Rajeev Aurora

Summary

Affiliation: Saint Louis University
Country: USA

Publications

  1. ncbi request reprint A network of genes regulated by light in cyanobacteria
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    OMICS 11:166-85. 2007
  2. pmc Osteoclasts and CD8 T cells form a negative feedback loop that contributes to homeostasis of both the skeletal and immune systems
    Zachary S Buchwald
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S Grand Boulevond DRC 605, St Louis, MO 63104, USA
    Clin Dev Immunol 2013:429373. 2013
  3. pmc Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro
    Zachary S Buchwald
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e38199. 2012
  4. pmc Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients
    Guanggan Hu
    The Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver, B C V6T 1Z4, Canada
    BMC Genomics 12:526. 2011
  5. pmc Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Clin Invest 119:225-36. 2009
  6. pmc Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e9032. 2010
  7. pmc A systems-level analysis of the effects of light quality on the metabolism of a cyanobacterium
    Abhay K Singh
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 151:1596-608. 2009
  8. pmc The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle
    Eric A Welsh
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 105:15094-9. 2008
  9. pmc Hepatitis C virus diversity and evolution in the full open-reading frame during antiviral therapy
    Nathan A Cannon
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 3:e2123. 2008
  10. pmc Integration of carbon and nitrogen metabolism with energy production is crucial to light acclimation in the cyanobacterium Synechocystis
    Abhay K Singh
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 148:467-78. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint A network of genes regulated by light in cyanobacteria
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    OMICS 11:166-85. 2007
    ..This study highlights how understanding the organization of the networks can provide insights into the coordination of physiologic responses...
  2. pmc Osteoclasts and CD8 T cells form a negative feedback loop that contributes to homeostasis of both the skeletal and immune systems
    Zachary S Buchwald
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S Grand Boulevond DRC 605, St Louis, MO 63104, USA
    Clin Dev Immunol 2013:429373. 2013
    ..In addition, we review data on a negative regulatory feedback loop between osteoclasts and CD8 T cells that contributes to homeostasis of both the skeletal and immune systems. ..
  3. pmc Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro
    Zachary S Buchwald
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e38199. 2012
    ..The activation of CD8 T-cells by osteoclasts also induced the cytokines IL-2, IL-6, IL-10 and IFN-γ. Individually, these cytokines can activate or suppress osteoclast resorption...
  4. pmc Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients
    Guanggan Hu
    The Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver, B C V6T 1Z4, Canada
    BMC Genomics 12:526. 2011
    ..Here, we examined the genome plasticity and phenotypes of monosomic and disomic strains, and compared their virulence in a mouse model of cryptococcosis..
  5. pmc Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Clin Invest 119:225-36. 2009
    ..Finally, covariance network analysis could be applicable to any virus with sufficient genetic variation, including most human RNA viruses...
  6. pmc Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e9032. 2010
    ..African American patients respond to interferon alpha-based therapy at about half the rate of Caucasian Americans. The effect of HCV's genetic variation on treatment outcome in both racial groups is poorly understood...
  7. pmc A systems-level analysis of the effects of light quality on the metabolism of a cyanobacterium
    Abhay K Singh
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 151:1596-608. 2009
    ....
  8. pmc The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle
    Eric A Welsh
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 105:15094-9. 2008
    ....
  9. pmc Hepatitis C virus diversity and evolution in the full open-reading frame during antiviral therapy
    Nathan A Cannon
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 3:e2123. 2008
    ..To determine if viral genetic differences contribute to the difference between response and relapse, we examined the inter-patient genetic diversity and mutation pattern in the full open reading frame HCV genotype 1a consensus sequences...
  10. pmc Integration of carbon and nitrogen metabolism with energy production is crucial to light acclimation in the cyanobacterium Synechocystis
    Abhay K Singh
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 148:467-78. 2008
    ..Up-regulation of a gene encoding the rate-limiting enzyme in the hexosamine pathway suggests a regulatory role for protein glycosylation in Synechocystis under HL...
