JEFFREY LASKIN

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Activation of adherent vascular neutrophils in the lung during acute endotoxemia
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Respir Res 3:21. 2002
  2. doi request reprint Oxidants and antioxidants in sulfur mustard-induced injury
    Jeffrey D Laskin
    Department of Environmental and Occupation Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:92-100. 2010
  3. ncbi request reprint Prooxidant and antioxidant functions of nitric oxide in liver toxicity
    J D Laskin
    Department of Environmental and Community Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 3:261-71. 2001
  4. ncbi request reprint Superoxide dismutase-overexpressing mice are resistant to ozone-induced tissue injury and increases in nitric oxide and tumor necrosis factor-alpha
    Ladan Fakhrzadeh
    Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, NJ, USA
    Am J Respir Cell Mol Biol 30:280-7. 2004
  5. ncbi request reprint Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity
    Donna M Dambach
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 211:157-65. 2006
  6. ncbi request reprint Activation of type II alveolar epithelial cells during acute endotoxemia
    Vasanthi R Sunil
    Department of Toxicology and Pharmacology, Rutgers University, 170 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Am J Physiol Lung Cell Mol Physiol 282:L872-80. 2002
  7. ncbi request reprint Acute endotoxemia prolongs the survival of rat lung neutrophils in response to 12-O-tetradecanoyl-phorbol 13-acetate
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    J Cell Physiol 190:382-9. 2002
  8. ncbi request reprint Deficiency in inducible nitric oxide synthase protects mice from ozone-induced lung inflammation and tissue injury
    Ladan Fakhrzadeh
    Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    Am J Respir Cell Mol Biol 26:413-9. 2002
  9. ncbi request reprint UVB light suppresses nitric oxide production by murine keratinocytes and macrophages
    Runa Sur
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Biochem Pharmacol 64:1469-81. 2002
  10. pmc Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 245:352-60. 2010

