Research Topics
Genomes and Genes | Jody HeySummaryAffiliation: Rutgers University Country: USA Publications
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Publications
Population genetics and objectivity in species diagnosisJody Hey
Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Evolution 66:1413-29. 2012..If used together, the two measures could be used to develop an objective (in the sense of being repeatable) measure for species diagnosis...
Regarding the confusion between the population concept and Mayr's "population thinking"Jody Hey
Department of Genetics Rutgers University Piscataway, New Jersey 08854 8082, USA
Q Rev Biol 86:253-64. 2011....
The divergence of chimpanzee species and subspecies as revealed in multipopulation isolation-with-migration analysesJody Hey
Department of Genetics, Rutgers University, USA
Mol Biol Evol 27:921-33. 2010....- Isolation with migration models for more than two populationsJody Hey
Department of Genetics, Rutgers University, USA
Mol Biol Evol 27:905-20. 2010..However, for histories with modest levels of gene flow, or for very large data sets, it is possible to study large complex divergence problems that involve multiple closely related populations or species... - Integration within the Felsenstein equation for improved Markov chain Monte Carlo methods in population geneticsJody Hey
Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08846, USA
Proc Natl Acad Sci U S A 104:2785-90. 2007..Several examples, including an application to the divergence of chimpanzee subspecies, are provided... - Recent advances in assessing gene flow between diverging populations and speciesJody Hey
Department of Genetics, Rutgers University, Nelson Biological Laboratories, Room B326A, 604 Allison Road, Piscataway, NJ 08854, USA
Curr Opin Genet Dev 16:592-6. 2006..Several recent studies have found significant signals of gene flow during species formation, calling into question the conventional wisdom that gene flow is absent during speciation... - On the failure of modern species conceptsJody Hey
Department of Genetics, Rutgers University, 604 Allison Rd, Piscataway, NJ 08854 8082, USA
Trends Ecol Evol 21:447-50. 2006..Recently, biologists have begun to recognize both the shortcomings of a lexicon of multiple species concepts and a common evolutionary idea that underlies them... 
On the number of New World founders: a population genetic portrait of the peopling of the AmericasJody Hey
Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
PLoS Biol 3:e193. 2005..Analyses of Asian and New World data support a model of a recent founding of the New World by a population of quite small effective size...- Multilocus methods for estimating population sizes, migration rates and divergence time, with applications to the divergence of Drosophila pseudoobscura and D. persimilisJody Hey
Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854, USA
Genetics 167:747-60. 2004..Several loci have nonzero estimates of gene flow since the initial separation of the species, with considerable variation in gene flow estimates among loci, in both directions between the species... - What's so hot about recombination hotspots?Jody Hey
Department of Genetics, Rutgers University, Piscataway, New Jersey, USA
PLoS Biol 2:e190. 2004 - Using nuclear haplotypes with microsatellites to study gene flow between recently separated Cichlid speciesJody Hey
Department of Genetics, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
Mol Ecol 13:909-19. 2004..An example using Cichlid fishes from Lake Malawi is described. The analysis suggests that the species have been exchanging genes since the time they began to diverge... - Inferring the history of speciation from multilocus DNA sequence data: the case of Drosophila pseudoobscura and close relativesCarlos A Machado
Department of Genetics, Nelson Biological Labs, Rutgers University, 604 Allison Road, Piscataway, NJ 08854 8082, USA
Mol Biol Evol 19:472-88. 2002..pseudoobscura and D. persimilis. We show that there is a good correspondence between the genomic regions associated with reproductive isolation and the regions that show little or no evidence of gene flow... - Nuclear gene variation and molecular dating of the cichlid species flock of Lake MalawiYong-Jin Won
Department of Genetics, Rutgers The State University of New Jersey, Piscataway, NJ, USA
Mol Biol Evol 23:828-37. 2006..An approximate splitting time between mbuna and nonmbuna lineages was estimated as 0.7 Myr. Oreochromis is estimated to have diverged from the cichlids in Lake Malawi and Lake Tanganyika about 18 MYA... - On the origin of Lake Malawi cichlid species: a population genetic analysis of divergenceYong-Jin Won
Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
Proc Natl Acad Sci U S A 102:6581-6. 2005..It appears that very recent speciation and gene flow are among the reasons why it has been difficult to discern the phylogenetic history of Malawi cichlids... - Sampling from natural populations with RNAI reveals high outcrossing and population structure in Caenorhabditis elegansArjun Sivasundar
Department of Genetics, Rutgers University, 604 Allison Road, Piscataway, New Jersey 08854, USA
