Jason Richardson

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Microglial ion channels as potential targets for neuroprotection in Parkinson's disease
    Jason R Richardson
    Department of Environmental and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Neural Plast 2013:587418. 2013
  2. pmc Alteration of the expression of pesticide-metabolizing enzymes in pregnant mice: potential role in the increased vulnerability of the developing brain
    Marie C Fortin
    Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08854, USA
    Drug Metab Dispos 41:326-31. 2013
  3. pmc β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease
    Jason R Richardson
    Department of Environmental and Occupational Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States
    Neurotoxicology 32:640-5. 2011
  4. pmc Elevated serum pesticide levels and risk of Parkinson disease
    Jason R Richardson
    Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Arch Neurol 66:870-5. 2009
  5. pmc Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, GA 30322, United States
    Neurotoxicology 29:855-63. 2008
  6. ncbi request reprint Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    FASEB J 20:1695-7. 2006
  7. ncbi request reprint Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    Jason R Richardson
    Department of Environmental and Occupational Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School and Environmental and Occupational Health Sciences Institute, Piscataway, New Jersey 08854, USA
    Toxicol Sci 95:196-204. 2007
  8. ncbi request reprint Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1
    Cecily E Hamill
    Department of Pharmacology, Emory University School of Medicine, 5025 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    Mol Pharmacol 72:653-64. 2007
  9. pmc Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system
    Jaime M Hatcher
    Center for Neurodegenerative Disease, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Exp Neurol 204:619-30. 2007
  10. ncbi request reprint Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to Parkinson's disease-associated dopamine toxicity
    W Michael Caudle
    Department of Environmental and Occupational Health, Rollins School of Public Health and Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322 3090, USA
    Toxicol Sci 92:490-9. 2006

