Katherine R Tuttle

Summary

Affiliation: Sacred Heart Medical Center
Country: USA

Publications

  1. ncbi request reprint Oxidative stress mediates protein kinase C activation and advanced glycation end product formation in a mesangial cell model of diabetes and high protein diet
    Katherine R Tuttle
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane Seattle, WA 99204, USA
    Am J Nephrol 29:171-80. 2009
  2. doi request reprint Can comprehensive lifestyle change alter the course of chronic kidney disease?
    Katherine R Tuttle
    Providence Medical Research Center at Sacred Heart Medical Center, Spokane, WA 99204, USA
    Semin Nephrol 29:512-23. 2009
  3. doi request reprint Protein kinase C-beta inhibition for diabetic kidney disease
    Katherine R Tuttle
    Providence Medical Research Center at Sacred Heart Medical Center, Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Spokane, WA 99204, USA
    Diabetes Res Clin Pract 82:S70-4. 2008
  4. doi request reprint Comparison of low-fat versus Mediterranean-style dietary intervention after first myocardial infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial)
    Katherine R Tuttle
    The Heart Institute of Spokane, Sacred Heart Medical Center, Spokane, Washington, USA
    Am J Cardiol 101:1523-30. 2008
  5. doi request reprint Dietary amino acids and blood pressure: a cohort study of patients with cardiovascular disease
    Katherine R Tuttle
    Providence Medical Research Center, Providence Sacred Heart Medical Center, Spokane, WA 99204, USA
    Am J Kidney Dis 59:803-9. 2012
  6. ncbi request reprint Implications of chronic kidney disease for dietary treatment in cardiovascular disease
    Diane P Packard
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane, WA 99204, USA
    J Ren Nutr 16:259-68. 2006
  7. ncbi request reprint Amino acids injure mesangial cells by advanced glycation end products, oxidative stress, and protein kinase C
    Katherine R Tuttle
    The Heart Institute of Spokane and Sacred Heart Medical Center, Spokane, Washington 99204, USA
    Kidney Int 67:953-68. 2005
  8. pmc Glomerular cell death and inflammation with high-protein diet and diabetes
    Rick L Meek
    Providence Medical Research Center, Providence Sacred Heart Medical Center, Spokane, WA, USA
    Nephrol Dial Transplant 28:1711-20. 2013
  9. doi request reprint Modulation of advanced glycation end products by candesartan in patients with diabetic kidney disease--a dose-response relationship study
    Sandeep A Saha
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane, WA 99204, USA
    Am J Ther 17:553-8. 2010
  10. ncbi request reprint Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease
    Katherine R Tuttle
    Providence Medical Research Center and University of Washington School of Medicine, Spokane, Washington, USA
    Clin J Am Soc Nephrol 2:631-6. 2007

