Kim S McKim
Affiliation: Rutgers University
Das A, Cesario J, Hinman A, Jang J, McKim K. Kinesin 6 Regulation in Drosophila Female Meiosis by the Non-conserved N- and C- Terminal Domains. G3 (Bethesda). 2018;8:1555-1569 pubmed publisher
Radford S, McKim K. Techniques for Imaging Prometaphase and Metaphase of Meiosis I in Fixed Drosophila Oocytes. J Vis Exp. 2016;: pubmed publisher
McKim K. When size does not matter: pairing sites during meiosis. Cell. 2005;123:989-92 pubmed
Radford S, Nguyen A, Schindler K, McKim K. The chromosomal basis of meiotic acentrosomal spindle assembly and function in oocytes. Chromosoma. 2017;126:351-364 pubmed publisher
..The study of meiosis in oocytes has revealed mechanisms that are operating in mitosis and will probably continue to do so. ..
McKim K, Hayashi Hagihara A. mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: evidence that the mechanism for initiating meiotic recombination is conserved. Genes Dev. 1998;12:2932-42 pubmed
..In contrast to spo11, mei-W68 is not required for synaptonemal complex formation and does have a mitotic role. ..
Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al
. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
..In combination our results support a model where the meiotic central spindle and associated proteins are essential for acentrosomal chromosome segregation. ..
Gyuricza M, Manheimer K, Apte V, Krishnan B, Joyce E, McKee B, et al
. Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation. Curr Biol. 2016;26:1688-1698 pubmed publisher
..For example, a dynamic complex may allow the chromosomes to regulate meiotic recombination, and a stable complex may be required for sister-chromatid cohesion. ..
Radford S, Go A, McKim K. Cooperation Between Kinesin Motors Promotes Spindle Symmetry and Chromosome Organization in Oocytes. Genetics. 2017;205:517-527 pubmed publisher
..The activities of several proteins, including NCD, KLP54D, and ASP, generate asymmetries within the acentrosomal spindle, while KLP61F and Subito balance these forces, resulting in the capacity to accurately segregate chromosomes. ..