Shigeko Yamashiro

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II
    Shigeko Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855, USA
    Mol Biol Cell 14:1745-56. 2003
  2. pmc Mutant Caldesmon lacking cdc2 phosphorylation sites delays M-phase entry and inhibits cytokinesis
    S Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Labs, Busch Campus, Piscataway, New Jersey 08855, USA
    Mol Biol Cell 12:239-50. 2001
  3. pmc Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
    Shigeko Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Dev Cell 14:787-97. 2008
  4. ncbi request reprint [Regulation of myosin II in cell division and cell migration]
    Fumio Matsumura
    Rutgers University, USA
    Tanpakushitsu Kakusan Koso 51:566-72. 2006
  5. pmc Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts
    Go Totsukawa
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Labs, Rm A323, 604 Allison Rd, Piscataway, NJ 08855, USA
    J Cell Biol 164:427-39. 2004
  6. pmc Fascin1 promotes cell migration of mature dendritic cells
    Yoshihiko Yamakita
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    J Immunol 186:2850-9. 2011
  7. pmc Myosin phosphatase-targeting subunit 1 controls chromatid segregation
    Fumio Matsumura
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 286:10825-33. 2011
  8. ncbi request reprint Phosphorylation of non-muscle caldesmon by p34cdc2 kinase during mitosis
    S Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855 1059
    Nature 349:169-72. 1991
  9. pmc In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cells
    Y Yamakita
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855 1059
    J Cell Biol 124:129-37. 1994
  10. ncbi request reprint Functions of fascin in dendritic cells
    Shigeko Yamashiro
    Department of Molecular Biology and Biochemistry, Nelson Labs, Rutgers University, Piscataway, NJ 08854, USA
    Crit Rev Immunol 32:11-21. 2012

