Nanjoo Suh

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. doi request reprint Strawberry fields forever?
    Nanjoo Suh
    Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 5:30-3. 2012
  2. ncbi request reprint Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats
    Nanjoo Suh
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 13:350-5. 2007
  3. pmc Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia
    Amanda K Smolarek
    Department of Pharmacology and Toxicology, Rutgers, The State University of New Jersey, Piscataway, New Jersey
    Mol Carcinog 52:514-25. 2013
  4. pmc Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in rats
    Nanjoo Suh
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Prev Res (Phila) 4:1895-902. 2011
  5. doi request reprint Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation
    Zheng Yuan Su
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States
    Chem Res Toxicol 26:477-85. 2013
  6. pmc Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats
    Shiby Paul
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 31:1272-8. 2010
  7. pmc Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 15:4242-9. 2009
  8. pmc Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Steroid Biochem Mol Biol 121:408-12. 2010
  9. pmc In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer
    Shiby Paul
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Eur J Med Chem 45:3702-8. 2010
  10. pmc A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer
    Jae Young So
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Pharmacol 79:360-7. 2011

Collaborators

Detail Information

Publications35

  1. doi request reprint Strawberry fields forever?
    Nanjoo Suh
    Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 5:30-3. 2012
    ..Clearly, however, this work is a good example of proof-of-principle and highlights the important role of diet, nutrition, and natural products in cancer prevention...
  2. ncbi request reprint Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats
    Nanjoo Suh
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 13:350-5. 2007
    ..Pterostilbene, a naturally occurring stilbene from blueberries, was tested for its preventive activity against colon carcinogenesis...
  3. pmc Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia
    Amanda K Smolarek
    Department of Pharmacology and Toxicology, Rutgers, The State University of New Jersey, Piscataway, New Jersey
    Mol Carcinog 52:514-25. 2013
    ....
  4. pmc Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in rats
    Nanjoo Suh
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Prev Res (Phila) 4:1895-902. 2011
    ..Our results suggest that low-dose atorvastatin with sulindac or naproxen might potentially be useful combinations for colon cancer prevention in humans...
  5. doi request reprint Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation
    Zheng Yuan Su
    Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States
    Chem Res Toxicol 26:477-85. 2013
    ..Epigenetic modifications of genes, including Nrf2, may therefore contribute to the overall health benefits of RAS, including the anticancer effect of RAS and its bioactive component, Lig...
  6. pmc Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats
    Shiby Paul
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 31:1272-8. 2010
    ..Our data with pterostilbene in suppressing colon tumorigenesis, cell proliferation as well as key inflammatory markers in vivo and in vitro suggest the potential use of pterostilbene for colon cancer prevention...
  7. pmc Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-gamma
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 15:4242-9. 2009
    ..In the present study, we investigated the inhibitory effect of a tocopherol mixture rich in gamma- and delta-tocopherols against mammary tumorigenesis...
  8. pmc Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Steroid Biochem Mol Biol 121:408-12. 2010
    ....
  9. pmc In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer
    Shiby Paul
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Eur J Med Chem 45:3702-8. 2010
    ..Overall, identification of the anti-tumorigenic potential of these compounds provides opportunities for their use against colorectal cancer...
  10. pmc A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer
    Jae Young So
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Pharmacol 79:360-7. 2011
    ..The novel Gemini vitamin D analog, BXL0124, represses CD44 expression in MCF10DCIS.com cells in vitro and in xenograft tumors, suggesting an inhibitory role of a Gemini vitamin D derivative on breast cancer stem cells...
  11. ncbi request reprint Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Biochem Pharmacol 72:332-43. 2006
    ....
  12. pmc Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells
    Shiby Paul
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 2:650-7. 2009
    ..Our data suggest that the p38 mitogen-activated protein kinase cascade is a key signal transduction pathway for eliciting the anti-inflammatory action of pterostilbene in cultured HT-29 colon cancer cells...
  13. pmc Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression
    Jae Young So
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 6:959-70. 2013
    ..The present study shows BXL0124, CDDO-Im, and the combination as potential agents for prevention, but not treatment, against the tumorigenesis of ErbB2-overexpressing breast cancer...
  14. pmc Dietary administration of δ- and γ-tocopherol inhibits tumorigenesis in the animal model of estrogen receptor-positive, but not HER-2 breast cancer
    Amanda K Smolarek
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Prev Res (Phila) 5:1310-20. 2012
    ..Both δ- and γ-tocopherols, but not α-tocopherol, seem to be promising agents for the prevention of hormone-dependent breast cancer...
  15. ncbi request reprint The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells
    Yan Ji
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Mol Cancer Ther 5:1452-8. 2006
    ..The combination of triterpenoids and D3 may have a practical use in differentiation therapy of myeloid leukemia as well as for promoting the formation of bone and cartilage...
  16. pmc Cancer-preventive activities of tocopherols and tocotrienols
    Jihyeung Ju
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 31:533-42. 2010
