Peter J Hotez

Summary

Affiliation: Sabin Vaccine Institute
Country: USA

Publications

  1. doi request reprint A handful of 'antipoverty' vaccines exist for neglected diseases, but the world's poorest billion people need more
    Peter Hotez
    Sabin Vaccine Institute, Washington, DC, USA
    Health Aff (Millwood) 30:1080-7. 2011
  2. doi request reprint Europe's neglected infections of poverty
    Peter J Hotez
    Sabin Vaccine Institute and Section of Pediatric Tropical Medicine, National School of Tropical Medicine at Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA
    Int J Infect Dis 15:e611-9. 2011
  3. doi request reprint Neglected tropical disease vaccines
    Peter J Hotez
    Sabin Vaccine Institute, DC 20006, USA
    Biologicals 37:160-4. 2009
  4. pmc Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration
    Angela L Williamson
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
    Infect Immun 74:961-7. 2006
  5. ncbi request reprint Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs
    Ricardo T Fujiwara
    Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
    Vaccine 24:501-9. 2006
  6. ncbi request reprint The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamsters
    Kashinath Ghosh
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    J Infect Dis 193:155-62. 2006
  7. ncbi request reprint Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials
    Gaddam Narsa Goud
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 736, 2300 Eye Street NW, Washington, DC 20037, USA
    Vaccine 23:4754-64. 2005
  8. pmc The Human Hookworm Vaccine
    Peter J Hotez
    Sabin Vaccine Institute Product Development Partnership, Houston, TX, USA
    Vaccine 31:B227-32. 2013
  9. doi request reprint Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen
    Gaddam Narsa Goud
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
    Protein Expr Purif 83:145-51. 2012
  10. pmc Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans
    Sujit S Nair
    Department of Biochemistry and Molecular Biology, George Washington University, Washington, DC 20016, USA
    Hepatology 54:1388-97. 2011

