Genomes and Genes
Affiliation: Rutgers University
- Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs geneXuefeng Ren
Department of Social and Preventive Medicine, The State University of New York, Buffalo, New York, United States of America Guangdong Medical Laboratory Animal Center, Foshan, Guangdong, China Fred Hutchinson Cancer Research Center FHCRC, Seattle, Washington, United States of America NIEHS Center for Ecogenetics and Environmental Health, and the Department of Environmental and Occupational Health, University of Washington, Seattle, Washington, United States of America
PLoS ONE 8:e70930. 2013..These results provide the foundation for analyzing the role of the human FRY gene in cancer susceptibility and progression. ..
- Use of cell-SELEX to generate DNA aptamers as molecular probes of HPV-associated cervical cancer cellsJessica C Graham
Department of Environmental and Occupational Medicine, Robert Wood Johnson, Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States of America
PLoS ONE 7:e36103. 2012..In the present study, we used live cell-based SELEX to identify DNA aptamers which recognize cell surface differences between HPV-transformed cervical carcinoma cancer cells and isogenic, nontumorigenic, revertant cell lines...
- The vanishing zero revisited: thresholds in the age of genomicsHelmut Zarbl
Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
Chem Biol Interact 184:273-8. 2010..This treatise explores how toxicogenomic responses at low doses may inform risk assessment and risk management by defining thresholds for cellular responses linked to modes or mechanisms of toxicity at the molecular level...
- Toxicogenomic analyses of genetic susceptibility to mammary gland carcinogenesis in rodents: implications for human breast cancerHelmut Zarbl
Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Rutgers University, Piscataway, NJ 08854, USA
Breast Dis 28:87-105. 2007..In the present review, we explore how the combination of toxicogenomic approaches with rodent models can accelerate the discovery of human breast cancer susceptibility genes...
- Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivoMing Zhu Fang
Environmental Occupational Health Sciences Institute, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
Cancer Prev Res (Phila) 3:640-52. 2010..These results suggest that dietary methylselenocysteine counteracted the disruptive effect of NMU on circadian expression of genes essential to normal mammary cell growth and differentiation...
- Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarraysYingying Guo
Departmental of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
Mutat Res 593:121-42. 2006....
- Dickkopf-1 mediated tumor suppression in human breast carcinoma cellsAndrei M Mikheev
Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
Breast Cancer Res Treat 112:263-73. 2008..Thus, our study supports the hypothesis that DKK-1 mediated tumor suppressor effect is independent of beta-catenin dependent transcription and identified the CamKII pathway that contributes into DKK-1 signaling...
- Chemopreventive doses of methylselenocysteine alter circadian rhythm in rat mammary tissueXun Zhang
Division of Human Biology, Fred Hutchinson Cancer, University of Washington, Seattle, Washington, USA
Cancer Prev Res (Phila) 1:119-27. 2008....
- Comparative genomics of susceptibility to mammary carcinogenesis among inbred rat strains: role of reduced prolactin signaling in resistance of the Copenhagen strainXuefeng Ren
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Carcinogenesis 29:177-85. 2008..Together, these finding indicated that in the rat, the molecular mechanisms underlying genetic susceptibility to mammary carcinogenesis include de-regulation of Prl signaling...
- Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicityWen Luo
Division of Human Biology, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
Chem Res Toxicol 18:619-29. 2005..Differences in the transcriptional response of TK6 cells to N-OH-AABP or BPDE exposure may explain the dramatic differences in the toxicity and mutagenicity of these human carcinogens...
- Frequent activation of CArG binding factor-A expression and binding in N-methyl-N-nitrosourea-induced rat mammary carcinomasAndrei M Mikheev
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Breast Cancer Res Treat 88:95-102. 2004..Together, these findings indicated that deregulation of CBF-A contributes to mammary carcinogenesis via a mechanism that is distinct from its hnRNP functions in binding and post-transcriptional regulation of RNA...
- Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analysesRichard P Beyer
University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
Toxicol Sci 99:326-37. 2007..We show that phenotypic anchoring of gene expression data is required for biologically meaningful analysis of toxicogenomic experiments...
- Dickkopf-1 activates cell death in MDA-MB435 melanoma cellsAndrei M Mikheev
Program in Cancer Biology, Divisions of Human Biology and Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092, USA
Biochem Biophys Res Commun 352:675-80. 2007..Thus, our results indicate that activation of DKK-1 in melanoma cells leads to activation of apoptosis in vivo and, thus, is incompatible with tumor growth in nude mice...
- A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformationAndrei M Mikheev
Program in Cancer Biology, Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092, USA
Carcinogenesis 25:47-59. 2004..Taken together, our results indicate that somatic cell genetics combining with gene expression profiling may be a useful approach for the identification of functional suppressors of malignant cell growth...
- Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damageYingying Guo
Departmental of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105 6099, USA
Mol Cell Biol 25:5823-33. 2005..Rev3 appears to mediate AFB1-induced mutagenesis when error-free pathways are compromised. The results further suggest unique roles for Rad5 and abasic endonuclease-dependent DNA intermediates in regulating AFB1-induced mutagenicity...
- MAPPING GENETIC SUPPRESSORS OF EPIGENETIC CARCINOGENESISHelmut Zarbl; Fiscal Year: 2002....
- The FHCRC/UW Toxicogenomics ConsortiumHelmut Zarbl; Fiscal Year: 2006..The latter will be essential for the generation of a public database for data generated by all members of the Consortium. ..