GOVINDASWAMY CHINNADURAI

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint CtBP, an unconventional transcriptional corepressor in development and oncogenesis
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, MO 63110, USA
    Mol Cell 9:213-24. 2002
  2. ncbi request reprint CtBP family proteins: more than transcriptional corepressors
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, Missouri 63110, USA
    Bioessays 25:9-12. 2003
  3. ncbi request reprint Transcriptional regulation by C-terminal binding proteins
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, 3681 Park Avenue, St Louis, MO 63110, USA
    Int J Biochem Cell Biol 39:1593-607. 2007
  4. pmc Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors
    Jessica Komorek
    Institute for Molecular Virology, Saint Louis University School of Medicine, Doisy Research Center, 1100 South Grand Boulevard, Saint Louis, Missouri 63104, USA
    J Virol 84:2719-31. 2010
  5. pmc Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2
    Ling Jun Zhao
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, St, Louis, Missouri 63104, USA
    BMC Mol Biol 10:89. 2009
  6. ncbi request reprint Modulation of oncogenic transformation by the human adenovirus E1A C-terminal region
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Ave, St Louis, MO 63110, USA
    Curr Top Microbiol Immunol 273:139-61. 2004
  7. ncbi request reprint CtIP, a candidate tumor susceptibility gene is a team player with luminaries
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, Missouri 63110, USA
    Biochim Biophys Acta 1765:67-73. 2006
  8. pmc Opposing oncogenic activities of small DNA tumor virus transforming proteins
    G Chinnadurai
    Institute for Molecular Virology, Doisy Research Center, Saint Louis University Medical School, 1100 South Grand Blvd, 6th Floor, St Louis, MO 63104, USA
    Trends Microbiol 19:174-83. 2011
  9. doi request reprint The transcriptional corepressor CtBP: a foe of multiple tumor suppressors
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, Doisy Research Center, St Louis, Missouri 63104, USA
    Cancer Res 69:731-4. 2009
  10. pmc BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, Doisy Research Center, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Oncogene 27:S20-9. 2008

Research Grants

  1. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
  2. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2010
  3. APOPTOSIS REGULATION BY VIRAL AND CELLULAR PROTEINS
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2003
  4. Modulation of Oncogenesis by E1A--Role of CtBP and CtIP
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2005
  5. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
  6. Apoptosis Regulation by Adenovirus and Cellular Genes
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
  7. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
  8. ONCOGENIC AND CHEMORESISTANCE BY BCL 2
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2002
  9. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1990
  10. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1993

Collaborators

  • Ling Jun Zhao
  • U Schaeper
  • Michie Yasuda
  • Subodh Verma
  • L K Venkatesh
  • Ken ichi Yoshida
  • E Uhlmann
  • J Ryerse
  • A Srinivasan
  • T Subramanian
  • Elena Lomonosova
  • S Vijayalingam
  • M Kuppuswamy
  • Jessica Komorek
  • R Rashmi
  • E Lomonosova
  • Bernhard Gillissen
  • P Balasubramanian
  • J Kamine
  • Paul Theodorakis
  • Joe S Mymryk
  • Mohan Kuppuswamy
  • Kimberly Schmitt
  • Mark Varvares
  • Yun Zhou
  • S G Pillai
  • Antje Richter
  • Frank Essmann
  • Philipp G Hemmati
  • Anja Richter
  • Peter T Daniel
  • Bernd Dorken
  • Ilker Oztop
  • J M Boyd
  • B Elangovan
  • D Coleman
  • C D'Sa-Eipper
  • M La Regina
  • S Malstrom
  • S Bayley
  • A M Ventura
  • S E Malstrom
  • M Q Arens
  • R J Nasr

Detail Information

Publications54

  1. ncbi request reprint CtBP, an unconventional transcriptional corepressor in development and oncogenesis
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, MO 63110, USA
    Mol Cell 9:213-24. 2002
    ..CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed...
