Bruce Bacon

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. pmc Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1
    R E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 96:3143-8. 1999
  2. pmc Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis
    R E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 98:2707-11. 2001
  3. pmc Hereditary hemochromatosis in the post-HFE era
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Hepatology 48:991-1001. 2008
  4. ncbi request reprint Hemochromatosis: discovery of the HFE gene
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, USA
    Mo Med 109:133-6. 2012
  5. doi request reprint Triple therapy with boceprevir for HCV genotype 1 infection: phase III results in relapsers and nonresponders
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, Mo 63110 0250, USA
    Liver Int 32:51-3. 2012
  6. pmc Expression of iron-related genes in human brain and brain tumors
    Milla M Hänninen
    Institute of Medical Technology and School of Medicine, University of Tampere, Tampere University Hospital, Tampere, Finland
    BMC Neurosci 10:36. 2009
  7. ncbi request reprint New therapies for hepatitis C virus infection
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center at Saint Louis University School of Medicine, USA
    Mo Med 108:255-9. 2011
  8. pmc Boceprevir for previously treated chronic HCV genotype 1 infection
    Bruce R Bacon
    Saint Louis University School of Medicine, St Louis, Mo 63110 0250, USA
    N Engl J Med 364:1207-17. 2011
  9. ncbi request reprint Hemochromatosis: diagnosis and management
    B R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, Missouri 63110 0250, USA
    Gastroenterology 120:718-25. 2001
  10. ncbi request reprint Into the light: strategies for battling hepatitis C
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University, 3635 Vista Ave, FDT 9th Fl S, St Louis, MO 63110, USA
    Am J Manag Care 13:S319-26. 2007

Research Grants

Detail Information

Publications83

  1. pmc Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1
    R E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 96:3143-8. 1999
    ..These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron, with resultant stabilization of DMT1(IRE) mRNA, up-regulation of DMT1, and increased absorption of dietary iron...
  2. pmc Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis
    R E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 98:2707-11. 2001
    ..Analysis of mice from crosses between C57BL/6 and AKR mice should allow the mapping and subsequent identification of genes modifying the severity of iron loading in this murine model of HH...
  3. pmc Hereditary hemochromatosis in the post-HFE era
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Hepatology 48:991-1001. 2008
    ....
  4. ncbi request reprint Hemochromatosis: discovery of the HFE gene
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, USA
    Mo Med 109:133-6. 2012
    ..The medical literature describes a colorful history of HH with important contributions from faculty at Saint Louis University...
  5. doi request reprint Triple therapy with boceprevir for HCV genotype 1 infection: phase III results in relapsers and nonresponders
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, Mo 63110 0250, USA
    Liver Int 32:51-3. 2012
    ..Resistance needs to be carefully monitored as these newer and more potent drugs are added to IFN and RBV backbone drugs. Adverse events will be more frequent and will require special attention...
  6. pmc Expression of iron-related genes in human brain and brain tumors
    Milla M Hänninen
    Institute of Medical Technology and School of Medicine, University of Tampere, Tampere University Hospital, Tampere, Finland
    BMC Neurosci 10:36. 2009
    ..The specimens included 5 normal brain tissue samples, 4 meningiomas, one medulloblastoma, 3 oligodendrocytic gliomas, 2 oligoastrocytic gliomas, 8 astrocytic gliomas, and 3 astrocytoma cell lines...
  7. ncbi request reprint New therapies for hepatitis C virus infection
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center at Saint Louis University School of Medicine, USA
    Mo Med 108:255-9. 2011
    ..We now are at the cusp of yet another such overhaul with the protease inhibitors about to be introduced into the market...
  8. pmc Boceprevir for previously treated chronic HCV genotype 1 infection
    Bruce R Bacon
    Saint Louis University School of Medicine, St Louis, Mo 63110 0250, USA
    N Engl J Med 364:1207-17. 2011
    ..Boceprevir, a protease inhibitor that binds to the HCV nonstructural 3 (NS3) active site, has been suggested as an additional treatment...
  9. ncbi request reprint Hemochromatosis: diagnosis and management
    B R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, Missouri 63110 0250, USA
    Gastroenterology 120:718-25. 2001
    ..With the identification of the HFE gene, we are beginning to unravel many of the mysteries of both normal iron absorption and the disorder of iron metabolism found in patients with HH...
