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Genomes and Genes | Vasanthi R SunilSummaryAffiliation: Rutgers University Country: USA Publications
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Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioningVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy Piscataway, NJ, USA
Toxicol Appl Pharmacol 261:22-30. 2012..Elucidating inflammatory mechanisms mediating vesicant-induced lung injury is key to the development of therapeutics to treat mustard poisoning...- Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfideVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
Toxicol Appl Pharmacol 250:245-55. 2011..These effects were most notable in the airways. These data suggest that targeting TNFα signaling may be useful in mitigating lung injury, inflammation and functional alterations induced by vesicants... 
Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liverVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
Exp Mol Pathol 83:177-87. 2007..These data suggest that the acute phase response to acute endotoxemia involves induction of 24p3 in both the lung and liver. This protein may be important in restoring tissue homeostasis following LPS-induced injury...- Pulmonary effects of inhaled limonene ozone reaction products in elderly ratsVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
Toxicol Appl Pharmacol 222:211-20. 2007..LOP are pulmonary irritants inducing distinct inflammatory responses in younger and older animals. This may contribute to the differential sensitivity of these populations to pulmonary irritants... - Pulmonary effects of inhaled diesel exhaust in aged miceVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
Toxicol Appl Pharmacol 241:283-93. 2009..Taken together, these results suggest that altered generation of inflammatory mediators and MnSOD may contribute to increased susceptibility of older mice to inhaled DE... 
Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustardVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
Toxicol Appl Pharmacol 250:10-8. 2011..Understanding the nature of the injury induced by nitrogen mustard and related analogs may aid in the development of efficacious therapies for treatment of pulmonary injury resulting from exposure to vesicants...- Activation of type II alveolar epithelial cells during acute endotoxemiaVasanthi R Sunil
Department of Toxicology and Pharmacology, Rutgers University, 170 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
Am J Physiol Lung Cell Mol Physiol 282:L872-80. 2002..In contrast, IRF-1 activation was delayed in AM. These data demonstrate that type II cells, like AM, are highly responsive during acute endotoxemia and may contribute to pulmonary inflammation... - Classical and alternative macrophage activation in the lung following ozone-induced oxidative stressVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA
Toxicol Appl Pharmacol 263:195-202. 2012..These data suggest that both proinflammatory/cytotoxic and anti-inflammatory/wound repair macrophages are activated early in the response to ozone-induced oxidative stress and tissue injury... - Inflammatory effects of inhaled sulfur mustard in rat lungRama Malaviya
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
Toxicol Appl Pharmacol 248:89-99. 2010..These data demonstrate that SM-induced oxidative stress and injury are associated with the generation of cytotoxic inflammatory proteins which may contribute to the pathogenic response to this vesicant... - Activation of adherent vascular neutrophils in the lung during acute endotoxemiaVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
Respir Res 3:21. 2002..In the present study, we analyzed the effects of acute endotoxemia on the response of a unique subpopulation of neutrophils tightly adhered to the lung vasculature... - Macrophages and tissue injury: agents of defense or destruction?Debra L Laskin
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
Annu Rev Pharmacol Toxicol 51:267-88. 2011.... - Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregatesManjeet Deshmukh
Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
J Control Release 164:65-73. 2012..This suggests that because of their flexible and non-toxic nature, SANPs may be a useful alternative for treating pulmonary diseases such as asthma, pneumonia, tuberculosis and disseminated lung cancer... - Macrophages, reactive nitrogen species, and lung injuryDebra L Laskin
Rutgers University, Piscataway, New Jersey, USA
Ann N Y Acad Sci 1203:60-5. 2010..The fact that expression of caveolin-1 is down-regulated in macrophages after ozone inhalation suggests a mechanism controlling the release of cytotoxic mediators by these inflammatory cells... - Acute endotoxemia prolongs the survival of rat lung neutrophils in response to 12-O-tetradecanoyl-phorbol 13-acetateVasanthi R Sunil
Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
J Cell Physiol 190:382-9. 2002..Moreover, this response was independent of TPA. These data suggest that NF-kappaB plays a role in TPA-induced signaling leading to prolonged survival of adherent vascular neutrophils in the lung during acute endotoxemia...