JUDITH R STORCH

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity
    Su Hyoun Chon
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, United States of America
    PLoS ONE 7:e43962. 2012
  2. pmc Intestinal mucosal triacylglycerol accumulation secondary to decreased lipid secretion in obese and high fat fed mice
    John D Douglass
    Department of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University New Brunswick, NJ, USA
    Front Physiol 3:25. 2012
  3. pmc Metabolism of apical versus basolateral sn-2-monoacylglycerol and fatty acids in rodent small intestine
    Judith Storch
    Department of Nutritional Sciences and Rutgers Center for Lipid Research, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA
    J Lipid Res 49:1762-9. 2008
  4. ncbi request reprint The fatty acid transport function of fatty acid-binding proteins
    J Storch
    Department of Nutritional Sciences, Cook College, Rutgers University, New Brunswick, NJ 08901 8525, USA
    Biochim Biophys Acta 1486:28-44. 2000
  5. doi request reprint The emerging functions and mechanisms of mammalian fatty acid-binding proteins
    Judith Storch
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    Annu Rev Nutr 28:73-95. 2008
  6. pmc Structural and functional analysis of fatty acid-binding proteins
    Judith Storch
    Department of Nutritional Sciences, Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Lipid Res 50:S126-31. 2009
  7. doi request reprint Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking
    Judith Storch
    Department of Nutritional Sciences and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1791:671-8. 2009
  8. pmc Tissue-specific functions in the fatty acid-binding protein family
    Judith Storch
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 285:32679-83. 2010
  9. ncbi request reprint Similar mechanisms of fatty acid transfer from human anal rodent fatty acid-binding proteins to membranes: liver, intestine, heart muscle, and adipose tissue FABPs
    Judith Storch
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA
    Mol Cell Biochem 239:25-33. 2002
  10. ncbi request reprint Liver and intestinal fatty acid-binding proteins obtain fatty acids from phospholipid membranes by different mechanisms
    A E Thumser
    Department of Nutritional Sciences, Cook College, Rutgers University, 96 Lipman Drive, New Brunswick, NJ 08901 8525, USA
    J Lipid Res 41:647-56. 2000

Research Grants

  1. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2005
  2. Liquid Chromatography Mass Spectrometry system
    Judith Storch; Fiscal Year: 2006
  3. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2006
  4. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2005
  5. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2003
  6. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2001
  7. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2000
  8. FATTY ACIDS TRANSPORT IN INTESTINE:STRUCTURAL ANALYSES
    Judith Storch; Fiscal Year: 2000
  9. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2000
  10. Lipid transport in the intestine
    Judith Storch; Fiscal Year: 2009

Collaborators

  • Betina Corsico
  • Alfred E Thumser
  • Su Hyoun Chon
  • John D Douglass
  • Yin Xiu Zhou
  • Nashmia Malik
  • William Stacy Lagakos
  • E R Smith
  • Kevin Wells
  • F M Herr
  • H L Liou
  • Joseph L Dixon
  • Loredana Quadro
  • Andrew S Choi
  • Laurie B Joseph
  • S Y Ho
  • Anita Brinker
  • Luis Agellon
  • Angela Marie Gajda
  • Bernadette Mandap
  • Timothy Russnak
  • Bert Binas
  • Victor Choi
  • S Shaughnessy
  • A Gericke
  • K T Hsu
  • S K Fried
  • S Kodukula
  • R Mendelsohn
  • D J Moore
  • J Aronson
  • V Matarese
  • D A Bernlohr