  2. ncbi request reprint CtBP family proteins: more than transcriptional corepressors
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, Missouri 63110, USA
    Bioessays 25:9-12. 2003
    ..Thus, the CtBP family proteins control cellular processes by serving as transcriptional activators and regulators of the cytoskeleton as well as transcriptional corepressors...
  3. ncbi request reprint Transcriptional regulation by C-terminal binding proteins
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, 3681 Park Avenue, St Louis, MO 63110, USA
    Int J Biochem Cell Biol 39:1593-607. 2007
    ..The nuclear dinucleotide ratio may differentially influence the repression activities of factors that recruit CtBP through PLDLS-like motifs and those through non-PLDLS-motifs...
  4. pmc Adenovirus type 5 E1A and E6 proteins of low-risk cutaneous beta-human papillomaviruses suppress cell transformation through interaction with FOXK1/K2 transcription factors
    Jessica Komorek
    Institute for Molecular Virology, Saint Louis University School of Medicine, Doisy Research Center, 1100 South Grand Boulevard, Saint Louis, Missouri 63104, USA
    J Virol 84:2719-31. 2010
    ..Our results suggest that the E1A C-terminal region may suppress cell proliferation and oncogenic transformation through interaction with three different cellular protein complexes: FOXK1/K2, DYRK(1A/1B)/HAN11, and CtBP1/2...
  5. pmc Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2
    Ling Jun Zhao
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, St, Louis, Missouri 63104, USA
    BMC Mol Biol 10:89. 2009
    ..CtBP proteins function as dimers to mediate transcriptional repression and dimerization is modulated by specific binding to NAD/NADH...
  6. ncbi request reprint Modulation of oncogenic transformation by the human adenovirus E1A C-terminal region
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Ave, St Louis, MO 63110, USA
    Curr Top Microbiol Immunol 273:139-61. 2004
    ....
  7. ncbi request reprint CtIP, a candidate tumor susceptibility gene is a team player with luminaries
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, Missouri 63110, USA
    Biochim Biophys Acta 1765:67-73. 2006
    ..Recent studies raise the possibility that Ctip may itself be a tumor susceptibility gene and suggest that it might be important for the activities of tumor suppressors BRCA1, pRb family proteins and Ikaros family members...
  8. pmc Opposing oncogenic activities of small DNA tumor virus transforming proteins
    G Chinnadurai
    Institute for Molecular Virology, Doisy Research Center, Saint Louis University Medical School, 1100 South Grand Blvd, 6th Floor, St Louis, MO 63104, USA
    Trends Microbiol 19:174-83. 2011
    ..The potential role of these opposing functions in viral replication in epithelial cells is also discussed...
  9. doi request reprint The transcriptional corepressor CtBP: a foe of multiple tumor suppressors
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, Doisy Research Center, St Louis, Missouri 63104, USA
    Cancer Res 69:731-4. 2009
    ..The role of CtBPs in modulating the activities of different tumor suppressors is reviewed here. The results discussed here suggest that CtBPs may constitute a novel p53-independent anticancer target...
  10. pmc BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, Doisy Research Center, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Oncogene 27:S20-9. 2008
    ..BIK appears to be a prominent target for anti-cancer drugs that inhibit proteasomal functions. BIK has also been used as a therapeutic molecule in gene therapy-based approaches to treat difficult cancers...
  11. pmc BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions
    G Chinnadurai
    Institute for Molecular Virology, Doisy Research Center, Saint Louis University Medical Center, St Louis, MO 63104, USA
    Oncogene 27:S114-27. 2008
    ..The results reviewed here suggest that BNIP3 and BNIP3L may be novel therapeutic targets for intervention because of their pathological roles in regulating cell death in disease states...
  12. pmc Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
    U Schaeper
    Institute for Molecular Virology, St Louis University Medical Center, MO 63110, USA
    Proc Natl Acad Sci U S A 92:10467-71. 1995
    ..These results suggest that interaction of CtBP with the E1A proteins may play a critical role in adenovirus replication and oncogenic transformation...
