DEBRA LYNN LASKIN

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi request reprint Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity
    Debra L Laskin
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey, Piscataway, USA
    Mol Cell Biochem 234:91-8. 2002
  2. pmc Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflammation
    Angela M Groves
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Am J Respir Cell Mol Biol 47:776-83. 2012
  3. pmc Activation of adherent vascular neutrophils in the lung during acute endotoxemia
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Respir Res 3:21. 2002
  4. ncbi request reprint Role of macrophages and inflammatory mediators in chemically induced toxicity
    D L Laskin
    Environmental and Occupational Health Sciences Institute, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicology 160:111-8. 2001
  5. ncbi request reprint The ribotoxic stress response as a potential mechanism for MAP kinase activation in xenobiotic toxicity
    Jeffrey D Laskin
    Department of Environmental and Community Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Toxicol Sci 69:289-91. 2002
  6. pmc Increased nitric oxide synthase in the lung after ozone inhalation is associated with activation of NF-kappa B
    D L Laskin
    Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Environ Health Perspect 106:1175-8. 1998
  7. pmc Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    J Leukoc Biol 88:373-82. 2010
  8. pmc Macrophages, reactive nitrogen species, and lung injury
    Debra L Laskin
    Rutgers University, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:60-5. 2010
  9. pmc Macrophages and tissue injury: agents of defense or destruction?
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 51:267-88. 2011
  10. ncbi request reprint Functional heterogeneity in liver and lung macrophages
    D L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey, USA
    J Leukoc Biol 70:163-70. 2001

Research Grants

  1. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    DEBRA LYNN LASKIN; Fiscal Year: 2010
  2. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    Debra Laskin; Fiscal Year: 2001
  3. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2001
  4. Macrophages and Inflammatory Mediators in Silica-Induced Carcinogenesis
    DEBRA LYNN LASKIN; Fiscal Year: 2010
  5. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
  6. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2007
  7. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    Debra Laskin; Fiscal Year: 2006
  8. ROLE OF KUPFFER CELLS IN CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 1992
  9. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    Debra Laskin; Fiscal Year: 1993

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity
    Debra L Laskin
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey, Piscataway, USA
    Mol Cell Biochem 234:91-8. 2002
    ..Taken together, these data suggest that biochemical signaling pathways that control the expression of genes critical for the inflammatory process play a role in ozone toxicity...
  2. pmc Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflammation
    Angela M Groves
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Am J Respir Cell Mol Biol 47:776-83. 2012
    ....
  3. pmc Activation of adherent vascular neutrophils in the lung during acute endotoxemia
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Respir Res 3:21. 2002
    ..In the present study, we analyzed the effects of acute endotoxemia on the response of a unique subpopulation of neutrophils tightly adhered to the lung vasculature...
  4. ncbi request reprint Role of macrophages and inflammatory mediators in chemically induced toxicity
    D L Laskin
    Environmental and Occupational Health Sciences Institute, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicology 160:111-8. 2001
    ..Our results suggest that the extent to which a particular mediator contributes to injury depends on the nature of the toxicant, the target tissue, and quantities of the mediator produced...
  5. ncbi request reprint The ribotoxic stress response as a potential mechanism for MAP kinase activation in xenobiotic toxicity
    Jeffrey D Laskin
    Department of Environmental and Community Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Toxicol Sci 69:289-91. 2002
  6. pmc Increased nitric oxide synthase in the lung after ozone inhalation is associated with activation of NF-kappa B
    D L Laskin
    Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Environ Health Perspect 106:1175-8. 1998
    ..Taken together, these data suggest that changes in the activity of NF-kappa B signaling are important in the response of lung macrophages and type II epithelial cells to cytokines after ozone inhalation...
  7. pmc Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    J Leukoc Biol 88:373-82. 2010
    ..These data suggest that MSP/STK signaling plays a role in up-regulating macrophage and endothelial cell anti-inflammatory activity during hepatic inflammatory responses. This may be important in protecting the liver from tissue injury...
  8. pmc Macrophages, reactive nitrogen species, and lung injury
    Debra L Laskin
    Rutgers University, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:60-5. 2010
    ..The fact that expression of caveolin-1 is down-regulated in macrophages after ozone inhalation suggests a mechanism controlling the release of cytotoxic mediators by these inflammatory cells...
  9. pmc Macrophages and tissue injury: agents of defense or destruction?
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    Annu Rev Pharmacol Toxicol 51:267-88. 2011
    ....
  10. ncbi request reprint Functional heterogeneity in liver and lung macrophages
    D L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey, USA
    J Leukoc Biol 70:163-70. 2001
    ..Evidence suggests that these represent distinct cell populations with unique functions and responsiveness to inflammatory agents...