Collaborators

Detail Information

Publications25

  1. pmc Microglial ion channels as potential targets for neuroprotection in Parkinson's disease
    Jason R Richardson
    Department of Environmental and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Neural Plast 2013:587418. 2013
    ..This review will discuss the potential of targeting microglia to reduce neuroinflammation in PD. Further, we discuss the potential of microglial ion channels to serve as novel targets for neuroprotection in PD. ..
  2. pmc Alteration of the expression of pesticide-metabolizing enzymes in pregnant mice: potential role in the increased vulnerability of the developing brain
    Marie C Fortin
    Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08854, USA
    Drug Metab Dispos 41:326-31. 2013
    ..These data demonstrate significant alterations in the expression of key enzymes that detoxify pesticides during pregnancy, which could alter exposure of developing animals to these chemicals...
  3. pmc β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease
    Jason R Richardson
    Department of Environmental and Occupational Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States
    Neurotoxicology 32:640-5. 2011
    ..8, 4.48; p value<0.001). These data are consistent with environmental decreases in β-HCH levels between 2001 and 2008, but they indicate that elevated levels of serum β-HCH are still associated with heightened risk for PD...
  4. pmc Elevated serum pesticide levels and risk of Parkinson disease
    Jason R Richardson
    Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Arch Neurol 66:870-5. 2009
    ..Three studies have found elevated levels of organochlorine pesticides in postmortem PD brains...
  5. pmc Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, GA 30322, United States
    Neurotoxicology 29:855-63. 2008
    ..These data suggest that developmental heptachlor exposure causes long-term alterations of the dopamine system thereby rendering it more susceptible to dopaminergic damage in adulthood...
  6. ncbi request reprint Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    FASEB J 20:1695-7. 2006
    ....
  7. ncbi request reprint Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    Jason R Richardson
    Department of Environmental and Occupational Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School and Environmental and Occupational Health Sciences Institute, Piscataway, New Jersey 08854, USA
    Toxicol Sci 95:196-204. 2007
    ..Furthermore, combined with reports of a complex I defect in Parkinson's disease (PD) patients, the present study affirms the utility of MPTP in understanding the molecular mechanisms underlying dopaminergic neurodegeneration in PD...
  8. ncbi request reprint Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1
    Cecily E Hamill
    Department of Pharmacology, Emory University School of Medicine, 5025 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    Mol Pharmacol 72:653-64. 2007
    ..Together, these data suggest that PAR1 might be a target for therapeutic intervention in Parkinson's disease...
  9. pmc Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system
    Jaime M Hatcher
    Center for Neurodegenerative Disease, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Exp Neurol 204:619-30. 2007
    ..These effects represent the ability of low doses of dieldrin to increase the vulnerability of nigrostriatal dopamine neurons by inducing oxidative stress and suggest that pesticide exposure may act as a promoter of PD...
  10. ncbi request reprint Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to Parkinson's disease-associated dopamine toxicity
    W Michael Caudle
    Department of Environmental and Occupational Health, Rollins School of Public Health and Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322 3090, USA
    Toxicol Sci 92:490-9. 2006
    ..Furthermore, DAT imaging may be useful in evaluating alterations in brain function in human populations exposed to PCBs...
  11. ncbi request reprint Mechanism of toxicity in rotenone models of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:10756-64. 2003
    ..These results, using three models of increasing complexity, demonstrate the involvement of oxidative damage in rotenone toxicity and support the evaluation of antioxidant therapies for Parkinson's disease...
  12. ncbi request reprint Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum
    W Michael Caudle
    Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building 505, 615 Michael Street, Atlanta, GA 30322, USA
    Neurotoxicology 26:721-8. 2005
    ....
  13. ncbi request reprint Treadmill gait analysis does not detect motor deficits in animal models of Parkinson's disease or amyotrophic lateral sclerosis
    Thomas S Guillot
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA, USA
    J Mot Behav 40:568-77. 2008
    ..On the basis of the authors' findings, they inferred that computerized gait analysis on a motorized treadmill is not suited to measuring motor deficits in either the MPTP mouse model of PD or the SOD1 G93A mouse model of ALS...
  14. doi request reprint Disruption of dopamine transport by DDT and its metabolites
    Jaime M Hatcher
    Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, United States
    Neurotoxicology 29:682-90. 2008
    ..These data suggest elevated DDE levels in PD patients may represent a measure of general pesticide exposure and that other pesticides may be responsible for the association between pesticide exposure and PD...
  15. ncbi request reprint Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis
    Thomas S Guillot
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia, USA
    J Neurochem 106:2205-17. 2008
    ..Elevated markers of neurotoxicity in VMAT2 LO mice and cultures suggest that the capacity to store DA determines the amount of oxidative stress and neurodegeneration after METH administration...
  16. ncbi request reprint Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation
    Sampath Ramachandiran
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 95:163-71. 2007
    ..In addition, intracellular dopamine does not seem to exacerbate the toxicity of these dopaminergic neurotoxicants in this model...
  17. ncbi request reprint Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels
    Jason R Richardson
    Center for Neurodegenerative Disease and Department of Environmental and Occupational Health, Rollins School of Public Health, Whitehead Biomedical Research Building 505, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Toxicol Lett 148:29-40. 2004
    ..These data suggest that PCB-induced reductions in striatal dopamine may be mediated by alterations in DAT and VMAT2 expression...
  18. ncbi request reprint Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brain
    Kavita Prasad
    Department of Pathology and Lab Medicine, Robert Wood Johnson Medical School RWJMS, University of Medicine and Dentistry New Jersey UMDNJ, Piscataway, NJ 08854, USA
    Exp Neurol 215:358-67. 2009
    ..These findings should alter our risk assessment of this compound and demonstrate a useful, but complex dynamic model for understanding the consequences of PQ in the brain...
  19. ncbi request reprint Pyrethroid pesticide-induced alterations in dopamine transporter function
    Mohamed A Elwan
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Toxicol Appl Pharmacol 211:188-97. 2006
    ....
  20. ncbi request reprint Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
    W Michael Caudle
    Center for Neurodegenerative Disease, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 27:8138-48. 2007
    ..In addition, the altered dopamine homeostasis resulting from reduced VMAT2 function may be conducive to pathogenic mechanisms induced by genetic or environmental factors thought to be involved in Parkinson's disease...
  21. ncbi request reprint Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Rollins School of Public Health, Atlanta, Georgia 15213, USA
    J Neurochem 100:1469-79. 2007
    ....
  22. ncbi request reprint Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions
    Marcelo A Rocha
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurochem 106:231-43. 2008
    ..The absence of NHE1 co-location on DAergic neurons suggests that the effects of HOE-642 on striatal DA overflow are either mediated via NHE1 located on other cell types or that HOE-642 is acting through multiple NHE isoforms...
  23. ncbi request reprint Paraquat neurotoxicity is distinct from that of MPTP and rotenone
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 88:193-201. 2005
    ..These data indicate that, despite the apparent structural similarity to MPP+, paraquat exerts its deleterious effects on dopamine neurons in a manner that is unique from rotenone and MPTP...
  24. ncbi request reprint Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats
    Jason R Richardson
    Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762, USA
    Toxicol Sci 84:352-9. 2005
    ..In addition, the long-term reduction of brain ChE activity observed following repeated postnatal exposure to CPS is attributable to permanent inactivation or "aging" of the enzyme...
  25. ncbi request reprint Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats
    Jason R Richardson
    Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762, USA
    Toxicol Sci 77:83-90. 2004
    ..These data suggest that gestational exposure to 7 mg/kg/day CPS results in long-term alterations of presynaptic cholinergic neurochemistry...

Research Grants8

  1. Developmental Pyrethroid Exposure and Parkinsons Disease
    Jason Richardson; Fiscal Year: 2005
    ....
  2. Developmental Pyrethroid Exposure and ADHD
    Jason Richardson; Fiscal Year: 2007
    ..Therefore, the purpose of this proposal is to determine the effects of developmental pyrethroid exposure on the dopamine system and whether alterations of the dopamine system result in a behavioral phenotype similar to that of ADHD. ..
  3. Mechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHD
    Jason Richardson; Fiscal Year: 2007
    ..The investigators will then use this information to exploit this novel model to identify molecular targets for therapeutic intervention in ADHD. ..
  4. Mechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHD
    Jason Richardson; Fiscal Year: 2009
    ..The investigators will then use this information to exploit this novel model to identify molecular targets for therapeutic intervention in ADHD. ..
  5. Mechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHD
    Jason R Richardson; Fiscal Year: 2010
    ..The investigators will then use this information to exploit this novel model to identify molecular targets for therapeutic intervention in ADHD. ..
  6. Mechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHD
    Jason Richardson; Fiscal Year: 2009
    ..The investigators will then use this information to exploit this novel model to identify molecular targets for therapeutic intervention in ADHD. ..
  7. Mechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHD
    Jason R Richardson; Fiscal Year: 2010
    ....