  13. ncbi request reprint Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2
    Ling Jun Zhao
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, Missouri 63110, USA
    J Biol Chem 281:4183-9. 2006
    ..Our studies have revealed the important roles of acetylation in regulating subcellular localization and transcriptional activity of CtBP2...
  14. ncbi request reprint Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins
    J M Boyd
    Institute for Molecular Virology, St Louis University Health Sciences Center, Missouri 63110
    Cell 79:341-51. 1994
    ..Our results suggest that two diverse proteins, the E1B 19 kDa and the Bcl-2 proteins, promote cell survival through interaction with a common set of cellular proteins...
  15. pmc PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions
    L J Zhao
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, St Louis, MO 63110, USA
    Oncogene 26:7544-51. 2007
    ..Our results raise a possibility that E1A may gain access to cellular promoters through PLDLS-dependent interaction with CtBPs...
  16. ncbi request reprint Changes in C-terminal binding protein 2 (CtBP2) corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2
    Ling Jun Zhao
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    J Biol Chem 281:36613-23. 2006
    ..Thus, the N-terminal domain of CtBP2 may contribute a unique transcriptional regulatory activity of CtBP2. Our results provide new insights by which CtBP might modulate the biochemical activities of E1A...
  17. ncbi request reprint Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif
    U Schaeper
    Institute for Molecular Virology, St Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    J Biol Chem 273:8549-52. 1998
    ..Our results suggest that the tumorigenesis-restraining activity of E1A exon 2 may be related to the disruption of the CtBP-CtIP complex through the PLDLS motif...
  18. ncbi request reprint Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog
    M Yasuda
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110, USA
    Oncogene 17:2525-30. 1998
    ..Our results suggest that ceBNIP3 may be a novel component of the C. elegans apoptosis paradigm and may initiate apoptosis by recruiting CED-3 to mitochondria and other cytoplasmic membranes...
  19. ncbi request reprint Nicotinamide adenine dinucleotide stimulates oligomerization, interaction with adenovirus E1A and an intrinsic dehydrogenase activity of CtBP
    P Balasubramanian
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, 3681 Park Avenue, MO 63110, USA
    FEBS Lett 537:157-60. 2003
    ..Thus, CtBP is a unique transcriptional regulator with an enzymatic activity similar to metabolic dehydrogenases. The levels of intracellular nicotinamide adenine dinucleotide may modulate transcriptional activity of CtBP...
  20. ncbi request reprint BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3
    M Yasuda
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110, USA
    Cancer Res 59:533-7. 1999
    ..These results suggest that although BNIP3 and BNIP3alpha may promote apoptosis simultaneously in most human tissues, BNIP3alpha may play a more universal role...
  21. pmc BH3-only proteins in apoptosis and beyond: an overview
    E Lomonosova
    Institute for Molecular Virology, Saint Louis University School of Medicine, Doisy Research Center, St Louis, MO 63104, USA
    Oncogene 27:S2-19. 2008
    ..The Chapters included in the current Oncogene Review issues provide in-depth discussions on various aspects of major BH3-only proteins...
  22. ncbi request reprint Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence
    M Yasuda
    Institute for Molecular Virology, St Louis University Medical Center, St Louis, Missouri 63110, USA
    J Biol Chem 273:12415-21. 1998
    ..These results suggest that BNIP3 is a member of the BH3-contaning BCL-2 family of pro-apoptotic proteins and functions in mitochondria...
  23. ncbi request reprint Association of class I histone deacetylases with transcriptional corepressor CtBP
    T Subramanian
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, 3681 Park Avenue, St Louis, MO 63110, USA
    FEBS Lett 540:255-8. 2003
    ..Some of these HDACs also interact with the Drosophila CtBP homolog, dCtBP. The CtBP protein complex exhibits significant HDAC activity in vitro suggesting that association of CtBP with HDACs may be functionally relevant...
