Chung Yang

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi Cancer prevention by different forms of tocopherols
    Chung S Yang
    Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, NJ, USA
    Top Curr Chem 329:21-33. 2013
  2. ncbi Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice
    Guangxun Li
    Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 5:963-72. 2012
  3. ncbi Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice
    Jing Hao
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    BMC Gastroenterol 9:59. 2009
  4. ncbi Antioxidative and anti-carcinogenic activities of tea polyphenols
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Arch Toxicol 83:11-21. 2009
  5. ncbi Bioavailability issues in studying the health effects of plant polyphenolic compounds
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Mol Nutr Food Res 52:S139-51. 2008
  6. ncbi Cancer prevention by tea and tea polyphenols
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Phar macy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Asia Pac J Clin Nutr 17:245-8. 2008
  7. ncbi Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma
    Chi Kwong So
    Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, New Jersey, USA
    Clin Cancer Res 10:19-27. 2004
  8. ncbi Tea and cancer prevention: molecular mechanisms and human relevance
    Chung S Yang
    Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, and Center for Cancer Prevention Research, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 224:265-73. 2007
  9. ncbi Green tea polyphenols: antioxidative and prooxidative effects
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854-8020, USA
    J Nutr 134:3181S. 2004
  10. ncbi Dietary factors may modify cancer risk by altering xenobiotic metabolism and many other mechanisms
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    J Nutr 136:2685S-6S. 2006

Research Grants

  1. Prevention of Colon Cancer by Epigallocatechin Gallate and Atorvastatin
    Chung S Yang; Fiscal Year: 2010
  2. Reactivation Methylation-Silenced Genes by Polyphenols
    Chung Yang; Fiscal Year: 2007
  3. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2007
  4. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2006
  5. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Chung Yang; Fiscal Year: 2005
  6. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
  7. Prevention of Colon Cancer by Epigallocatechin Gallate and Atorvastatin
    Chung Yang; Fiscal Year: 2009
  8. Prevention of Colon Cancer by Epigallocatechin Gallate and Atorvastatin
    Chung S Yang; Fiscal Year: 2010
  9. Inhibition of Lung Carcinogenesis by Tea Polyphenols and Atorvastatin
    Chung Yang; Fiscal Year: 2009
  10. Mechanistic Studies on Lung Cancer Prevention by Tea Polyphenols
    Chung Yang; Fiscal Year: 2009

Collaborators

Detail Information

Publications85

  1. ncbi Cancer prevention by different forms of tocopherols
    Chung S Yang
    Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, NJ, USA
    Top Curr Chem 329:21-33. 2013
    ....
  2. ncbi Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice
    Guangxun Li
    Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 5:963-72. 2012
    ..This dietary carcinogen-induced prostate cancer model, recapitulating important features of early human prostate carcinogenesis, constitutes a new experimental system for prostate cancer research...
  3. ncbi Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice
    Jing Hao
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    BMC Gastroenterol 9:59. 2009
    ..However, use of this rat model for mechanistic and chemopreventive studies is limited due to lack of genetically modified rat strains. Therefore, a mouse model of esophageal adenocarcinoma is needed...
  4. ncbi Antioxidative and anti-carcinogenic activities of tea polyphenols
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Arch Toxicol 83:11-21. 2009
    ..Finally, we discuss the effects of tea consumption on cancer risk in humans. It is our aim to raise some of the unanswered questions regarding cancer prevention by tea and to stimulate further research in this area...
  5. ncbi Bioavailability issues in studying the health effects of plant polyphenolic compounds
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Mol Nutr Food Res 52:S139-51. 2008
    ..Further research on both the biological activity and bioavailability of dietary polyphenols is needed to properly assess their usefulness for the prevention and treatment of disease...
  6. ncbi Cancer prevention by tea and tea polyphenols
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Phar macy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Asia Pac J Clin Nutr 17:245-8. 2008
    ..Human intervention trials and large prospective studies are needed to further assess the cancer preventive activities of tea constituents...
