Karl Herrup

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. ncbi request reprint Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
    Samantha Cicero
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:9658-68. 2005
  2. pmc A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death
    Luming Li
    Department of Cell Biology and Neuroscience, Rutgers University, B211 Nelson Labs, 604 Allison Road, Piscataway, NJ 08854 6999, USA
    Int J Alzheimers Dis 2011:171464. 2011
  3. pmc Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia
    Jiali Li
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, Piscataway, New Jersey, USA
    Nat Med 18:783-90. 2012
  4. pmc Post-mitotic role of the cell cycle machinery
    Karl Herrup
    Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Dept of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, United States Electronic address
    Curr Opin Cell Biol 25:711-6. 2013
  5. pmc ATM and the epigenetics of the neuronal genome
    Karl Herrup
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, United States Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Electronic address
    Mech Ageing Dev 134:434-9. 2013
  6. pmc The role of ATM and DNA damage in neurons: upstream and downstream connections
    Karl Herrup
    Division of Life Sciences, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    DNA Repair (Amst) 12:600-4. 2013
  7. ncbi request reprint The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease
    Karl Herrup
    Dept of Cell Biology and Neuroscience, Nelson Biological Laboratories, 604 Allison Road, Piscataway, NJ 0854, USA
    Front Biosci (Elite Ed) 4:2101-9. 2012
  8. pmc The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events
    Kiran Bhaskar
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, USA
    Mol Neurodegener 4:14. 2009
  9. pmc The involvement of cell cycle events in the pathogenesis of Alzheimer's disease
    Karl Herrup
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Alzheimers Res Ther 2:13. 2010
  10. ncbi request reprint Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
    Karl Herrup
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nat Rev Neurosci 8:368-78. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
    Samantha Cicero
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:9658-68. 2005
    ..These data indicate that Cdk5 is necessary for both neuronal differentiation and cell cycle inhibition...
  2. pmc A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death
    Luming Li
    Department of Cell Biology and Neuroscience, Rutgers University, B211 Nelson Labs, 604 Allison Road, Piscataway, NJ 08854 6999, USA
    Int J Alzheimers Dis 2011:171464. 2011
    ..Comparison with the pattern of neuron death in human AD suggests that each may represent a distinctly different disease model when used in preclinical trials...
  3. pmc Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia
    Jiali Li
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, Piscataway, New Jersey, USA
    Nat Med 18:783-90. 2012
    ..Our results define a crucial role of the cellular localization of HDAC4 in the events leading to ataxia telangiectasia neurodegeneration...
  4. pmc Post-mitotic role of the cell cycle machinery
    Karl Herrup
    Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Dept of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, United States Electronic address
    Curr Opin Cell Biol 25:711-6. 2013
    ..There is little apparent logic to the second use, but the sheer number of examples suggests that there must be a significant evolutionary advantage to this repurposing strategy. ..
  5. pmc ATM and the epigenetics of the neuronal genome
    Karl Herrup
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, United States Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Electronic address
    Mech Ageing Dev 134:434-9. 2013
    ....
  6. pmc The role of ATM and DNA damage in neurons: upstream and downstream connections
    Karl Herrup
    Division of Life Sciences, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    DNA Repair (Amst) 12:600-4. 2013
    ....
  7. ncbi request reprint The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease
    Karl Herrup
    Dept of Cell Biology and Neuroscience, Nelson Biological Laboratories, 604 Allison Road, Piscataway, NJ 0854, USA
    Front Biosci (Elite Ed) 4:2101-9. 2012
    ..Defining the biochemistry behind cell cycle initiation holds promise as a fresh therapeutic approach in the battle against this devastating disease...
  8. pmc The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events
    Kiran Bhaskar
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, USA
    Mol Neurodegener 4:14. 2009
    ..Taken together, these results demonstrate that Abeta oligomer-based induction of neuronal CCEs involve the PI3K-Akt-mTOR pathway...
  9. pmc The involvement of cell cycle events in the pathogenesis of Alzheimer's disease
    Karl Herrup
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Alzheimers Res Ther 2:13. 2010
    ..The quest for understanding is worthwhile, however, as fresh avenues for therapeutic intervention are the prizes for success...
  10. ncbi request reprint Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
    Karl Herrup
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nat Rev Neurosci 8:368-78. 2007
    ..Failure of cell cycle regulation might be a root cause of several neurodegenerative disorders and a final common pathway for others...
