Vasanthi R Sunil

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    Toxicol Sci 133:309-19. 2013
  2. pmc Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 263:195-202. 2012
  3. pmc Pulmonary effects of inhaled diesel exhaust in aged mice
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 241:283-93. 2009
  4. pmc Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy Piscataway, NJ, USA
    Toxicol Appl Pharmacol 261:22-30. 2012
  5. pmc Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 250:245-55. 2011
  6. pmc Pulmonary effects of inhaled limonene ozone reaction products in elderly rats
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 222:211-20. 2007
  7. pmc Activation of adherent vascular neutrophils in the lung during acute endotoxemia
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Respir Res 3:21. 2002
  8. doi request reprint Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 250:10-8. 2011
  9. ncbi request reprint Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Exp Mol Pathol 83:177-87. 2007
  10. pmc Macrophages and tissue injury: agents of defense or destruction?
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 51:267-88. 2011

Collaborators

Detail Information

Publications15

  1. pmc Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    Toxicol Sci 133:309-19. 2013
    ..Collectively, these studies demonstrate that bronchiolar epithelium is highly susceptible to injury and oxidative stress induced by acute exposure to ozone; moreover, this is accompanied by altered lung functioning...
  2. pmc Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 263:195-202. 2012
    ..These data suggest that both proinflammatory/cytotoxic and anti-inflammatory/wound repair macrophages are activated early in the response to ozone-induced oxidative stress and tissue injury...
  3. pmc Pulmonary effects of inhaled diesel exhaust in aged mice
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 241:283-93. 2009
    ..Taken together, these results suggest that altered generation of inflammatory mediators and MnSOD may contribute to increased susceptibility of older mice to inhaled DE...
  4. pmc Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy Piscataway, NJ, USA
    Toxicol Appl Pharmacol 261:22-30. 2012
    ..Elucidating inflammatory mechanisms mediating vesicant-induced lung injury is key to the development of therapeutics to treat mustard poisoning...
  5. pmc Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 250:245-55. 2011
    ..These effects were most notable in the airways. These data suggest that targeting TNF╬▒ signaling may be useful in mitigating lung injury, inflammation and functional alterations induced by vesicants...
  6. pmc Pulmonary effects of inhaled limonene ozone reaction products in elderly rats
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 222:211-20. 2007
    ..LOP are pulmonary irritants inducing distinct inflammatory responses in younger and older animals. This may contribute to the differential sensitivity of these populations to pulmonary irritants...
  7. pmc Activation of adherent vascular neutrophils in the lung during acute endotoxemia
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Respir Res 3:21. 2002
    ..In the present study, we analyzed the effects of acute endotoxemia on the response of a unique subpopulation of neutrophils tightly adhered to the lung vasculature...
  8. doi request reprint Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 250:10-8. 2011
    ..Understanding the nature of the injury induced by nitrogen mustard and related analogs may aid in the development of efficacious therapies for treatment of pulmonary injury resulting from exposure to vesicants...
  9. ncbi request reprint Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Exp Mol Pathol 83:177-87. 2007
    ..These data suggest that the acute phase response to acute endotoxemia involves induction of 24p3 in both the lung and liver. This protein may be important in restoring tissue homeostasis following LPS-induced injury...
  10. pmc Macrophages and tissue injury: agents of defense or destruction?
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 51:267-88. 2011
    ....
  11. ncbi request reprint Activation of type II alveolar epithelial cells during acute endotoxemia
    Vasanthi R Sunil
    Department of Toxicology and Pharmacology, Rutgers University, 170 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Am J Physiol Lung Cell Mol Physiol 282:L872-80. 2002
    ..In contrast, IRF-1 activation was delayed in AM. These data demonstrate that type II cells, like AM, are highly responsive during acute endotoxemia and may contribute to pulmonary inflammation...
  12. doi request reprint Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates
    Manjeet Deshmukh
    Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Control Release 164:65-73. 2012
    ..This suggests that because of their flexible and non-toxic nature, SANPs may be a useful alternative for treating pulmonary diseases such as asthma, pneumonia, tuberculosis and disseminated lung cancer...
  13. doi request reprint Inflammatory effects of inhaled sulfur mustard in rat lung
    Rama Malaviya
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 248:89-99. 2010
    ..These data demonstrate that SM-induced oxidative stress and injury are associated with the generation of cytotoxic inflammatory proteins which may contribute to the pathogenic response to this vesicant...
  14. pmc Macrophages, reactive nitrogen species, and lung injury
    Debra L Laskin
    Rutgers University, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:60-5. 2010
    ..The fact that expression of caveolin-1 is down-regulated in macrophages after ozone inhalation suggests a mechanism controlling the release of cytotoxic mediators by these inflammatory cells...
  15. ncbi request reprint Acute endotoxemia prolongs the survival of rat lung neutrophils in response to 12-O-tetradecanoyl-phorbol 13-acetate
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    J Cell Physiol 190:382-9. 2002
    ..Moreover, this response was independent of TPA. These data suggest that NF-kappaB plays a role in TPA-induced signaling leading to prolonged survival of adherent vascular neutrophils in the lung during acute endotoxemia...