  7. ncbi Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma
    Chi Kwong So
    Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, New Jersey, USA
    Clin Cancer Res 10:19-27. 2004
    ..Additional ESCC samples were analyzed using different sets of microsatellite markers (CS1-CS5) within the introns or in close proximity to the 3' end of the CBP gene...
  8. ncbi Tea and cancer prevention: molecular mechanisms and human relevance
    Chung S Yang
    Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, and Center for Cancer Prevention Research, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 224:265-73. 2007
    ..Some interesting examples in this area are discussed...
  9. ncbi Green tea polyphenols: antioxidative and prooxidative effects
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854-8020, USA
    J Nutr 134:3181S. 2004
  10. ncbi Dietary factors may modify cancer risk by altering xenobiotic metabolism and many other mechanisms
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    J Nutr 136:2685S-6S. 2006
  11. ncbi Possible mechanisms of the cancer-preventive activities of green tea
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Nutr Food Res 50:170-5. 2006
    ..We also need to distinguish between primary and subsequent events. Possible artifacts should be recognized. The cancer-preventive mechanisms need to be validated in animal models or human samples...
  12. ncbi Inhibition of lung tumorigenesis by tea
    Chung S Yang
    Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, NJ 08854, USA
    Exp Lung Res 31:135-44. 2005
    ..In many of the experiments, tea consumption resulted in the reduction of body fat and body weight; these factors may also contribute to the inhibition of tumorigenesis...
  13. ncbi Polyphenols as inhibitors of carcinogenesis
    C S Yang
    Laboratory for Cancer Research, Rutgers University, Piscataway, New Jersey 08855 0789, USA
    Environ Health Perspect 105:971-6. 1997
    ..More mechanistic and dose-response studies will help us to understand the effects of tea consumption on human carcinogenesis...
  14. ncbi Green tea and cancer prevention
    Chung S Yang
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Nutr Cancer 62:931-7. 2010
    ..This article reviews data on the cancer preventive activities of green tea polyphenols, possible mechanisms involved, and the relationship between green tea consumption and human cancer risk...
  15. ncbi Mechanisms of inhibition of carcinogenesis by tea
    C S Yang
    Laboratory Cancer Research, College of Pharmacy Rutgers, The State University of New Jersey, Piscataway 08854 8020, USA
    Biofactors 13:73-9. 2000
    ..More mechanistic and human studies in these areas will help us to understand the possible inhibitory action of tea against carcinogenesis in humans...
  16. ncbi Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols
    Chung S Yang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Rutgers, The State University of New Jersey, New Jersey, USA
    Ann N Y Acad Sci 1203:29-34. 2010
    ..These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols...
  17. ncbi Prevention of carcinogenesis by tea polyphenols
    C S Yang
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854 8020, USA
    Drug Metab Rev 33:237-53. 2001
    ..The bioavailability and tissue levels of tea polyphenols is a key topic to be studied in order to understand the mechanisms of action of tea and its possible protection against cancer in humans...
  18. ncbi Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic
    C S Yang
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    J Nutr 131:1041S-5S. 2001
    ..The biological activities of garlic and its related compounds at lower concentrations that mimic human consumption remain to be studied further...
  19. ncbi Inhibition of carcinogenesis by dietary polyphenolic compounds
    C S Yang
    Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Annu Rev Nutr 21:381-406. 2001
    ..Perspectives on the application of dietary polyphenols for the prevention of human cancer and possible concerns on the consumption of excessive amounts of polyphenols are discussed...
  20. ncbi Inhibition of carcinogenesis by tea
    Chung S Yang
    Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Annu Rev Pharmacol Toxicol 42:25-54. 2002
    ..These mechanisms need to be evaluated and verified in animal models or humans in order to gain more understanding on the effect of tea consumption on human cancer...
  21. ncbi Mechanistic issues concerning cancer prevention by tea catechins
    Chung S Yang
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Mol Nutr Food Res 55:819-31. 2011
    ..This article discusses the key issues involved in extrapolating results from cell line studies to mechanistic information in vivo and in translating animal studies to human cancer prevention...
  22. ncbi Cancer chemopreventive activity and bioavailability of tea and tea polyphenols
    Joshua D Lambert
    Department of Chemical Biology, Laboratory for Cancer Research, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Mutat Res 523:201-8. 2003
    ..We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability and cancer chemoprevention...
