated interferon as maintenance therapy for chronic hepatitis C in previous interferon nonresponders
    William M Lee
    Control Clin Trials 25:472-92. 2004
    ..The protocol changes enhanced enrollment while upholding the original goals of the study and its integrity...
  101. ncbi request reprint Screening for hepatocellular carcinoma: being old is not all bad
    Adrian M Di Bisceglie
    Am J Gastroenterol 99:1477-8. 2004
    ..Thus, specialized liver centers have to deal with larger number of patients with HCC...

Research Grants8

  1. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 1999
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  2. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2000
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  3. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2001
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  4. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2001
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  5. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2002
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..
  6. HEPATITIS C VIRAL QUASISPECIES WITHIN THE LIVER
    Adrian Di Bisceglie; Fiscal Year: 2003
    ..These studies have great potential significance for understanding of viral clearance, development of persistent infection and for the development of a vaccine against HCV. ..