  24. pmc Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex
    M Kuppuswamy
    Institute for Molecular Virology, Saint Louis University School of Medicine, Daisy Research Center, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Mol Cell Biol 28:269-81. 2008
    ..We also provide evidence that CtBP1 functions as a platform for sumoylation of cofactors...
  25. pmc A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
    J M Boyd
    Institute for Molecular Virology, St Louis University Medical Center, MO 63110
    EMBO J 12:469-78. 1993
    ..CtBP is a phosphoprotein and the level of phosphorylation of CtBP appears to be regulated during the cell cycle, suggesting that it may play an important role during cellular proliferation...
  26. ncbi request reprint Sox9 transactivation and testicular expression of a novel human gene, KIAA0800
    Ling Jun Zhao
    Institute for Molecular Virology, St Louis University Health Sciences Center, 3681 Park Avenue, Missouri 63110, USA
    J Cell Biochem 86:277-89. 2002
    ..Thus, KIAA0800 is a novel Sox9-activated gene that is evolutionarily conserved and potentially involved in sexual differentiation...
  27. pmc A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein
    L K Venkatesh
    Institute for Molecular Virology, Saint Louis University School of Medicine, Saint Louis, Missouri 63108, USA
    J Virol 77:7236-43. 2003
    ..Thus, REBP displays the characteristics expected of an authentic mediator of Rev NES function and may play a role in RRE RNA transport during HIV infection...
  28. ncbi request reprint An N-terminal region of adenovirus E1a essential for cell transformation and induction of an epithelial cell growth factor
    T Subramanian
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
    Oncogene 2:105-12. 1988
    ....
  29. ncbi request reprint Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis
    S Verma
    Institute for Molecular Virology, St. Louis University Health Sciences Center, St. Louis, MO 63110, USA
    J Biol Chem 276:4671-6. 2001
    ..Partial purification of the protein kinase from HeLa cell cytoplasmic extracts suggest that BIK may be phosphorylated by a casein kinase II-related enzyme...
  30. pmc Evidence for involvement of BH3-only proapoptotic members in adenovirus-induced apoptosis
    T Subramanian
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Ave, St Louis, MO 63110, USA
    J Virol 81:10486-95. 2007
    ..Depletion of BIK by the use of small interfering RNA reduced the level of Ad-induced apoptosis. Our results are consistent with a model that activation of the BH3-only members may initiate Ad-induced apoptosis...
  31. pmc BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells
    R Rashmi
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, St Louis, MO 63110, USA
    Oncogene 27:1366-75. 2008
    ..Our results suggest enhanced expression of BIK in the Bcl-2 deficient cells leads to cell death with autophagic features and the extent of such cell death could be increased by inhibition of caspases...
  32. ncbi request reprint Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K
    Elena Lomonosova
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, MO 63110, USA
    Oncogene 24:6796-808. 2005
    ..We suggest that p53-induced apoptosis may be important for efficient cell lysis and viral spread and that E1B-19K may neutralize the apoptotic activity of p53 at multiple levels...
  33. doi request reprint Inhibition of transcriptional activation and cell proliferation activities of adenovirus E1A by the unique N-terminal domain of CtBP2
    L J Zhao
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, Doisy Research Center, St Louis, MO 63104, USA
    Oncogene 27:5214-22. 2008
    ..These results are consistent with a hypothesis that CtBP2 may inhibit E1A induced cell proliferation by antagonizing the transcriptional activation function controlled by the N-terminal region of E1A...
  34. ncbi request reprint Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK
    T Subramanian
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Ave, St Louis, Missouri 63110, USA
    J Cell Biochem 89:1102-14. 2003
    ..Our results suggest that BCL-2 contains an intrinsic pro-apoptotic activity and can induce apoptosis independent of BAX and BAK under specific conditions...
  35. ncbi request reprint Adenovirus transforming 19-kD T antigen has an enhancer-dependent trans-activation function and relieves enhancer repression mediated by viral and cellular genes
    K Yoshida
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
    Genes Dev 1:645-58. 1987
    ..The enhancer activation function of the 19-kD T antigen may be important for cell transformation and cell differentiation...