  23. ncbi Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib
    Ning Li
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers-State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Clin Cancer Res 11:2089-96. 2005
    ..Zileuton and celecoxib prevented oral carcinogenesis at the post-initiation stage through their inhibitory effects on arachidonic acid metabolism...
  24. ncbi Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 16445-0687, USA
    Cancer Res 66:11494-501. 2006
    ..This effect is closely associated with decreased cell proliferation, enhanced apoptosis, and lowered levels of c-Jun and Erk1/2 phosphorylation...
  25. ncbi Inhibition of intestinal tumorigenesis in Apc(min/+) mice by green tea polyphenols (polyphenon E) and individual catechins
    Xingpei Hao
    Department of Chemical Biology, Ernest Mario School of Pharmacy Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Nutr Cancer 59:62-9. 2007
    ..The results suggest that these molecular events contribute to the cancer prevention activity of EGCG and PPE. Furthermore, diet appears to be a better route of administration for PPE than drinking fluid...
  26. ncbi Biotransformation of green tea polyphenols and the biological activities of those metabolites
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Mol Pharm 4:819-25. 2007
    ..We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability, biotransformation, and the biological activities of tea catechin metabolites...
  27. ncbi Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract
    Mao-Jung Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Epidemiol Biomarkers Prev 13:132-7. 2004
    ..These results indicate that tea leaves can be used as a convenient, slow-release source of catechins and theaflavins and provide information for the possible use of tea in the prevention of oral cancer and dental caries...
  28. ncbi Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols and atorvastatin
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Clin Cancer Res 14:4981-8. 2008
    ....
  29. ncbi Mechanisms of cancer prevention by tea constituents
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr 133:3262S-3267S. 2003
    ..Such discussion, it is hoped, will clarify some misunderstandings of cancer prevention by tea and stimulate new research efforts...
  30. ncbi A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Prev Res (Phila) 2:143-52. 2009
    ....
  31. ncbi Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model
    Jihyeung Ju
    Graduate Program of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854, USA
    Nutr Cancer 46:172-8. 2003
    ..Green tea inhibits ACF formation in mice on a high corn oil diet, suggesting its possible inhibitory effect on colon carcinogenesis in populations such as those in Western countries that consume high amounts of fat...
  32. ncbi Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans
    Xiaoxin Chen
    Laboratory for Cancer Research, College of Pharmacy, Rutgers-State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 23:123-30. 2002
    ..Since Grp94 is known to inhibit apoptosis by maintaining intracellular Ca(2+) homeostasis, our data suggest a possible correlation between oxidative stress, Grp94 overexpression and apoptosis regulation in esophageal adenocarcinogenesis...
  33. ncbi Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Cancer Res 65:10623-31. 2005
    ....
  34. ncbi Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells
    Zhihong Yang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Int J Cancer 126:852-63. 2010
    ..The synergistic action of these three compounds was also illustrated by their induction of G(0)/G(1) phase cell cycle arrest and apoptosis...
  35. ncbi Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells
    Hang Xiao
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Int J Cancer 122:2115-24. 2008
    ..The present work suggests the possible therapeutic application of this combination and provides leads for mechanistic and biomarker investigations in clinical trials...
  36. ncbi Inhibition of carcinogenesis by tea constituents
    Jihyeung Ju
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Semin Cancer Biol 17:395-402. 2007
    ..Human intervention trials are warranted to determine the possible prevention of cancer of specific sites by preparation of tea constituents...
  37. ncbi Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA
    Bioorg Med Chem Lett 15:873-6. 2005
    ..The possible antiinflammatory activity of 1 and its trimethoxy derivative was also evaluated. Neither compound inhibited the release of arachidonic acid, although 1 inhibited NO production by 50% at 20 microM...
  38. ncbi Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    Ming Zhu Fang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA
    Cancer Res 63:7563-70. 2003
    ....
  39. ncbi Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray
    Ragini Vittal
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Mol Cancer Ther 3:1091-9. 2004
    ..The elucidation of gene expression changes between H2O2-dependent and H2O2-independent responses helps us better understand the cancer chemopreventive and anticancer actions of EGCG...
