E M Brunt

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi Nonalcoholic steatohepatitis
    Elizabeth M Brunt
    Saint Louis University Liver Center, Saint Louis University Health Sciences Center, Department of Pathology, St Louis, Missouri 63110, USA
    Semin Liver Dis 24:3-20. 2004
  2. ncbi Pathological features of NASH
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, MO, USA
    Front Biosci 10:1475-84. 2005
  3. doi Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?
    Grace Guzman
    Department of Pathology, University of Illinois at Chicago, Chicago, IL 60614, USA
    Arch Pathol Lab Med 132:1761-6. 2008
  4. ncbi Hepatocyte senescence in end-stage chronic liver disease: a study of cyclin-dependent kinase inhibitor p21 in liver biopsies as a marker for progression to hepatocellular carcinoma
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Liver Int 27:662-71. 2007
  5. ncbi Pathology of fatty liver disease
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, MO, USA
    Mod Pathol 20:S40-8. 2007
  6. ncbi Nonalcoholic steatohepatitis: definition and pathology
    E M Brunt
    Department of Pathology, 4th Floor, Saint Louis University Hospital, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 21:3-16. 2001
  7. ncbi Nonalcoholic steatohepatitis: pathologic features and differential diagnosis
    Elizabeth M Brunt
    Saint Louis University School of Medicine, Saint Louis University Liver Center, Missouri, USA
    Semin Diagn Pathol 22:330-8. 2005
  8. ncbi Pathology of hepatic iron overload
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, Saint Louis University Liver Center, Saint Louis, Missouri 63110, USA
    Semin Liver Dis 25:392-401. 2005
  9. ncbi Benign hepatocellular tumors (adenomatosis) in nonalcoholic steatohepatitis: a case report
    Elizabeth M Brunt
    Saint Louis University Liver Center, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    Semin Liver Dis 25:230-6. 2005
  10. ncbi Metabolic storage diseases: amyloidosis
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, 4 th Floor, SLUH, 3635 Vista Avenue, St Louis, MO 63110, USA
    Clin Liver Dis 8:915-30, x. 2004

Detail Information

Publications61

  1. ncbi Nonalcoholic steatohepatitis
    Elizabeth M Brunt
    Saint Louis University Liver Center, Saint Louis University Health Sciences Center, Department of Pathology, St Louis, Missouri 63110, USA
    Semin Liver Dis 24:3-20. 2004
    ....
  2. ncbi Pathological features of NASH
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, MO, USA
    Front Biosci 10:1475-84. 2005
    ..While largely focused on adult NAFLD, the manuscript also summarizes what has been reported to date for NAFLD in the pediatric population...
  3. doi Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?
    Grace Guzman
    Department of Pathology, University of Illinois at Chicago, Chicago, IL 60614, USA
    Arch Pathol Lab Med 132:1761-6. 2008
    ..Diabetes and the metabolic syndrome are also associated with HCC. However, it is not clear whether NAFLD predisposes patients to HCC in the absence of cirrhosis...
  4. ncbi Hepatocyte senescence in end-stage chronic liver disease: a study of cyclin-dependent kinase inhibitor p21 in liver biopsies as a marker for progression to hepatocellular carcinoma
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Liver Int 27:662-71. 2007
    ..Histologic markers to predict hepatocellular carcinoma (HCC) include small cell change and dysplastic nodules. Hepatocyte senescence is noted in chronic liver disease and may or may not be important in progression to HCC...
  5. ncbi Pathology of fatty liver disease
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, MO, USA
    Mod Pathol 20:S40-8. 2007
    ..In this review, these concepts as well as the pathophysiologic bases for them are discussed...
  6. ncbi Nonalcoholic steatohepatitis: definition and pathology
    E M Brunt
    Department of Pathology, 4th Floor, Saint Louis University Hospital, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 21:3-16. 2001
    ..A histological "grading and staging" system has been developed to reflect the unique features of steatohepatitis, gradations of severity and fibrosis, and to promote uniform reporting of the histopathology...
  7. ncbi Nonalcoholic steatohepatitis: pathologic features and differential diagnosis
    Elizabeth M Brunt
    Saint Louis University School of Medicine, Saint Louis University Liver Center, Missouri, USA
    Semin Diagn Pathol 22:330-8. 2005
    ..When pertinent, pathophysiology of this metabolic liver disease and recent treatment considerations have been mentioned as well...