Detail Information

Publications35

  1. ncbi request reprint Oxidative stress mediates protein kinase C activation and advanced glycation end product formation in a mesangial cell model of diabetes and high protein diet
    Katherine R Tuttle
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane Seattle, WA 99204, USA
    Am J Nephrol 29:171-80. 2009
    ..The aim was to determine whether oxidative stress mediates bidirectional interactions between AGE and PKC ('cross-activation') in this model...
  2. doi request reprint Can comprehensive lifestyle change alter the course of chronic kidney disease?
    Katherine R Tuttle
    Providence Medical Research Center at Sacred Heart Medical Center, Spokane, WA 99204, USA
    Semin Nephrol 29:512-23. 2009
    ....
  3. doi request reprint Protein kinase C-beta inhibition for diabetic kidney disease
    Katherine R Tuttle
    Providence Medical Research Center at Sacred Heart Medical Center, Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Spokane, WA 99204, USA
    Diabetes Res Clin Pract 82:S70-4. 2008
    ..Large-scale clinical trials will be required to confirm safety and to validate prospective benefits of ruboxistaurin on relevant clinical endpoints in DKD...
  4. doi request reprint Comparison of low-fat versus Mediterranean-style dietary intervention after first myocardial infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial)
    Katherine R Tuttle
    The Heart Institute of Spokane, Sacred Heart Medical Center, Spokane, Washington, USA
    Am J Cardiol 101:1523-30. 2008
    ..13 to 0.63, p = 0.002), respectively. In conclusion, active intervention with either a low-fat or a Mediterranean-style diet similarly and significantly benefits overall and cardiovascular-event-free survival after MI...
  5. doi request reprint Dietary amino acids and blood pressure: a cohort study of patients with cardiovascular disease
    Katherine R Tuttle
    Providence Medical Research Center, Providence Sacred Heart Medical Center, Spokane, WA 99204, USA
    Am J Kidney Dis 59:803-9. 2012
    ..Dietary protein has been variably reported to either lower or raise blood pressure. The purpose of this study was to determine whether intakes of specific amino acids differentially associate with blood pressure...
  6. ncbi request reprint Implications of chronic kidney disease for dietary treatment in cardiovascular disease
    Diane P Packard
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane, WA 99204, USA
    J Ren Nutr 16:259-68. 2006
    ..Because many in this population have CKD, indicators of kidney damage and function are prespecified secondary end points. Results of this trial should provide insight into optimal dietary interventions for persons with both CVD and CKD...
  7. ncbi request reprint Amino acids injure mesangial cells by advanced glycation end products, oxidative stress, and protein kinase C
    Katherine R Tuttle
    The Heart Institute of Spokane and Sacred Heart Medical Center, Spokane, Washington 99204, USA
    Kidney Int 67:953-68. 2005
    ..Increased levels of amino acids could injure cells by providing free amino groups for glycation reactions leading to advanced glycation end products (AGEs)...
  8. pmc Glomerular cell death and inflammation with high-protein diet and diabetes
    Rick L Meek
    Providence Medical Research Center, Providence Sacred Heart Medical Center, Spokane, WA, USA
    Nephrol Dial Transplant 28:1711-20. 2013
    ..This study assessed receptor for AGE (RAGE)-mediated apoptosis and inflammation in glomerular cells exposed to metabolic stressors characteristic of high-protein diets and/or diabetes in vitro with proof-of-concept appraisal in vivo...
  9. doi request reprint Modulation of advanced glycation end products by candesartan in patients with diabetic kidney disease--a dose-response relationship study
    Sandeep A Saha
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane, WA 99204, USA
    Am J Ther 17:553-8. 2010
    ..Reducing kidney exposure to AGEs may be a mechanism of protection by angiotensin receptor blockade in DKD. AGEs may also impact the diabetic kidney through mechanisms independent of transforming growth factor-β₁...
  10. ncbi request reprint Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease
    Katherine R Tuttle
    Providence Medical Research Center and University of Washington School of Medicine, Spokane, Washington, USA
    Clin J Am Soc Nephrol 2:631-6. 2007
    ..In contrast, in a trial of patients with diabetic retinopathy, investigators reported the adverse event "diabetic nephropathy" more frequently in patients who received RBX...
  11. doi request reprint Classification of chronic kidney disease biomarkers to predict coronary artery calcium