  40. ncbi Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway 08854, USA
    Carcinogenesis 23:2095-102. 2002
    ..Inhibition of tumor formation by sulindac was correlated with lowered levels of PGE2. In conclusion, sulindac exerted its chemopreventive effect against the formation of EAC in the rat EGDA model possibly through its inhibition of Cox...
  41. ncbi Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate
    Avantika Barve
    Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Pharm Res 25:2181-9. 2008
    ..Hence, this study was undertaken to examine the potential chemopreventive properties of the two agents against transgenic adenocarcinoma of the mouse prostate...
  42. ncbi Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats
    Yingying Liu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Nutr Cancer 60:660-5. 2008
    ..These results indicate that the combination of calcium and aspirin did not produce a synergistic effect on the ACF formation in AOM-treated mice and rats...
  43. ncbi Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro
    Guang Xun Li
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 31:902-10. 2010
    ..Although EGCG is generally considered to be an antioxidant, the present study demonstrates the pro-oxidative activities of EGCG in vivo and in vitro in the described experimental system...
  44. ncbi Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase
    Jungil Hong
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 25:1671-9. 2004
    ..These activities may contribute to the anti-inflammatory and anticarcinogenic actions of curcumin and its analogs...
  45. ncbi Peracetylation as a means of enhancing in vitro bioactivity and bioavailability of epigallocatechin-3-gallate
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Drug Metab Dispos 34:2111-6. 2006
    ..4- and 6.0-fold, respectively). These data suggest that acetylation represents a means of increasing the biological potency in vitro, increasing the bioavailability of EGCG in vivo, and may improve cancer-preventive activity...
  46. ncbi Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells
    Zhe Hou
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020, USA
    Cancer Res 65:8049-56. 2005
    ..In future studies of EGCG and other polyphenolic compounds in cell culture, SOD may be added to stabilize EGCG and to avoid possible artifacts...
  47. ncbi Stability of tea polyphenol (-)-epigallocatechin-3-gallate and formation of dimers and epimers under common experimental conditions
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854-8020, USA
    J Agric Food Chem 53:9478-84. 2005
    ..In future studies with EGCG, its stability should be considered in order to avoid possible artifacts...
  48. ncbi Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines
    Ming Zhu Fang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA
    Int J Oncol 26:615-22. 2005
    ....
  49. ncbi Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability
    Mao-Jung Lee
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020, USA
    Cancer Epidemiol Biomarkers Prev 11:1025-32. 2002
    ..These results may be useful for designing the dose and dose frequency in intervention studies with tea and for development of biomarkers of tea consumption...
  50. ncbi N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Free Radic Biol Med 44:1069-74. 2008
    ..The present results show that under cell culture conditions, EGCG and NAC interact to form a previously unreported adduct, EGCG-2'-NAC, which may contribute to enhancement of EGCG-mediated cell killing...
  51. ncbi Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    J Agric Food Chem 57:10645-50. 2009
    ..In addition, we found that [6]-shogaol had much stronger inhibitory effects on arachidonic acid release and nitric oxide (NO) synthesis than [6]-gingerol...
  52. ncbi Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (-)-epigallocatechin-3-gallate in HT-29 human colon adenocarcinoma cells
    Jungil Hong
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020, USA
    Cancer Res 62:7241-6. 2002
    ....
  53. ncbi Analysis of theaflavins and thearubigins from black tea extract by MALDI-TOF mass spectrometry
    Marie-Claude Menet
    Department of Food Science and Center for Advanced Food Technology, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520, USA
    J Agric Food Chem 52:2455-61. 2004
    ..The analysis of MALDI-TOF spectra of black tea fractions shows the structure of some TRs, which are similar to those of TFs because the same loss of mass is observed...
  54. ncbi Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
    Chung S Yang
    Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Nat Rev Cancer 9:429-39. 2009
    ..Here, we review these biological activities and existing data relating tea consumption to human cancer risk in an attempt to understand the potential use of tea for cancer prevention...