  10. ncbi request reprint Into the light: strategies for battling hepatitis C
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University, 3635 Vista Ave, FDT 9th Fl S, St Louis, MO 63110, USA
    Am J Manag Care 13:S319-26. 2007
    ..Future pharmacologic agents are currently in development for patients failing treatment or those who have relapsed...
  11. ncbi request reprint HFE genotype in patients with hemochromatosis and other liver diseases
    B R Bacon
    Saint Louis University School of Medicine, Missouri, USA
    Ann Intern Med 130:953-62. 1999
    ..Hereditary hemochromatosis is a common inherited disorder of iron metabolism. The gene HFE, which contains two missense mutations (C282Y and H63D), was recently identified...
  12. ncbi request reprint Treatment for chronic hepatitis C
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, 3635 Vista Avenue at Grand Boulevard, St Louis, Mo 63110 0250, USA
    Curr Gastroenterol Rep 5:1-2. 2003
  13. ncbi request reprint Assessing evidence from clinical trials in chronic hepatitis C
    B R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    J Viral Hepat 13:1-5. 2006
    ..The articles in this supplement describe the issues in clinical trial design and the evaluation of evidence from clinical trials in patients with chronic hepatitis C...
  14. ncbi request reprint Treatment issues with chronic hepatitis C: special populations and pharmacy strategies
    Bruce R Bacon
    Saint Louis University, Division of Gastroenterology 3635 Vista Ave, St Louis, MO 63110 2539, USA
    Am J Manag Care 11:S296-306; quiz S307-11. 2005
    ....
  15. ncbi request reprint Certificate of added qualification in transplant hepatology
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, 3635 Vista Avenue at Grand Blvd, St Louis, MO 63110, USA
    Liver Transpl 11:4-6. 2005
  16. doi request reprint Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin: DIRECT results
    Bruce R Bacon
    Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, Mo 63110 0250, USA
    Hepatology 49:1838-46. 2009
    ..7% and 31.6% in the 9 microg and 15 microg groups, respectively. CIFN/RBV combination retreatment was safe and well tolerated...
  17. ncbi request reprint Subspecialty certification in transplant hepatology
    Bruce R Bacon
    Saint Louis University School of Medicine, St Louis, MO, USA
    Liver Transpl 13:1479-81. 2007
  18. ncbi request reprint Combination of interferon and ribavirin in chronic hepatitis C: re-treatment of nonresponders to interferon
    A M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    Hepatology 33:704-7. 2001
    ..This study suggests that the combination of IFN and ribavirin is a useful modality of therapy in patients with chronic hepatitis C who did not respond to IFN alone...
  19. pmc Excess mortality in patients with advanced chronic hepatitis C treated with long-term peginterferon
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA
    Hepatology 53:1100-8. 2011
    ..No specific cause of death accounted for the excess mortality and only one death was suspected to be a direct complication of peginterferon...
  20. pmc HFE gene knockout produces mouse model of hereditary hemochromatosis
    X Y Zhou
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 95:2492-7. 1998
    ..The knockout mouse model of HH will facilitate investigation into the pathogenesis of increased iron accumulation in HH and provide opportunities to evaluate therapeutic strategies for prevention or correction of iron overload...
  21. ncbi request reprint Molecular medicine and hemochromatosis: at the crossroads
    B R Bacon
    Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 116:193-207. 1999
  22. ncbi request reprint Hepatic alpha-smooth muscle actin expression in hepatitis C patients before and after interferon therapy
    M A Khan
    Department of Internal Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, USA
    Hepatogastroenterology 48:212-5. 2001
    ..This however did not reach statistical significance. CONCLUSIONS: Hepatic alpha-smooth muscle actin expression, as a marker of hepatic stellate cell activation appears reversible and tends to correlate with necroinflammatory activity...
  23. ncbi request reprint Hepatology in the new millennium. Advances in viral hepatitis, hepatic disorders, and liver transplantation
    S Ramrakhiani
    Department of Internal Medicine, Saint Louis University School of Medicine, Missouri, USA
    Med Clin North Am 84:1085-105. 2000
    ..Liver transplantation has been established as an effective therapy for patients with end-stage liver disease...
  24. ncbi request reprint Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: a multicenter, prospective, randomized, controlled trial
    A M Di Bisceglie
    Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Hepatology 32:135-8. 2000
    ....
  25. pmc Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
    S Parkkila
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104, USA
    Proc Natl Acad Sci U S A 94:2534-9. 1997
    ....
