Charles E Martin

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi request reprint Yeast desaturases
    C E Martin
    Department of Cell Biology and Neuroscience, Bureau of Biological Research, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA
    Biochem Soc Trans 30:1080-2. 2002
  2. ncbi request reprint Regulation of long chain unsaturated fatty acid synthesis in yeast
    Charles E Martin
    Rutgers University, Department of Cell Biology and Neuroscience, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854 8082, USA
    Biochim Biophys Acta 1771:271-85. 2007
  3. ncbi request reprint Candida albicans Spt23p controls the expression of the Ole1p Delta9 fatty acid desaturase and regulates unsaturated fatty acid biosynthesis
    Chan Seok Oh
    Department of Cell Biology and Neuroscience, Nelson Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854 8082, USA
    J Biol Chem 281:7030-9. 2006
  4. ncbi request reprint Regulation of unsaturated fatty acid biosynthesis in Saccharomyces: the endoplasmic reticulum membrane protein, Mga2p, a transcription activator of the OLE1 gene, regulates the stability of the OLE1 mRNA through exosome-mediated mechanisms
    Pitchaimani Kandasamy
    Division of Life Sciences, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA
    J Biol Chem 279:36586-92. 2004
  5. ncbi request reprint Maintenance and regulation of mRNA stability of the Saccharomyces cerevisiae OLE1 gene requires multiple elements within the transcript that act through translation-independent mechanisms
    Muralikrishna Vemula
    Division of Life Sciences, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08854, USA
    J Biol Chem 278:45269-79. 2003
  6. pmc Identification of a quality-control mechanism for mRNA 5'-end capping
    Xinfu Jiao
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Nature 467:608-11. 2010
  7. ncbi request reprint The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levels
    J Y Choi
    Division of Life Sciences, the Bureau of Biological Research, Nelson Laboratories, Rutgers University, Piscataway, New Jersey 08854 808
    J Biol Chem 274:4671-83. 1999
  8. ncbi request reprint A novel cytochrome b5-like domain is linked to the carboxyl terminus of the Saccharomyces cerevisiae delta-9 fatty acid desaturase
    A G Mitchell
    Department of Biological Sciences, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 270:29766-72. 1995
  9. ncbi request reprint Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae
    D A Toke
    Department of Biological Sciences and the Bureau of Biological Research, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 271:18413-22. 1996
  10. ncbi request reprint Fatty acid-responsive control of mRNA stability. Unsaturated fatty acid-induced degradation of the Saccharomyces OLE1 transcript
    C I Gonzalez
    Department of Biological Sciences and the Bureau of Biological Research, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 271:25801-9. 1996

Research Grants

  1. Molecular and Cellular Biology of Lipids
    Charles Martin; Fiscal Year: 2007
  2. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 2002
  3. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 1992

Collaborators

  • Megerditch Kiledjian
  • Henry A Boumann
  • Anton I P M de Kroon
  • Chan Seok Oh
  • Pitchaimani Kandasamy
  • Muralikrishna Vemula
  • Xinfu Jiao
  • Ramesh Chellappa
  • C S Oh
  • A G Mitchell
  • Yide Jiang
  • R Chellappa
  • Chanseok Oh
  • Song Xiang
  • Liang Tong
  • D A Toke
  • J Y Choi
  • Carlos I Gonzalez
  • Mark A Goldberg
  • Laura Gilooly
  • Sharon Wretzel
  • Kevin McDaid
  • Michael J Vasconcelles
  • Anne Light
  • C I Gonzalez
  • M Vemula
  • P Kandasamy
  • Y Jiang
  • S Mandala
  • J E Stukey
  • V M McDonough