  55. ncbi Characterization of genetic alteration patterns in human esophageal squamous cell carcinoma using selected microsatellite markers spanning multiple loci
    Yuyang Christine Cai
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Int J Oncol 30:1059-67. 2007
    ..The results demonstrate the degree of genetic alterations at different loci of the chromosomes. Some of the microsatellite markers may be useful for the early detection of ESCC...
  56. ncbi Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy
    Ming Zhu Fang
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Clin Cancer Res 11:7033-41. 2005
    ..To determine whether other polyphenolic compounds have similar activities, we studied the effects of soy isoflavones on DNA methylation...
  57. ncbi Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Natl Cancer Inst 95:1053-61. 2003
    ..We used this model and human EAC and non-tumor tissues to elucidate the expression pattern of LTA4H and to evaluate it as a target for chemoprevention...
  58. ncbi Dietary polyphenols may affect DNA methylation
    Mingzhu Fang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    J Nutr 137:223S-228S. 2007
    ..On the other hand, the consumption of excessive amounts of polyphenols in dietary supplements may affect DNA methylation status. All these possibilities remain to be examined...
  59. ncbi A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth
    Gang Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 31:687-94. 2010
    ..These results demonstrate the inhibitory effect of gamma-TmT against lung tumorigenesis and the growth of xenograft tumors of human lung cancer cells. The inhibitory activity may be due mainly to the actions of delta-T and gamma-T...
  60. ncbi Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA
    Am J Clin Nutr 81:284S-291S. 2005
    ....
  61. ncbi Apple polyphenols, phloretin and phloridzin: new trapping agents of reactive dicarbonyl species
    Xi Shao
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Chem Res Toxicol 21:2042-50. 2008
    ..Our results suggest that dietary flavonoids that have the same A ring structure as phloretin may have the potential to trap reactive dicarbonyl species and therefore inhibit the formation of AGEs...
  62. ncbi Chemical studies of the antioxidant mechanism of tea catechins: radical reaction products of epicatechin with peroxyl radicals
    Shengmin Sang
    Department of Food Science and Center for Advanced Food Technology, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901 8520, USA
    Bioorg Med Chem 11:3371-8. 2003
    ..The observation of these compounds confirmed that the B-ring is the initial site for formation of reaction products in the peroxyl radical oxidant system...
  63. ncbi The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice
    Mousumi Bose
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr 138:1677-83. 2008
    ..Short-term EGCG treatment appeared to reverse preexisting high-fat-induced metabolic pathologies in obese mice. These effects may be mediated by decreased lipid absorption, decreased inflammation, and other mechanisms...
  64. ncbi Metabolism of dietary polyphenols and possible interactions with drugs
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Curr Drug Metab 8:499-507. 2007
    ..The potential consequences of these effects on drug metabolism will also be discussed...
  65. ncbi Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Nutr 133:4172-7. 2003
    ..This is the first report of the pharmacokinetic parameters of EGCG in mice. Such information provides a basis for understanding the bioavailability of EGCG in mice and should aid in understanding the cancer preventive activity of EGCG...
  66. ncbi Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Bioorg Med Chem 12:459-67. 2004
    ..7 cells. Their cytotoxic activities against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated...
  67. ncbi Tea polyphenol (-)-epigallocatechin-3-gallate: a new trapping agent of reactive dicarbonyl species
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Chem Res Toxicol 20:1862-70. 2007
    ..The purified mono-MGO adducts of EGCG in this study can be used as standards for further in vivo studies on the possible trapping of reactive dicarbonyl species by EGCG...
  68. ncbi Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats
    Hang Xiao
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 29:113-9. 2008
    ..Taken together, our results strongly suggest the colon cancer-preventive activity of PPE and identified possible molecular markers for future colon cancer prevention studies...
  69. ncbi Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine
    Darren N Seril
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA
    Carcinogenesis 23:993-1001. 2002
    ..This study indicates that the antioxidant NAC has the potential to serve as a preventive agent for UC-associated colorectal cancer, possibly via inhibition of cellular proliferation and nitrosative stress-caused cellular damage...
  70. ncbi Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 10:6703-9. 2004
    ....
