Jody Hey

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells
    Ann B Moser
    Department of Biochemistry and Molecular Biology, Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA 90089, USA
    Lipids Health Dis 12:10. 2013
  2. doi request reprint Population genetics and objectivity in species diagnosis
    Jody Hey
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Evolution 66:1413-29. 2012
  3. ncbi request reprint Regarding the confusion between the population concept and Mayr's "population thinking"
    Jody Hey
    Department of Genetics Rutgers University Piscataway, New Jersey 08854 8082, USA
    Q Rev Biol 86:253-64. 2011
  4. pmc On the number of New World founders: a population genetic portrait of the peopling of the Americas
    Jody Hey
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    PLoS Biol 3:e193. 2005
  5. ncbi request reprint On the failure of modern species concepts
    Jody Hey
    Department of Genetics, Rutgers University, 604 Allison Rd, Piscataway, NJ 08854 8082, USA
    Trends Ecol Evol 21:447-50. 2006
  6. ncbi request reprint Recent advances in assessing gene flow between diverging populations and species
    Jody Hey
    Department of Genetics, Rutgers University, Nelson Biological Laboratories, Room B326A, 604 Allison Road, Piscataway, NJ 08854, USA
    Curr Opin Genet Dev 16:592-6. 2006
  7. pmc Integration within the Felsenstein equation for improved Markov chain Monte Carlo methods in population genetics
    Jody Hey
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08846, USA
    Proc Natl Acad Sci U S A 104:2785-90. 2007
  8. pmc Multilocus methods for estimating population sizes, migration rates and divergence time, with applications to the divergence of Drosophila pseudoobscura and D. persimilis
    Jody Hey
    Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854, USA
    Genetics 167:747-60. 2004
  9. pmc What's so hot about recombination hotspots?
    Jody Hey
    Department of Genetics, Rutgers University, Piscataway, New Jersey, USA
    PLoS Biol 2:e190. 2004
  10. ncbi request reprint Using nuclear haplotypes with microsatellites to study gene flow between recently separated Cichlid species
    Jody Hey
    Department of Genetics, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Ecol 13:909-19. 2004

Research Grants

  1. The Population Genetics of Divergence
    EMANUEL HEY; Fiscal Year: 2010
  2. GENETICS OF SPECIATION IN DROSOPHILA
    EMANUEL HEY; Fiscal Year: 2001
  3. The Population Genetics of Divergence
    EMANUEL HEY; Fiscal Year: 2007
  4. The Population Genetics of Divergence
    EMANUEL HEY; Fiscal Year: 2009

