Eileen White

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi request reprint The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines
    Eileen White
    Howard Hughes Medical Institute, Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 17:1813-6. 2003
  2. ncbi request reprint Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis
    E White
    Department of Molecular Biology and Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA
    Cell Death Differ 13:1371-7. 2006
  3. pmc Entosis: it's a cell-eat-cell world
    Eileen White
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Cell 131:840-2. 2007
  4. pmc Autophagy suppresses tumor progression by limiting chromosomal instability
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 21:1367-81. 2007
  5. pmc Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cancer Cell 10:51-64. 2006
  6. pmc Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Genes Dev 21:1621-35. 2007
  7. pmc Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression
    Cristina M Karp
    Department of Molecular Biology and Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, NJ 08854, USA
    Cancer Res 68:4105-15. 2008
  8. pmc DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
    Andrea Cuconati
    Howard Hughes Medical Institute, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 17:2922-32. 2003
  9. pmc Role of autophagy in cancer
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nat Rev Cancer 7:961-7. 2007
  10. ncbi request reprint Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling
    Ramya Sundararajan
    Rutgers University, 679 Hoes Lane, Room 140, Piscataway, NJ 08854, USA
    Oncogene 24:4908-20. 2005

Research Grants

  1. FUNCTION OF THE ADENOVIRUS E1B ONCOGENE
    Eileen White; Fiscal Year: 2007

Collaborators

Detail Information

Publications59

  1. ncbi request reprint The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines
    Eileen White
    Howard Hughes Medical Institute, Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 17:1813-6. 2003
  2. ncbi request reprint Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis
    E White
    Department of Molecular Biology and Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA
    Cell Death Differ 13:1371-7. 2006
    ..Thus, both infected cells and tumor cells require inhibition of the apoptotic host defense mechanism, the insights from which can be exploited for therapy development...
  3. pmc Entosis: it's a cell-eat-cell world
    Eileen White
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Cell 131:840-2. 2007
    ..Given that surviving detachment from the ECM is an event associated with the progression of epithelial cancers, entosis--along with apoptosis--may contribute to tumor suppression by promoting the elimination of cancer cells...
  4. pmc Autophagy suppresses tumor progression by limiting chromosomal instability
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 21:1367-81. 2007
    ..Identification of this novel role of autophagy may be important for rational chemotherapy and therapeutic exploitation of autophagy inducers as potential chemopreventive agents...
  5. pmc Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cancer Cell 10:51-64. 2006
    ..Thus, autophagy may function in tumor suppression by mitigating metabolic stress and, in concert with apoptosis, by preventing death by necrosis...
  6. pmc Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Genes Dev 21:1621-35. 2007
    ..Therefore, we propose that autophagy limits metabolic stress to protect the genome, and that defective autophagy increases DNA damage and genomic instability that ultimately facilitate breast cancer progression...
  7. pmc Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression
    Cristina M Karp
    Department of Molecular Biology and Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, NJ 08854, USA
    Cancer Res 68:4105-15. 2008
    ..These findings suggest a role for mammalian polarity determinants in suppressing tumorigenesis that may be analogous to the well-studied polarity tumor suppressor mechanisms in Drosophila...
  8. pmc DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
    Andrea Cuconati
    Howard Hughes Medical Institute, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 17:2922-32. 2003
    ....
  9. pmc Role of autophagy in cancer
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nat Rev Cancer 7:961-7. 2007
    ..Recent evidence suggests that autophagy provides a protective function to limit tumour necrosis and inflammation, and to mitigate genome damage in tumour cells in response to metabolic stress...
  10. ncbi request reprint Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling
    Ramya Sundararajan
    Rutgers University, 679 Hoes Lane, Room 140, Piscataway, NJ 08854, USA
    Oncogene 24:4908-20. 2005
    ..DBC-1, like its homolog cell cycle and apoptosis regulatory protein-1 (CARP-1), may function in the regulation of apoptosis...
  11. doi request reprint Immortalized mouse epithelial cell models to study the role of apoptosis in cancer
