Catherine Lawson

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Outcome of the first electron microscopy validation task force meeting
    Richard Henderson
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Structure 20:205-14. 2012
  2. pmc EMDataBank.org: unified data resource for CryoEM
    Catherine L Lawson
    Department of Chemistry and Chemical Biology and Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, 610 Taylor Road Piscataway, NJ 08854, USA
    Nucleic Acids Res 39:D456-64. 2011
  3. pmc Catabolite activator protein: DNA binding and transcription activation
    Catherine L Lawson
    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA
    Curr Opin Struct Biol 14:10-20. 2004
  4. pmc Signatures of protein-DNA recognition in free DNA binding sites
    Jason W Locasale
    Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA
    J Mol Biol 386:1054-65. 2009
  5. pmc E. coli trp repressor forms a domain-swapped array in aqueous alcohol
    Catherine L Lawson
    Rutgers University, Department of Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, USA
    Structure 12:1099-108. 2004
  6. pmc Representation of viruses in the remediated PDB archive
    Catherine L Lawson
    RCSB Protein Data Bank, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 8087, USA
    Acta Crystallogr D Biol Crystallogr . 2008
  7. pmc Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae
    Catherine L Lawson
    Department of Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, USA
    J Bacteriol 188:4522-30. 2006
  8. ncbi request reprint Structural basis of transcription activation: the CAP-alpha CTD-DNA complex
    Brian Benoff
    Waksman Institute and Department of Chemistry, Howard Hughes Medical Institute, Rutgers University, Piscataway, NJ 08854, USA
    Science 297:1562-6. 2002
  9. pmc Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps
    Andrew A Napoli
    Department of Chemistry and Chemical Biology and Waksman Institute Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Mol Biol 357:173-83. 2006
  10. ncbi request reprint A structure-based method for identifying DNA-binding proteins and their sites of DNA-interaction
    William A McLaughlin
    Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 8087, USA
    J Struct Funct Genomics 5:255-65. 2004

Research Grants

  1. BIOMOLECULAR STRUCTURE AND INTERACTIONS
    Catherine Lawson; Fiscal Year: 2003
  2. Complexes of CAP in Transcription Activation
    Catherine Lawson; Fiscal Year: 2006
  3. Complexes of CAP in Transcription Activation
    Catherine Lawson; Fiscal Year: 2007
  4. Complexes of CAP in Transcription Activation
    Catherine Lawson; Fiscal Year: 2009

