Carolyn L Waite
Affiliation: Rutgers University
- Acetylation of PAMAM dendrimers for cellular delivery of siRNACarolyn L Waite
Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, USA
BMC Biotechnol 9:38. 2009..In this work, the extent of primary amine acetylation of generation 5 poly(amidoamine) (PAMAM) dendrimers was studied as a modification for the delivery of siRNA to U87 malignant glioma cells...
- Efficient intracellular siRNA delivery by ethyleneimine-modified amphiphilic macromoleculesSarah M Sparks
Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, USA
Macromol Biosci 11:1192-200. 2011..This work highlights the promise of cationic AMs as safe and efficient synthetic vectors for siRNA delivery. Specifically, a novel polymer (9N) was identified for efficient siRNA delivery to cancer cells and will be further evaluated...
- Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunitiesCarolyn L Waite
Department of Chemical and Biochemical Engineering, Rutgers University, New Brunswick, New Jersey, USA
Crit Rev Biomed Eng 40:21-41. 2012..We conclude with an overview of the important nanoparticle design parameters governing their tumor penetration, as well as by highlighting critical directions in this field...
- Binding and transport of PAMAM-RGD in a tumor spheroid model: the effect of RGD targeting ligand densityCarolyn L Waite
Department of Chemical and Biochemical Engineering, Rutgers University, 599 Taylor Rd, Piscataway, New Jersey 08854, USA
Biotechnol Bioeng 108:2999-3008. 2011....