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Methods Enzymol 446:77-106. 2008
    ..Applying this technology to other mouse models can provide insight into additional aspects of oncogenesis...
  12. pmc Autophagy suppresses tumorigenesis through elimination of p62
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 137:1062-75. 2009
    ....
  13. ncbi request reprint Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
    Ting Ting Tan
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Cancer Cell 7:227-38. 2005
    ....
  14. ncbi request reprint Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity
    Sylvain Lesne
    UMR CNRS 6185, Universite de Caen, Bd H Becquerel BP5229, 14074 Caen, France and Howard Hughes Medical Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:24941-7. 2005
    ..Together, these findings demonstrate that NT-3 signaling counters Abeta-dependent neuronal cell death and may represent an innovative therapeutic intervention to limit neuronal death in Alzheimer disease...
  15. pmc Role of autophagy in breast cancer
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Autophagy 3:610-3. 2007
    ....
  16. pmc Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma
    Gaofeng Fan
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, Piscataway, USA
    Blood 115:3559-69. 2010
    ..Furthermore, because bfl-1 is up-regulated in many human hematopoietic tumors, this finding suggests that strategies to promote Bfl-1 ubiquitination may improve therapy...
  17. pmc Metabolic catastrophe as a means to cancer cell death
    Shengkan Jin
    Department of Pharmacology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Cell Sci 120:379-83. 2007
    ..The challenge now is to induce metabolic catastrophe therapeutically as an approach to killing the unkillable cells...
  18. pmc Hypoxia and defective apoptosis drive genomic instability and tumorigenesis
    Deirdre A Nelson
    Howard Hughes Medical Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 18:2095-107. 2004
    ....
  19. ncbi request reprint A mouse model system to genetically dissect the molecular mechanisms regulating tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854 and Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
    Clin Cancer Res 12:5298-304. 2006
    ..We have applied this model to establish the role of apoptosis in epithelial solid tumor progression and in treatment response, which has provided novel opportunities for cancer therapies in humans...
  20. pmc Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors
    Sameera Kongara
    Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA
    Mol Cancer Res 8:873-84. 2010
    ..High phospho(Ser73)-K8 expression may be a marker of autophagy functional status in breast tumors and, as such, could have therapeutic implications for breast cancer patients...
  21. pmc Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach
    Janice M Mehnert
    Department of Medicine, Division of Medical Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Mol Cancer Ther 10:1509-19. 2011
    ....
  22. pmc A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Methods Enzymol 446:61-76. 2008
    ....
  23. pmc NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
    Tsutomu Shimazu
    Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 21:929-41. 2007
    ..Although NBK/BIK is dispensable for development, it is the BH3-only protein targeted for inactivation by viruses, suggesting that it plays a role in pathogen/toxin response through apoptosis activation...
  24. ncbi request reprint Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes
    YARI E MARIN
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, 213, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Neuropharmacology 49:70-9. 2005
    ..Taken together, these results indicate that Grm1 can act as an oncogene in melanocytes independently of Grm5 expression...
  25. pmc Production of membrane proteins for NMR studies using the condensed single protein (cSPP) production system
    Lili Mao
    New York Center on Membrane Protein Structure, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA
    J Struct Funct Genomics 10:281-9. 2009
    ....
  26. pmc Assessing metabolic stress and autophagy status in epithelial tumors
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Methods Enzymol 453:53-81. 2009
    ..Additionally these cell lines provide an efficient way to perform biochemical analyses, and high throughput screening for modulators of autophagy for potential use in cancer therapy and prevention...
  27. pmc Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors
    Anne M Strohecker
    1Cancer Institute of New Jersey, New Brunswick 2Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey and 3Department of Cellular and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California
    Cancer Discov 3:1272-85. 2013
    ....
  28. ncbi request reprint BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis
    Celine Gelinas
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 19:1263-8. 2005
  29. ncbi request reprint A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation
    Mohamed M Rafi
    Department of Food Science, New Jersey Agricultural Experimentation Station, Cook College, Rutgers University, New Brunswick, New Jersey 08901 8520, USA
    Anticancer Res 25:313-8. 2005
    ..Although initially active in clinical studies, current anti-microtubule agents are only temporarily effective and the discovery of new agents is warranted...
  30. pmc Induction of apoptosis by diterpenes from the soft coral Xenia elongata
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08901 8521, USA
    J Nat Prod 70:1551-7. 2007
    ..The diterpenes induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by marine diterpenes in xenicane skeletons...
  31. doi request reprint Therapeutic targeting of death pathways in cancer: mechanisms for activating cell death in cancer cells
    Ting Ting Tan
    Center for Advanced Biotechnology and Medicine and Rutgers University, Piscataway, NJ 08854, USA
    Adv Exp Med Biol 615:81-104. 2008
    ..This chapter summarizes the current knowledge of the apoptotic pathways and provides a selective review on the development of drugs that target the apoptotic machinery...
  32. pmc Why sick cells produce tumors: the protective role of autophagy
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Autophagy 3:502-5. 2007
    ..The protective role of autophagy may be exploited in developing novel autophagy modulators as rational chemotherapeutic as well as chemopreventive agents...
  33. ncbi request reprint Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection
    Andrea Cuconati
    Howard Hughes Medical Institute, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 16:2465-78. 2002
  34. pmc ASAP, a novel protein complex involved in RNA processing and apoptosis
    Christian Schwerk
    Howard Hughes Medical Institute and Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 23:2981-90. 2003
    ..Importantly, after induction of apoptosis the ASAP complex disassembles. Taken together, our results suggest an important role for the ASAP complexes in linking RNA processing and apoptosis...
  35. pmc Tumor suppression by autophagy through the management of metabolic stress
    Shengkan Jin
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Autophagy 4:563-6. 2008
    ..Furthermore, we need to be able to identify human tumors with deficient autophagy, and to develop rational cancer therapies that take advantage of the altered metabolic state and stress responses inherent to this autophagy defect...
  36. pmc Autophagy-mediated tumor promotion
    Jessie Yanxiang Guo
    Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Cell 155:1216-9. 2013
    ..Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas. ..
  37. pmc Role of autophagy in cancer: management of metabolic stress
    Shengkan Jin
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Newark, NJ 08854, USA
    Autophagy 3:28-31. 2007
    ....
  38. ncbi request reprint Exploiting different ways to die
    Deirdre A Nelson
    Howard Hughes Medical Institute and Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 18:1223-6. 2004
  39. doi request reprint Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
    Mark Stein
    Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08901, USA
    Prostate 70:1388-94. 2010
    ....
  40. ncbi request reprint Augmentation of apoptosis by the combination of bleomycin with trifluoperazine in the presence of mutant p53
    Gregory F Sullivan
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Cancer Institute of New Jersey, USA
    J Exp Ther Oncol 2:19-26. 2002
    ..These results indicate that the enhancement of bleomycin induced DNA damage by trifluoperazine is mediated, at least in part, through the induction of apoptosis...
  41. pmc E1A sensitizes cells to tumor necrosis factor alpha by downregulating c-FLIP S
    Denise Perez
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, 679 Hoes Lane, Piscataway, NJ 08854, USA
    J Virol 77:2651-62. 2003
    ....
  42. ncbi request reprint FLIPping the balance between apoptosis and proliferation in thyroid cancer
    Robin Mathew
    Center for Advanced Biotechnology and Medicine, Rutgers University, USA
    Clin Cancer Res 12:3648-51. 2006
  43. ncbi request reprint BAX and BAK mediate p53-independent suppression of tumorigenesis
    Kurt Degenhardt
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, 679 Hoes Lane, Room 140, Piscataway, NJ 08854, USA
    Cancer Cell 2:193-203. 2002
    ..Thus, BAX and BAK function to suppress tumorigenesis, and their deficiency was selected for in vivo...
  44. ncbi request reprint Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death
    Holly Henry
    Howard Hughes Medical Institute, 679 Hoes Lane, Piscataway, New Jersey, NJ 08854, USA
    Oncogene 21:748-60. 2002
    ..Thus, p53 induces apoptosis in part through Bax and Bak, and even an incomplete inhibition of this mitochondrial checkpoint may be sufficient to confer resistance to cell death...
  45. ncbi request reprint Bax and Bak independently promote cytochrome C release from mitochondria
    Kurt Degenhardt
    Department of Molecular Biology, The Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:14127-34. 2002
