Mehmet Uzumcu

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. doi request reprint Epigenetic mechanisms in the actions of endocrine-disrupting chemicals: gonadal effects and role in female reproduction
    M Uzumcu
    Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8525, USA
    Reprod Domest Anim 47:338-47. 2012
  2. ncbi request reprint Early postnatal methoxychlor exposure inhibits folliculogenesis and stimulates anti-Mullerian hormone production in the rat ovary
    Mehmet Uzumcu
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901 8525, USA
    J Endocrinol 191:549-58. 2006
  3. pmc Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function
    Mehmet Uzumcu
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901 8525, United States
    Reprod Toxicol 23:337-52. 2007
  4. pmc Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats
    AnnMarie E Armenti
    Department of Animal Sciences School of Environmental and Biological Sciences Rutgers, The State 84 Lipman Drive University of New Jersey New Brunswick, NJ 08901 8525, USA
    Toxicol Appl Pharmacol 233:286-96. 2008
  5. pmc Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro
    Craig N Harvey
    Joint Graduate Program in Toxicology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Toxicol Sci 110:95-106. 2009
  6. pmc Targeted genome-wide methylation and gene expression analyses reveal signaling pathways involved in ovarian dysfunction after developmental EDC exposure in rats
    Aparna Mahakali Zama
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Biol Reprod 88:52. 2013
  7. ncbi request reprint Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro
    Mehmet Uzumcu
    Department of Animal Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    Reproduction 132:291-9. 2006
  8. pmc Orthotopic transplantation of neonatal GFP rat ovary as experimental model to study ovarian development and toxicology
    Jason E Marano
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901 8525, USA
    Reprod Toxicol 26:191-6. 2008
  9. pmc Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes
    Aparna Mahakali Zama
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Endocrinology 150:4681-91. 2009
  10. pmc Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective
    Aparna Mahakali Zama
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8525, USA
    Front Neuroendocrinol 31:420-39. 2010

Research Grants

Collaborators

  • Michael K Skinner
  • Rob Zachow
  • Qi Wang
  • Aparna Mahakali Zama
  • Matthew D Anway
  • Andrea S Cupp
  • Craig N Harvey
  • Jason E Marano
  • AnnMarie E Armenti
  • Tracy M Clement
  • Christopher L Small
  • Andrew I Brooks
  • Mahmoud Esmail
  • Lisa Passantino
  • Wise Young
  • Dongming Sun
  • Mushtaq A Memon
  • James E Shima
  • Michael D Griswold
  • Kristen Dirks
  • Brigette Phillips
  • Hiroetsu Suzuki