    ..Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research...
  17. doi request reprint Diastereotopic and deuterium effects in gemini
    Hubert Maehr
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854, USA
    J Med Chem 56:3878-88. 2013
    ..We solved the crystal structures of these compounds in the zebra fish zVDR ligand binding domain as complexes with NCoA-2 coactivator peptide and correlated the findings with growth inhibition in a breast cancer cell line...
  18. pmc Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer
    Jae Young So
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS ONE 8:e54020. 2013
    ..com basal-like human breast cancer cells and inhibited MCF10DCIS xenograft tumor growth. In the present study, we investigated potential factors downstream of CD44 and the biological role of CD44 repression by BXL0124 in MCF10DCIS cells...
  19. pmc Does vitamin E prevent or promote cancer?
    Chung S Yang
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Cancer Prev Res (Phila) 5:701-5. 2012
    ....
  20. pmc A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation
    Ying Huang
    Department of Pharmaceutics, Center for Cancer Prevention Research, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    J Nutr 142:818-23. 2012
    ....
  21. pmc Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherol
    Amanda K Smolarek
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Nutrients 3:962-86. 2011
    ..We recommend that a γ-enriched mixture, γ- and δ-tocopherol, but not α-tocopherol, are promising agents for breast cancer prevention and warrant further investigation...
  22. pmc Calcitriol derivatives with two different side chains at C-20. V. Potent inhibitors of mammary carcinogenesis and inducers of leukemia differentiation
    Hubert Maehr
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Med Chem 52:5505-19. 2009
    ....
  23. ncbi request reprint Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a gemini vitamin d analog
    Joseph Wahler
    Authors Affiliations Department of Chemical Biology, Ernest Mario School of Pharmacy Center for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway and Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
    Cancer Prev Res (Phila) 7:617-26. 2014
    ..Our results suggest that the maintenance of DCIS plays a significant role in the cancer preventive action of the Gemini vitamin D BXL0124 during the progression of breast lesions. Cancer Prev Res; 7(6); 617-26. ©2014 AACR. ..
  24. pmc Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Prev Res (Phila) 1:476-84. 2008
    ..Our results suggest that Gemini vitamin D analogues may be potent agents for the prevention and treatment of both ER-positive and ER-negative breast cancer without hypercalcemia toxicity...
  25. pmc The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice
    Yingying Liu
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Cancer Res 6:1215-24. 2008
    ..This makes it an attractive candidate for drug therapy for different types of cancer...
  26. doi request reprint Cancer prevention by different forms of tocopherols
    Chung S Yang
    Department of Chemical Biology, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, NJ, USA
    Top Curr Chem 329:21-33. 2013
    ....
  27. ncbi request reprint Activation of bone morphogenetic protein signaling by a Gemini vitamin D3 analogue is mediated by Ras/protein kinase C alpha
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Res 67:11840-7. 2007
    ..In conclusion, Ro3582 inhibits cell proliferation and activates BMP/Smad signaling via a Ras and PKC alpha pathway in breast epithelial cells...
  28. doi request reprint Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice
    Avantika Barve
    Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Int J Cancer 124:1693-9. 2009
    ..Gamma-T-enriched mixed tocopherols significantly up-regulated the expression of Nrf2 and its related detoxifying and antioxidant enzymes thereby suppressing PIN and tumor development...
  29. ncbi request reprint Mixed tocopherols inhibit N-methyl-N-nitrosourea-induced mammary tumor growth in rats
    Nanjoo Suh
    Department of Chemical Biology, The State University of New Jersey, Piscataway, NJ 08854, USA
    Nutr Cancer 59:76-81. 2007
    ..The treatment increased the serum levels of gamma- and delta-tocopherols without affecting the body weight. The results of this study suggest that mixed tocopherols may be safe and effective agents for the prevention of breast cancer...
  30. ncbi request reprint A novel vitamin D derivative activates bone morphogenetic protein signaling in MCF10 breast epithelial cells
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854
    Mol Pharmacol 69:1840-8. 2006
    ..This is the first report to show that 1alpha,25(OH)(2)D(3) and its derivatives activate BMP/Smad-specific signaling in human breast epithelial cells...
  31. ncbi request reprint Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives
    Jungil Hong
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 27:278-86. 2006
    ..These activities may contribute to the anti-inflammatory and anticarcinogenic actions of garcinol and its derivatives...
  32. ncbi request reprint Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition
    Hubert Maehr
    Bioxell Inc, 340 Kingsland Street, Nutley, NJ 07110, USA
    J Steroid Biochem Mol Biol 103:277-81. 2007
    ....
  33. ncbi request reprint Efficient synthesis of (-)- and (+)-tricyclic compounds with enone functionalities in rings A and C. A novel class of orally active anti-inflammatory and cancer chemopreventive agents
    Tadashi Honda
    Department of Chemistry, Dartmouth College, 6128 Burke Laboratory, Hanover, New Hampshire 03755, USA
    Org Biomol Chem 1:4384-91. 2003
    ..In contrast, (-)-3 inhibits proliferation of MCF-7 breast cancer cells, whereas (+)-3 does not...
  34. ncbi request reprint The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo
    Andrew E Place
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Clin Cancer Res 9:2798-806. 2003
    ..Moreover, CDDO-Im inhibits growth of B16 murine melanoma and L1210 murine leukemia cells in vivo. The potent effects of CDDO-Im, both in vitro and in vivo, suggest it should be considered for clinical use...
  35. ncbi request reprint Chemoprevention: an essential approach to controlling cancer
    Michael B Sporn
    Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Nat Rev Cancer 2:537-43. 2002
    ....