  11. pmc DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease
    Jianmin Chen
    Dept, of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Mol Neurodegener 5:60. 2010
    ..abstract:..
  12. pmc Reimagining Alzheimer's disease--an age-based hypothesis
    Karl Herrup
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Neurosci 30:16755-62. 2010
    ..The implications of this new model are discussed with respect to our current diagnostic criteria, and suggestions are put forward for expanding our future research efforts...
  13. pmc Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex
    Jie Zhang
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 30:5219-28. 2010
    ..Formation of this complex excludes the E2F1 cofactor, DP1, thus inhibiting E2F1 binding to the promoters of various cell cycle genes. This anti-cell cycle activity is most likely a neuroprotective function of Cdk5...
  14. pmc EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia
    Jiali Li
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA
    Nat Neurosci 16:1745-53. 2013
    ..Lentiviral knockdown of EZH2 rescued Purkinje cell degeneration and behavioral abnormalities in Atm(-/-) mice, demonstrating that EZH2 hyperactivity is another key factor in A-T neurodegeneration. ..
  15. ncbi request reprint Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons
    Jie Zhang
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Cell Cycle 10:1208-14. 2011
    ..To the extent that these approaches either directly or indirectly influence Cdk5 levels or location, they may produce unexpected and possibly unwanted consequences...
  16. pmc Cytoplasmic ATM in neurons modulates synaptic function
    Jiali Li
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    Curr Biol 19:2091-6. 2009
    ..Also, cytoplasmic ATM physically associates with the homologous PI 3-kinase, ATR. The neurological symptoms of ataxia-telangiectasia may thus result from defective nonnuclear functions of ATM not associated with DNA repair...
  17. pmc Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation
    Jie Zhang
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8082, USA
    J Biol Chem 285:14052-61. 2010
    ..These data suggest a model in which Cdk5 exerts a double protective function in neurons: chronically suppressing the cell cycle when located in the nucleus and transiently delaying cell death in the cytoplasm...
  18. pmc Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress
    Jianmin Chen
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 7:e33177. 2012
    ..Together, our observations suggest that healthy neuronal cells require both intracellular and extracellular glutamine, and that the neuroprotective effects of glutamine supplementation may prove beneficial in the treatment of AD...
  19. pmc Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia
    Jiali Li
    Department of Cell Biology and Neuroscience, Nelson Biological Laboratories, Rutgers University, Piscataway, New Jersey 08854, USA
    J Neurosci 31:7568-77. 2011
    ..These findings offer important new insights into the human disease and the role of brain ATM activity in the severity of the neurological symptoms of A-T...
  20. pmc Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease
    Karl Herrup
    Hong Kong University of Science and Technology, Division of Biology Life Science, Hong Kong
    Alzheimers Dement 9:452-458.e1. 2013
    ....
  21. pmc Cdk5 and the non-catalytic arrest of the neuronal cell cycle
    Jie Zhang
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8082, USA
    Cell Cycle 7:3487-90. 2008
    ..The shift in sub-cellular location is accompanied by cell cycle re-entry and neuronal death. This "new" function of Cdk5 raises cautions in the design of Cdk5-directed drugs for the therapy of neurodegenerative diseases...
  22. ncbi request reprint Selective vulnerability of neurons in primary cultures and in neurodegenerative diseases
    Jianmin Chen
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08901, USA
    Rev Neurosci 19:317-26. 2008
    ..Selective vulnerability is a common feature of neurodegenerative disease, thus it is critical to use the right primary culture. Do you know what is in your culture?..
  23. pmc Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons
    Jie Zhang
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 105:8772-7. 2008
    ..We propose that the nuclear Cdk5 plays an active role in allowing neurons to remain postmitotic as they mature and that loss of nuclear Cdk5 leads to cell cycle entry...
  24. pmc Modulation of neuritogenesis by a protein implicated in X-linked mental retardation
    Xinfu Jiao
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 8082, USA
    J Neurosci 29:12419-27. 2009
    ..It is plausible that defects of these functions in the absence of the VCX genes could contribute to a mental retardation phenotype...
  25. ncbi request reprint Divide and die: cell cycle events as triggers of nerve cell death
    Karl Herrup
    Department of Neurosciences, Case School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio 44120, USA
    J Neurosci 24:9232-9. 2004
  26. ncbi request reprint Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism
    Yan Yang
    Department of Neurology, Alzheimer Research Laboratory E504, Case School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:2522-9. 2005
    ..These results suggest that loss of cell cycle control represents a common disease mechanism that underlies the defects in the affected tissues in both human and mouse diseases...