Collaborators

Detail Information

Publications29

  1. pmc Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells
    Ann B Moser
    Department of Biochemistry and Molecular Biology, Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA 90089, USA
    Lipids Health Dis 12:10. 2013
    ..In contrast, humans cannot derive PA from chlorophyll and instead normally obtain it only from meat, dairy, and fish products...
  2. doi request reprint Population genetics and objectivity in species diagnosis
    Jody Hey
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Evolution 66:1413-29. 2012
    ..If used together, the two measures could be used to develop an objective (in the sense of being repeatable) measure for species diagnosis...
  3. ncbi request reprint Regarding the confusion between the population concept and Mayr's "population thinking"
    Jody Hey
    Department of Genetics Rutgers University Piscataway, New Jersey 08854 8082, USA
    Q Rev Biol 86:253-64. 2011
    ....
  4. pmc On the number of New World founders: a population genetic portrait of the peopling of the Americas
    Jody Hey
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    PLoS Biol 3:e193. 2005
    ..Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size...
  5. ncbi request reprint On the failure of modern species concepts
    Jody Hey
    Department of Genetics, Rutgers University, 604 Allison Rd, Piscataway, NJ 08854 8082, USA
    Trends Ecol Evol 21:447-50. 2006
    ..Recently, biologists have begun to recognize both the shortcomings of a lexicon of multiple species concepts and a common evolutionary idea that underlies them...
  6. ncbi request reprint Recent advances in assessing gene flow between diverging populations and species
    Jody Hey
    Department of Genetics, Rutgers University, Nelson Biological Laboratories, Room B326A, 604 Allison Road, Piscataway, NJ 08854, USA
    Curr Opin Genet Dev 16:592-6. 2006
    ..Several recent studies have found significant signals of gene flow during species formation, calling into question the conventional wisdom that gene flow is absent during speciation...
  7. pmc Integration within the Felsenstein equation for improved Markov chain Monte Carlo methods in population genetics
    Jody Hey
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08846, USA
    Proc Natl Acad Sci U S A 104:2785-90. 2007
    ..Several examples, including an application to the divergence of chimpanzee subspecies, are provided...
  8. pmc Multilocus methods for estimating population sizes, migration rates and divergence time, with applications to the divergence of Drosophila pseudoobscura and D. persimilis
    Jody Hey
    Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854, USA
    Genetics 167:747-60. 2004
    ..Several loci have nonzero estimates of gene flow since the initial separation of the species, with considerable variation in gene flow estimates among loci, in both directions between the species...
  9. pmc What's so hot about recombination hotspots?
    Jody Hey
    Department of Genetics, Rutgers University, Piscataway, New Jersey, USA
    PLoS Biol 2:e190. 2004
  10. ncbi request reprint Using nuclear haplotypes with microsatellites to study gene flow between recently separated Cichlid species
    Jody Hey
    Department of Genetics, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Ecol 13:909-19. 2004
    ..An example using Cichlid fishes from Lake Malawi is described. The analysis suggests that the species have been exchanging genes since the time they began to diverge...
  11. pmc Isolation with migration models for more than two populations
    Jody Hey
    Department of Genetics, Rutgers University, USA
    Mol Biol Evol 27:905-20. 2010
    ..However, for histories with modest levels of gene flow, or for very large data sets, it is possible to study large complex divergence problems that involve multiple closely related populations or species...
  12. pmc The divergence of chimpanzee species and subspecies as revealed in multipopulation isolation-with-migration analyses
    Jody Hey
    Department of Genetics, Rutgers University, USA
    Mol Biol Evol 27:921-33. 2010
    ....
  13. ncbi request reprint Inferring the history of speciation from multilocus DNA sequence data: the case of Drosophila pseudoobscura and close relatives
    Carlos A Machado
    Department of Genetics, Nelson Biological Labs, Rutgers University, 604 Allison Road, Piscataway, NJ 08854 8082, USA
    Mol Biol Evol 19:472-88. 2002
    ..pseudoobscura and D. persimilis. We show that there is a good correspondence between the genomic regions associated with reproductive isolation and the regions that show little or no evidence of gene flow...
  14. ncbi request reprint Nuclear gene variation and molecular dating of the cichlid species flock of Lake Malawi
    Yong Jin Won
    Department of Genetics, Rutgers The State University of New Jersey, Piscataway, NJ, USA
    Mol Biol Evol 23:828-37. 2006
    ..An approximate splitting time between mbuna and nonmbuna lineages was estimated as 0.7 Myr. Oreochromis is estimated to have diverged from the cichlids in Lake Malawi and Lake Tanganyika about 18 MYA...
  15. pmc On the origin of Lake Malawi cichlid species: a population genetic analysis of divergence
    Yong Jin Won
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Proc Natl Acad Sci U S A 102:6581-6. 2005
    ..It appears that very recent speciation and gene flow are among the reasons why it has been difficult to discern the phylogenetic history of Malawi cichlids...
  16. ncbi request reprint Sampling from natural populations with RNAI reveals high outcrossing and population structure in Caenorhabditis elegans
    Arjun Sivasundar
    Department of Genetics, Rutgers University, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Curr Biol 15:1598-602. 2005