  36. ncbi request reprint Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator
    J Kamine
    Institute for Molecular Virology, St Louis University School of Medicine, Missouri 63110, USA
    Virology 216:357-66. 1996
    ..These data together with the genetic and in vitro binding data support the notion that Tip60 might be a cofactor of Tat involved in the regulation of HIV gene expression...
  37. ncbi request reprint Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells
    Paul Theodorakis
    Institute for Molecular Virology, Saint Louis University Health Sciences Center, Missouri 63110, USA
    Cancer Res 62:3373-6. 2002
    ..Our results also suggest that the integrity of BAX may have important consequences in the progression of epithelial tumors and in determining the outcome of chemotherapeutic regimens of such tumors...
  38. ncbi request reprint Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1b
    T Subramanian
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
    Oncogene 6:1171-3. 1991
    ..E1a/E1b cooperative transformation therefore requires an additional E1a activity encoded within the C-terminal region of E1a...
  39. pmc Requirement of BAX for efficient adenovirus-induced apoptosis
    Elena Lomonosova
    Institute for Molecular Virology, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:11283-90. 2002
    ..Our results suggest that at least a part of the mechanism utilized by E1B-19K to suppress apoptosis during Ad infection may involve modulation of the activities of BAX...
  40. ncbi request reprint Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences
    S Verma
    Institute for Molecular Virology, St Louis University Health Sciences Center, 3681 Park Avenue, St Louis, MO 63110, USA
    Gene 254:157-62. 2000
    ..Northern blot analysis showed a ubiquitous expression profile of the Bik mRNA with elevated levels of expression in heart and skeletal muscle...
  41. pmc Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein
    J Kamine
    Institute for Molecular Virology, St Louis University Medical Center, MO 63110
    Proc Natl Acad Sci U S A 88:8510-4. 1991
    ....
  42. pmc Silencing of human immunodeficiency virus long terminal repeat expression by an adenovirus E1a mutant
    A M Ventura
    Institute for Molecular Virology, Saint Louis University School of Medicine, MO 63110
    Proc Natl Acad Sci U S A 87:1310-4. 1990
    ..Cotransfection of HIV-1 proviral DNA with hr5 DNA resulted in a significant reduction of HIV production...
  43. pmc Down-regulation of multiple cell survival proteins in head and neck cancer cells by an apoptogenic mutant of adenovirus type 5
    S Vijayalingam
    Institute for Molecular Virology, Saint Louis University School of Medicine, 1100 South Grand Blvd, St Louis, MO 63104, USA
    Virology 392:62-72. 2009
    ..Our results suggest that adenoviral vectors defective in E1B-19K would be valuable for efficient down-regulation of cell survival proteins and EGFR in epithelial cancers and could be exploited as oncolytic agents to treat HNSCCs...
  44. ncbi request reprint Separation of immortalization and T24-ras oncogene cooperative functions of adenovirus E1a
    M Kuppuswamy
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
    Oncogene 2:613-5. 1988
    ....
  45. ncbi request reprint Adenovirus E1a as a tumor-suppressor gene
    G Chinnadurai
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
    Oncogene 7:1255-8. 1992
    ..Thus, E1a appears to meet the definition of both a dominant oncogene and a tumor-suppressor gene...
  46. pmc Activation of a heterologous promoter by human immunodeficiency virus type 1 Tat requires Sp1 and is distinct from the mode of activation by acidic transcriptional activators
    J Kamine
    Institute for Molecular Virology, St Louis University School of Medicine, Missouri 63110
    J Virol 67:6828-34. 1993
    ....
  47. ncbi request reprint Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization
    L K Venkatesh
    Institute for Molecular Virology, St Louis University School of Medicine, Missouri 63110
    Virology 176:39-47. 1990
    ....
  48. pmc BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition?