  27. ncbi request reprint Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer's disease
    Karl Herrup
    Department of Neurosciences, Case Western Reserve University School of Medicine E504 and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Alzheimers Dis 4:243-7. 2002
  28. ncbi request reprint E2F1 works as a cell cycle suppressor in mature neurons
    Li Wang
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44120, USA
    J Neurosci 27:12555-64. 2007
    ..These events are cell autonomous, because cultured E2f1-/- cortical neurons "cycle" in vitro, whereas wild-type neurons do not. Our results suggest that, in mature CNS neurons, E2F1 functions as a cell cycle suppressor...
  29. pmc Cell division in the CNS: protective response or lethal event in post-mitotic neurons?
    Yan Yang
    Department of Neurology, University Hospitals of Cleveland, Alzheimer Research Lab, E504, Case Western Reserve University School of Medicine, 10900 Euclid Avenue Cleveland, OH 44106, USA
    Biochim Biophys Acta 1772:457-66. 2007
    ..What is not known is whether, in an adult neuron, the cell cycle event is part of the pathology or rather a desperate attempt of a neuron under stress to protect itself...
  30. doi request reprint Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function
    IVY S SAMUELS
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106 4928, USA
    J Neurosci 28:6983-95. 2008
    ..These findings demonstrate an important role for ERK2 in cellular proliferation and differentiation during neural development as well as in cognition and memory formation...
  31. ncbi request reprint Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    Yan Yang
    Alzheimer Research Laboratory, University Hospitals of Cleveland and Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 23:2557-63. 2003
    ..The implication of the findings for human clinical trials is discussed...
  32. ncbi request reprint Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models
    Yan Yang
    Department of Neurology, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Neurosci 26:775-84. 2006
    ..Finally, the relative timing suggests that neither the activated microglia nor the amyloid plaques themselves are necessary to initiate the pathogenic events in AD...

Research Grants39

  1. NEURON TARGET INTERACTION--A DEVELOPMENTAL GENETIC STUDY
    Karl Herrup; Fiscal Year: 2002
    ....
  2. NEURON TARGET INTERACTION--A DEVELOPMENTAL GENETIC STUDY
    Karl Herrup; Fiscal Year: 2001
    ....
  3. Neuron Target Interaction-A Developmental Genetic Study
    Karl Herrup; Fiscal Year: 2006
    ..Transgenic mice will be produced that block the formation of the replication complex on the DNA. If origin based replication is required for cell death then the neurons should be resistant to cell cycle induced death. ..
  4. PURKINJE CELL DEVELOPMENT--A NUMERICAL STUDY
    Karl Herrup; Fiscal Year: 1999
    ..Once this aspect of the project is completed we will search for the trans-acting proteins that interact with these elements and through their identity learn more about the genetic regulation of the second compartmentalization event. ..
  5. Neuron Target Interaction-A Developmental Genetic Study
    Karl Herrup; Fiscal Year: 2005
    ..Transgenic mice will be produced that block the formation of the replication complex on the DNA. If origin based replication is required for cell death then the neurons should be resistant to cell cycle induced death. ..
  6. Purkinje Cell Development: A Numerical Study
    Karl Herrup; Fiscal Year: 2001
    ..We will subdivide the 3.2kb region to more precisely identify the Purkinje cell enhancer. BAC transgenic mice will be used to identify the cis-element responsible for the banding. ..
  7. Purkinje Cell Development: A Numerical Study
    Karl Herrup; Fiscal Year: 2005
    ..We will subdivide the 3.2kb region to more precisely identify the Purkinje cell enhancer. BAC transgenic mice will be used to identify the cis-element responsible for the banding. ..
  8. Purkinje Cell Development: A Numerical Study
    Karl Herrup; Fiscal Year: 2002
    ..We will subdivide the 3.2kb region to more precisely identify the Purkinje cell enhancer. BAC transgenic mice will be used to identify the cis-element responsible for the banding. ..
  9. Purkinje Cell Development: A Numerical Study
    Karl Herrup; Fiscal Year: 2003
    ..We will subdivide the 3.2kb region to more precisely identify the Purkinje cell enhancer. BAC transgenic mice will be used to identify the cis-element responsible for the banding. ..
  10. NEURON TARGET INTERACTION--A DEVELOPMENTAL GENETIC STUDY
    Karl Herrup; Fiscal Year: 1999
    ....