    Sterling McPherson
    Washington State University, College of Nursing, Washington State University, Spokane, WA, USA
    Kidney Blood Press Res 36:26-35. 2012
    ..The aim of this study was to examine if there are distinct trajectory classes of serum phosphorus (controlling for eGFR) that are associated CAC in a relatively healthy, community sample...
  12. doi request reprint Risks of subsequent hospitalization and death in patients with kidney disease
    Kenn B Daratha
    Providence Medical Research Center, University of Washington School of Medicine, Spokane, 99210 1495, USA
    Clin J Am Soc Nephrol 7:409-16. 2012
    ..The primary objective was to evaluate patients with kidney disease for long-term risks of subsequent hospitalization, including admissions resulting in death...
  13. doi request reprint Management of the diabetic patient with advanced chronic kidney disease
    Radica Z Alicic
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane, WA 99204, USA
    Semin Dial 23:140-7. 2010
    ..However, with heightened awareness of risks and a multifactorial management approach, the impact of DKD on micro- and macrovascular complications and death can be reduced...
  14. ncbi request reprint Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Nat Clin Pract Nephrol 1:80-6. 2005
    ..Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition...
  15. ncbi request reprint The effect of ruboxistaurin on nephropathy in type 2 diabetes
    Katherine R Tuttle
    Research Department, The Heart Institute and Sacred Heart Medical Center, Spokane, WA 99204 2340, USA
    Diabetes Care 28:2686-90. 2005
    ..Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans...
  16. doi request reprint Direct and indirect effects of obesity on the kidney
    Radica Z Alicic
    Providence Medical Research Center Department of Medicine, University of Washington School of Medicine, Spokane, WA 99204, USA
    Adv Chronic Kidney Dis 20:121-7. 2013
    ..The purpose of this article is to review current knowledge regarding adverse effects of obesity on the kidney...
  17. ncbi request reprint Do agents that block the RAS truly offer renoprotective effects in early stage, nonproteinuric nephropathy?
    Radica Alicic
    Providence Medical Research Center, University of Washington School of Medicine, PO Box 2555, 101 West 8th Avenue, Spokane, WA 99220 2555, USA
    Curr Hypertens Rep 9:393-402. 2007
    ..Long-term studies with clinically relevant outcomes (death and loss of kidney function) are needed to clarify whether specific agents provide benefits beyond that of BP control in early stage, nonproteinuric nephropathy...
  18. ncbi request reprint Uric acid, microalbuminuria and cardiovascular events in high-risk patients
    Robert A Short
    The Heart Institute of Spokane and Sacred Heart Medical Center, Spokane, WA 99204 2340, USA
    Am J Nephrol 25:36-44. 2005
    ..The purpose of this study was to evaluate people at high risk for cardiovascular disease for the influence of uric acid and microalbuminuria on cardiovascular events...
  19. ncbi request reprint Clinical evidence for the influence of uric acid on hypertension, cardiovascular disease, and kidney disease: a statistical modeling perspective
    Robert A Short
    Research Department, The Heart Institute of Spokane, WA 99204 2340, USA
    Semin Nephrol 25:25-31. 2005
    ....
  20. doi request reprint Co-occurring mood disorders among hospitalized patients and risk for subsequent medical hospitalization
    Kenn B Daratha
    College of Nursing, Washington State University, Spokane, WA, USA
    Gen Hosp Psychiatry 34:500-5. 2012
    ....
  21. ncbi request reprint Amino acids induce indicators of response to injury in glomerular mesangial cells
    Rick L Meek
    Research Department, The Heart Institute of Spokane, Spokane, Washington 99204, USA
    Am J Physiol Renal Physiol 285:F79-86. 2003
    ..In conditions associated with increased circulating amino acids, such as diabetes and/or a high-protein diet, direct cellular effects could contribute to glomerular injury...
  22. pmc Kidney disease and increased mortality risk in type 2 diabetes
    Maryam Afkarian
    Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98014, USA
    J Am Soc Nephrol 24:302-8. 2013
    ..2%-29.6%) when further adjusted. We observed similar patterns for cardiovascular and noncardiovascular mortality. In conclusion, those with kidney disease predominantly account for the increased mortality observed in type 2 diabetes...
  23. doi request reprint Influence of glycemic control on the development of diabetic cardiovascular and kidney disease
    Sandeep A Saha