Research Grants

  1. A molecular target for nutrients in the prostate
    JEFFREY LASKIN; Fiscal Year: 2007

Collaborators

Detail Information

Publications55

  1. pmc Activation of adherent vascular neutrophils in the lung during acute endotoxemia
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Respir Res 3:21. 2002
    ..In the present study, we analyzed the effects of acute endotoxemia on the response of a unique subpopulation of neutrophils tightly adhered to the lung vasculature...
  2. doi request reprint Oxidants and antioxidants in sulfur mustard-induced injury
    Jeffrey D Laskin
    Department of Environmental and Occupation Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:92-100. 2010
    ..These data indicate that drugs that target oxidative stress pathways may represent important candidates for reducing SM-induced tissue injury...
  3. ncbi request reprint Prooxidant and antioxidant functions of nitric oxide in liver toxicity
    J D Laskin
    Department of Environmental and Community Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 3:261-71. 2001
    ....
  4. ncbi request reprint Superoxide dismutase-overexpressing mice are resistant to ozone-induced tissue injury and increases in nitric oxide and tumor necrosis factor-alpha
    Ladan Fakhrzadeh
    Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, NJ, USA
    Am J Respir Cell Mol Biol 30:280-7. 2004
    ..This response was significantly reduced in SOD+/+ mice. These data demonstrate that antioxidant enzymes play a critical role in ozone-induced tissue injury and in inflammatory mediator production...
  5. ncbi request reprint Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity
    Donna M Dambach
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 211:157-65. 2006
    ..However, NF-kappaB p50-dependent responses do not appear to play a major role in the pathogenesis of toxicity in this model...
  6. ncbi request reprint Activation of type II alveolar epithelial cells during acute endotoxemia
    Vasanthi R Sunil
    Department of Toxicology and Pharmacology, Rutgers University, 170 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Am J Physiol Lung Cell Mol Physiol 282:L872-80. 2002
    ..In contrast, IRF-1 activation was delayed in AM. These data demonstrate that type II cells, like AM, are highly responsive during acute endotoxemia and may contribute to pulmonary inflammation...
  7. ncbi request reprint Acute endotoxemia prolongs the survival of rat lung neutrophils in response to 12-O-tetradecanoyl-phorbol 13-acetate
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    J Cell Physiol 190:382-9. 2002
    ..Moreover, this response was independent of TPA. These data suggest that NF-kappaB plays a role in TPA-induced signaling leading to prolonged survival of adherent vascular neutrophils in the lung during acute endotoxemia...
  8. ncbi request reprint Deficiency in inducible nitric oxide synthase protects mice from ozone-induced lung inflammation and tissue injury
    Ladan Fakhrzadeh
    Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    Am J Respir Cell Mol Biol 26:413-9. 2002
    ..Taken together, these data demonstrate that NO, produced via NOSII, and potentially, its reactive oxidative product peroxynitrite, play a critical role in ozone-induced release of inflammatory mediators and in tissue injury...
  9. ncbi request reprint UVB light suppresses nitric oxide production by murine keratinocytes and macrophages
    Runa Sur
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Biochem Pharmacol 64:1469-81. 2002
    ..In contrast, in keratinocytes, inhibition occurs downstream of NOS2 promoter activity...
  10. pmc Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 245:352-60. 2010
    ..Inhibiting the capacity of keratinocytes to generate eicosanoids may be important in limiting inflammation and protecting the skin from vesicant-induced oxidative stress and injury...
  11. ncbi request reprint Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells
    Blase Billack
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Am J Physiol Cell Physiol 283:C1267-77. 2002
    ..These data indicate that both ERK1/2 kinase and p38 kinase play a role in regulating HSP60-induced expression of COX-2...
  12. ncbi request reprint Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice
    Hawjyh Chiu
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 193:218-27. 2003
    ..Delayed cytokine signaling may account for reduced hepatocyte proliferation and contribute to exaggerated acetaminophen-induced hepatotoxicity in TNFR1-/- mice...
  13. pmc Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation
    Ladan Fakhrzadeh
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 227:380-9. 2008
    ....
  14. pmc Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia
    Li C Chen
    Rutgers University, Piscataway, New Jersey 08854, USA
    Exp Mol Pathol 84:145-55. 2008
    ..These results suggest that TREM proteins are important in the inflammatory response of hepatic macrophages and endothelial cells to acute endotoxemia...
  15. ncbi request reprint Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia
    Nosheen Ahmad
    Rutgers University and University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Leukoc Biol 71:1005-11. 2002
    ..Moreover, nitric oxide is involved in regulating COX-2 in activated liver macrophages during acute endotoxemia...
  16. ncbi request reprint Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense
    Hawjyh Chiu
    Dept of Pharmacology and Toxicology, Rutgers Univ, 170 Frelinghuysen Rd, Piscataway, NJ 08854 8020, USA
    Am J Physiol Gastrointest Liver Physiol 285:G959-66. 2003
    ..Reduced generation of antioxidants may contribute to the increased sensitivity of TNFR1-/- mice to acetaminophen...
  17. ncbi request reprint Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators
    Carol R Gardner
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 192:119-30. 2003
    ..In contrast, increases in IL-10 were more rapid and more pronounced. These data demonstrate that signaling through TNFR1 is important in inflammatory mediator production and toxicity induced by acetaminophen...
  18. pmc Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 249:178-87. 2010
    ..These effects are similar to human responses to vesicants in vivo and suggest that the full thickness skin equivalent is a useful in vitro model to characterize the biological effects of mustards and to develop potential therapeutics...
  19. pmc Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia
    Li C Chen
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Exp Mol Pathol 83:311-26. 2007
    ..These studies demonstrate that liver macrophages and endothelial cells are highly responsive to acute endotoxemia. Moreover, this activity is largely dependent on TLR-4...
  20. doi request reprint Inflammatory effects of inhaled sulfur mustard in rat lung
    Rama Malaviya
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 248:89-99. 2010
    ..These data demonstrate that SM-induced oxidative stress and injury are associated with the generation of cytotoxic inflammatory proteins which may contribute to the pathogenic response to this vesicant...
  21. pmc Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity
    Carol R Gardner
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 245:36-46. 2010
    ..Taken together, these data demonstrate that Cav-1 plays a role in promoting inflammation and toxicity during the pathogenesis of acetaminophen-induced injury...
  22. pmc Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 250:245-55. 2011
    ..These effects were most notable in the airways. These data suggest that targeting TNF╬▒ signaling may be useful in mitigating lung injury, inflammation and functional alterations induced by vesicants...
  23. pmc Pulmonary effects of inhaled diesel exhaust in aged mice
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 241:283-93. 2009
    ..Taken together, these results suggest that altered generation of inflammatory mediators and MnSOD may contribute to increased susceptibility of older mice to inhaled DE...
  24. pmc Macrophages, reactive nitrogen species, and lung injury
    Debra L Laskin
    Rutgers University, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:60-5. 2010
    ..The fact that expression of caveolin-1 is down-regulated in macrophages after ozone inhalation suggests a mechanism controlling the release of cytotoxic mediators by these inflammatory cells...
  25. pmc Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    J Leukoc Biol 88:373-82. 2010
    ..These data suggest that MSP/STK signaling plays a role in up-regulating macrophage and endothelial cell anti-inflammatory activity during hepatic inflammatory responses. This may be important in protecting the liver from tissue injury...
  26. pmc Pulmonary effects of inhaled limonene ozone reaction products in elderly rats
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 222:211-20. 2007
    ..LOP are pulmonary irritants inducing distinct inflammatory responses in younger and older animals. This may contribute to the differential sensitivity of these populations to pulmonary irritants...
  27. pmc Macrophages and tissue injury: agents of defense or destruction?
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 51:267-88. 2011
    ....
  28. ncbi request reprint Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Exp Mol Pathol 83:177-87. 2007
    ..These data suggest that the acute phase response to acute endotoxemia involves induction of 24p3 in both the lung and liver. This protein may be important in restoring tissue homeostasis following LPS-induced injury...
  29. ncbi request reprint UVB light stimulates production of reactive oxygen species: unexpected role for catalase
    Diane E Heck
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 278:22432-6. 2003
    ..Accumulation of excessive ROS, generated through the action of catalase, may lead to oxidative stress, DNA damage, and the development of skin cancer...
  30. ncbi request reprint Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50
    Ladan Fakhrzadeh
    Department of Pharmacology and ToxicologyRutgers University, Piscataway, NJ 08854, USA
    Am J Physiol Lung Cell Mol Physiol 287:L279-85. 2004
    ..These findings demonstrate that NF-kappaB and possibly C/EBP signaling are important in ozone-induced production of reactive nitrogen intermediates and TNF-alpha and in tissue injury...
  31. ncbi request reprint Characterization of the oxidase activity in mammalian catalase
    Anna M Vetrano
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:35372-81. 2005
    ..Our results describe a novel function for catalase potentially important in metabolism of endogenous substrates and in the action of carcinogens and chemopreventative agents...
  32. ncbi request reprint The ribotoxic stress response as a potential mechanism for MAP kinase activation in xenobiotic toxicity
    Jeffrey D Laskin
    Department of Environmental and Community Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Toxicol Sci 69:289-91. 2002
  33. ncbi request reprint Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity
    Debra L Laskin
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey, Piscataway, USA
    Mol Cell Biochem 234:91-8. 2002
    ..Taken together, these data suggest that biochemical signaling pathways that control the expression of genes critical for the inflammatory process play a role in ozone toxicity...
  34. ncbi request reprint An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis
    Diane E Heck
    Departments of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicology 208:259-71. 2005
    ....
  35. ncbi request reprint Influence of labor on neonatal neutrophil apoptosis, and inflammatory activity
    Barry Weinberger
    Department of Pediatrics Neonatology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Pediatr Res 61:572-7. 2007
    ..Although increased neutrophil longevity after labor is important for host defense in the immediate newborn period, it may contribute to inflammatory or oxidative injury in susceptible infants...
  36. pmc Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries
    SivaNaga S Anumolu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8022, USA
    Biomaterials 32:1204-17. 2011
    ..In conclusion, PEG-based doxycycline hydrogels are promising for dermal wound healing application of mustard injuries...
  37. pmc Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity
    Yun Wang
    Environmental and Occupational Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cancer Ther 9:1852-63. 2010
    ..These data indicate that NADPH cytochrome P450 reductase-mediated MMC redox cycling is not involved in the cytotoxicity of this chemotherapeutic agent...
  38. doi request reprint Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 250:10-8. 2011
    ..Understanding the nature of the injury induced by nitrogen mustard and related analogs may aid in the development of efficacious therapies for treatment of pulmonary injury resulting from exposure to vesicants...