  8. ncbi Pathology of hepatic iron overload
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, Saint Louis University Liver Center, Saint Louis, Missouri 63110, USA
    Semin Liver Dis 25:392-401. 2005
    ..In this article, histopathologic findings in conditions of iron overload and in several forms of liver disease are discussed...
  9. ncbi Benign hepatocellular tumors (adenomatosis) in nonalcoholic steatohepatitis: a case report
    Elizabeth M Brunt
    Saint Louis University Liver Center, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    Semin Liver Dis 25:230-6. 2005
  10. ncbi Metabolic storage diseases: amyloidosis
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, 4 th Floor, SLUH, 3635 Vista Avenue, St Louis, MO 63110, USA
    Clin Liver Dis 8:915-30, x. 2004
    ..Clinical characteristics and clues to the diagnosis are discussed as well as the importance of histologic confirmation and the controversy surrounding liver biopsy...
  11. ncbi Alcoholic and nonalcoholic steatohepatitis
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, 4th Floor, SLUH, 3635 Vista Avenue, St Louis, MO 63110, USA
    Clin Liver Dis 6:399-420, vii. 2002
    ..In many instances, however, the microscopic lesions of these two processes are similar, likely as a reflection of common pathogenetic pathways, and the distinction between the two is ultimately clinically derived...
  12. pmc Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis
    R E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 98:2707-11. 2001
    ..Analysis of mice from crosses between C57BL/6 and AKR mice should allow the mapping and subsequent identification of genes modifying the severity of iron loading in this murine model of HH...
  13. pmc Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    N Engl J Med 359:2429-41. 2008
    ..Whether long-term antiviral therapy can prevent progressive liver disease in such patients remains uncertain...
  14. ncbi Hepatic alpha-smooth muscle actin expression in hepatitis C patients before and after interferon therapy
    M A Khan
    Department of Internal Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, USA
    Hepatogastroenterology 48:212-5. 2001
    ..This however did not reach statistical significance. CONCLUSIONS: Hepatic alpha-smooth muscle actin expression, as a marker of hepatic stellate cell activation appears reversible and tends to correlate with necroinflammatory activity...
  15. pmc Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1
    R E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 96:3143-8. 1999
    ..These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron, with resultant stabilization of DMT1(IRE) mRNA, up-regulation of DMT1, and increased absorption of dietary iron...
  16. ncbi Combination of interferon and ribavirin in chronic hepatitis C: re-treatment of nonresponders to interferon
    A M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Hepatology 33:704-7. 2001
    ..This study suggests that the combination of IFN and ribavirin is a useful modality of therapy in patients with chronic hepatitis C who did not respond to IFN alone...
  17. ncbi HFE genotype in patients with hemochromatosis and other liver diseases
    B R Bacon
    Saint Louis University School of Medicine, Missouri, USA
    Ann Intern Med 130:953-62. 1999
    ..Hereditary hemochromatosis is a common inherited disorder of iron metabolism. The gene HFE, which contains two missense mutations (C282Y and H63D), was recently identified...
  18. ncbi Immunoreactivity for c-erbB-2 oncopeptide in benign and malignant diseases of the liver
    E M Brunt
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Clin Pathol 97:S53-61. 1992
    ....
  19. pmc Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver
    K E Brown
    John Cochran Veteran s Administration Medical Center, St Louis, Missouri, USA
    Am J Pathol 159:2081-8. 2001
    ..These findings identify myeloperoxidase as a component of human Kupffer cells. Oxidative damage resulting from the action of myeloperoxidase may contribute to acute liver injury and hepatic fibrogenesis...
  20. ncbi Liver biopsy interpretation for the gastroenterologist
    E M Brunt
    Department of Surgical Pathology, 4th Floor FDT, Saint Louis University Hospital, 3635 Vista Avenue, St Louis, MO 63110, USA
    Curr Gastroenterol Rep 2:27-32. 2000
    ....
  21. ncbi Chronology of histological changes after band ligation of esophageal varices in humans
    J M Polski
    Dept. of Pathology, Saint Louis University School of Medicine, Missouri, USA
    Endoscopy 33:443-7. 2001
    ..The delay in ulcer healing, compared with the gross changes reported during follow-up endoscopic examinations, may be related to the severity of the underlying illness and the compromised immune status of patients in the present series...