Collaborators

Detail Information

Publications19

  1. pmc Outcome of the first electron microscopy validation task force meeting
    Richard Henderson
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Structure 20:205-14. 2012
    ..The specific recommendations resulting from the workshop aim to increase the impact of 3DEM in biology and medicine...
  2. pmc EMDataBank.org: unified data resource for CryoEM
    Catherine L Lawson
    Department of Chemistry and Chemical Biology and Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, 610 Taylor Road Piscataway, NJ 08854, USA
    Nucleic Acids Res 39:D456-64. 2011
    ....
  3. pmc Catabolite activator protein: DNA binding and transcription activation
    Catherine L Lawson
    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA
    Curr Opin Struct Biol 14:10-20. 2004
    ....
  4. pmc Signatures of protein-DNA recognition in free DNA binding sites
    Jason W Locasale
    Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA
    J Mol Biol 386:1054-65. 2009
    ..Together, our findings show that crystal structures of free DNA binding sites provide new information about the nature of protein-DNA interactions and thus lend insights towards a structural code for DNA recognition...
  5. pmc E. coli trp repressor forms a domain-swapped array in aqueous alcohol
    Catherine L Lawson
    Rutgers University, Department of Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, USA
    Structure 12:1099-108. 2004
    ..Small angle X-ray scattering measurements show that the self-association properties of trpR in solution are fundamentally altered by isopropanol...
  6. pmc Representation of viruses in the remediated PDB archive
    Catherine L Lawson
    RCSB Protein Data Bank, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 8087, USA
    Acta Crystallogr D Biol Crystallogr . 2008
    ..Complete correct information for building full assemblies, subassemblies and crystal asymmetric units of all virus entries is now available in the remediated PDB archive...
  7. pmc Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae
    Catherine L Lawson
    Department of Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, USA
    J Bacteriol 188:4522-30. 2006
    ....
  8. ncbi request reprint Structural basis of transcription activation: the CAP-alpha CTD-DNA complex
    Brian Benoff
    Waksman Institute and Department of Chemistry, Howard Hughes Medical Institute, Rutgers University, Piscataway, NJ 08854, USA
    Science 297:1562-6. 2002
    ..There are no large-scale conformational changes in CAP and alphaCTD, and the interface between CAP and alphaCTD is small. These findings are consistent with the proposal that activation involves a simple "recruitment" mechanism...
  9. pmc Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps
    Andrew A Napoli
    Department of Chemistry and Chemical Biology and Waksman Institute Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Mol Biol 357:173-83. 2006
    ....
  10. ncbi request reprint A structure-based method for identifying DNA-binding proteins and their sites of DNA-interaction
    William A McLaughlin
    Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 8087, USA
    J Struct Funct Genomics 5:255-65. 2004
    ..For each of the candidate structures, possible sites of DNA-binding are indicated by listing the residue ranges of alpha helices likely to interact with DNA...
  11. pmc Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domain
    Samuel Lara-Gonzalez
    Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA
    Acta Crystallogr D Biol Crystallogr 66:806-12. 2010
    ..The new coordinates will facilitate the improved modeling of alphaCTD-containing multi-component complexes visualized at lower resolution using X-ray crystallography and electron-microscopy reconstruction...
  12. pmc Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
    Brian P Hudson
    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 106:19830-5. 2009
    ..The structure also reveals the positions and shapes of species-specific domains within the RNAP beta', beta, and sigma(70) subunits...
  13. ncbi request reprint Biophysical characterization of natural and mutant fluorescent proteins cloned from zooxanthellate corals
    Yi Sun
    Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers University, 71 Dudley Road, New Brunswick, NJ 08901, USA
    FEBS Lett 570:175-83. 2004
    ..Time-resolved emission lifetimes and anisotropies suggest that the electronic structure of the chromophore is highly dependent on the protonation state of adjoining residues...
  14. ncbi request reprint Crystals of trp repressor suitable for high-resolution neutron Laue diffraction studies
    Brenda V Daniels
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Acta Crystallogr D Biol Crystallogr 59:136-8. 2003
    ..Direct observation of hydrogen bonding between protein and solvent should enhance understanding of the role of solvent in protein-DNA recognition...
  15. ncbi request reprint Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target
    Michael Becker
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Biol Chem 280:17363-70. 2005
    ..OspB structure, stability, and possible mechanisms of killing by H6831 and other bactericidal Fabs are discussed in light of the structural data...
  16. ncbi request reprint Approaches toward the directed design of a vaccine against Borrelia burgdorferi
    Benjamin J Luft
    Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8160, USA
    J Infect Dis 185:S46-51. 2002
    ..Detailed epitope mapping will provide the information needed for the bioengineering of antigens needed to expand the specificity of a candidate vaccine...
  17. ncbi request reprint Design of a data model for developing laboratory information management and analysis systems for protein production
    Anne Pajon
    EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    Proteins 58:278-84. 2005
    ..The model is described in Unified Modeling Language (UML). In addition, we present relational database schemas derived from the UML. These relational schemas are already in use in a number of data management projects...
  18. pmc Remediation of the protein data bank archive
    Kim Henrick
    MSD EBI, EMBL Outstation Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 36:D426-33. 2008
    ..The scope and methods used in this project are presented...
  19. ncbi request reprint Residual brain infection in relapsing-fever borreliosis
    Diego Cadavid
    Department of Neurology and Neuroscience and Center for the Study of Emerging Pathogens, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103, USA
    J Infect Dis 193:1451-8. 2006
    ..Less understood is the persistence of RF borreliae in the brain after they are cleared from the blood, referred to as residual brain infection (RBI). Our goal was to investigate the phenomenon of RBI in RF...

Research Grants5

  1. BIOMOLECULAR STRUCTURE AND INTERACTIONS
    Catherine Lawson; Fiscal Year: 2003
    ..In addition, we are determining the structures of selected oligonucleotides in an attempt to understand the effects of sequence and environment on DNA structure. ..
  2. Complexes of CAP in Transcription Activation
    Catherine Lawson; Fiscal Year: 2006
    ..The proposed studies of the CAP system provide a means to rapidly advance our understanding of fundamental structural principles underlying transcriptional control. ..
  3. Complexes of CAP in Transcription Activation
    Catherine Lawson; Fiscal Year: 2007
    ..The proposed studies of the CAP system provide a means to rapidly advance our understanding of fundamental structural principles underlying transcriptional control. ..
  4. Complexes of CAP in Transcription Activation
    Catherine Lawson; Fiscal Year: 2009
    ..The proposed studies of the CAP system provide a means to rapidly advance our understanding of fundamental structural principles underlying transcriptional control. ..