  71. ncbi δ-tocopherol is more active than α - or γ -tocopherol in inhibiting lung tumorigenesis in vivo
    Guang Xun Li
    Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Prev Res (Phila) 4:404-13. 2011
    ....
  72. ncbi Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice
    Yao-Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854-8020, USA
    Proc Natl Acad Sci U S A 99:12455-60. 2002
    ..The results suggest a need for further studies to determine whether topical applications of caffeine or EGCG can inhibit sunlight-induced skin cancer in humans...
  73. ncbi Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China
    Can Lan Sun
    USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Carcinogenesis 23:1497-503. 2002
    ..The present study provides direct evidence that tea polyphenols may act as chemopreventive agents against gastric and esophageal cancer development...
  74. ncbi Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention
    Xiaoxin Chen
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
    Curr Cancer Drug Targets 6:613-22. 2006
    ..Inhibition of the 5-lipoxygenase pathways clearly has chemopreventive effects on various cancers, and hence further studies on its enzymes, metabolites and receptors for cancer chemoprevention and therapy are warranted...
  75. ncbi Molecular targets for the cancer preventive activity of tea polyphenols
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Mol Carcinog 45:431-5. 2006
    ..Validating the related cancer preventive mechanisms found in in vitro studies in animal models and human samples would be exciting...
  76. ncbi Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 26:1465-72. 2005
    ..Our studies indicate that the chemopreventive effect of caffeine or green tea may occur by a proapoptotic effect preferentially in early precancerous lesions...
  77. ncbi Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort Study
    Jian Min Yuan
    The Cancer Center, University of Minnesota, 1300 South 2nd Street, Minneapolis, MN 55454, USA
    Int J Cancer 120:1344-50. 2007
    ..Urinary levels of tea polyphenols and their metabolites were not associated with rectal cancer risk. The present study supports the notion of tea catechins as chemopreventive agents against the development of colon cancer in humans...
  78. ncbi Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 224:209-13. 2007
    ..Further studies are needed to determine mechanisms of these effects of caffeine and to determine the effects of caffeine administration on sunlight-induced actinic keratoses and squamous cell carcinomas in humans...
  79. ncbi Possible controversy over dietary polyphenols: benefits vs risks
    Joshua D Lambert
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Chem Res Toxicol 20:583-5. 2007
  80. ncbi Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects
    Jungil Hong
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, The State University of New Jersey, Piscataway, NJ 08854, USA
    Free Radic Biol Med 42:1211-21. 2007
    ..It remains to be determined whether the currently observed stimulatory and inhibitory effects of garcinol on colon cell growth occur in vivo...
  81. ncbi Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus
    Yinghao Su
    Center for Swallowing and Motility Disorders, VA Boston Healthcare System and Harvard Medical School, Boston, MA 02132, USA
    Lab Invest 84:753-65. 2004
    ..EGDA rats may serve as a useful model to study the pathogenesis, molecular biology, and chemopreventive interventions of human BE and EAC...
  82. ncbi Redox properties of tea polyphenols and related biological activities
    Shengmin Sang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:1704-14. 2005
    ....
  83. ncbi Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition
    Shengmin Sang
    Human Nutrition Program, North Carolina Research Campus, Biomedical Biotechnology Research Institute, North Carolina Central University, Kannapolis, NC 28081, USA
    Rapid Commun Mass Spectrom 22:1567-78. 2008
    ..This method can also be used for thorough investigations of the metabolite profiles of many other dietary constituents...
  84. ncbi Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention
    Hang Xiao
    Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA
    Int J Cancer 123:983-90. 2008
    ..This article reviews the evidence for the cancer preventive actions of statins and NSAIDs, as well as their possible synergistic action and the mechanisms involved...
  85. ncbi Glucuronides of tea catechins: enzymology of biosynthesis and biological activities
    Hong Lu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Drug Metab Dispos 31:452-61. 2003
    ..These results provide foundations for understanding the biotransformation and biological activities of tea catechins...