    Providence Medical Research Center, Spokane, WA 99204, USA
    Cardiol Clin 28:497-516. 2010
    ..This article discusses the various drug classes used to treat diabetes mellitus, and reviews the current clinical evidence linking glycemic control using these drug classes on diabetic kidney and cardiovascular disease...
  24. ncbi request reprint Should albuminuria be a focus of antihypertensive therapy goals?
    Radica Z Alicic
    Providence Medical Research Center, Spokane, WA 99204, USA
    Curr Hypertens Rep 11:354-62. 2009
    ....
  25. ncbi request reprint A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition
    Katherine R Tuttle
    Heart Institute of Spokane, Research Department, Spokane, WA 99204 2340, USA
    Am J Kidney Dis 42:456-65. 2003
    ..Such therapies are needed to reduce the occurrence of devastating diabetic complications...
  26. ncbi request reprint Advanced glycation end products and nephrotoxicity of high-protein diets
    Jaime Uribarri
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Clin J Am Soc Nephrol 1:1293-9. 2006
    ..Future research should consider dietary AGE as a potential therapeutic target for kidney disease in obesity, diabetes, and perhaps other causes of chronic kidney disease...
  27. pmc Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach
    Crystal A Gadegbeku
    Department of Medicine, Temple University, Philadelphia, Pennsylvania, USA
    Kidney Int 83:749-56. 2013
    ..Thus, understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies...
  28. ncbi request reprint Effects of amino acids and glucose on mesangial cell aminopeptidase a and angiotensin receptors
    Robert F Chouinard
    Department of Research, The Heart Institute of Spokane, Spokane, Washington 99204 2340, USA
    Kidney Int 61:S106-9. 2002
    ..We evaluated whether amino acids and glucose alter expression of APA, AT1 receptor and AT2 receptor in a manner that further augments RAS activity...
  29. ncbi request reprint A causal role for uric acid in fructose-induced metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 290:F625-31. 2006
    ..Fructose may have a major role in the epidemic of metabolic syndrome and obesity due to its ability to raise uric acid...
  30. ncbi request reprint Cardiovascular implications of albuminuria
    Katherine R Tuttle
    Research Department, The Heart Institute of Spokane, 122 West 7th Avenue, Suite 230, Spokane, WA 99204, USA
    J Clin Hypertens (Greenwich) 6:13-7. 2004
    ..Nevertheless, the measurement of albuminuria is clinically useful to identify high-risk individuals who should receive intensive risk factor management based on current treatment guidelines...
  31. pmc Longitudinal relationships among coronary artery calcification, serum phosphorus, and kidney function
    Katherine R Tuttle
    Providence Medical Research Center, Spokane, WA 99224, USA
    Clin J Am Soc Nephrol 4:1968-73. 2009
    ..The study objective was to assess longitudinal relationships among CAC, kidney function, and traditional and putative cardiovascular disease (CVD) risk factors...
  32. doi request reprint National Kidney Foundation consensus conference on cardiovascular and kidney diseases and diabetes risk: an integrated therapeutic approach to reduce events
    George Bakris
    Department of Medicine, University of Chicago, Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Kidney Int 78:726-36. 2010
    ..This paper summarizes the results of a consensus conference utilizing a patient case to discuss the integrated management of hypertension, kidney disease, dyslipidemia, diabetes, and heart failure across disciplines...
  33. doi request reprint Novel therapies for diabetic kidney disease
    Radica Z Alicic
    Providence Medical Research Center, Providence Sacred Heart Medical Center and Children s Hospital, Spokane, WA and Providence Medical Research Center, Providence Sacred Heart Medical Center and Children s Hospital, Spokane, WA and University of Washington School of Medicine, Spokane and Seattle, WA Electronic address
    Adv Chronic Kidney Dis 21:121-33. 2014
    ....
  34. ncbi request reprint Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    ..Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy...
  35. ncbi request reprint Effects of amino acids and glucagon on renal hemodynamics in type 1 diabetes
    Katherine R Tuttle
    Department of Research, The Heart Institute of Spokane, Spokane, Washington 99204 2340, USA
    Am J Physiol Renal Physiol 282:F103-12. 2002
    ..Glomerular hyperfiltration responses induced by amino acids or glucagon occur by divergent pathways in diabetes; only the response to glucagon is prostaglandin dependent...