  26. ncbi request reprint Ascorbate-stimulated lipid peroxidation and non-heme iron concentrations in Alzheimer disease
    A C Andorn
    Department of Psychiatry, Saint Louis University School of Medicine, MO 63014, USA
    Mol Chem Neuropathol 33:15-26. 1998
    ....
  27. ncbi request reprint Intracellular signaling pathways in stellate cell activation
    R S Britton
    Department of Internal Medicine, Saint Louis University School of Medicine, Missouri 63110, USA
    Alcohol Clin Exp Res 23:922-5. 1999
    ..Implications for alcohol-induced hepatic fibrosis and future directions for research will also be discussed...
  28. pmc Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells
    A Waheed
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 94:12384-9. 1997
    ..The block in intracellular transport, accelerated turnover, and failure of the C282Y protein to be presented normally on the cell surface provide a possible basis for impaired function of this mutant protein in HH...
  29. ncbi request reprint Changes in serum lipoprotein profile during interferon therapy in chronic hepatitis C
    M Naeem
    Department of Internal Medicine, Saint Louis University School of Medicine, Missouri 63110, USA
    Am J Gastroenterol 96:2468-72. 2001
    ..These changes do not seem to be associated with clinical signs or complications and triglyceride levels decline while patients are still on therapy and return to normal after stopping...
  30. pmc Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
    S Parkkila
    The Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104, USA
    Proc Natl Acad Sci U S A 94:13198-202. 1997
    ..These findings also raise the question of whether mutations in the HFE gene can disrupt this association and thereby contribute to some forms of neonatal iron overload...
  31. pmc Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
    R E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 97:2214-9. 2000
    ....
  32. ncbi request reprint Orchestration of iron homeostasis
    Robert E Fleming
    Saint Louis University School of Medicine, St Louis, USA
    N Engl J Med 352:1741-4. 2005
  33. ncbi request reprint Effect of significant histologic steatosis or steatohepatitis on response to antiviral therapy in patients with chronic hepatitis C
    Stephen A Harrison
    Saint Louis University Liver Center, Saint Louis University, St Louis, MS, USA
    Clin Gastroenterol Hepatol 3:604-9. 2005
    ..A control group (group 2) of 231 CHC patients was identified by using a 2-year database (January 2000-June 2001) of patients without evidence of greater than 33% steatosis or SH...
  34. ncbi request reprint Duration of hepatic iron exposure increases the risk of significant fibrosis in hereditary hemochromatosis: a new role for magnetic resonance imaging
    John K Olynyk
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia
    Am J Gastroenterol 100:837-41. 2005
    ..Hepatic fibrosis is a complication of hereditary hemochromatosis. The aim of this study was to determine whether the product of the magnitude and duration of hepatic iron exposure is related to the risk of significant fibrosis...
  35. ncbi request reprint Survival after liver transplantation in patients with hepatic iron overload: the national hemochromatosis transplant registry
    Kris V Kowdley
    University of Washington, Seattle, 98195, USA
    Gastroenterology 129:494-503. 2005
    ..We examined the effect of HFE mutations on posttransplantation survival in patients with hepatic iron overload...
  36. ncbi request reprint Chronic hepatitis C: an age wave of disease burden
    John G McHutchison
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Manag Care 11:S286-95; quiz S307-11. 2005
    ..This article reviews the epidemiology, natural history, clinical and economic burden, and screening and treatment options for HCV...
  37. ncbi request reprint Relation of hemochromatosis with hepatocellular carcinoma: epidemiology, natural history, pathophysiology, screening, treatment, and prevention
    Stephen A Harrison
    Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA
    Med Clin North Am 89:391-409. 2005
    ..Palliative measures, including ablative therapy and chemoembolization, can be used. With increasing clinical recognition,hemochromatosis should be diagnosed earlier and progression to cirrhosis and HCC should be minimized...
  38. ncbi request reprint Differential findings for CD14-positive hepatic monocytes/macrophages in primary biliary cirrhosis, chronic hepatitis C and nonalcoholic steatohepatitis
    Katherine L Leicester
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Liver Int 26:559-65. 2006
    ..The aims of this study were to determine (1) whether hepatic CD14-positive cells are present in various forms of chronic liver disease, and (2) the relationship between CD14-positive cells, myofibroblasts, and fibrosis in these diseases...
  39. pmc Pathophysiology of hereditary hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Semin Liver Dis 25:411-9. 2005
    ..The mechanism by which HFE influences hepcidin expression is an area of current investigation and may offer insights into the phenotypic variability observed in persons with mutations in HFE...
