Research Topics
| Peter J HotezSummaryAffiliation: Sabin Vaccine Institute Country: USA Publications
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Detail Information
Publications
Neglected tropical disease vaccinesPeter J Hotez
Sabin Vaccine Institute, DC 20006, USA
Biologicals 37:160-4. 2009..This would be an important step towards achieving the Millennium Development Goals for sustainable poverty reduction by 2015...- Europe's neglected infections of povertyPeter J Hotez
Sabin Vaccine Institute and Section of Pediatric Tropical Medicine, National School of Tropical Medicine at Texas Children s Hospital and Baylor College of Medicine, Houston, Texas, USA
Int J Infect Dis 15:e611-9. 2011..To review the prevalence, incidence, and geographic distribution of the major neglected infections of poverty in Europe as a basis for future policy recommendations... - A handful of 'antipoverty' vaccines exist for neglected diseases, but the world's poorest billion people need morePeter Hotez
Sabin Vaccine Institute, Washington, DC, USA
Health Aff (Millwood) 30:1080-7. 2011.... 
Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migrationAngela L Williamson
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
Infect Immun 74:961-7. 2006..The data strongly suggest that Ac-MTP-1 is critical for the invasion process of hookworm larvae, and moreover, that antibodies against the enzyme can neutralize its function and inhibit migration...
The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamstersKashinath Ghosh
Department of Microbiology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
J Infect Dis 193:155-62. 2006..The hookworm-associated immunodepression may have important implications for design of clinical trials of human vaccines and vaccination strategies...- Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogsRicardo T Fujiwara
Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
Vaccine 24:501-9. 2006.... - Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninumBin Zhan
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
Infect Immun 73:6903-11. 2005..7%) following challenge with heterologous Necator americanus larvae. These studies suggest that Ac-GST-1 is a possible drug and vaccine target for hookworm infection... - Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trialsGaddam Narsa Goud
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall 736, 2300 Eye Street NW, Washington, DC 20037, USA
Vaccine 23:4754-64. 2005..The processes developed and tested for the high yield production of recombinant Na-ASP-2 provide a foundation for clinical vaccine development... - Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigenGaddam Narsa Goud
Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC, USA
Protein Expr Purif 83:145-51. 2012..The expression and purification methods described here are suitable for further scale-up product development and for its use to design formulation processes suitable to generate a vaccine for clinical testing... - Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humansSujit S Nair
Department of Biochemistry and Molecular Biology, George Washington University, Washington, DC 20016, USA
Hepatology 54:1388-97. 2011..CONCLUSION: These findings suggest that MTA1 status plays an important role in conferring an optimal cytokine response in mice following infection with O. viverrini and is a major player in parasite-induced CCA in humans... - Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookwormJeffrey Bethony
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
Lancet 367:1521-32. 2006..Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools... - Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animalsJeffrey Bethony
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
FASEB J 19:1743-5. 2005..These findings provide strong support for the development of an effective recombinant vaccine against hookworm infection in humans... - Vaccines to combat the neglected tropical diseasesJeffrey M Bethony
Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
Immunol Rev 239:237-70. 2011..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access... - Developing vaccines to combat hookworm infection and intestinal schistosomiasisPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
Nat Rev Microbiol 8:814-26. 2010..New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development... - The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and eliminationPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
PLoS Negl Trop Dis 2:e300. 2008..Ultimately, the roadmap for the control and elimination of the more widespread NTDs will require an inter-sectoral approach that bridges public health, social services, and environmental interventions... - Potency testing for the experimental Na-GST-1 hookworm vaccineAmar R Jariwala
Albert B Sabin Vaccine Institute, Washington, DC, USA
Expert Rev Vaccines 9:1219-30. 2010..Our experience is that much of the existing information is proprietary and needs to be pulled together in a single source to aid in our overall understanding of potency testing... - Neglected tropical diseases of the Middle East and North Africa: review of their prevalence, distribution, and opportunities for controlPeter J Hotez
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
PLoS Negl Trop Dis 6:e1475. 2012.... - Hookworm vaccinesDavid J Diemert
Sabin Vaccine Institute, George Washington University, Washington, DC 20037, USA
Clin Infect Dis 46:282-8. 2008..Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens--one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract... - Control of neglected tropical diseasesPeter J Hotez
Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
N Engl J Med 357:1018-27. 2007 - Host cytokine production, lymphoproliferation, and antibody responses during the course of Ancylostoma ceylanicum infection in the Golden Syrian hamsterSusana Mendez
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Ross Hall, Rm 726, 2300 Eye St NW, Washington, DC 20037, USA
Infect Immun 73:3402-7. 2005..The findings demonstrate a similarity in immune responses between hamsters and humans infected with hookworms, suggesting that hamsters will be a useful animal model species for examining host immunity to human hookworm infections... - Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasisPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
Expert Rev Vaccines 7:745-52. 2008..A multivalent anthelminthic vaccine for hookworm infection and schistosomiasis would represent an important new tool for combating disease and poverty... - Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminthsDavid J Diemert
Albert B Sabin Vaccine Institute, Washington, DC 20037, USA
J Allergy Clin Immunol 130:169-76.e6. 2012..Vaccination of laboratory animals with recombinant Na-ASP-2 provides significant protection against challenge infections. In endemic areas antibodies to Na-ASP-2 are associated with reduced risk of heavy N americanus infections... - The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancerSujit S Nair
Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA
Hepatology 54:285-95. 2011..CONCLUSION: These findings raise the possibility to develop intervention strategies targeting MTA1 to reduce the global burden of schistosomiasis, inflammation, and neoplasia... - Helminth infections of children: prospects for controlPeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Adv Exp Med Biol 568:135-44. 2005 - Hookworm: "the great infection of mankind"Peter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC, USA
PLoS Med 2:e67. 2005 - Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific regionPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia, USA
Adv Parasitol 72:31-53. 2010..Through a global network for NTDs, an innovative finance mechanism Is being created to control the most common neglected diseases across Asia... - Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicumSusana Mendez
Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, Rose Hall 736, 2300 Eye Street, NW, Washington, DC 20037, USA
Vaccine 23:3123-30. 2005..Taken together, these data suggest that combination of two or more antigens may present an effective vaccine development strategy to improve protection and/or disease symptoms in affected individuals... - Neglected infections of poverty in the United States of AmericaPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, D C, USA
PLoS Negl Trop Dis 2:e256. 2008.... - Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malariaPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia, USA
PLoS Med 3:e102. 2006 - An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseasesMaria Elena Bottazzi
The George Washington University, The Human Hookworm Vaccine Initiative, Department of Microbiology, Immunology and Tropical Medicine, 2300 Eye Street NW, Ross Hall Room 733, Washington, DC 20037, USA
Expert Rev Vaccines 5:189-98. 2006..Throughout this perspective, special emphasis is placed on the growing promise that product development public-private partnerships hold for developing vaccines for the world's poorest people... - The antipoverty vaccinesPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and the Sabin Vaccine Institute, Washington, DC 20037, USA
Vaccine 24:5787-99. 2006..Early development of such antipoverty vaccines will require the establishment of product development public-private partnerships and partnerships with innovative developing countries where these diseases are endemic... - Helminth infections: the great neglected tropical diseasesPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
J Clin Invest 118:1311-21. 2008..Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans... - Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studiesJordan L Plieskatt
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA
Hum Vaccin Immunother 8:765-76. 2012..Based on these evaluations, the recombinant Na-GST-1 antigen was reformulated and ultimately produced under Good Manufacturing Practices and with an acceptable stability profile... - The National Institutes of Health roadmap and the developing worldPeter J Hotez
Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
J Investig Med 52:246-7. 2004 - Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries ProjectPeter J Hotez
George Washington University, Washington, DC, USA
Clin Infect Dis 38:871-8. 2004..Application of technologies must be cost-effective and intensified research is essential if these and other scourges are to be controlled or eliminated in the 21st century... - Control of onchocerciasis--the next generationPeter J Hotez
Sabin Vaccine Institute and Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
Lancet 369:1979-80. 2007 - Should we establish a North American school of global health sciences?Peter J Hotez
Department of Microbiology and Tropical Medicine, Global Health, Epidemiology and Biostatistics, The George Washington University, Washington, DC 20037, USA
Am J Med Sci 328:71-7. 2004..The North American school, possibly in association with one of the existing schools of medicine or public health, would provide interdisciplinary training to produce a new generation of global health scientists...