  39. pmc Mechanisms mediating the biologic activity of synthetic proline, glycine, and hydroxyproline polypeptides in human neutrophils
    Barry Weinberger
    Division of Neonatology, Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Mediators Inflamm 2005:31-8. 2005
    ..However, distinct calcium-independent signaling pathways appear to be involved in these activities...
  40. ncbi request reprint Cell-impermeant pyridinium derivatives of psoralens as inhibitors of keratinocyte growth
    Thomas M Mariano
    Department of Environmental and Community Medicine, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Biochem Pharmacol 63:31-9. 2002
    ..These findings further support the model that the cell membrane is an important target for the psoralens...
  41. pmc Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes
    Adrienne T Black
    Department of Pharmacology and Toxicology, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 29:219-25. 2008
    ..Moreover, MAP kinases are critical regulators of this response. Alterations in antioxidants are likely to be important mechanisms for protecting the skin from UVB-induced oxidative stress...
  42. ncbi request reprint Solar ultraviolet radiation as a trigger of cell signal transduction
    Diane E Heck
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 195:288-97. 2004
    ..The present review summarizes some of the mechanisms by which ultraviolet light alters signaling pathways as well as the genes important in the beneficial and toxic effects of ultraviolet light...
  43. pmc Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells
    Yi Hua Jan
    Environmental and Occupational Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Chem Res Toxicol 23:1045-53. 2010
    ..Taken together, these data suggest that sulfur mustard vesicants target TrxR and that this may be an important mechanism mediating oxidative stress and tissue injury...
  44. ncbi request reprint Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase
    Joshua P Gray
    Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:7939-49. 2007
    ..Reactive oxygen intermediates and subsequent oxidative stress generated from this enzyme are likely to contribute to paraquat-induced lung toxicity...
  45. doi request reprint Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity
    Yun Wang
    Department of Environmental and Occupational Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Free Radic Biol Med 44:1169-79. 2008
    ....
  46. pmc Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4
    Barry Weinberger
    Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA
    Pediatr Res 64:393-8. 2008
    ..This may contribute to diseases associated with chronic inflammation in neonates...
  47. pmc Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes
    Vladimir Mishin
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Free Radic Biol Med 48:1485-91. 2010
    ..Moreover, substrate binding is not required for the cytochrome P450s to generate reactive oxygen species...
  48. ncbi request reprint Percutaneous absorption of trihalomethanes, haloacetic acids, and haloketones
    Xu Xu
    Joint Graduate Program in Exposure Measurement and Assessment, Rutgers University and UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Toxicol Appl Pharmacol 184:19-26. 2002
    ..In addition to ingestion, dermal absorption is an important route of exposure to THMs and HKs and must be considered in models of risk assessment...
  49. pmc Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat
    Adrienne T Black
    Department of Pharmacology and Toxicology, Rutgers University, USA
    Toxicol Appl Pharmacol 231:384-92. 2008
    ..These intracellular proteins may be important in protecting the skin from paraquat-mediated cytotoxicity...
  50. pmc UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes
    Adrienne T Black
    Department of Pharmacology and Toxicology, Rutgers University, USA
    Toxicol Appl Pharmacol 232:14-24. 2008
    ..Moreover, both the capacity of keratinocytes to generate prostaglandins and their ability to respond to these lipid mediators are stimulated by exposure to UVB...
  51. ncbi request reprint Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10
    Carol R Gardner
    Environmental and Occupational Health Sciences Institute, Rutgers University, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway 08854, USA
    Toxicol Appl Pharmacol 184:27-36. 2002
    ..Moreover, some of its effects may be mediated by altering production of pro- and antiinflammatory cytokines and proteins important in tissue repair...
  52. ncbi request reprint Mechanisms underlying reduced apoptosis in neonatal neutrophils
    Nazeeh Hanna
    Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, New Brunswick, NJ 08903, USA
    Pediatr Res 57:56-62. 2005
    ..This may be related to decreased expression of both FasR and Bcl-2-family proteins that mediate neutrophil apoptosis...
  53. ncbi request reprint Oxygen toxicity in premature infants
    Barry Weinberger
    Department of Pediatrics Neonatology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Toxicol Appl Pharmacol 181:60-7. 2002
    ..These include limiting oxygen supplementation and light exposure, the use of antiinflammatory agents or antioxidants, and the use of room air in neonatal resuscitation...
  54. ncbi request reprint Inhibition of interferon-gamma signaling by a mercurio-substituted dihydropsoralen in murine keratinocytes
    Christine A Martey
    Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA
    Biochem Pharmacol 70:1726-34. 2005
    ..Inhibition of AP-1 suggests that the psoralen functions by interfering with an important transcription factor that regulates expression of NOS2 in keratinocytes...
  55. ncbi request reprint Mechanisms of growth inhibition in keratinocytes by mercurio-substituted 4',5'-dihydropsoralens
    Christine A Martey
    Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA
    Biochem Pharmacol 63:2001-9. 2002
    ..Taken together, our data demonstrate that there are multiple sites of action for mercuriopsoralens. These compounds may prove useful for understanding the mechanisms of psoralen-induced growth inhibition in the skin...

Research Grants7

  1. A molecular target for nutrients in the prostate
    JEFFREY LASKIN; Fiscal Year: 2007
    ..We will also assess the effects of dietary nutrients on this enzyme activity in prostate cells. These studies will provide important information on a unique target for chemopreventative agents in the prostate. ..