  40. ncbi request reprint Splenectomy for thrombocytopenia in patients with hepatitis C cirrhosis
    Paul H Hayashi
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, FDT 9th Floor, St Louis, Mo 63110 0250, USA
    J Clin Gastroenterol 40:740-4. 2006
    ..Many patients with hepatitis C cirrhosis and low Model for End-Stage Liver Disease scores are too early for transplant but too thrombocytopenic to treat with interferon...
  41. ncbi request reprint Peginterferon alfa-2a and ribavirin for 16 or 24 weeks in HCV genotype 2 or 3
    Mitchell L Shiffman
    Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    N Engl J Med 357:124-34. 2007
    ..We conducted a large, randomized, multinational, noninferiority trial to determine whether similar efficacy could be achieved with only 16 weeks of treatment with peginterferon alfa-2a and ribavirin...
  42. ncbi request reprint Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells
    Yoshimasa Kobayashi
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO, USA
    Liver Int 27:1066-75. 2007
    ..This study investigated the expression and regulation of protein kinase C (PKC) in HSC...
  43. ncbi request reprint Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus
    John G McHutchison
    ALT Alliance for Liver Therapy Group, Division of Gastroenterology and Hepatology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Hepatology 46:1341-9. 2007
    ..The data support further clinical studies of CPG 10101 for treating chronic HCV infection...
  44. ncbi request reprint Making it happen: managed care considerations in vanquishing hepatitis C
    John G McHutchison
    Duke Clinical Research Institute, Duke University Medical Center, P O Box 17969, Durham, NC 27715, USA
    Am J Manag Care 13:S327-36; quiz S337-40. 2007
    ....
  45. doi request reprint Clinical penetrance of hereditary hemochromatosis
    Bruce R Bacon
    N Engl J Med 358:291-2. 2008
  46. ncbi request reprint Pathogenesis of hereditary hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, Cardinal Glennon Childrens Hospital, 1465 S Grand Blvd, St Louis, MO 63104, USA
    Clin Liver Dis 8:755-73, vii. 2004
    ..Two major hypotheses have been proposed to explain the pathogenesis of HFE-related hereditary hemochromatosis: the hepcidin hypothesis and the duodenal crypt cell programming hypothesis...
  47. ncbi request reprint Decreased liver hepcidin expression in the Hfe knockout mouse
    Kaashif A Ahmad
    Department of Pediatrics, Saint Louis University School of Medicine, 1402 South Grand Avenue, St Louis, MO 63130, USA
    Blood Cells Mol Dis 29:361-6. 2002
    ..We speculate that decreased hepcidin expression relative to body iron stores contributes to the iron homeostasis abnormalities characteristic of HH...
  48. ncbi request reprint Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis
    Brent A Neuschwander-Tetri
    Department of Internal Medicine, Saint Louis University Liver Center, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Hepatol 38:434-40. 2003
    ....
  49. ncbi request reprint Iron toxicity and chelation therapy
    Robert S Britton
    Int J Hematol 76:219-28. 2002
    ..The use of the oral chelator deferiprone remains controversial, and work is continuing on the development of new orally effective iron chelators...
  50. ncbi request reprint Treatment of patients with hepatitis C and normal serum aminotransferase levels
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, St Louis University Liver Center, St Louis University School of Medicine, St Louis, MO 63110, USA
    Hepatology 36:S179-84. 2002
    ....
  51. pmc Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
    Robert E Fleming
    Department of Pediatrics, Saint Louis University School of Medicine, MO 63104, USA
    Proc Natl Acad Sci U S A 99:10653-8. 2002
    ..This study confirms the important role for TFR2 in iron homeostasis and provides a tool for investigating the excess iron absorption and abnormal iron distribution in iron-overload disorders...
  52. ncbi request reprint Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    Brent A Neuschwander-Tetri
    University Liver Center, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    Hepatology 38:1008-17. 2003
    ....
  53. pmc Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis
    Shunji Tomatsu
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 100:15788-93. 2003
    ..These observations indicate that the H67D mutation leads to partial loss of Hfe function and can contribute to murine HH...
  54. ncbi request reprint Infection with hepatitis C virus genotype 4 in the United States
    Andre C Lyra
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Clin Gastroenterol 38:68-71. 2004
    ..HCV genotype 4 is rare in the United States and there are few published data regarding response to therapy in patients with HCV genotype 4 infection...