  22. pmc HFE gene knockout produces mouse model of hereditary hemochromatosis
    X Y Zhou
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 95:2492-7. 1998
    ..The knockout mouse model of HH will facilitate investigation into the pathogenesis of increased iron accumulation in HH and provide opportunities to evaluate therapeutic strategies for prevention or correction of iron overload...
  23. ncbi Chemoprevention of hepatocellular carcinoma: use of tamoxifen in an animal model of hepatocarcinogenesis
    Adrian M Di Bisceglie
    Saint Louis University Liver Center, Department of Medicine, Saint Louis University, 3635 Vista Ave at Grand Blvd, MO 63110, USA
    J Lab Clin Med 145:134-8. 2005
    ....
  24. ncbi Duration of hepatic iron exposure increases the risk of significant fibrosis in hereditary hemochromatosis: a new role for magnetic resonance imaging
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia
    Am J Gastroenterol 100:837-41. 2005
    ..Hepatic fibrosis is a complication of hereditary hemochromatosis. The aim of this study was to determine whether the product of the magnitude and duration of hepatic iron exposure is related to the risk of significant fibrosis...
  25. ncbi Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    ..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH."..
  26. ncbi Differential findings for CD14-positive hepatic monocytes/macrophages in primary biliary cirrhosis, chronic hepatitis C and nonalcoholic steatohepatitis
    Katherine L Leicester
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Liver Int 26:559-65. 2006
    ..The aims of this study were to determine (1) whether hepatic CD14-positive cells are present in various forms of chronic liver disease, and (2) the relationship between CD14-positive cells, myofibroblasts, and fibrosis in these diseases...
  27. pmc Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    Naga Chalasani
    Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
    J Hepatol 48:829-34. 2008
    ..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied...
  28. ncbi Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction
    Michelle M Richardson
    School of Medicine, Southern Clinical Division, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Gastroenterology 133:80-90. 2007
    ..We propose that activation of this pathway, with increased cell injury in NASH, also induces a periportal ductular reaction (DR) that could produce a profibrogenic stimulus...
  29. ncbi AAV vector integration sites in mouse hepatocellular carcinoma
    Anthony Donsante
    Department of Internal Medicine, Washington University School of Medicine, Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 317:477. 2007
    ..Transcripts from adjacent genes encoding snoRNAs and microRNAs were overexpressed in tumors. Our findings implicate this locus in the development of HCC and raise concerns over the clinical use of AAV vectors...
  30. ncbi The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis
    Stephen H Caldwell
    Gastrointestinal Hepatology Division, Digestive Health Center of Excellence, University of Virginia, Charlottesville, VA 22908, USA
    Hepatology 46:1101-7. 2007
    ..Macrosteatosis (P < 0.001) and Mallory bodies (P = 0.05) significantly decreased, but no change was evident in microsteatosis, cellular enlargement, dilated endoplasmic reticulum, or apoptosis...
  31. doi The genetic background modulates susceptibility to mouse liver Mallory-Denk body formation and liver injury
    Shinichiro Hanada
    Department of Medicine, Veterans Administration Palo Alto Health Care System and Stanford University, Palo Alto, CA, USA
    Hepatology 48:943-52. 2008
    ..The extent of steatosis correlated with the total (large+small) number of MDBs, and there was a limited correlation between large MDBs and acidophil bodies...
  32. ncbi Do you see what I see? The role of quality histopathology in scientific study
    Elizabeth M Brunt
    Hepatology 47:771-4. 2008
  33. ncbi Pathology of nonalcoholic fatty liver disease
    Matthew M Yeh
    Department of Pathology, University of Washington School of Medicine, Seattle 98195 6100, USA
    Am J Clin Pathol 128:837-47. 2007
    ..Finally, other aspects for consideration by practicing pathologists, such as sampling issues, histopathologic findings after therapeutic interventions, and recurrence after liver transplantation, are addressed...
  34. ncbi Expression of P-glycoprotein and C-MOAT in human hepatocellular carcinoma: detection by immunostaining
    John Richart
    Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Dig Dis Sci 47:2454-8. 2002
    ....
  35. ncbi Hepatic iron overload in blacks and whites: a comparative autopsy study
    Kyle E Brown
    John Cochran Veterans Affairs Medical Center, St Louis, Missouri, USA
    Am J Gastroenterol 98:1594-8. 2003
    ..The aim of this study was to compare the prevalence, histological features, and clinical correlates of hepatic iron overload in a group of autopsied black and white veterans...