Detail Information

Publications16

  1. ncbi request reprint Yeast desaturases
    C E Martin
    Department of Cell Biology and Neuroscience, Bureau of Biological Research, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA
    Biochem Soc Trans 30:1080-2. 2002
    ..Surprisingly, Mga2p also plays a critical role in controlling OLE1 mRNA stability, suggesting that there may be a functional linkage between OLE1 transcription and the regulation of OLE1 mRNA stability...
  2. ncbi request reprint Regulation of long chain unsaturated fatty acid synthesis in yeast
    Charles E Martin
    Rutgers University, Department of Cell Biology and Neuroscience, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854 8082, USA
    Biochim Biophys Acta 1771:271-85. 2007
    ..OLE1 is regulated through Spt23p and Mga2p by multiple systems that control its transcription and mRNA stability in response to diverse stimuli that include nutrient fatty acids, carbon source, metal ions and the availability of oxygen...
  3. ncbi request reprint Candida albicans Spt23p controls the expression of the Ole1p Delta9 fatty acid desaturase and regulates unsaturated fatty acid biosynthesis
    Chan Seok Oh
    Department of Cell Biology and Neuroscience, Nelson Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854 8082, USA
    J Biol Chem 281:7030-9. 2006
    ..In addition we show caSPT23 is essential for the expression of one of the two Delta9 desaturase homologues in Candida and potentially other functions associated with fatty acid metabolism...
  4. ncbi request reprint Regulation of unsaturated fatty acid biosynthesis in Saccharomyces: the endoplasmic reticulum membrane protein, Mga2p, a transcription activator of the OLE1 gene, regulates the stability of the OLE1 mRNA through exosome-mediated mechanisms
    Pitchaimani Kandasamy
    Division of Life Sciences, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA
    J Biol Chem 279:36586-92. 2004
    ....
  5. ncbi request reprint Maintenance and regulation of mRNA stability of the Saccharomyces cerevisiae OLE1 gene requires multiple elements within the transcript that act through translation-independent mechanisms
    Muralikrishna Vemula
    Division of Life Sciences, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08854, USA
    J Biol Chem 278:45269-79. 2003
    ....
  6. pmc Identification of a quality-control mechanism for mRNA 5'-end capping
    Xinfu Jiao
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Nature 467:608-11. 2010
    ..We propose that Rai1 is involved in an as yet uncharacterized quality control process that ensures mRNA 5'-end integrity by an aberrant-cap-mediated mRNA decay mechanism...
  7. ncbi request reprint The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levels
    J Y Choi
    Division of Life Sciences, the Bureau of Biological Research, Nelson Laboratories, Rutgers University, Piscataway, New Jersey 08854 808
    J Biol Chem 274:4671-83. 1999
    ..Simultaneous disruption of FAA1 and FAA4, which encode long chain (C14-C18) fatty acyl-CoA synthetases, effectively blocks the import of long chain saturated and unsaturated fatty acids...
  8. ncbi request reprint A novel cytochrome b5-like domain is linked to the carboxyl terminus of the Saccharomyces cerevisiae delta-9 fatty acid desaturase
    A G Mitchell
    Department of Biological Sciences, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 270:29766-72. 1995
    ....
  9. ncbi request reprint Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae
    D A Toke
    Department of Biological Sciences and the Bureau of Biological Research, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 271:18413-22. 1996
    ..It is rapidly induced in wild type cells that are supplemented with 14:0 and is repressed when cells are supplied with 16- and 18-carbon fatty acids...
  10. ncbi request reprint Fatty acid-responsive control of mRNA stability. Unsaturated fatty acid-induced degradation of the Saccharomyces OLE1 transcript
    C I Gonzalez
    Department of Biological Sciences and the Bureau of Biological Research, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 271:25801-9. 1996
    ....
  11. ncbi request reprint ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation
    C S Oh
    Bureau of Biological Research, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 272:17376-84. 1997
    ....
  12. ncbi request reprint Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids
    A G Mitchell
    Department of Biological Sciences and the Bureau of Biological Research, Rutgers University, Nelson Laboratories, P O Box 1059, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 272:28281-8. 1997
    ....
  13. ncbi request reprint The membrane proteins, Spt23p and Mga2p, play distinct roles in the activation of Saccharomyces cerevisiae OLE1 gene expression. Fatty acid-mediated regulation of Mga2p activity is independent of its proteolytic processing into a soluble transcription act
    R Chellappa
    Division of Life Sciences and the Bureau of Biological Research, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 276:43548-56. 2001
    ..The fatty acid repression of transcription under those conditions is attenuated by Spt23Deltatm, however, suggesting that the two proteins may interact to modulate OLE1 gene expression...
  14. ncbi request reprint The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene
    J E Stukey
    Nelson Biological Laboratory, Rutgers University, Piscataway, New Jersey 08855 1059
    J Biol Chem 265:20144-9. 1990
    ....
  15. pmc Mga2p processing by hypoxia and unsaturated fatty acids in Saccharomyces cerevisiae: impact on LORE-dependent gene expression
    Yide Jiang
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Eukaryot Cell 1:481-90. 2002
    ..Data from this study suggest that the Mga2p-LORE interaction plays an important role in OLE1 expression under both normoxic and hypoxic conditions...
  16. pmc Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote
    Henry A Boumann
    Department of Biochemistry of Membranes, Bijvoet Institute, Utrecht University, 3584 CH Utrecht, The Netherlands
    Mol Biol Cell 17:1006-17. 2006
    ..The shortening and increased saturation of the PE acyl chains were shown to decrease the nonbilayer propensity of PE. The results point to a regulatory mechanism in yeast that maintains intrinsic membrane curvature in an optimal range...

Research Grants10

  1. Molecular and Cellular Biology of Lipids
    Charles Martin; Fiscal Year: 2007
    ..Proper facilities are available to accommodate handicapped individuals who will be considered equally in the selection of attendees and speakers. ..
  2. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 2002
    ..abstract_text> ..
  3. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 1992
    ....