Collaborators

Detail Information

Publications45

  1. doi request reprint A handful of 'antipoverty' vaccines exist for neglected diseases, but the world's poorest billion people need more
    Peter Hotez
    Sabin Vaccine Institute, Washington, DC, USA
    Health Aff (Millwood) 30:1080-7. 2011
    ....
  2. doi request reprint Europe's neglected infections of poverty
    Peter J Hotez
    Sabin Vaccine Institute and Section of Pediatric Tropical Medicine, National School of Tropical Medicine at Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA
    Int J Infect Dis 15:e611-9. 2011
    ..To review the prevalence, incidence, and geographic distribution of the major neglected infections of poverty in Europe as a basis for future policy recommendations...
  3. doi request reprint Neglected tropical disease vaccines
    Peter J Hotez
    Sabin Vaccine Institute, DC 20006, USA
    Biologicals 37:160-4. 2009
    ..This would be an important step towards achieving the Millennium Development Goals for sustainable poverty reduction by 2015...
  4. pmc Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration
    Angela L Williamson
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
    Infect Immun 74:961-7. 2006
    ..The data strongly suggest that Ac-MTP-1 is critical for the invasion process of hookworm larvae, and moreover, that antibodies against the enzyme can neutralize its function and inhibit migration...
  5. ncbi request reprint Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs
    Ricardo T Fujiwara
    Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
    Vaccine 24:501-9. 2006
    ....
  6. ncbi request reprint The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamsters
    Kashinath Ghosh
    Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    J Infect Dis 193:155-62. 2006
    ..The effect of concurrent (active) and treated hookworm infections on the immunogenicity of vaccination with the recombinant fusion protein Ay-Ancylostoma-secreted protein 2 was analyzed in the Golden Syrian hamster...
  7. ncbi request reprint Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials
    Gaddam Narsa Goud
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 736, 2300 Eye Street NW, Washington, DC 20037, USA
    Vaccine 23:4754-64. 2005
    ..The processes developed and tested for the high yield production of recombinant Na-ASP-2 provide a foundation for clinical vaccine development...
  8. pmc The Human Hookworm Vaccine
    Peter J Hotez
    Sabin Vaccine Institute Product Development Partnership, Houston, TX, USA
    Vaccine 31:B227-32. 2013
    ..Ultimately, the vaccine could become an essential tool for achieving hookworm control and elimination, a key target in the 2012 London Declaration on Neglected Tropical Diseases...
  9. doi request reprint Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen
    Gaddam Narsa Goud
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
    Protein Expr Purif 83:145-51. 2012
    ..The expression and purification methods described here are suitable for further scale-up product development and for its use to design formulation processes suitable to generate a vaccine for clinical testing...
  10. pmc Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans
    Sujit S Nair
    Department of Biochemistry and Molecular Biology, George Washington University, Washington, DC 20016, USA
    Hepatology 54:1388-97. 2011
    ..Immunohistochemical analysis of ≈ 300 liver tissue cores from confirmed cases of O. viverrini-induced CCA showed that MTA1 expression was elevated in >80% of the specimens...
  11. ncbi request reprint Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    Jeffrey Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
    Lancet 367:1521-32. 2006
    ..Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools...
  12. pmc Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum
    Bin Zhan
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    Infect Immun 73:6903-11. 2005
    ..7%) following challenge with heterologous Necator americanus larvae. These studies suggest that Ac-GST-1 is a possible drug and vaccine target for hookworm infection...
  13. ncbi request reprint Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals
    Jeffrey Bethony
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    FASEB J 19:1743-5. 2005
    ..These findings provide strong support for the development of an effective recombinant vaccine against hookworm infection in humans...
  14. pmc Vaccines to combat the neglected tropical diseases
    Jeffrey M Bethony
    Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Immunol Rev 239:237-70. 2011
    ..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access...
  15. doi request reprint Developing vaccines to combat hookworm infection and intestinal schistosomiasis
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    Nat Rev Microbiol 8:814-26. 2010
    ..New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development...
  16. doi request reprint Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies
    Jordan L Plieskatt
    Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA
    Hum Vaccin Immunother 8:765-76. 2012
    ..Based on these evaluations, the recombinant Na-GST-1 antigen was reformulated and ultimately produced under Good Manufacturing Practices and with an acceptable stability profile...
  17. doi request reprint Potency testing for the experimental Na-GST-1 hookworm vaccine
    Amar R Jariwala
    Albert B Sabin Vaccine Institute, Washington, DC, USA
    Expert Rev Vaccines 9:1219-30. 2010
    ..Our experience is that much of the existing information is proprietary and needs to be pulled together in a single source to aid in our overall understanding of potency testing...
  18. pmc The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
    PLoS Negl Trop Dis 2:e300. 2008
    ..Ultimately, the roadmap for the control and elimination of the more widespread NTDs will require an inter-sectoral approach that bridges public health, social services, and environmental interventions...
  19. pmc Neglected tropical diseases of the Middle East and North Africa: review of their prevalence, distribution, and opportunities for control
    Peter J Hotez
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Negl Trop Dis 6:e1475. 2012
    ....
  20. doi request reprint Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
    Expert Rev Vaccines 7:745-52. 2008
    ..A multivalent anthelminthic vaccine for hookworm infection and schistosomiasis would represent an important new tool for combating disease and poverty...
  21. pmc Host cytokine production, lymphoproliferation, and antibody responses during the course of Ancylostoma ceylanicum infection in the Golden Syrian hamster
    Susana Mendez
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall, Rm 726, 2300 Eye St NW, Washington, DC 20037, USA
    Infect Immun 73:3402-7. 2005
    ..The findings demonstrate a similarity in immune responses between hamsters and humans infected with hookworms, suggesting that hamsters will be a useful animal model species for examining host immunity to human hookworm infections...
  22. doi request reprint Hookworm vaccines
    David J Diemert
    Sabin Vaccine Institute, George Washington University, Washington, DC 20037, USA
    Clin Infect Dis 46:282-8. 2008