Detail Information

Publications21

  1. pmc Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity
    Su Hyoun Chon
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, United States of America
    PLoS ONE 7:e43962. 2012
    ..The results therefore suggest a role for intestinal MGL, and intestinal 2-AG and perhaps other MG species, in whole body energy balance via regulation of food intake as well as metabolic rate...
  2. pmc Intestinal mucosal triacylglycerol accumulation secondary to decreased lipid secretion in obese and high fat fed mice
    John D Douglass
    Department of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University New Brunswick, NJ, USA
    Front Physiol 3:25. 2012
    ..Moreover, even in the absence of frank obesity, HF feeding leads to a large decrease in the rate of intestinal lipid secretion...
  3. pmc Metabolism of apical versus basolateral sn-2-monoacylglycerol and fatty acids in rodent small intestine
    Judith Storch
    Department of Nutritional Sciences and Rutgers Center for Lipid Research, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA
    J Lipid Res 49:1762-9. 2008
    ..These results support the existence of separate pools of TG and glycerolipid intermediates in the intestinal epithelial cell, and underscore the importance of substrate trafficking in the regulation of enterocyte lipid metabolism...
  4. ncbi request reprint The fatty acid transport function of fatty acid-binding proteins
    J Storch
    Department of Nutritional Sciences, Cook College, Rutgers University, New Brunswick, NJ 08901 8525, USA
    Biochim Biophys Acta 1486:28-44. 2000
    ..Further studies are necessary to elucidate the fundamental mechanisms by which cellular fatty acid trafficking is modulated by the FABPs...
  5. doi request reprint The emerging functions and mechanisms of mammalian fatty acid-binding proteins
    Judith Storch
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    Annu Rev Nutr 28:73-95. 2008
    ..This review will focus on these emerging functions and mechanisms of the FABPs, highlighting the unique functional properties of each as well as the similarities among them...
  6. pmc Structural and functional analysis of fatty acid-binding proteins
    Judith Storch
    Department of Nutritional Sciences, Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    J Lipid Res 50:S126-31. 2009
    ..Thus, the FABPs modulate intracellular lipid homeostasis by regulating FA transport in the nuclear and extra-nuclear compartments of the cell; in so doing, they also impact systemic energy homeostasis...
  7. doi request reprint Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking
    Judith Storch
    Department of Nutritional Sciences and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1791:671-8. 2009
    ..This review discusses the role of the NPC2 protein in cholesterol transport, and the potential for concerted action of NPC1 and NPC2 in regulating normal intracellular cholesterol homeostasis...
  8. pmc Tissue-specific functions in the fatty acid-binding protein family
    Judith Storch
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Biol Chem 285:32679-83. 2010
    ..The regulation of these diverse processes is accompanied by the expression of different and sometimes multiple FABPs in these tissues and may be driven by protein-protein and protein-membrane interactions...
  9. ncbi request reprint Similar mechanisms of fatty acid transfer from human anal rodent fatty acid-binding proteins to membranes: liver, intestine, heart muscle, and adipose tissue FABPs
    Judith Storch
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA
    Mol Cell Biochem 239:25-33. 2002
    ..Moreover, it appears that the Ala to Thr substitution at residue 54 of the human IFABP does not alter the fundamental mechanism of ligand transfer to membranes, but nevertheless causes a consistent decrease in the rate of transfer...
  10. ncbi request reprint Liver and intestinal fatty acid-binding proteins obtain fatty acids from phospholipid membranes by different mechanisms
    A E Thumser
    Department of Nutritional Sciences, Cook College, Rutgers University, 96 Lipman Drive, New Brunswick, NJ 08901 8525, USA
    J Lipid Res 41:647-56. 2000
    ..In summary, the results suggest that I-FABP, but not L-FABP, can directly extract fatty acids from membranes, supporting the concept that I-FABP may increase the cytosolic flux of fatty acids via intermembrane transfer...
  11. ncbi request reprint Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein
    S Shaughnessy
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901 8525, USA
    Diabetes 49:904-11. 2000
    ....
  12. ncbi request reprint Surface lysine residues modulate the collisional transfer of fatty acid from adipocyte fatty acid binding protein to membranes
    F M Herr
    Department of Nutritional Sciences, Cook College, Rutgers University, New Brunswick, New Jersey 08903, USA
    Biochemistry 34:11840-5. 1995
    ..Finally, an increase in the negative charge density of the acceptor SUV resulted in a marked increase in the rate of transfer from native A-FABP but did not increase the rate from acetylated A-FABP.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. ncbi request reprint Fatty acid transfer from liver and intestinal fatty acid-binding proteins to membranes occurs by different mechanisms
    K T Hsu
    Department of Nutritional Sciences, Cook College, Rutgers University, New Brunswick, New Jersey 08903, USA
    J Biol Chem 271:13317-23. 1996
    ....
  14. ncbi request reprint Collision-mediated transfer of long-chain fatty acids by neural tissue fatty acid-binding proteins (FABP): studies with fluorescent analogs
    A E Thumser
    Department of Nutritional Sciences, Cook College, Rutgers University, New Brunswick, New Jersey 08901-8525, USA
    J Mol Neurosci 16:143-50; discussion 151-7. 2001
    ..These results are consistent with a mechanism by which FA are transferred from B-FABP to phospholipid membranes by a transient collision-based mechanism...
  15. ncbi request reprint The adipocyte fatty acid-binding protein binds to membranes by electrostatic interactions
    E R Smith
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901 8525, USA
    J Biol Chem 274:35325-30. 1999
    ....
  16. ncbi request reprint Role of portal region lysine residues in electrostatic interactions between heart fatty acid binding protein and phospholipid membranes
    F M Herr
    Department of Nutritional Sciences, Cook College, Rutgers University, New Brunswick, New Jersey 08903, USA
    Biochemistry 35:1296-303. 1996
    ..These studies demonstrate that the helical cap region of HFABP may play an important role in governing ionic interactions between binding protein and membranes...
  17. ncbi request reprint Adipocyte fatty acid-binding protein: interaction with phospholipid membranes and thermal stability studied by FTIR spectroscopy
    A Gericke
    Department of Chemistry, Rutgers University, Newark, New Jersey 07102, USA
    Biochemistry 36:8311-7. 1997
    ..With the exception of minor differences between the pure and lipid-associated A-FABP in the 1640-1660 cm-1 region, both the protein structure and thermal stability appeared essentially unchanged upon interaction with the lipid...
  18. pmc The helical domain of intestinal fatty acid binding protein is critical for collisional transfer of fatty acids to phospholipid membranes
    B Corsico
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901 8525, USA
    Proc Natl Acad Sci U S A 95:12174-8. 1998
    ..Collectively, these results indicate that the alpha-helical region of IFABP is involved in membrane interactions and thus plays a critical role in the collisional mechanism of fatty acid transfer from IFABP to phospholipid membranes...
  19. ncbi request reprint Role of surface lysine residues of adipocyte fatty acid-binding protein in fatty acid transfer to phospholipid vesicles
    H L Liou
    Department of Nutritional Sciences, Rutgers University, 96 Lipman Drive, New Brunswick, New Jersey 08901-8525, USA
    Biochemistry 40:6475-85. 2001
    ..Furthermore, it appears that more than one distinct region, including the alphaI-helix, alphaII-helix, beta C-D turn, and the beta-A strand, is involved in these charge-charge interactions...
  20. ncbi request reprint Common mechanisms of monoacylglycerol and fatty acid uptake by human intestinal Caco-2 cells
    S Y Ho
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901-8525, USA
    Am J Physiol Cell Physiol 281:C1106-17. 2001
    ..These putative plasma membrane LCFA transporters may be involved in the uptake of sn-2-monoolein into Caco-2 cells...
  21. pmc Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis
    William Stacy Lagakos
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, USA
    Am J Physiol Gastrointest Liver Physiol 300:G803-14. 2011
    ..The metabolic changes observed in both null models appear to occur by nontranscriptional mechanisms, supporting the hypothesis that the enterocyte FABPs are specifically trafficking their ligands to their respective metabolic fates...

