David S Talaga

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Information theoretical approach to single-molecule experimental design and interpretation
    David S Talaga
    Rutgers The State University of New Jersey, New Brunswick, Department of Chemistry and Chemical Biology and BIOMAPS Institute, 610 Taylor Road, Piscataway, NJ 08854, USA
    J Phys Chem A 110:9743-57. 2006
  2. pmc Information-theoretical analysis of time-correlated single-photon counting measurements of single molecules
    David S Talaga
    Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08854, USA
    J Phys Chem A 113:5251-63. 2009
  3. pmc Single-molecule protein unfolding in solid state nanopores
    David S Talaga
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Am Chem Soc 131:9287-97. 2009
  4. pmc Role of small oligomers on the amyloidogenic aggregation free-energy landscape
    Xianglan He
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Mol Biol 395:134-54. 2010
  5. doi request reprint Separation and analysis of dynamic Stokes shift with multiple fluorescence environments: coumarin 153 in bovine beta-lactoglobulin A
    Jeremy Pronchik
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, USA
    J Phys Chem B 112:11422-34. 2008
  6. doi request reprint In vitro formation of amyloid from alpha-synuclein is dominated by reactions at hydrophobic interfaces
    Jeremy Pronchik
    Department of Chemistry and Chemical Biology, Wright Rieman Laboratories, Rutgers, The State University of New Jersey, New Brunswick, 610 Taylor Road, Piscataway, New Jersey 08854, USA
    J Am Chem Soc 132:9797-803. 2010
  7. doi request reprint Global fitting without a global model: regularization based on the continuity of the evolution of parameter distributions
    Jason T Giurleo
    Department of Chemistry and Chemical Biology and BIOMAPS Institute, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Chem Phys 128:114114. 2008
  8. doi request reprint Beta-lactoglobulin assembles into amyloid through sequential aggregated intermediates
    Jason T Giurleo
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA
    J Mol Biol 381:1332-48. 2008
  9. pmc Protein free energy landscapes remodeled by ligand binding
    Troy C Messina
    Department of Chemistry and Chemical Biology, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Biophys J 93:579-85. 2007

Research Grants

Collaborators

  • Jiali Li
  • Jason T Giurleo
  • Xianglan He
  • Jeremy Pronchik
  • Troy C Messina

Detail Information

Publications9

  1. pmc Information theoretical approach to single-molecule experimental design and interpretation
    David S Talaga
    Rutgers The State University of New Jersey, New Brunswick, Department of Chemistry and Chemical Biology and BIOMAPS Institute, 610 Taylor Road, Piscataway, NJ 08854, USA
    J Phys Chem A 110:9743-57. 2006
    ..We consider the effect of background and other "imperfections" on the measurement through the decrease in information...
  2. pmc Information-theoretical analysis of time-correlated single-photon counting measurements of single molecules
    David S Talaga
    Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08854, USA
    J Phys Chem A 113:5251-63. 2009
    ....
  3. pmc Single-molecule protein unfolding in solid state nanopores
    David S Talaga
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Am Chem Soc 131:9287-97. 2009
    ....
  4. pmc Role of small oligomers on the amyloidogenic aggregation free-energy landscape
    Xianglan He
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Mol Biol 395:134-54. 2010
    ..We discuss existing kinetic mechanisms in terms of the different types of oligomers. We provide a possible resolution to the toxic oligomer-amyloid coincidence...
  5. doi request reprint Separation and analysis of dynamic Stokes shift with multiple fluorescence environments: coumarin 153 in bovine beta-lactoglobulin A
    Jeremy Pronchik
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, USA
    J Phys Chem B 112:11422-34. 2008
    ..Our experiments show dynamics ranging from 3-12,00 ps. The analysis shows a decrease in the encapsulated dye's heterogeneity during the relaxation, which is taken as evidence of the breakdown of linear response...
  6. doi request reprint In vitro formation of amyloid from alpha-synuclein is dominated by reactions at hydrophobic interfaces
    Jeremy Pronchik
    Department of Chemistry and Chemical Biology, Wright Rieman Laboratories, Rutgers, The State University of New Jersey, New Brunswick, 610 Taylor Road, Piscataway, New Jersey 08854, USA
    J Am Chem Soc 132:9797-803. 2010
    ..Comparable hydrophobic interfaces are not found in vivo...
  7. doi request reprint Global fitting without a global model: regularization based on the continuity of the evolution of parameter distributions
    Jason T Giurleo
    Department of Chemistry and Chemical Biology and BIOMAPS Institute, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Chem Phys 128:114114. 2008
    ..We show how our approach allows one to start from an essentially model-free fit and progress to a specific model by moving from probabilistic to deterministic constraints in both Laplace transformed and nontransformed coordinates...
  8. doi request reprint Beta-lactoglobulin assembles into amyloid through sequential aggregated intermediates
    Jason T Giurleo
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA
    J Mol Biol 381:1332-48. 2008
    ....
  9. pmc Protein free energy landscapes remodeled by ligand binding
    Troy C Messina
    Department of Chemistry and Chemical Biology, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Biophys J 93:579-85. 2007
    ..These results and their implications are discussed in terms of the two types of specific and nonspecific interactions GGBP has with cytoplasmic membrane proteins...

Research Grants6

  1. New statistical tools for single molecule experiments
    David Talaga; Fiscal Year: 2006
    ..Aim 3 provides useable tools for experimental design and analysis to allow other investigators to exploit these methods for their own research. ..
  2. New statistical tools for single molecule experiments
    David Talaga; Fiscal Year: 2007
    ..Aim 3 provides useable tools for experimental design and analysis to allow other investigators to exploit these methods for their own research. ..
  3. New statistical tools for single molecule experiments
    David S Talaga; Fiscal Year: 2010
    ..Aim 3 provides useable tools for experimental design and analysis to allow other investigators to exploit these methods for their own research. ..