  55. ncbi request reprint Treatment of nonalcoholic steatohepatitis
    Bruce R Bacon
    Curr Gastroenterol Rep 6:9. 2004
  56. ncbi request reprint Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2
    Jokke Hannuksela
    Department of Clinical Chemistry, University of Oulu, Oulu, Finland
    Eur J Haematol 70:201-6. 2003
    ..HFE, the protein defective in hereditary hemochromatosis, and transferrin receptor 2 (TfR2) are two novel protein candidates that could be involved in mechanisms of iron transport across the platelet plasma membrane...
  57. ncbi request reprint Accelerated hepatic fibrosis in patients with combined hereditary hemochromatosis and chronic hepatitis C infection
    Hari H Diwakaran
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, Mo 63110 0250, USA
    J Hepatol 36:687-91. 2002
    ..This study determined if HH patients with HCV would present with hepatic fibrosis/cirrhosis at a younger age and at a lower hepatic iron concentration compared to patients with HH or HCV alone...
  58. ncbi request reprint Chronic hepatitis C and normal ALT: considerations for treatment
    Bruce R Bacon
    Am J Gastroenterol 99:1706-7. 2004
    ..ALT levels are a poor marker of disease severity and/or indication for treatment in patients with chronic hepatitis C...
  59. ncbi request reprint Hepatic iron concentration does not influence response to therapy with interferon plus ribavirin in chronic HCV infection
    Stephen Pianko
    Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA
    J Interferon Cytokine Res 22:483-9. 2002
    ..IFN monotherapy nonresponder patients tended to have a higher HIC. With IFN plus ribavirin, the sustained virologic response rate was not affected by the HIC...
  60. ncbi request reprint Pathogenesis of hereditary hemochromatosis: genetics and beyond
    Robert S Britton
    Department of Internal Medicine, Saint Louis University School of Medicine, Mo 63110 0250, USA
    Semin Gastrointest Dis 13:68-79. 2002
    ..Future investigations will refine our knowledge of the mechanisms of action of HFE protein, the phenotypic variability observed in persons homozygous for the C282Y mutation, and the mechanisms responsible for non-HFE-related HH...
  61. ncbi request reprint Managing hepatitis C
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Missouri, USA
    Am J Manag Care 10:S30-40. 2004
    ....
  62. ncbi request reprint Nonalcoholic steatohepatitis: histologic features and clinical correlations with 30 blinded biopsy specimens
    Elizabeth M Brunt
    Department of Pathology, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
    Hum Pathol 35:1070-82. 2004
    ....
  63. pmc Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis
    Abdul Waheed
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 99:3117-22. 2002
    ....
  64. ncbi request reprint Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease
    Elizabeth M Brunt
    Saint Louis University Liver Center Department of Pathology, Saint Louis University Health Sciences Center, St Louis, Missouri, USA
    Mod Pathol 16:49-56. 2003
    ..Diabetes was reported in 35%, 25%, and 9%. The concurrence of clinical and histologic features of steatohepatitis with another chronic liver disease may be a reflection of the frequency of steatohepatitis in the population at large...
  65. ncbi request reprint Macro-aspartate aminotransferase in a female with antibodies to hepatitis C virus
    John Collins
    Departments of Pathology and Laboratory Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
    Liver 22:501-6. 2002
    ..A brief review of the clinical enzymology of AST and methods used to quantify serum macro-AST activity is provided...
  66. doi request reprint Hepatology: small steps forward
    Bruce R Bacon
    Gastroenterology 134:381. 2008
  67. ncbi request reprint Workforce issues in hepatology: what is needed?
    Bruce R Bacon
    Division of Gastroenterology and Hepatology, Saint Louis University Liver Center, Saint Louis University School of Medicine, St Louis, MO, USA
    Hepatology 47:1801-4. 2008
  68. ncbi request reprint Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells
    John K Olynyk
    Department of Medicine, University of Western Australia, Western Australian Institute of Medical Research, Perth, Australia
    J Gastroenterol Hepatol 17:785-90. 2002
    ....
  69. ncbi request reprint Evaluation of serum anion gap in patients with liver cirrhosis of diverse etiologies
    Hatim Hassan
    Division of Nephrology, Saint Louis University School of Medicine, Saint Louis, MO, USA
    Mt Sinai J Med 71:281-4. 2004
    ..Serum immunoglobulin G (IgG) (elevated in chronic viral hepatitis) and IgA (elevated in alcoholic cirrhosis) have different isoelectric points, and thus may affect serum AG in opposite directions...