  36. ncbi Expression of GP73, a resident Golgi membrane protein, in viral and nonviral liver disease
    Raleigh D Kladney
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA
    Hepatology 35:1431-40. 2002
    ..In conclusion, increased expression of GP73 in hepatocytes appears to be a general feature of advanced liver disease, and may be regulated via distinct pathways that involve hepatotropic viruses or cytokines...
  37. ncbi Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    Brent A Neuschwander-Tetri
    University Liver Center, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    Hepatology 38:1008-17. 2003
    ....
  38. ncbi Orlistat in the treatment of NASH: a case series
    Stephen A Harrison
    Saint Louis University Liver Center, Division of Gastroenterology and Hepatology, St Louis, Missouri 63110, USA
    Am J Gastroenterol 98:926-30. 2003
    ....
  39. ncbi Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis
    Brent A Neuschwander-Tetri
    Department of Internal Medicine, Saint Louis University Liver Center, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Hepatol 38:434-40. 2003
    ....
  40. ncbi Evolution of hepatitis C viral quasispecies after liver transplantation
    Andre C Lyra
    Division of Gastroenterology and Hepatology, Department of Internal Medicine and Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 123:1485-93. 2002
    ..To determine whether HCV quasispecies diversity correlated positively with liver disease progression after orthotopic liver transplantation (OLT)...
  41. ncbi Nonalcoholic steatohepatitis: histologic features and clinical correlations with 30 blinded biopsy specimens
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    Hum Pathol 35:1070-82. 2004
    ....
  42. ncbi Pathology of steatohepatitis
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, 4th Floor, 3635 Vista Avenue, St Louis, MO 63110, USA
    Best Pract Res Clin Gastroenterol 16:691-707. 2002
    ..This chapter will elucidate the constellation of microscopic findings, the issues of concern for pathological evaluation and the knowledge to date of their significance in various forms of fatty liver disease...
  43. ncbi Hepatocellular carcinoma: predisposing conditions and precursor lesions
    Marie Ann Bailey
    Division of Gastroenterology, Hospital of the Medical College of Philadelphia, 7th Floor, 3300 Henry Avenue, Philadelphia, PA 19129, USA
    Gastroenterol Clin North Am 31:641-62. 2002
    ..Refinements of all of these may lead to better HCC detection, earlier intervention, and successful treatment. Randomized controlled trials are necessary to evaluate the most efficacious and cost-effective approach to screening...
  44. ncbi Epstein-Barr virus hepatitis: diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patients
    Namsoo Suh
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Surg Pathol 31:1403-9. 2007
    ..However, EBER-positive cells can be sparse and easily overlooked. Immunohistochemistry for EBV latent membrane proteins apparently has no utility in the diagnosis of EBV hepatitis...
  45. ncbi Hepatic iron concentration does not influence response to therapy with interferon plus ribavirin in chronic HCV infection
    Stephen Pianko
    Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA
    J Interferon Cytokine Res 22:483-9. 2002
    ..IFN monotherapy nonresponder patients tended to have a higher HIC. With IFN plus ribavirin, the sustained virologic response rate was not affected by the HIC...
  46. doi Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis
    Carolin Lackner
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
    J Hepatol 48:821-8. 2008
    ..Ballooning degeneration is considered a hallmark of steatohepatitis, but enlarged hepatocytes may also be observed in a variety of other acute and chronic liver diseases...
  47. pmc Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, California, USA
    Gastroenterology 134:1169-79. 2008
    ..We sought direct evidence for a keratin mutation-related predisposition to liver fibrosis using transgenic mouse models because the relationship between keratin mutations and cirrhosis is based primarily on human association studies...
  48. ncbi Accelerated hepatic fibrosis in patients with combined hereditary hemochromatosis and chronic hepatitis C infection
    Hari H Diwakaran
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, Mo 63110 0250, USA
    J Hepatol 36:687-91. 2002
    ..This study determined if HH patients with HCV would present with hepatic fibrosis/cirrhosis at a younger age and at a lower hepatic iron concentration compared to patients with HH or HCV alone...
