Gutian Xiao

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi request reprint Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
    Gutian Xiao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:30099-105. 2004
  2. pmc Autophagy and NF-kappaB: fight for fate
    Gutian Xiao
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cytokine Growth Factor Rev 18:233-43. 2007
  3. ncbi request reprint Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease
    Gutian Xiao
    Department of Cell Biology and Neuroscience, W M Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cytokine Growth Factor Rev 17:281-93. 2006
  4. ncbi request reprint Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms
    Zhaoxia Qu
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:44563-72. 2004
  5. ncbi request reprint Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions
    Pengrong Yan
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA
    Autophagy 3:600-3. 2007
  6. ncbi request reprint Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Rd, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:9765-8. 2005
  7. pmc Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:5324-9. 2007
  8. ncbi request reprint Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cell Res 17:520-30. 2007
  9. ncbi request reprint Regulation of NF-kappa B2 p100 processing by its cis-acting domain
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:18-27. 2005
  10. ncbi request reprint Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:40578-82. 2005

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
    Gutian Xiao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:30099-105. 2004
    ..These data also provide the first evidence for explaining why overexpression of IKKalpha or its activation by many other stimuli such as tumor necrosis factor and mitogens fails to induce p100 processing...
  2. pmc Autophagy and NF-kappaB: fight for fate
    Gutian Xiao
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cytokine Growth Factor Rev 18:233-43. 2007
    ..We also list some most intriguing and outstanding questions that are likely to engage researchers in the near future...
  3. ncbi request reprint Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease
    Gutian Xiao
    Department of Cell Biology and Neuroscience, W M Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cytokine Growth Factor Rev 17:281-93. 2006
    ..We review current understandings of NF-kappaB activation, particularly the mechanisms of p100 processing under both physiological and pathological conditions...
  4. ncbi request reprint Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms
    Zhaoxia Qu
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:44563-72. 2004
    ....
  5. ncbi request reprint Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions
    Pengrong Yan
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA
    Autophagy 3:600-3. 2007
    ....
  6. ncbi request reprint Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Rd, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:9765-8. 2005
    ..Additionally, we find that IKKalpha is not required for the nuclear translocation of p100. Thus, these results also indicate that p100 nuclear translocation is not sufficient for the constitutive processing of p100...
  7. pmc Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:5324-9. 2007
    ..Our studies demonstrate a different mechanism of p100 processing and also present evidence showing that the proteasome modulates the action of transcription factors at promoter regions through endoproteolysis...
  8. ncbi request reprint Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cell Res 17:520-30. 2007
    ..These findings also suggest a new therapeutic strategy for diseases associated with p100 processing...
  9. ncbi request reprint Regulation of NF-kappa B2 p100 processing by its cis-acting domain
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:18-27. 2005
    ..Taken together, these studies highlight the mechanism by which the different sequences within p100 work in concert to regulate its processing and shed light on the mechanisms of how p100 processing is tightly and delicately controlled...
  10. ncbi request reprint Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:40578-82. 2005
    ....
  11. ncbi request reprint Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK)
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Road, Piscataway, NJ 08854, USA
    Cell Res 16:895-901. 2006
    ..These findings provide the first evidence that an Hsp90 client may be degraded by a mechanism different from the proteasome pathway and establish a molecular link among Hsp90, NF-kappaB and autophagy...
  12. ncbi request reprint Study of T-cell signaling by somatic cell mutagenesis and complementation cloning
    Mary Ellen Cvijic
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Immunol Methods 278:293-304. 2003
    ..Clearly, creation of a somatic cell genetic system can yield exciting new advances in deciphering signal transduction events by discovery of novel pathway participants...
  13. ncbi request reprint Deregulation of NF-kappaB and its upstream kinases in cancer
    Shao Cong Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Metastasis Rev 22:405-22. 2003
    ..In this review, we discuss our current knowledge of NF-kappaB activation, with a focus on the NF-kappaB-activating kinases and their roles in cancer formation...

Research Grants2

  1. HTLV deregulation of NF-kappaB2 p100 processing in tumor
    Gutian Xiao; Fiscal Year: 2006
    ..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..