    ..Thus, either Bax or Bak is required for death signaling through mitochondria in response to TNF-alpha, but both are dispensable for p53-dependent transformation inhibition...
  46. pmc Bak and Bax function to limit adenovirus replication through apoptosis induction
    Andrea Cuconati
    Howard Hughes Medical Institute Department of Molecular Biology, Rutgers University, Piscataway, New Jersey 08854, USA
    J Virol 76:4547-58. 2002
    ..Thus, Bax- and Bak-mediated apoptosis severely limits adenoviral replication, demonstrating that Bax and Bak function as an antiviral response at the cellular level...
  47. pmc The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
    L Rao
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854
    Proc Natl Acad Sci U S A 89:7742-6. 1992
    ..High-frequency transformation requires a second function encoded by the E1B 19-kDa protein to block apoptosis...
  48. pmc The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha
    E White
    Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854
    Mol Cell Biol 12:2570-80. 1992
    ....
  49. ncbi request reprint Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
    R Sundararajan
    Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 276:45120-7. 2001
    ....
  50. ncbi request reprint The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein
    J Han
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854 USA
    Genes Dev 10:461-77. 1996
    ..With the death pathway disabled, induction of growth arrest by p53 can then be manifested...
  51. pmc ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
    Katherine E Ewings
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    EMBO J 26:2856-67. 2007
    ..These results provide new insights into the role of Bim in cell death and its regulation by the ERK1/2 survival pathway...
  52. ncbi request reprint Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release
    Valery Mikhailov
    Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 278:5367-76. 2003
    ..These results suggest a degree of functional cooperation between Bax and Bak in this form of cell injury, but also demonstrate an absolute requirement of Bax for mitochondrial permeabilization...
  53. pmc Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy
    Robert S DiPaola
    Department of Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Prostate 68:1743-52. 2008
    ..The understanding of autophagy, as either a mechanism of resistance to therapies that induce metabolic stress, or as a means to cell death, is rapidly expanding and supportive of a new paradigm of therapeutic starvation...
  54. pmc Apoptosis-inducing galactolipids from a cultured marine diatom, Phaeodactylum tricornutum
    Eric H Andrianasolo
    Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8521, USA
    J Nat Prod 71:1197-201. 2008
    ..The galactolipids induce apoptosis in micromolar concentrations. This is the first report of apoptosis induction by galactolipids...
  55. pmc Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis
    Eileen White
    Autophagy 4:399-401. 2008
    ..1) This radically alters the interpretation of earlier findings reporting induction of autophagic cell death by zVAD,(2) instead, suggests that autophagy functions to promote cell survival...
  56. ncbi request reprint Epothilone induced cytotoxicity is dependent on p53 status in prostate cells
    Margarita L Ioffe
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School UMDNJ, New Brunswick, New Jersey 08901, USA
    Prostate 61:243-7. 2004
    ..We hypothesized that epothilone induced cytotoxicity would be influenced by the status of p53 in prostate cells...
  57. ncbi request reprint A novel proteomic coculture model of prostate cancer cell growth
    Dmitri Dvorzhinski
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08901, USA
    Proteomics 4:3268-75. 2004
    ..These data, therefore, demonstrate a novel coculture model for further study of agents that target proteins in pathways of paracrine or autocrine stimulated cell growth...
  58. pmc Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation
    Man Jiang
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Augusta, Georgia 30912, USA
    J Biol Chem 282:2636-45. 2007
    ..Importantly, it blocked both Bax and Bak oligomerization under these conditions. Together, the results have uncovered a new pharmacological function of nutlins, i.e. suppression of Bax and Bak, two critical mediators of apoptosis...
  59. pmc Does control of mutant p53 by Mdm2 complicate cancer therapy?
    Carol Prives
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genes Dev 22:1259-64. 2008
    ..Once stabilized, mutant p53 promotes metastasis. Therefore, therapies that release p53 from Mdm2 might have unwanted consequences when cells have sustained a mutation in p53...

Research Grants3

  1. FUNCTION OF THE ADENOVIRUS E1B ONCOGENE
    Eileen White; Fiscal Year: 2007
    ..Knowledge gained from this approach will be useful in the development of new anti-viral and anti-cancer regimens. ..