  49. ncbi A 32-year-old man with hepatitis C who developed progressive liver failure after a bone marrow transplant
    Andre C Lyra
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 22:103-8. 2002
  50. ncbi Hepatocellular progenitor cell tumor of the gallbladder: a case report and review of the literature
    Indira Vadlamani
    Department of Pathology, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Mod Pathol 18:864-70. 2005
    ..This report is, to our knowledge, the first such case of a tumor of this cell type reported in the gallbladder. In addition, we present a review of the literature...
  51. ncbi Budd-Chiari syndrome and hepatocellular carcinoma: a case report and review of the literature
    Necat Havlioglu
    Department of Pathology, Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, Missouri 63110 0250, USA
    Am J Gastroenterol 98:201-4. 2003
    ..This case is unusual in two aspects: the patient survived 30 yr after shunt surgery with undiagnosed Budd-Chiari syndrome; and the association of Budd-Chiari syndrome with subsequent hepatocellular carcinoma is uncommon...
  52. ncbi CD14-positive hepatic monocytes/macrophages increase in hereditary hemochromatosis
    Katherine L Leicester
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Liver Int 24:446-51. 2004
    ..The aims of this study were to determine (1) whether CD14-positive monocytes/macrophages are present in the livers of patients with HH and (2) the potential relationship between CD14-positive cells and hepatic fibrosis in HH...
  53. ncbi Expression of HSP47, a collagen-specific chaperone, in normal and diseased human liver
    Kyle E Brown
    Iowa City Veterans Administration Medical Center, Iowa City, IA 52242, USA
    Lab Invest 85:789-97. 2005
    ..These observations suggest that HSP47 is constitutively expressed in human HSC and that HSP47 may be a target for antifibrotic therapy...
  54. ncbi Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers
    Tania A Roskams
    Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
    Hepatology 39:1739-45. 2004
    ....
  55. ncbi Evaluating liver disease in chronic hepatitis C--the role of the liver biopsy
    Laura Baalmann-Mangano
    Saint Louis University School of Medicine, Missouri, USA
    MedGenMed 5:21. 2003
  56. ncbi Effect of significant histologic steatosis or steatohepatitis on response to antiviral therapy in patients with chronic hepatitis C
    Stephen A Harrison
    Saint Louis University Liver Center, Saint Louis University, St Louis, MS, USA
    Clin Gastroenterol Hepatol 3:604-9. 2005
    ..A control group (group 2) of 231 CHC patients was identified by using a 2-year database (January 2000-June 2001) of patients without evidence of greater than 33% steatosis or SH...
  57. ncbi Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats
    Kyle E Brown
    Gastroenterology Section, John Cochran VAMC, St Louis, MO, USA
    Liver Int 23:232-42. 2003
    ..The aim of this study was to determine the effects of dietary fat of varying PUFA content on iron-induced oxidative stress and fibrosis...
  58. ncbi Diabetic hepatosclerosis: diabetic microangiopathy of the liver
    Stephen A Harrison
    Liver Center, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Arch Pathol Lab Med 130:27-32. 2006
    ..After observing a noncirrhotic form of hepatic sinusoidal fibrosis in patients with long-standing diabetes mellitus who underwent liver biopsy, we set about to characterize this novel entity...
  59. ncbi Comparison of liver biopsy and noninvasive methods for diagnosis of hepatocellular carcinoma
    Eldad S Bialecki
    Department of Internal Medicine, Saint Louis University School of Medicine St Louis, Missouri, USA
    Clin Gastroenterol Hepatol 4:361-8. 2006
    ..We evaluated our experience of patients with liver disease and hepatic lesions suspicious for HCC who underwent both fine-needle aspiration and core biopsy and correlated the results with those from commonly used noninvasive approaches...
  60. ncbi Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease
    Elizabeth M Brunt
    Saint Louis University Liver Center Department of Pathology, Saint Louis University Health Sciences Center, St Louis, Missouri, USA
    Mod Pathol 16:49-56. 2003
    ..Diabetes was reported in 35%, 25%, and 9%. The concurrence of clinical and histologic features of steatohepatitis with another chronic liver disease may be a reflection of the frequency of steatohepatitis in the population at large...
  61. ncbi Sustained resolution of fibrosing cholestatic hepatitis C despite viremic relapse after stopping pegylated interferon and ribavirin therapy
    Ahmed Bolkhir
    Liver Transpl 13:309-11; author reply 312. 2007