Research Grants6

  1. Mechanism Based Chemoprevention of Cancer
    Nanjoo Suh; Fiscal Year: 2005
    ..My long-term goal is to become an independent investigator who can contribute to the entire process of making basic scientific knowledge effective in preventing cancer in men and women. ..
  2. Chemoprevention of cancer by nuclear receptor ligands
    Nanjoo Suh; Fiscal Year: 2005
    ..The goal of this proposal is to develop novel ligands for the vitamin D receptor as potential chemopreventive agents that can ultimately be used to prevent breast cancer. ..
  3. Inhibition of breast cancer progression by vitamin D analogs and triterpenoids
    Nanjoo Suh; Fiscal Year: 2009
    ..This research will be an important precursor for a clinical cancer prevention trial in patients with a high risk of estrogen receptor negative breast cancer. ..
  4. Inhibition of breast cancer progression by vitamin D analogs and triterpenoids
    Nanjoo Suh; Fiscal Year: 2010
    ..This research will be an important precursor for a clinical cancer prevention trial in patients with a high risk of estrogen receptor negative breast cancer. ..
  5. Inhibition of breast cancer progression by vitamin D analogs and triterpenoids
    Nanjoo Suh; Fiscal Year: 2009
    ..This research will be an important precursor for a clinical cancer prevention trial in patients with a high risk of estrogen receptor negative breast cancer. ..