Research Topics
Genomes and Genes | Gutian XiaoSummaryAffiliation: Rutgers University Country: USA Publications
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Detail Information
Publications
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylationGutian Xiao
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 279:30099-105. 2004..These data also provide the first evidence for explaining why overexpression of IKKalpha or its activation by many other stimuli such as tumor necrosis factor and mitogens fails to induce p100 processing...
Autophagy and NF-kappaB: fight for fateGutian Xiao
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Cytokine Growth Factor Rev 18:233-43. 2007..We also list some most intriguing and outstanding questions that are likely to engage researchers in the near future...- Alternative pathways of NF-kappaB activation: a double-edged sword in health and diseaseGutian Xiao
Department of Cell Biology and Neuroscience, W M Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Cytokine Growth Factor Rev 17:281-93. 2006..We review current understandings of NF-kappaB activation, particularly the mechanisms of p100 processing under both physiological and pathological conditions... - Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanismsZhaoxia Qu
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
J Biol Chem 279:44563-72. 2004.... - Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventionsPengrong Yan
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA
Autophagy 3:600-3. 2007.... - Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100Guoliang Qing
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Rd, Piscataway, New Jersey 08854, USA
J Biol Chem 280:9765-8. 2005..Additionally, we find that IKKalpha is not required for the nuclear translocation of p100. Thus, these results also indicate that p100 nuclear translocation is not sufficient for the constitutive processing of p100... - Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promotersGuoliang Qing
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 104:5324-9. 2007..Our studies demonstrate a different mechanism of p100 processing and also present evidence showing that the proteasome modulates the action of transcription factors at promoter regions through endoproteolysis... - Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradationGuoliang Qing
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Cell Res 17:520-30. 2007..These findings also suggest a new therapeutic strategy for diseases associated with p100 processing... - Regulation of NF-kappa B2 p100 processing by its cis-acting domainGuoliang Qing
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
J Biol Chem 280:18-27. 2005..Taken together, these studies highlight the mechanism by which the different sequences within p100 work in concert to regulate its processing and shed light on the mechanisms of how p100 processing is tightly and delicately controlled... - Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100Guoliang Qing
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
J Biol Chem 280:40578-82. 2005.... - Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK)Guoliang Qing
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Road, Piscataway, NJ 08854, USA
Cell Res 16:895-901. 2006..These findings provide the first evidence that an Hsp90 client may be degraded by a mechanism different from the proteasome pathway and establish a molecular link among Hsp90, NF-kappaB and autophagy... - Study of T-cell signaling by somatic cell mutagenesis and complementation cloningMary Ellen Cvijic
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
J Immunol Methods 278:293-304. 2003..Clearly, creation of a somatic cell genetic system can yield exciting new advances in deciphering signal transduction events by discovery of novel pathway participants... - Deregulation of NF-kappaB and its upstream kinases in cancerShao Cong Sun
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Cancer Metastasis Rev 22:405-22. 2003..In this review, we discuss our current knowledge of NF-kappaB activation, with a focus on the NF-kappaB-activating kinases and their roles in cancer formation...
Research Grants
- HTLV deregulation of NF-kappaB2 p100 processing in tumorGutian Xiao; Fiscal Year: 2006..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..