Helmut Zarbl

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene
    Xuefeng Ren
    Department of Social and Preventive Medicine, The State University of New York, Buffalo, New York, United States of America Guangdong Medical Laboratory Animal Center, Foshan, Guangdong, China Fred Hutchinson Cancer Research Center FHCRC, Seattle, Washington, United States of America NIEHS Center for Ecogenetics and Environmental Health, and the Department of Environmental and Occupational Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e70930. 2013
  2. pmc Use of cell-SELEX to generate DNA aptamers as molecular probes of HPV-associated cervical cancer cells
    Jessica C Graham
    Department of Environmental and Occupational Medicine, Robert Wood Johnson, Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States of America
    PLoS ONE 7:e36103. 2012
  3. ncbi request reprint The vanishing zero revisited: thresholds in the age of genomics
    Helmut Zarbl
    Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Chem Biol Interact 184:273-8. 2010
  4. ncbi request reprint Toxicogenomic analyses of genetic susceptibility to mammary gland carcinogenesis in rodents: implications for human breast cancer
    Helmut Zarbl
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Rutgers University, Piscataway, NJ 08854, USA
    Breast Dis 28:87-105. 2007
  5. pmc Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo
    Ming Zhu Fang
    Environmental Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 3:640-52. 2010
  6. ncbi request reprint Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays
    Yingying Guo
    Departmental of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Mutat Res 593:121-42. 2006
  7. ncbi request reprint Dickkopf-1 mediated tumor suppression in human breast carcinoma cells
    Andrei M Mikheev
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Breast Cancer Res Treat 112:263-73. 2008
  8. pmc Chemopreventive doses of methylselenocysteine alter circadian rhythm in rat mammary tissue
    Xun Zhang
    Division of Human Biology, Fred Hutchinson Cancer, University of Washington, Seattle, Washington, USA
    Cancer Prev Res (Phila) 1:119-27. 2008
  9. ncbi request reprint Comparative genomics of susceptibility to mammary carcinogenesis among inbred rat strains: role of reduced prolactin signaling in resistance of the Copenhagen strain
    Xuefeng Ren
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Carcinogenesis 29:177-85. 2008
  10. ncbi request reprint Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity
    Wen Luo
    Division of Human Biology, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Chem Res Toxicol 18:619-29. 2005

