Rajeev Aurora

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint A network of genes regulated by light in cyanobacteria
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    OMICS 11:166-85. 2007
  2. pmc Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients
    Guanggan Hu
    The Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver, B C V6T 1Z4, Canada
    BMC Genomics 12:526. 2011
  3. pmc Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Clin Invest 119:225-36. 2009
  4. pmc Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e9032. 2010
  5. pmc A systems-level analysis of the effects of light quality on the metabolism of a cyanobacterium
    Abhay K Singh
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 151:1596-608. 2009
  6. pmc The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle
    Eric A Welsh
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 105:15094-9. 2008
  7. pmc Hepatitis C virus diversity and evolution in the full open-reading frame during antiviral therapy
    Nathan A Cannon
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 3:e2123. 2008
  8. pmc Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO 63104, USA
    J Virol 81:8211-24. 2007
  9. pmc Integration of carbon and nitrogen metabolism with energy production is crucial to light acclimation in the cyanobacterium Synechocystis
    Abhay K Singh
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 148:467-78. 2008
  10. pmc Genome-wide networks of amino acid covariances are common among viruses
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis, University School of Medicine, St Louis, Missouri, USA
    J Virol 86:3050-63. 2012

Collaborators

Detail Information

Publications19

  1. ncbi request reprint A network of genes regulated by light in cyanobacteria
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    OMICS 11:166-85. 2007
    ..This study highlights how understanding the organization of the networks can provide insights into the coordination of physiologic responses...
  2. pmc Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients
    Guanggan Hu
    The Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver, B C V6T 1Z4, Canada
    BMC Genomics 12:526. 2011
    ..Here, we examined the genome plasticity and phenotypes of monosomic and disomic strains, and compared their virulence in a mouse model of cryptococcosis..
  3. pmc Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Clin Invest 119:225-36. 2009
    ..Finally, covariance network analysis could be applicable to any virus with sufficient genetic variation, including most human RNA viruses...
  4. pmc Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e9032. 2010
    ..African American patients respond to interferon alpha-based therapy at about half the rate of Caucasian Americans. The effect of HCV's genetic variation on treatment outcome in both racial groups is poorly understood...
  5. pmc A systems-level analysis of the effects of light quality on the metabolism of a cyanobacterium
    Abhay K Singh
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 151:1596-608. 2009
    ....
  6. pmc The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle
    Eric A Welsh
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 105:15094-9. 2008
    ....
  7. pmc Hepatitis C virus diversity and evolution in the full open-reading frame during antiviral therapy
    Nathan A Cannon
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 3:e2123. 2008
    ..To determine if viral genetic differences contribute to the difference between response and relapse, we examined the inter-patient genetic diversity and mutation pattern in the full open reading frame HCV genotype 1a consensus sequences...
  8. pmc Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO 63104, USA
    J Virol 81:8211-24. 2007
    ..No evidence was found for novel HCV strains in the AA population, implying that AA patients may be infected with a higher proportion of the same resistant strains that are found in CA patients...
  9. pmc Integration of carbon and nitrogen metabolism with energy production is crucial to light acclimation in the cyanobacterium Synechocystis
    Abhay K Singh
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 148:467-78. 2008
    ..Up-regulation of a gene encoding the rate-limiting enzyme in the hexosamine pathway suggests a regulatory role for protein glycosylation in Synechocystis under HL...
  10. pmc Genome-wide networks of amino acid covariances are common among viruses
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis, University School of Medicine, St Louis, Missouri, USA
    J Virol 86:3050-63. 2012
    ..Five examples with hepatitis B virus and poliovirus are presented to illustrate how covariance network analysis can lead to inferences about viral biology...
  11. pmc The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    PLoS Pathog 9:e1003125. 2013
    ..Finally, differential inhibition of HBV genotype D and H RNAseHs indicates that viral genetic variability will be a factor during drug development...
  12. pmc Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro
    Zachary S Buchwald
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e38199. 2012
    ..The activation of CD8 T-cells by osteoclasts also induced the cytokines IL-2, IL-6, IL-10 and IFN-γ. Individually, these cytokines can activate or suppress osteoclast resorption...
  13. pmc Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Genome Med 3:8. 2011
    ..Direct-acting inhibitors of HCV that will be used in combination with IFNα are nearing approval, so genetic prediction for anti-HCV therapy will soon need to incorporate viral genetic markers of viral resistance to the new drugs...
  14. doi request reprint Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice
    Zachary S Buchwald
    Dept of Molecular Microbiology and Immunology, St Louis University, Saint Louis, MO 63104, USA
    Bone 56:163-73. 2013
    ..Our results provide the first in vivo evidence that OC-iTc(REG) have anti-resorptive activity and repress the immune system, thus extending the purview of osteoimmunology...
  15. pmc Global transcriptomic analysis of Cyanothece 51142 reveals robust diurnal oscillation of central metabolic processes
    Jana Stöckel
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 105:6156-61. 2008
    ..These studies provide a comprehensive picture of how a physiologically relevant diurnal light-dark cycle influences the metabolism in a photosynthetic bacterium...
  16. doi request reprint Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells
    Jennifer R Kiesel
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Immunol 182:5477-87. 2009
    ..These observations open a new avenue of investigation for the pathogenesis of autoimmune-mediated inflammatory bone diseases...
  17. pmc Osteoclasts and CD8 T cells form a negative feedback loop that contributes to homeostasis of both the skeletal and immune systems
    Zachary S Buchwald
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S Grand Boulevond DRC 605, St Louis, MO 63104, USA
    Clin Dev Immunol 2013:429373. 2013
    ..In addition, we review data on a negative regulatory feedback loop between osteoclasts and CD8 T cells that contributes to homeostasis of both the skeletal and immune systems. ..
  18. ncbi request reprint Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions
    Jennifer Kiesel
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Dev Dyn 236:2181-97. 2007
    ..The resulting model provides an essential framework for a better understanding of the epigenetic program of osteoclastogenesis...
  19. pmc Critical roles of bacterioferritins in iron storage and proliferation of cyanobacteria
    Nir Keren
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 135:1666-73. 2004
    ..In addition, they triggered iron starvation responses even in the presence of normal levels of external iron, thus demonstrating a central role of bacterioferritins in iron homeostasis in these photosynthetic organisms...