Research Grants51

  1. Prevention of Colon Cancer by Epigallocatechin Gallate and Atorvastatin
    Chung S Yang; Fiscal Year: 2010
    ..From these studies, we hope to develop a better understanding of the chemopreventive activities of EGCG and their combination with ATST against colon carcinogenesis. as well as promising biomarkers for future studies. ..
  2. Reactivation Methylation-Silenced Genes by Polyphenols
    Chung Yang; Fiscal Year: 2007
    ..5. To determine whether EGCG, alone or in combination with other agents, can prevent hypermethylation of genes and tumor development in the intestinal tumorigenesis model in the Min mice. ..
  3. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2007
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  4. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2006
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  5. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Chung Yang; Fiscal Year: 2005
    ..Jointly, we intend to make major contributions to the use of tea for the I chemoprevention of cancer. ..
  6. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..
  7. Prevention of Colon Cancer by Epigallocatechin Gallate and Atorvastatin
    Chung Yang; Fiscal Year: 2009
    ..From these studies, we hope to develop a better understanding of the chemopreventive activities of EGCG and their combination with ATST against colon carcinogenesis. as well as promising biomarkers for future studies. ..
  8. Prevention of Colon Cancer by Epigallocatechin Gallate and Atorvastatin
    Chung S Yang; Fiscal Year: 2010
    ..From these studies, we hope to develop a better understanding of the chemopreventive activities of EGCG and their combination with ATST against colon carcinogenesis. as well as promising biomarkers for future studies. ..
  9. Inhibition of Lung Carcinogenesis by Tea Polyphenols and Atorvastatin
    Chung Yang; Fiscal Year: 2009
    ..The possible use of the combination of tea polyphenols and Lipitor for lung cancer prevention is an attractive strategy and could have a large impact in public health. ..
  10. Mechanistic Studies on Lung Cancer Prevention by Tea Polyphenols
    Chung Yang; Fiscal Year: 2009
    ..Project Description Page 6 ..
  11. Inhibition of Lung Carcinogenesis by Tea Polyphenols and Atorvastatin
    Chung S Yang; Fiscal Year: 2010
    ..The possible use of the combination of tea polyphenols and Lipitor for lung cancer prevention is an attractive strategy and could have a large impact in public health. ..
  12. Mechanistic Studies on Lung Cancer Prevention by Tea Polyphenols
    Chung S Yang; Fiscal Year: 2010
    ..The results will help us to design future lung cancer prevention trials in humans and to assess the effects of tea consumption on human lung cancer. ..
  13. Prevention of Colon Cancer by Epigallocatechin Gallate and Atorvastatin
    Chung Yang; Fiscal Year: 2009
    ..From these studies, we hope to develop a better understanding of the chemopreventive activities of EGCG and their combination with ATST against colon carcinogenesis. as well as promising biomarkers for future studies. ..
  14. Inhibition of Lung Carcinogenesis by Tea Polyphenols and Atorvastatin
    Chung Yang; Fiscal Year: 2009
    ..The possible use of the combination of tea polyphenols and Lipitor for lung cancer prevention is an attractive strategy and could have a large impact in public health. ..
  15. Mechanistic Studies on Lung Cancer Prevention by Tea Polyphenols
    Chung Yang; Fiscal Year: 2009
    ..The results will help us to design future lung cancer prevention trials in humans and to assess the effects of tea consumption on human lung cancer. ..
  16. MECHANISMS OF HUMAN ESOPHAGEAL CARCINOGENESIS
    Chung Yang; Fiscal Year: 1999
    ..This information is important for the prevention, early detection, and prognosis of EC not only in this high incidence area but also in other areas, including the United States. ..
  17. EFFECTS OF TEA ON CARCINOGENESIS
    Chung Yang; Fiscal Year: 1993
    ..It will develop theoretical basis and laboratory methods for future epidemiological and intervention studies on tea and human cancer...
  18. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2003
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  19. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2001
    ..4) To develop a model for studying the progression of esophageal metaplasia to adenocarcinoma and to study its inhibition by antioxidants and NASIDs. ..
  20. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2000
    ..Together, these results will provide the basis for a quantitative assessment of the effects of tea consumption of human cancers in epidemiological studies and for designing cancer prevention trials. ..