  70. ncbi request reprint Hereditary hemochromatosis: update for 2003
    Stephen A Harrison
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, Mo 63110 0250, USA
    J Hepatol 38:S14-23. 2003
  71. ncbi request reprint CD14-positive hepatic monocytes/macrophages increase in hereditary hemochromatosis
    Katherine L Leicester
    School of Medicine and Pharmacology, University of Western Australia, Australia
    Liver Int 24:446-51. 2004
    ..The aims of this study were to determine (1) whether CD14-positive monocytes/macrophages are present in the livers of patients with HH and (2) the potential relationship between CD14-positive cells and hepatic fibrosis in HH...
  72. ncbi request reprint Testing for hepatitis C virus infection should be routine for persons at increased risk for infection
    Miriam J Alter
    Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 141:715-7. 2004
    ....
  73. ncbi request reprint Hepatitis C: a 20-year debt comes due
    John G McHutchison
    Gastroenterology and Hepatology Research, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Manag Care 10:S20. 2004
  74. ncbi request reprint Disease- and cell-specific expression of GP73 in human liver disease
    Rehan Iftikhar
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Am J Gastroenterol 99:1087-95. 2004
    ..Its expression in other forms of liver disease has not been investigated. Therefore, we studied GP73 expression in patients with noncirrhotic liver disease...
  75. ncbi request reprint A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients
    Ting Tsung Chang
    National Cheng Kung University Medical College, Tainan, Taiwan
    Gastroenterology 129:1198-209. 2005
    ..This randomized, dose-ranging, phase 2 study compared the efficacy and safety of entecavir with lamivudine in lamivudine-refractory patients...
  76. ncbi request reprint Screening for hemochromatosis
    Bruce R Bacon
    Arch Intern Med 166:269-70. 2006
  77. ncbi request reprint The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells
    Jianjun Li
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, The Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27858 4354, USA
    Life Sci 73:1083-96. 2003
    ..The stimulation of intracellular signaling pathways in HSC by this well-characterized ethanol metabolite may contribute to ethanol-induced hepatic fibrogenesis...
  78. ncbi request reprint Insurance, employment, and psychosocial consequences of a diagnosis of hereditary hemochromatosis in subjects without end organ damage
    Nicholas J Shaheen
    Center for Gastrointestinal Biology and Disease, and the Division of Digestive Diseases and Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Gastroenterol 98:1175-80. 2003
    ..The extent to which these difficulties occur is unclear. The aim of this study was to assess the insurance, employment, and psychosocial consequences of a diagnosis of HH in subjects with no end organ damage...
  79. ncbi request reprint Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation
    Grant A Ramm
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63110 0250, USA
    Dig Dis Sci 48:790-6. 2003
    ..The demonstration that hepatic stellate cell activation can be suppressed by PKC inhibitors suggests a role for PKC in the regulation of hepatic stellate cell activation...
  80. ncbi request reprint Hepatology: where do we go from here?
    Bruce R Bacon
    Gastroenterology 131:1373-4. 2006
  81. ncbi request reprint Genetics in liver diseases
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena, Via del Pozza 71, 41100 Modena, Italy
    J Hepatol 46:1143-8. 2007
    ..This article reports the highlights of the conference and summarizes the main conclusions and implications for clinical and experimental hepatology...
  82. ncbi request reprint Orlistat in the treatment of NASH: a case series
    Stephen A Harrison
    Saint Louis University Liver Center, Division of Gastroenterology and Hepatology, St Louis, Missouri 63110, USA
    Am J Gastroenterol 98:926-30. 2003
    ....
  83. ncbi request reprint Hereditary hemochromatosis and alcohol: a fibrogenic cocktail
    Robert S Britton
    Gastroenterology 122:563-5. 2002

Research Grants13

  1. HEPATOTOXICITY OF EXPERIMENTAL HEMOCHROMATOSIS
    Bruce Bacon; Fiscal Year: 1993
    ....
  2. HEPATIC FIBROGENESIS IN EXPERIMENTAL HEMOCHROMATOSIS
    Bruce Bacon; Fiscal Year: 2000
    ....
  3. Signaling Pathways in Hepatic Fibrogenesis
    Bruce Bacon; Fiscal Year: 2005
    ..Since activated HSC play a key role in hepatic fibrogenesis, these experiments will contribute to an improved understanding of the basic biochemical processes underlying hepatic fibrosis. ..