Collaborators

Detail Information

Publications18

  1. pmc Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II
    Shigeko Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855, USA
    Mol Biol Cell 14:1745-56. 2003
    ..Because citron kinase is localized in cleavage furrows, citron kinase may be involved in regulating di-phosphorylation of MLC during cytokinesis...
  2. pmc Mutant Caldesmon lacking cdc2 phosphorylation sites delays M-phase entry and inhibits cytokinesis
    S Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Labs, Busch Campus, Piscataway, New Jersey 08855, USA
    Mol Biol Cell 12:239-50. 2001
    ..Because mutant caldesmon did not inhibit cyclin B/cdc2 kinase activity, our results suggest that alterations in microfilament assembly caused by caldesmon phosphorylation are important for M-phase progression...
  3. pmc Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
    Shigeko Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Dev Cell 14:787-97. 2008
    ..Taken together, our results identify a previously unrecognized role for MYPT1 in regulating mitosis by antagonizing PLK1...
  4. ncbi request reprint [Regulation of myosin II in cell division and cell migration]
    Fumio Matsumura
    Rutgers University, USA
    Tanpakushitsu Kakusan Koso 51:566-72. 2006
  5. pmc Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts
    Go Totsukawa
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Labs, Rm A323, 604 Allison Rd, Piscataway, NJ 08855, USA
    J Cell Biol 164:427-39. 2004
    ..Our results suggest that myosin II activated by MLCK at the cell periphery controls membrane ruffling, and that the spatial regulation of MLC phosphorylation plays critical roles in controlling cell migration of fibroblasts...
  6. pmc Fascin1 promotes cell migration of mature dendritic cells
    Yoshihiko Yamakita
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    J Immunol 186:2850-9. 2011
    ..These results indicate that fascin1 positively regulates migration of mature DCs into lymph nodes, most likely by increasing dynamics of membrane protrusions, as well as by disassembling podosomes...
  7. pmc Myosin phosphatase-targeting subunit 1 controls chromatid segregation
    Fumio Matsumura
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 286:10825-33. 2011
    ..We propose that SA2 at the centromeres is protected by two phosphatases. One is PP2A directly dephosphorylating SA2, and the other is myosin phosphatase counteracting PLK1...
  8. ncbi request reprint Phosphorylation of non-muscle caldesmon by p34cdc2 kinase during mitosis
    S Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855 1059
    Nature 349:169-72. 1991
    ..Because caldesmon inhibits actomyosin ATPase, our results suggest that cdc2 kinase directly causes microfilament reorganization during mitosis...
  9. pmc In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cells
    Y Yamakita
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855 1059
    J Cell Biol 124:129-37. 1994
    ..The ratio is increased to 0.49 +/- 0.05 at 30 min after the release of mitotic arrest. These results suggest that the change in the phosphorylation site from Ser-1/2 to Ser-19 plays an important role in signaling cytokinesis...
  10. ncbi request reprint Functions of fascin in dendritic cells
    Shigeko Yamashiro
    Department of Molecular Biology and Biochemistry, Nelson Labs, Rutgers University, Piscataway, NJ 08854, USA
    Crit Rev Immunol 32:11-21. 2012
    ..Furthermore, attempts have been made to explore the use of a fascin-1 promoter for DNA vaccination because it is strong and specific to DCs...
  11. pmc Myosin light chain kinases and phosphatase in mitosis and cytokinesis
    Fumio Matsumura
    Department of Molecular Biology and Biochemistry, Rutgers, Piscataway, NJ 08854, USA
    Arch Biochem Biophys 510:76-82. 2011
    ..In this review, we summarize current understanding of the functions of myosin II in mitosis and cytokinesis of higher eukaryotes, and discuss the roles of possible upstream molecules that control myosin II in these mitotic events...
  12. pmc Fascin1 is dispensable for mouse development but is favorable for neonatal survival
    Yoshihiko Yamakita
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA
    Cell Motil Cytoskeleton 66:524-34. 2009
    ..These results indicate that fascin1-mediated filopodia assembly is dispensable for mouse development. Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc...
  13. ncbi request reprint Caldesmon inhibits Arp2/3-mediated actin nucleation
    Yoshihiko Yamakita
    Rutgers University, Department of Molecular Biology and Biochemistry, Nelson Laboratories, Busch Campus, Piscataway, New Jersey 08854, USA
    J Biol Chem 278:17937-44. 2003
    ..Our results suggest that caldesmon may be a key protein that modulates membrane ruffling and that this may involve changes in caldesmon phosphorylation and/or intracellular calcium concentrations during signal transduction...
  14. pmc Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells
    F Matsumura
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Labs, Busch Campus, Piscataway, New Jersey 08855, USA
    J Cell Biol 140:119-29. 1998
    ....
  15. ncbi request reprint Role of myosin light chain phosphorylation in the regulation of cytokinesis
    F Matsumura
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08855, USA
    Cell Struct Funct 26:639-44. 2001
    ..Future studies should examine whether these multiple kinases are redundant or whether they control distinct aspects of cell division...
  16. ncbi request reprint Characterization of the COOH terminus of non-muscle caldesmon mutants lacking mitosis-specific phosphorylation sites
    S Yamashiro
    Department of Molecular Biology and Biochemistry, Rutgers, Piscataway, New Jersey 08855 1059
    J Biol Chem 270:4023-30. 1995
    ..This mutant should thus be useful to explore the functions of the mitosis-specific phosphorylation of caldesmon...
  17. ncbi request reprint Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin
    S Ono
    Department of Molecular Biology and Biochemistry, Nelson Laboratory, Busch Campus, Rutgers University, Piscataway New Jersey 08855 1059, USA
    J Biol Chem 272:2527-33. 1997
    ..The mutation replacing Ser-39 with Ala eliminated the phosphorylation-dependent regulation of actin binding of fascin, indicating that phosphorylation at this site regulates the actin binding ability of fascin...
  18. ncbi request reprint Phosphorylation of human fascin inhibits its actin binding and bundling activities
    Y Yamakita
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 271:12632-8. 1996
    ..7 x 10(6) to 1.5 x 10(6) m(-1). The actin bundling activity is also decreased. These results suggest that phosphorylation of fascin plays a role in actin reorganization after treatment with 12-O-tetradecanoylphorbol-13-acetate...