  11. PURKINJE CELL DEVELOPMENT--A NUMERICAL STUDY
    Karl Herrup; Fiscal Year: 1999
    ..Once this aspect of the project is completed we will search for the trans-acting proteins that interact with these elements and through their identity learn more about the genetic regulation of the second compartmentalization event. ..
  12. Neuron Target Interaction - a Developmental Genetic Study
    Karl Herrup; Fiscal Year: 2010
    ....
  13. Neuron Target Interaction - a Developmental Genetic Study
    Karl Herrup; Fiscal Year: 2009
    ....
  14. Purkinje Cell Development: A Numerical Study
    Karl Herrup; Fiscal Year: 2004
    ..We will subdivide the 3.2kb region to more precisely identify the Purkinje cell enhancer. BAC transgenic mice will be used to identify the cis-element responsible for the banding. ..
  15. Neuron Target Interaction-A Developmental Genetic Study
    Karl Herrup; Fiscal Year: 2006
    ..Transgenic mice will be produced that block the formation of the replication complex on the DNA. If origin based replication is required for cell death then the neurons should be resistant to cell cycle induced death. ..
  16. Cell cycle events: outcomes measures in Alzheimer models
    Karl Herrup; Fiscal Year: 2006
    ....
  17. Neuron Target Interaction-A Developmental Genetic Study
    Karl Herrup; Fiscal Year: 2007
    ..Transgenic mice will be produced that block the formation of the replication complex on the DNA. If origin based replication is required for cell death then the neurons should be resistant to cell cycle induced death. ..
  18. Cell cycle events: outcomes measures in Alzheimer models
    Karl Herrup; Fiscal Year: 2010
    ....
  19. Cell cycle events: outcome measures in Alzheimer models
    Karl Herrup; Fiscal Year: 2007
    ....
  20. Neuron Target Interaction-A Developmental Genetic Study
    Karl Herrup; Fiscal Year: 2004
    ..Transgenic mice will be produced that block the formation of the replication complex on the DNA. If origin based replication is required for cell death then the neurons should be resistant to cell cycle induced death. ..
  21. Cell cycle events: outcomes measures in Alzheimer models
    Karl Herrup; Fiscal Year: 2009
    ....
  22. Purkinje Cell Development: A Numerical Study
    Karl Herrup; Fiscal Year: 2002
    ..We will subdivide the 3.2kb region to more precisely identify the Purkinje cell enhancer. BAC transgenic mice will be used to identify the cis-element responsible for the banding. ..
  23. CEREBELLAR PURKINJE CELL DEVELOPMENT--A NUMERICAL STUDY
    Karl Herrup; Fiscal Year: 1993
    ..Mouse genomic clones are near at hand, and when they are available,the 5' regulatory sequences will be analyzed in transgenic mice in order to define potential mammalian "zebra-stripe" elements...
  24. CEREBELLAR PURKINJE CELL DEVELOPMENT--A NUMERICAL STUDY
    Karl Herrup; Fiscal Year: 1992
    ..Together, these approaches render the inherent "genetic logic" of development clearer such that our understanding of human genetic disorders, ranging from neural tube defects to psychiatric disorders, becomes that much more complete...
  25. NEURON-TARGET INTERACTION: A DEVELOPMENTAL GENETIC STUDY
    Karl Herrup; Fiscal Year: 1993
    ..The malformations that result from the inclusion of mutant cells in the interaction will provide important hints to the pathogenesis of neurologic disease in humans as well as mice...
  26. NEURON-TARGET INTERACTION--A DEVELOPMENTAL GENETIC STUDY
    Karl Herrup; Fiscal Year: 1992
    ..The malformations that result from the inclusion of mutant cells in the interaction will provide important hints to the pathogenesis of neurologic disease in humans as well as mice...
  27. NEURON TARGET INTERACTION--A DEVELOPMENTAL GENETIC STUDY
    Karl Herrup; Fiscal Year: 2000
    ....
  28. PURKINJE CELL DEVELOPMENT--A NUMERICAL STUDY
    Karl Herrup; Fiscal Year: 2000
    ..Once this aspect of the project is completed we will search for the trans-acting proteins that interact with these elements and through their identity learn more about the genetic regulation of the second compartmentalization event. ..
  29. The function of ATM protein in the biology of the adult neuron CNS:
    Karl Herrup; Fiscal Year: 2010
    ..The exploration of these phenomena will thus have significant value for our basic biological understanding of brain function as well as its malfunction in a number of different clinically relevant situations. ..