  11. ncbi request reprint Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50
    Ladan Fakhrzadeh
    Department of Pharmacology and ToxicologyRutgers University, Piscataway, NJ 08854, USA
    Am J Physiol Lung Cell Mol Physiol 287:L279-85. 2004
    ..These findings demonstrate that NF-kappaB and possibly C/EBP signaling are important in ozone-induced production of reactive nitrogen intermediates and TNF-alpha and in tissue injury...
  12. pmc Role of nitric oxide in hematosuppression and benzene-induced toxicity
    D L Laskin
    Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey, USA
    Environ Health Perspect 104:1283-7. 1996
    ..Taken together, these data suggest that nitric oxide may be an important mediator of benzene-induced bone marrow suppression...
  13. ncbi request reprint Superoxide dismutase-overexpressing mice are resistant to ozone-induced tissue injury and increases in nitric oxide and tumor necrosis factor-alpha
    Ladan Fakhrzadeh
    Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, NJ, USA
    Am J Respir Cell Mol Biol 30:280-7. 2004
    ..This response was significantly reduced in SOD+/+ mice. These data demonstrate that antioxidant enzymes play a critical role in ozone-induced tissue injury and in inflammatory mediator production...
  14. ncbi request reprint Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity
    Donna M Dambach
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 211:157-65. 2006
    ..However, NF-kappaB p50-dependent responses do not appear to play a major role in the pathogenesis of toxicity in this model...
  15. ncbi request reprint Activation of type II alveolar epithelial cells during acute endotoxemia
    Vasanthi R Sunil
    Department of Toxicology and Pharmacology, Rutgers University, 170 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Am J Physiol Lung Cell Mol Physiol 282:L872-80. 2002
    ..In contrast, IRF-1 activation was delayed in AM. These data demonstrate that type II cells, like AM, are highly responsive during acute endotoxemia and may contribute to pulmonary inflammation...
  16. ncbi request reprint Deficiency in inducible nitric oxide synthase protects mice from ozone-induced lung inflammation and tissue injury
    Ladan Fakhrzadeh
    Environmental and Occupational Health Science Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    Am J Respir Cell Mol Biol 26:413-9. 2002
    ..Taken together, these data demonstrate that NO, produced via NOSII, and potentially, its reactive oxidative product peroxynitrite, play a critical role in ozone-induced release of inflammatory mediators and in tissue injury...
  17. ncbi request reprint Acute endotoxemia prolongs the survival of rat lung neutrophils in response to 12-O-tetradecanoyl-phorbol 13-acetate
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    J Cell Physiol 190:382-9. 2002
    ..Moreover, this response was independent of TPA. These data suggest that NF-kappaB plays a role in TPA-induced signaling leading to prolonged survival of adherent vascular neutrophils in the lung during acute endotoxemia...
  18. ncbi request reprint Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells
    Blase Billack
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Am J Physiol Cell Physiol 283:C1267-77. 2002
    ..These data indicate that both ERK1/2 kinase and p38 kinase play a role in regulating HSP60-induced expression of COX-2...
  19. pmc Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 245:352-60. 2010
    ..Inhibiting the capacity of keratinocytes to generate eicosanoids may be important in limiting inflammation and protecting the skin from vesicant-induced oxidative stress and injury...
  20. pmc Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia
    Li C Chen
    Rutgers University, Piscataway, New Jersey 08854, USA
    Exp Mol Pathol 84:145-55. 2008
    ..These results suggest that TREM proteins are important in the inflammatory response of hepatic macrophages and endothelial cells to acute endotoxemia...
  21. pmc Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation
    Ladan Fakhrzadeh
    Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 227:380-9. 2008
    ....
  22. ncbi request reprint Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice
    Hawjyh Chiu
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 193:218-27. 2003
    ..Delayed cytokine signaling may account for reduced hepatocyte proliferation and contribute to exaggerated acetaminophen-induced hepatotoxicity in TNFR1-/- mice...
  23. ncbi request reprint Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10
    Carol R Gardner
    Environmental and Occupational Health Sciences Institute, Rutgers University, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway 08854, USA
    Toxicol Appl Pharmacol 184:27-36. 2002
    ..Moreover, some of its effects may be mediated by altering production of pro- and antiinflammatory cytokines and proteins important in tissue repair...
  24. ncbi request reprint Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia
    Nosheen Ahmad
    Rutgers University and University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Leukoc Biol 71:1005-11. 2002
    ..Moreover, nitric oxide is involved in regulating COX-2 in activated liver macrophages during acute endotoxemia...