Research Grants

Collaborators

Detail Information

Publications15

  1. pmc Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene
    Xuefeng Ren
    Department of Social and Preventive Medicine, The State University of New York, Buffalo, New York, United States of America Guangdong Medical Laboratory Animal Center, Foshan, Guangdong, China Fred Hutchinson Cancer Research Center FHCRC, Seattle, Washington, United States of America NIEHS Center for Ecogenetics and Environmental Health, and the Department of Environmental and Occupational Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e70930. 2013
    ..These results provide the foundation for analyzing the role of the human FRY gene in cancer susceptibility and progression. ..
  2. pmc Use of cell-SELEX to generate DNA aptamers as molecular probes of HPV-associated cervical cancer cells
    Jessica C Graham
    Department of Environmental and Occupational Medicine, Robert Wood Johnson, Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States of America
    PLoS ONE 7:e36103. 2012
    ..In the present study, we used live cell-based SELEX to identify DNA aptamers which recognize cell surface differences between HPV-transformed cervical carcinoma cancer cells and isogenic, nontumorigenic, revertant cell lines...
  3. ncbi request reprint The vanishing zero revisited: thresholds in the age of genomics
    Helmut Zarbl
    Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Chem Biol Interact 184:273-8. 2010
    ..This treatise explores how toxicogenomic responses at low doses may inform risk assessment and risk management by defining thresholds for cellular responses linked to modes or mechanisms of toxicity at the molecular level...
  4. ncbi request reprint Toxicogenomic analyses of genetic susceptibility to mammary gland carcinogenesis in rodents: implications for human breast cancer
    Helmut Zarbl
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Rutgers University, Piscataway, NJ 08854, USA
    Breast Dis 28:87-105. 2007
    ..In the present review, we explore how the combination of toxicogenomic approaches with rodent models can accelerate the discovery of human breast cancer susceptibility genes...
  5. pmc Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo
    Ming Zhu Fang
    Environmental Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 3:640-52. 2010
    ..These results suggest that dietary methylselenocysteine counteracted the disruptive effect of NMU on circadian expression of genes essential to normal mammary cell growth and differentiation...
  6. ncbi request reprint Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays
    Yingying Guo
    Departmental of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Mutat Res 593:121-42. 2006
    ....
  7. ncbi request reprint Dickkopf-1 mediated tumor suppression in human breast carcinoma cells
    Andrei M Mikheev
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Breast Cancer Res Treat 112:263-73. 2008
    ..Thus, our study supports the hypothesis that DKK-1 mediated tumor suppressor effect is independent of beta-catenin dependent transcription and identified the CamKII pathway that contributes into DKK-1 signaling...
  8. pmc Chemopreventive doses of methylselenocysteine alter circadian rhythm in rat mammary tissue
    Xun Zhang
    Division of Human Biology, Fred Hutchinson Cancer, University of Washington, Seattle, Washington, USA
    Cancer Prev Res (Phila) 1:119-27. 2008
    ....
  9. ncbi request reprint Comparative genomics of susceptibility to mammary carcinogenesis among inbred rat strains: role of reduced prolactin signaling in resistance of the Copenhagen strain
    Xuefeng Ren
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Carcinogenesis 29:177-85. 2008
    ..Together, these finding indicated that in the rat, the molecular mechanisms underlying genetic susceptibility to mammary carcinogenesis include de-regulation of Prl signaling...
  10. ncbi request reprint Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity
    Wen Luo
    Division of Human Biology, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Chem Res Toxicol 18:619-29. 2005
    ..Differences in the transcriptional response of TK6 cells to N-OH-AABP or BPDE exposure may explain the dramatic differences in the toxicity and mutagenicity of these human carcinogens...
  11. ncbi request reprint Frequent activation of CArG binding factor-A expression and binding in N-methyl-N-nitrosourea-induced rat mammary carcinomas
    Andrei M Mikheev
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 88:95-102. 2004
    ..Together, these findings indicated that deregulation of CBF-A contributes to mammary carcinogenesis via a mechanism that is distinct from its hnRNP functions in binding and post-transcriptional regulation of RNA...
  12. ncbi request reprint Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses
    Richard P Beyer
    University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    Toxicol Sci 99:326-37. 2007
    ..We show that phenotypic anchoring of gene expression data is required for biologically meaningful analysis of toxicogenomic experiments...
  13. pmc Dickkopf-1 activates cell death in MDA-MB435 melanoma cells
    Andrei M Mikheev
    Program in Cancer Biology, Divisions of Human Biology and Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092, USA
    Biochem Biophys Res Commun 352:675-80. 2007
    ..Thus, our results indicate that activation of DKK-1 in melanoma cells leads to activation of apoptosis in vivo and, thus, is incompatible with tumor growth in nude mice...
  14. ncbi request reprint A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation
    Andrei M Mikheev
    Program in Cancer Biology, Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092, USA
    Carcinogenesis 25:47-59. 2004
    ..Taken together, our results indicate that somatic cell genetics combining with gene expression profiling may be a useful approach for the identification of functional suppressors of malignant cell growth...
  15. pmc Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage
    Yingying Guo
    Departmental of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105 6099, USA
    Mol Cell Biol 25:5823-33. 2005
    ..Rev3 appears to mediate AFB1-induced mutagenesis when error-free pathways are compromised. The results further suggest unique roles for Rad5 and abasic endonuclease-dependent DNA intermediates in regulating AFB1-induced mutagenicity...

Research Grants7

  1. MAPPING GENETIC SUPPRESSORS OF EPIGENETIC CARCINOGENESIS
    Helmut Zarbl; Fiscal Year: 1999
    ....
  2. MAPPING GENETIC SUPPRESSORS OF EPIGENETIC CARCINOGENESIS
    Helmut Zarbl; Fiscal Year: 2000
    ....
  3. MAPPING GENETIC SUPPRESSORS OF EPIGENETIC CARCINOGENESIS
    Helmut Zarbl; Fiscal Year: 2001
    ....
  4. MAPPING GENETIC SUPPRESSORS OF EPIGENETIC CARCINOGENESIS
    Helmut Zarbl; Fiscal Year: 2002
    ....
  5. The FHCRC/UW Toxicogenomics Consortium
    Helmut Zarbl; Fiscal Year: 2005
    ..The latter will be essential for the generation of a public database for data generated by all members of the Consortium. ..
  6. The FHCRC/UW Toxicogenomics Consortium
    Helmut Zarbl; Fiscal Year: 2006
    ..The latter will be essential for the generation of a public database for data generated by all members of the Consortium. ..