Long Jun Wu
Affiliation: Rutgers University
Eyo U, Gu N, De S, Dong H, Richardson J, Wu L. Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium. J Neurosci. 2015;35:2417-22 pubmed publisher
..These results indicate that microglia monitor and interact with neurons during conditions of cerebral calcium reduction in the normal and diseased brain. ..
Gu N, Eyo U, Murugan M, Peng J, Matta S, Dong H, et al
. Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain Behav Immun. 2016;55:82-92 pubmed publisher
Eyo U, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu L. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J Neurosci. 2014;34:10528-40 pubmed publisher
..Our results elucidate the molecular mechanisms underlying microglia-neuron communication that may be potentially neuroprotective in the epileptic brain. ..
Swiatkowski P, Murugan M, Eyo U, Wang Y, Rangaraju S, Oh S, et al
. Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience. 2016;318:22-33 pubmed publisher
..These results suggest that the quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury. ..
Gu N, Peng J, Murugan M, Wang X, Eyo U, Sun D, et al
. Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury. Cell Rep. 2016;16:605-14 pubmed publisher
..These results suggest that local microglial proliferation is the sole source of spinal microgliosis, which represents a potential therapeutic target for neuropathic pain management. ..
Tian D, Li C, Qin C, Murugan M, Wu L, Liu J. Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke. J Neurochem. 2016;139:96-105 pubmed publisher
..Our study suggests that the microglial Hv1 proton channel is a unique target for modulation of microglial M1/M2 polarization in the pathogenesis of ischemic stroke. ..