Research Grants28

  1. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2005
    ..Such modulation has important implications for the treatment of obesity, diabetes, and hyperlipidemias. ..
  2. Liquid Chromatography Mass Spectrometry system
    Judith Storch; Fiscal Year: 2006
    ..There are no comparable instruments at Rutgers University that are available for this research. ..
  3. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2006
    ..Such modulation has important implications for the treatment of obesity, diabetes, and hyperlipidemias. ..
  4. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2005
    ..Such modulation has important implications for the treatment of obesity, diabetes, and hyperlipidemias. ..
  5. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2003
    ..Such modulation has important implications for the treatment of obesity, diabetes, and hyperlipidemias. ..
  6. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2001
    ..The long term goal of this research is to enable the control of lipid assimilation by modulation of specific transport processes. ..
  7. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2000
    ..The long term goal of this research is to enable the control of lipid assimilation by modulation of specific transport processes. ..
  8. FATTY ACIDS TRANSPORT IN INTESTINE:STRUCTURAL ANALYSES
    Judith Storch; Fiscal Year: 2000
    ..The long term goal of this research is to enable the control of lipid assimilation by modulation of specific transport processes. ..
  9. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2000
    ..The long term goal of this research is to enable the control of lipid assimilation by modulation of specific transport processes. ..
  10. Lipid transport in the intestine
    Judith Storch; Fiscal Year: 2009
    ..These studies will enable us to understand how to regulate the rate and extent of dietary lipid assimilation. ..
  11. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 1993
    ....
  12. Lipid transport in the intestine
    Judith Storch; Fiscal Year: 2010
    ..These studies will enable us to understand how to regulate the rate and extent of dietary lipid assimilation. ..
  13. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2007
    ..Such modulation has important implications for the treatment of obesity, diabetes, and hyperlipidemias. ..
  14. Lipid transport in the intestine
    Judith Storch; Fiscal Year: 2009
    ..These studies will enable us to understand how to regulate the rate and extent of dietary lipid assimilation. ..
  15. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2004
    ..Such modulation has important implications for the treatment of obesity, diabetes, and hyperlipidemias. ..
  16. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2003
    ..The long term goal of this research is to enable the control of lipid assimilation by modulation of specific transport processes. ..
  17. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2002
    ..The long term goal of this research is to enable the control of lipid assimilation by modulation of specific transport processes. ..
  18. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 1999
    ..The long term goal of this research is to enable the control of lipid assimilation by modulation of specific transport processes. ..
  19. FATTY ACID TRANSPORT IN THE INTESTINE
    Judith Storch; Fiscal Year: 2004
    ..Such modulation has important implications for the treatment of obesity, diabetes, and hyperlipidemias. ..
  20. Lipid transport in the intestine
    Judith Storch; Fiscal Year: 2009
    ..These studies will enable us to understand how to regulate the rate and extent of dietary lipid assimilation. ..