    Elena Lomonosova
    Institute for Molecular Virology, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Mol Cancer Res 7:1268-84. 2009
    ..Our results also establish a rationale for the broader use of proteasome inhibitors to kill apoptosis-resistant tumor cells that lack functional BAX/BAK proteins...
  49. ncbi request reprint Modulation of HIV-enhancer activity by heterologous agents: a minireview
    G Chinnadurai
    Institute for Molecular Virology, St Louis University Medical Center, MO 63110
    Gene 101:165-70. 1991
    ..Viral genes and chemical agents, which interfere with the activity of the enhancers may be useful in inhibiting HIV gene expression, thereby suppressing HIV replication...
  50. ncbi request reprint Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein
    T Subramanian
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
    Oncogene 4:415-20. 1989
    ..Our results suggest that the C-terminal region of the 243R protein may have a novel function in suppression of cell transformation, tumorigenesis and tumor progression...
  51. pmc Synergistic activation of the human immunodeficiency virus type 1 promoter by the viral Tat protein and cellular transcription factor Sp1
    J Kamine
    Institute for Molecular Virology, St Louis University School of Medicine, Missouri 63110
    J Virol 66:3932-6. 1992
    ..The Sp1 synergism is relatively specific, since another chimeric transcriptional activator, GAL-VP16, does not appear to be significantly synergistic with Tat...
  52. ncbi request reprint Cell type dependent transformation by adenovirus 5 E1a proteins
    M Kuppuswamy
    Institute for Molecular Virology, St Louis University Medical Center, Missouri 63110
    Oncogene 2:567-72. 1988
    ..Our results suggest that the unique region of the 289R protein has the potential to inhibit immortalization of primary epithelial cells...
  53. pmc Genetic identification of adenovirus type 5 genes that influence viral spread
    T Subramanian
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, MO 63110, USA
    J Virol 80:2000-12. 2006
    ..Our studies have identified novel mutations that could be exploited in designing efficient oncolytic Ad vectors...
  54. pmc Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis
    Bernhard Gillissen
    Department of Hematology, Oncology, and Tumor Immunology, University Medical Center Charite, 13125 Berlin, Germany
    J Cell Biol 179:701-15. 2007
    ..The finding that different BH3-only proteins rely specifically on Bax, Bak, or both has important implications for the design of anticancer drugs targeting Bcl-2...

Research Grants39

  1. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
    ..Our proposed studies will harness the knowledge gained from the study of the viral oncoprotein E1A to unravel potential new mechanisms governing oncogenesis and suggest strategies to inhibit the process in humans. ..
  2. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2010
    ..Our proposed studies will harness the knowledge gained from the study of the viral oncoprotein E1A to unravel potential new mechanisms governing oncogenesis and suggest strategies to inhibit the process in humans. ..
  3. APOPTOSIS REGULATION BY VIRAL AND CELLULAR PROTEINS
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2003
    ..The proposed studies should illuminate the mechanisms by which E1B-19K and related BCL-2 family proteins control cellular life and death cycles. ..
  4. Modulation of Oncogenesis by E1A--Role of CtBP and CtIP
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2005
    ..Thus, our proposed studies should illuminate how a viral oncoprotein, adenovirus EtA, modulates oncogenesis novel pathways that involve cellular proteins CtBP and CtIP. ..
  5. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. ..
  6. Apoptosis Regulation by Adenovirus and Cellular Genes
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
    ..abstract_text> ..
  7. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  8. ONCOGENIC AND CHEMORESISTANCE BY BCL 2
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2002
    ..These studies hope to provide tools and strategies to interfere with Bcl-2 activity in neoplastic diseases. ..
  9. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1990
    ..Since 175R T antigen is also localized on the nuclear envelope, we will investigate whether this protein could play a role in the nucleocytoplasmic transport of RNA via enhanced nucleoside triphophatase activity...
  10. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1993
    ..The role of the chimeric receptor in calcium mobilization and ligand-dependent internalization will be determined. The proposed studies should facilitate understanding of the biochemical mechanism of 19K-mediated transformation...