    ..Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens--one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract...
  23. ncbi request reprint Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  24. ncbi request reprint Global progress towards eliminating gastrointestinal helminth infections
    Thomas R McCarty
    National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA Thomas R McCarty and Joshua A Turkeltaub are medical students at Baylor College of Medicine and contributed equally to the writing of the manuscript
    Curr Opin Gastroenterol 30:18-24. 2014
    ..To highlight the gastrointestinal helminths in the context of renewed global commitment to control or eliminate neglected tropical diseases in the coming decade...
  25. pmc Neglected tropical diseases of Oceania: review of their prevalence, distribution, and opportunities for control
    Kevin Kline
    Departments of Pediatrics and Molecular Virology and Microbiology, and National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Negl Trop Dis 7:e1755. 2013
    ..Australia's Aboriginal population may benefit from appropriately integrated MDA into primary health care systems. Several emerging viral NTDs remain important threats to the region...
  26. doi request reprint Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths
    David J Diemert
    Albert B Sabin Vaccine Institute, Washington, DC 20037, USA
    J Allergy Clin Immunol 130:169-76.e6. 2012
    ..Vaccination of laboratory animals with recombinant Na-ASP-2 provides significant protection against challenge infections. In endemic areas antibodies to Na-ASP-2 are associated with reduced risk of heavy N americanus infections...
  27. pmc The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer
    Sujit S Nair
    Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA
    Hepatology 54:285-95. 2011
    ....
  28. ncbi request reprint Helminth infections of children: prospects for control
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Adv Exp Med Biol 568:135-44. 2005
  29. doi request reprint Global trends in neglected tropical disease control and elimination: impact on child health
    Meagan A Barry
    Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Dis Child 98:635-41. 2013
    ..Efforts are underway to harness the momentum of a 2012 London Declaration on NTDs and a 2013 World Health Assembly (WHA) resolution as a means to control or in some cases eliminate by 2020 these NTDs that affect children worldwide. ..
  30. ncbi request reprint Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas
    Peter J Hotez
    Sabin Vaccine Institute, Texas Children s Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Tropical Medicine, Baylor College of Medicine, Houston, USA
    Adv Exp Med Biol 764:1-12. 2013
    ..Together, MDA and the development of new anti-poverty vaccines afford an opportunity to implement effective control and elimination strategies for the major NTDs in the Americas...
  31. doi request reprint Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific region
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia, USA
    Adv Parasitol 72:31-53. 2010
    ..Through a global network for NTDs, an innovative finance mechanism Is being created to control the most common neglected diseases across Asia...
  32. pmc Hookworm: "the great infection of mankind"
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
    PLoS Med 2:e67. 2005
  33. pmc Neglected infections of poverty in the United States of America
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, D C, USA
    PLoS Negl Trop Dis 2:e256. 2008
    ....
  34. pmc Helminth infections: the great neglected tropical diseases
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    J Clin Invest 118:1311-21. 2008
    ..Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans...
  35. ncbi request reprint The antipoverty vaccines
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and the Sabin Vaccine Institute, Washington, DC 20037, USA
    Vaccine 24:5787-99. 2006
    ..Early development of such antipoverty vaccines will require the establishment of product development public-private partnerships and partnerships with innovative developing countries where these diseases are endemic...
  36. pmc Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia, USA
    PLoS Med 3:e102. 2006
  37. ncbi request reprint An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseases
    Maria Elena Bottazzi
    The George Washington University, The Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, 2300 Eye Street NW, Ross Hall Room 733, Washington, DC 20037, USA
    Expert Rev Vaccines 5:189-98. 2006
    ..Throughout this perspective, special emphasis is placed on the growing promise that product development public-private partnerships hold for developing vaccines for the world's poorest people...
  38. pmc Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections
    Bin Zhan
    Sabin Vaccine Institute and Texas Children s Hospital Center for Vaccine Development, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA
    Expert Rev Vaccines 13:321-31. 2014
    ....
  39. doi request reprint Childhood parasitic infections endemic to the United States
    Meagan A Barry
    Interdepartmental Program in Translational Biology and Molecular Medicine, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Clin North Am 60:471-85. 2013
    ..Local, vector-borne transmission of T cruzi and Leishmania infections has been documented in southern states. Parasitic diseases endemic to the United States are not uncommon but are understudied...
  40. ncbi request reprint The National Institutes of Health roadmap and the developing world
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    J Investig Med 52:246-7. 2004
  41. ncbi request reprint Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries Project
    Peter J Hotez
    George Washington University, Washington, DC, USA
    Clin Infect Dis 38:871-8. 2004
    ..Application of technologies must be cost-effective and intensified research is essential if these and other scourges are to be controlled or eliminated in the 21st century...
  42. ncbi request reprint Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum
    Susana Mendez
    Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, Rose Hall 736, 2300 Eye Street, NW, Washington, DC 20037, USA
    Vaccine 23:3123-30. 2005
    ..Taken together, these data suggest that combination of two or more antigens may present an effective vaccine development strategy to improve protection and/or disease symptoms in affected individuals...
  43. ncbi request reprint Should we establish a North American school of global health sciences?
    Peter J Hotez
    Department of Microbiology and Tropical Medicine, Global Health, Epidemiology and Biostatistics, The George Washington University, Washington, DC 20037, USA
    Am J Med Sci 328:71-7. 2004
    ..The North American school, possibly in association with one of the existing schools of medicine or public health, would provide interdisciplinary training to produce a new generation of global health scientists...
  44. ncbi request reprint Control of onchocerciasis--the next generation
    Peter J Hotez
    Sabin Vaccine Institute and Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    Lancet 369:1979-80. 2007