  25. ncbi request reprint Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense
    Hawjyh Chiu
    Dept of Pharmacology and Toxicology, Rutgers Univ, 170 Frelinghuysen Rd, Piscataway, NJ 08854 8020, USA
    Am J Physiol Gastrointest Liver Physiol 285:G959-66. 2003
    ..Reduced generation of antioxidants may contribute to the increased sensitivity of TNFR1-/- mice to acetaminophen...
  26. ncbi request reprint Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators
    Carol R Gardner
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 192:119-30. 2003
    ..In contrast, increases in IL-10 were more rapid and more pronounced. These data demonstrate that signaling through TNFR1 is important in inflammatory mediator production and toxicity induced by acetaminophen...
  27. ncbi request reprint Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse
    Donna M Dambach
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Hepatology 35:1093-103. 2002
    ..In conclusion, these data indicate that MCP-1 and CCR2 contribute to the recruitment of a subset of activated macrophages into the liver during acetaminophen-induced hepatotoxicity that may be important in resolution of tissue injury...
  28. doi request reprint Inflammatory effects of inhaled sulfur mustard in rat lung
    Rama Malaviya
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 248:89-99. 2010
    ..These data demonstrate that SM-induced oxidative stress and injury are associated with the generation of cytotoxic inflammatory proteins which may contribute to the pathogenic response to this vesicant...
  29. pmc Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia
    Li C Chen
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Exp Mol Pathol 83:311-26. 2007
    ..These studies demonstrate that liver macrophages and endothelial cells are highly responsive to acute endotoxemia. Moreover, this activity is largely dependent on TLR-4...
  30. ncbi request reprint Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin
    Hawjyh Chiu
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Toxicol Appl Pharmacol 181:106-15. 2002
    ..Pretreatment of rats with biliverdin (40 micromol/kg, ip) was also found to block acetaminophen-induced injury. These data suggest that HO-1 is an important component of antioxidant defense during acetaminophen-induced hepatotoxicity...
  31. pmc Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 249:178-87. 2010
    ..These effects are similar to human responses to vesicants in vivo and suggest that the full thickness skin equivalent is a useful in vitro model to characterize the biological effects of mustards and to develop potential therapeutics...
  32. doi request reprint Oxidants and antioxidants in sulfur mustard-induced injury
    Jeffrey D Laskin
    Department of Environmental and Occupation Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:92-100. 2010
    ..These data indicate that drugs that target oxidative stress pathways may represent important candidates for reducing SM-induced tissue injury...
  33. pmc Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity
    Carol R Gardner
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 245:36-46. 2010
    ..Taken together, these data demonstrate that Cav-1 plays a role in promoting inflammation and toxicity during the pathogenesis of acetaminophen-induced injury...
  34. pmc Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 250:245-55. 2011
    ..These effects were most notable in the airways. These data suggest that targeting TNF╬▒ signaling may be useful in mitigating lung injury, inflammation and functional alterations induced by vesicants...
  35. doi request reprint Janus kinase-3 dependent inflammatory responses in allergic asthma
    Rama Malaviya
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Int Immunopharmacol 10:829-36. 2010
    ..We propose that targeting JAK-3 is a rationale approach to control the inflammatory responses of multiple cell types responsible for the pathogenesis of allergic asthma...
  36. ncbi request reprint Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Exp Mol Pathol 83:177-87. 2007
    ..These data suggest that the acute phase response to acute endotoxemia involves induction of 24p3 in both the lung and liver. This protein may be important in restoring tissue homeostasis following LPS-induced injury...
  37. pmc Pulmonary effects of inhaled diesel exhaust in aged mice
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 241:283-93. 2009
    ..Taken together, these results suggest that altered generation of inflammatory mediators and MnSOD may contribute to increased susceptibility of older mice to inhaled DE...
  38. pmc Macrophages and inflammatory mediators in chemical toxicity: a battle of forces
    Debra L Laskin
    Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy, Piscataway, New Jersey 08854
    Chem Res Toxicol 22:1376-85. 2009
    ..It is the balance in the production of mediators by these two macrophage subpopulations that ultimately determines the outcome of the tissue response to chemical toxicants...
  39. ncbi request reprint Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products
    Robert J Laumbach
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Occup Environ Med 47:1182-9. 2005
    ....
  40. pmc Pulmonary effects of inhaled limonene ozone reaction products in elderly rats
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 222:211-20. 2007
    ..LOP are pulmonary irritants inducing distinct inflammatory responses in younger and older animals. This may contribute to the differential sensitivity of these populations to pulmonary irritants...
  41. pmc UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Biochem Pharmacol 81:873-80. 2011
    ..Alterations in expression of these mediators are likely to be important in regulating inflammation and protecting the cornea from UVB-induced oxidative stress...