Curr Biol 15:1598-602. 2005..The occurrence of substantial outcrossing suggests that the extinction of local populations is probably not driven by the accumulation of harmful mutations... - The causes of phylogenetic conflict in a classic Drosophila species groupCarlos A Machado
Department of Genetics, Rutgers University, 604 Allison Road, Nelson Biological Laboratories, Piscataway, NJ 08854 8082, USA
Proc Biol Sci 270:1193-202. 2003.... - Divergent haplotypes and human history as revealed in a worldwide survey of X-linked DNA sequence variationMakoto K Shimada
Department of Genetics, Rutgers University, NJ, USA
Mol Biol Evol 24:687-98. 2007..Taken together, these features of hX-that it is much older than other haplotypes and uncommon and patchily distributed throughout Africa, Europe, and Asia-present a cautionary tale for interpretations of human history... - Speciation and inversions: chimps and humansJody Hey
Department of Genetics, Rutgers, The State University of New Jersey, 604 Allison Rd Piscataway, NJ 08854 8082, USA
Bioessays 25:825-8. 2003..However, it remains uncertain whether this interesting finding is actually consistent with the proposed model... - Joint inference of population assignment and demographic historySang Chul Choi
Department of Genetics, Rutgers University, Piscataway, New Jersey 08846, USA
Genetics 189:561-77. 2011..The new method is compared to results of a widely used assignment method, using simulated and published empirical data sets... - Divergence population genetics of chimpanzeesYong-Jin Won
Department of Genetics, Rutgers The State University of New Jersey, Piscataway, New Jersey, USA
Mol Biol Evol 22:297-307. 2005..No evidence of gene flow was found in the comparisons involving P. paniscus; however a clear signal of unidirectional gene flow was found from P. t. verus to P. t. troglodytes (2Nm = 0.51)... - The study of structured populations--new hope for a difficult and divided scienceJody Hey
Department of Genetics, Rutgers The State University of New Jersey, 604 Allison Road, Piscataway, New Jersey 08854, USA
Nat Rev Genet 4:535-43. 2003..Both approaches have limitations, but there is promise in newer probabilistic methods that offer the flexibility and data exploitation of the phylogeographic approach in an explicitly model-based mathematical framework... - Estimating divergence parameters with small samples from a large number of lociYong Wang
Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854
Genetics 184:363-79. 2010..We applied the method to the divergence of Drosophila melanogaster and D. simulans and detected a low, but statistically significant, signal of gene flow from D. simulans to D. melanogaster... - Population genetics of Caenorhabditis elegans: the paradox of low polymorphism in a widespread speciesArjun Sivasundar
Department of Genetics, Rutgers University, Piscataway, New Jersey 08854-8082, USA
Genetics 163:147-57. 2003..A possible explanation for the observed patterns is the action of background selection to reduce polymorphism, coupled with ongoing gene flow among populations worldwide... - Non-equilibrium allele frequency spectra via spectral methodsSergio Lukić
Department of Genetics and BioMaPS Institute, Rutgers University, Piscataway, NJ 08854, USA
Theor Popul Biol 79:203-19. 2011.... - Systematics and the origin of species: an introductionJody Hey
Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
Proc Natl Acad Sci U S A 102:6515-9. 2005 - Demographic inference using spectral methods on SNP data, with an analysis of the human out-of-Africa expansionSergio Lukić
Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
Genetics 192:619-39. 2012..The estimated time of founding of a human population outside of Africa was 52,000 years (95% confidence interval: 36,000-80,800 years)... - Interactions between natural selection, recombination and gene density in the genes of DrosophilaJody Hey
Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8082, USA
Genetics 160:595-608. 2002..These factors appear to overlay the more subtle effect of linkage among selected sites that gives rise to the association between recombination rate and codon bias...
Research Grants
- The Population Genetics of DivergenceEMANUEL HEY; Fiscal Year: 2010..These new methods will be applied to a case study of divergence among species and subspecies of Chimpanzee. The methods will also be applied to large multi-population multi-locus data sets from human populations. ..
- GENETICS OF SPECIATION IN DROSOPHILAEMANUEL HEY; Fiscal Year: 2001....
- The Population Genetics of DivergenceEMANUEL HEY; Fiscal Year: 2007..These new methods will be applied to a case study of divergence among species and subspecies of Chimpanzee. The methods will also be applied to large multi-population multi-locus data sets from human populations. ..
- The Population Genetics of DivergenceEMANUEL HEY; Fiscal Year: 2009..These new methods will be applied to a case study of divergence among species and subspecies of Chimpanzee. The methods will also be applied to large multi-population multi-locus data sets from human populations. ..