Detail Information

Publications17

  1. doi request reprint Epigenetic mechanisms in the actions of endocrine-disrupting chemicals: gonadal effects and role in female reproduction
    M Uzumcu
    Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8525, USA
    Reprod Domest Anim 47:338-47. 2012
    ..We conclude the review by describing several critical issues in studying epigenetic effects of EDCs in the ovary, including transgenerational epigenetic effects...
  2. ncbi request reprint Early postnatal methoxychlor exposure inhibits folliculogenesis and stimulates anti-Mullerian hormone production in the rat ovary
    Mehmet Uzumcu
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, New Jersey 08901 8525, USA
    J Endocrinol 191:549-58. 2006
    ..This novel finding suggests that elevated AMH may play a role in MXC's inhibitory effect in the ovary...
  3. pmc Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function
    Mehmet Uzumcu
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901 8525, United States
    Reprod Toxicol 23:337-52. 2007
    ..This latter finding adds another level of importance for identifying and understanding the mechanisms of action of these agents...
  4. pmc Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats
    AnnMarie E Armenti
    Department of Animal Sciences School of Environmental and Biological Sciences Rutgers, The State 84 Lipman Drive University of New Jersey New Brunswick, NJ 08901 8525, USA
    Toxicol Appl Pharmacol 233:286-96. 2008
    ..These results demonstrated that developmental MXC exposure results in reduced ovulation and fertility and premature aging, possibly by altering ovarian gene expression and folliculogenesis...
  5. pmc Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro
    Craig N Harvey
    Joint Graduate Program in Toxicology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Toxicol Sci 110:95-106. 2009
    ..This study further established that HPTE exerts differential effects within the granulosa cell steroidogenic pathway and revealed that these effects include broader changes in gene expression...
  6. pmc Targeted genome-wide methylation and gene expression analyses reveal signaling pathways involved in ovarian dysfunction after developmental EDC exposure in rats
    Aparna Mahakali Zama
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    Biol Reprod 88:52. 2013
    ....
  7. ncbi request reprint Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro
    Mehmet Uzumcu
    Department of Animal Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    Reproduction 132:291-9. 2006
    ..Advanced folliculogenesis led to a change in the cellular distribution of the HGF, c-met, and HGFA, suggesting that the ovarian HGF system is hormonally regulated in vivo...
  8. pmc Orthotopic transplantation of neonatal GFP rat ovary as experimental model to study ovarian development and toxicology
    Jason E Marano
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901 8525, USA
    Reprod Toxicol 26:191-6. 2008
    ..This new strain and neonatal orthotopic transplantation could be useful for many biomedical fields including transplantation, development, and reproductive toxicology...
  9. pmc Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes
    Aparna Mahakali Zama
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Endocrinology 150:4681-91. 2009
    ..Overall, these data suggest that transient exposure to MXC during fetal and neonatal development affects adult ovarian function via altered methylation patterns...
  10. pmc Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective
    Aparna Mahakali Zama
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8525, USA
    Front Neuroendocrinol 31:420-39. 2010
    ..Importantly, EDCs that can directly target the ovary can alter epigenetic mechanisms in the oocyte, leading to transgenerational epigenetic effects. The potential mechanisms involved in such effects are also discussed...
  11. ncbi request reprint The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro
    Rob Zachow
    Department of Animal Sciences, Rutgers University, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8525, USA
    Reprod Toxicol 22:659-65. 2006
    ....
  12. ncbi request reprint The hepatocyte growth factor system as a regulator of female and male gonadal function
    Rob Zachow
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School UMDNJ, 675 Hoes Lane West, Piscataway, New Jersey 08854, USA
    J Endocrinol 195:359-71. 2007
    ..This review presents what is currently known regarding the expression of the HGF system and its function within the ovary and testis...
  13. ncbi request reprint Effect of transient embryonic in vivo exposure to the endocrine disruptor methoxychlor on embryonic and postnatal testis development
    Andrea S Cupp
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    J Androl 24:736-45. 2003
    ..Therefore, transient embryonic exposure to an endocrine disruptor (methoxychlor) during gestation can influence the germline and fertility in adult males...
  14. ncbi request reprint Epigenetic transgenerational actions of endocrine disruptors and male fertility
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Science 308:1466-9. 2005
    ..The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology...
  15. ncbi request reprint Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    J Androl 27:868-79. 2006
    ....
  16. pmc Profiling gene expression during the differentiation and development of the murine embryonic gonad
    Christopher L Small
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 72:492-501. 2005
    ..With this study, a large number of transcripts comprising the murine transcriptome can be examined throughout male and female embryonic gonad development and allow for a more complete description of gonad differentiation and development...
  17. ncbi request reprint Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes
    Tracy M Clement
    School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA
    Reproduction 134:455-72. 2007
    ..However, the genes and gene network identified influence numerous cellular processes with cellular differentiation, proliferation, focal contact, RNA localization, and development being predominant...

Research Grants1

  1. EPIGENETIC EFFECT OF METHOXYCHLOR ON OVARIAN DEVELOPMENT
    Mehmet Uzumcu; Fiscal Year: 2007
    ..The findings will improve our understanding of the fetal basis of epigenetic adult ovarian dysfunction. ..