  42. pmc Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat
    Adrienne T Black
    Department of Pharmacology and Toxicology, Rutgers University, USA
    Toxicol Appl Pharmacol 231:384-92. 2008
    ..These intracellular proteins may be important in protecting the skin from paraquat-mediated cytotoxicity...
  43. pmc UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes
    Adrienne T Black
    Department of Pharmacology and Toxicology, Rutgers University, USA
    Toxicol Appl Pharmacol 232:14-24. 2008
    ..Moreover, both the capacity of keratinocytes to generate prostaglandins and their ability to respond to these lipid mediators are stimulated by exposure to UVB...
  44. doi request reprint Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard
    Vasanthi R Sunil
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 250:10-8. 2011
    ..Understanding the nature of the injury induced by nitrogen mustard and related analogs may aid in the development of efficacious therapies for treatment of pulmonary injury resulting from exposure to vesicants...
  45. doi request reprint Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model
    Piyun Chao
    Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Anticancer Drugs 21:65-76. 2010
    ....
  46. pmc Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats
    Hilliard L Kutscher
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Control Release 143:31-7. 2010
    ....
  47. ncbi request reprint Effects of ibuprofen and hypoxia on neutrophil apoptosis in neonates
    Nazeeh Hanna
    Division of Neonatology, Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08903, USA
    Biol Neonate 86:235-9. 2004
    ..Apoptosis of neutrophils is impaired in newborns, leading to reduced clearance of activated cells and possibly contributing to the susceptibility of infants to these inflammatory diseases...
  48. ncbi request reprint Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase
    Joshua P Gray
    Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 282:7939-49. 2007
    ..Reactive oxygen intermediates and subsequent oxidative stress generated from this enzyme are likely to contribute to paraquat-induced lung toxicity...
  49. ncbi request reprint Characterization of the oxidase activity in mammalian catalase
    Anna M Vetrano
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:35372-81. 2005
    ..Our results describe a novel function for catalase potentially important in metabolism of endogenous substrates and in the action of carcinogens and chemopreventative agents...
  50. ncbi request reprint Mechanisms underlying reduced apoptosis in neonatal neutrophils
    Nazeeh Hanna
    Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, New Brunswick, NJ 08903, USA
    Pediatr Res 57:56-62. 2005
    ..This may be related to decreased expression of both FasR and Bcl-2-family proteins that mediate neutrophil apoptosis...
  51. pmc Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells
    Yi Hua Jan
    Environmental and Occupational Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Chem Res Toxicol 23:1045-53. 2010
    ..Taken together, these data suggest that sulfur mustard vesicants target TrxR and that this may be an important mechanism mediating oxidative stress and tissue injury...
  52. pmc Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity
    Yun Wang
    Environmental and Occupational Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cancer Ther 9:1852-63. 2010
    ..These data indicate that NADPH cytochrome P450 reductase-mediated MMC redox cycling is not involved in the cytotoxicity of this chemotherapeutic agent...
  53. pmc Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes
    Adrienne T Black
    Department of Pharmacology and Toxicology, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 29:219-25. 2008
    ..Moreover, MAP kinases are critical regulators of this response. Alterations in antioxidants are likely to be important mechanisms for protecting the skin from UVB-induced oxidative stress...
  54. doi request reprint Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity
    Yun Wang
    Department of Environmental and Occupational Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Free Radic Biol Med 44:1169-79. 2008
    ....
  55. ncbi request reprint Oxygen toxicity in premature infants
    Barry Weinberger
    Department of Pediatrics Neonatology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Toxicol Appl Pharmacol 181:60-7. 2002
    ..These include limiting oxygen supplementation and light exposure, the use of antiinflammatory agents or antioxidants, and the use of room air in neonatal resuscitation...

Research Grants49

  1. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    DEBRA LYNN LASKIN; Fiscal Year: 2010
    ....
  2. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    Debra Laskin; Fiscal Year: 2001
    ....
  3. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2001
    ..The results of these studies will provide important information on mechanisms underlying chemical-induced liver injury. ..
  4. Macrophages and Inflammatory Mediators in Silica-Induced Carcinogenesis
    DEBRA LYNN LASKIN; Fiscal Year: 2010
    ....
  5. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..
  6. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2007
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..
  7. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    Debra Laskin; Fiscal Year: 2006
    ..abstract_text> ..
  8. ROLE OF KUPFFER CELLS IN CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 1992
    ..These studies should provide clues on the mechanisms underlying the contribution of Kupffer cells to chemically-induced hepatotoxicity...
  9. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    Debra Laskin; Fiscal Year: 1993
    ..We will then characterize the mechanism underlying the accumulation and activation of macrophages in the lungs and the potential contribution of these cells to ozone induced pulmonary injury...