  11. pmc Pretreatment sequence diversity differences in the full-length hepatitis C virus open reading frame correlate with early response to therapy
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S Grand Blvd, Saint Louis, MO 63104, USA
    J Virol 81:8211-24. 2007
    ..No evidence was found for novel HCV strains in the AA population, implying that AA patients may be infected with a higher proportion of the same resistant strains that are found in CA patients...
  12. pmc Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice
    Zachary S Buchwald
    Dept of Molecular Microbiology and Immunology, St Louis University, Saint Louis, MO 63104, USA
    Bone 56:163-73. 2013
    ..Our results provide the first in vivo evidence that OC-iTc(REG) have anti-resorptive activity and repress the immune system, thus extending the purview of osteoimmunology...
  13. doi request reprint Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells
    Jennifer R Kiesel
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Immunol 182:5477-87. 2009
    ..These observations open a new avenue of investigation for the pathogenesis of autoimmune-mediated inflammatory bone diseases...
  14. pmc Genome-wide networks of amino acid covariances are common among viruses
    Maureen J Donlin
    Department of Molecular Microbiology and Immunology, Saint Louis, University School of Medicine, St Louis, Missouri, USA
    J Virol 86:3050-63. 2012
    ..Five examples with hepatitis B virus and poliovirus are presented to illustrate how covariance network analysis can lead to inferences about viral biology...
  15. pmc The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    PLoS Pathog 9:e1003125. 2013
    ..Finally, differential inhibition of HBV genotype D and H RNAseHs indicates that viral genetic variability will be a factor during drug development...
  16. pmc Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics
    John E Tavis
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Genome Med 3:8. 2011
    ..Direct-acting inhibitors of HCV that will be used in combination with IFNα are nearing approval, so genetic prediction for anti-HCV therapy will soon need to incorporate viral genetic markers of viral resistance to the new drugs...
  17. ncbi request reprint Patients with Pediatric Obstructive Sleep Apnea Show Altered T-Cell Populations with a Dominant TH17 Profile
    Martin E Anderson
    Department of Otolaryngology Head and Neck Surgery, Saint Louis University School of Medicine, St Louis, Missouri, USA
    Otolaryngol Head Neck Surg 150:880-6. 2014
    ..To characterize the immunologic changes of the tonsil as they correlate with increasing apnea-hypopnea index (AHI) in children...
  18. ncbi request reprint Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions
    Jennifer Kiesel
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Dev Dyn 236:2181-97. 2007
    ..The resulting model provides an essential framework for a better understanding of the epigenetic program of osteoclastogenesis...
  19. pmc Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner
    Tingting Zhu
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 288:5268-77. 2013
    ..Thus, optimal PIP5KIγ and PI(4,5)P(2) expression, by osteoclasts, are essential for skeletal homeostasis...
  20. pmc Global transcriptomic analysis of Cyanothece 51142 reveals robust diurnal oscillation of central metabolic processes
    Jana Stöckel
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 105:6156-61. 2008
    ..These studies provide a comprehensive picture of how a physiologically relevant diurnal light-dark cycle influences the metabolism in a photosynthetic bacterium...
  21. ncbi request reprint Contrasting the microbiomes from healthy volunteers and patients with chronic rhinosinusitis
    Rajeev Aurora
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, Missouri
    JAMA Otolaryngol Head Neck Surg 139:1328-38. 2013
    ..Chronic rhinosinusitis (CRS) is the persistent inflammation of the sinus and nasal passages lasting over 3 months. The etiology of CRS is not well understood...
  22. pmc Control of cellular Bcl-xL levels by deamidation-regulated degradation
    So Hee Dho
    Division of Urology and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS Biol 11:e1001588. 2013
    ..Our findings strongly suggest that deamidation-regulated Bcl-xL degradation is an important component of the cellular rheostat that determines susceptibility to DNA-damaging agents and other death stimuli. ..
  23. pmc Critical roles of bacterioferritins in iron storage and proliferation of cyanobacteria
    Nir Keren
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Plant Physiol 135:1666-73. 2004
    ..In addition, they triggered iron starvation responses even in the presence of normal levels of external iron, thus demonstrating a central role of bacterioferritins in iron homeostasis in these photosynthetic organisms...