    ..The occurrence of substantial outcrossing suggests that the extinction of local populations is probably not driven by the accumulation of harmful mutations...
  17. ncbi request reprint Divergent haplotypes and human history as revealed in a worldwide survey of X-linked DNA sequence variation
    Makoto K Shimada
    Department of Genetics, Rutgers University, NJ, USA
    Mol Biol Evol 24:687-98. 2007
    ..Taken together, these features of hX-that it is much older than other haplotypes and uncommon and patchily distributed throughout Africa, Europe, and Asia-present a cautionary tale for interpretations of human history...
  18. ncbi request reprint Speciation and inversions: chimps and humans
    Jody Hey
    Department of Genetics, Rutgers, The State University of New Jersey, 604 Allison Rd Piscataway, NJ 08854 8082, USA
    Bioessays 25:825-8. 2003
    ..However, it remains uncertain whether this interesting finding is actually consistent with the proposed model...
  19. pmc The causes of phylogenetic conflict in a classic Drosophila species group
    Carlos A Machado
    Department of Genetics, Rutgers University, 604 Allison Road, Nelson Biological Laboratories, Piscataway, NJ 08854 8082, USA
    Proc Biol Sci 270:1193-202. 2003
    ....
  20. pmc Joint inference of population assignment and demographic history
    Sang Chul Choi
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08846, USA
    Genetics 189:561-77. 2011
    ..The new method is compared to results of a widely used assignment method, using simulated and published empirical data sets...
  21. ncbi request reprint Divergence population genetics of chimpanzees
    Yong Jin Won
    Department of Genetics, Rutgers The State University of New Jersey, Piscataway, New Jersey, USA
    Mol Biol Evol 22:297-307. 2005
    ..No evidence of gene flow was found in the comparisons involving P. paniscus; however a clear signal of unidirectional gene flow was found from P. t. verus to P. t. troglodytes (2Nm = 0.51)...
  22. pmc Demographic inference using spectral methods on SNP data, with an analysis of the human out-of-Africa expansion
    Sergio Lukić
    Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Genetics 192:619-39. 2012
    ..The estimated time of founding of a human population outside of Africa was 52,000 years (95% confidence interval: 36,000-80,800 years)...
  23. ncbi request reprint The study of structured populations--new hope for a difficult and divided science
    Jody Hey
    Department of Genetics, Rutgers The State University of New Jersey, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nat Rev Genet 4:535-43. 2003
    ..Both approaches have limitations, but there is promise in newer probabilistic methods that offer the flexibility and data exploitation of the phylogeographic approach in an explicitly model-based mathematical framework...
  24. doi request reprint Understanding the origin of species with genome-scale data: modelling gene flow
    Vitor Sousa
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Rev Genet 14:404-14. 2013
    ..Current data, models, methods and the potential pitfalls in using them will be considered here...
  25. pmc Non-equilibrium allele frequency spectra via spectral methods
    Sergio Lukić
    Department of Genetics and BioMaPS Institute, Rutgers University, Piscataway, NJ 08854, USA
    Theor Popul Biol 79:203-19. 2011
    ....
  26. pmc Estimating divergence parameters with small samples from a large number of loci
    Yong Wang
    Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854
    Genetics 184:363-79. 2010
    ..We applied the method to the divergence of Drosophila melanogaster and D. simulans and detected a low, but statistically significant, signal of gene flow from D. simulans to D. melanogaster...
  27. pmc Population genetics of Caenorhabditis elegans: the paradox of low polymorphism in a widespread species
    Arjun Sivasundar
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Genetics 163:147-57. 2003
    ..A possible explanation for the observed patterns is the action of background selection to reduce polymorphism, coupled with ongoing gene flow among populations worldwide...
  28. pmc Systematics and the origin of species: an introduction
    Jody Hey
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Proc Natl Acad Sci U S A 102:6515-9. 2005
  29. pmc Interactions between natural selection, recombination and gene density in the genes of Drosophila
    Jody Hey
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Genetics 160:595-608. 2002
    ..These factors appear to overlay the more subtle effect of linkage among selected sites that gives rise to the association between recombination rate and codon bias...

Research Grants8

  1. The Population Genetics of Divergence
    EMANUEL HEY; Fiscal Year: 2010
    ..These new methods will be applied to a case study of divergence among species and subspecies of Chimpanzee. The methods will also be applied to large multi-population multi-locus data sets from human populations. ..
  2. GENETICS OF SPECIATION IN DROSOPHILA
    EMANUEL HEY; Fiscal Year: 2001
    ....
  3. The Population Genetics of Divergence
    EMANUEL HEY; Fiscal Year: 2007
    ..These new methods will be applied to a case study of divergence among species and subspecies of Chimpanzee. The methods will also be applied to large multi-population multi-locus data sets from human populations. ..
  4. The Population Genetics of Divergence
    EMANUEL HEY; Fiscal Year: 2009
    ..These new methods will be applied to a case study of divergence among species and subspecies of Chimpanzee. The methods will also be applied to large multi-population multi-locus data sets from human populations. ..