Barth Grant

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc The regulation of endocytosis by kinases: cell biology meets genomics
    Zita Balklava
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Genome Biol 6:245. 2005
  2. ncbi request reprint The ins and outs of endocytic transport
    Barth D Grant
    Department of Molecular Biology and Biochemistry, Rutgers University, 604 Allison Road, Nelson Biological Laboratories Room A307, Piscataway, NJ 08854, USA
    Nat Cell Biol 7:1151-4. 2005
  3. ncbi request reprint Functional genomic maps in Caenorhabditis elegans
    Barth D Grant
    Rutgers, State University of New Jersey, Department of Molecular Biology and Biochemistry, 604 Allison Road, Nelson Biological Laboratories, room A307, Piscataway, NJ 08854, USA
    Curr Opin Cell Biol 15:206-12. 2003
  4. pmc Mechanisms of EHD/RME-1 protein function in endocytic transport
    Barth D Grant
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Traffic 9:2043-52. 2008
  5. pmc Pathways and mechanisms of endocytic recycling
    Barth D Grant
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Nat Rev Mol Cell Biol 10:597-608. 2009
  6. pmc A novel requirement for C. elegans Alix/ALX-1 in RME-1-mediated membrane transport
    Anbing Shi
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Biol 17:1913-24. 2007
  7. pmc Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit
    Miyuki Sato
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Nat Cell Biol 7:559-69. 2005
  8. pmc Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein
    Miyuki Sato
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA
    EMBO J 27:1183-96. 2008
  9. pmc Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8
    Anbing Shi
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA
    EMBO J 28:3290-302. 2009
  10. ncbi request reprint Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic
    Zita Balklava
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Nat Cell Biol 9:1066-73. 2007

Research Grants

Collaborators

  • Andrew W Singson
  • Ken Sato
  • Pavan Kadandale
  • Anjon Audhya
  • J G Donaldson
  • Eric Lambie
  • Asako Sugimoto
  • H Fares
  • Elizabeth Smythe
  • Greg J Hermann
  • Fabio Piano
  • Carlos Chih Hsiung Chen
  • Saumya Pant
  • Zita Balklava
  • Julie S Hang
  • Anbing Shi
  • Miyuki Sato
  • Jean M Parry
  • Rika Maruyama
  • Paul Fonarev
  • Lars Nilsson
  • Sophia Semerdjieva
  • Nathalie V Velarde
  • Richard Klancer
  • Doreen R Glodowski
  • Willisa Liou
  • Clifford M Babbey
  • Peter J Schweinsberg
  • Anne Braun
  • Dong Won Lee
  • Sebastian Treusch
  • John A Picciano
  • Chavela M Carr
  • Kruti Patel
  • Yinhua Zhang
  • Michael Tobin
  • Lin Sun
  • Jonathan Ohm
  • Marina K Druzhinina
  • Riju Banerjee
  • Steve Caplan
  • Matthew H Zegarek
  • Mahak Sharma
  • Ariel J Lefkovith
  • Giampietro Schiavo
  • Barbara Conradt
  • Sukhdeep Singh
  • Simon Tuck
  • Julia Hatzold
  • Anne Françoise Ruaud
  • Barry Shortt
  • Akihiro Harada
  • Jonathan Hansen
  • Jean Louis Bessereau
  • Emma Maxwell
  • Vanesa Figueroa
  • Jacob Rubin
  • Allison Stewart-Michaelis
  • Christopher Rongo
  • Henry Schaefer
  • Peter Schweinsberg
  • Scott Gordon
  • Shilpa Vashist
  • Exing Wang
  • Nahid Ahktar
  • Kenneth W Dunn
  • Darren P Mareiniss
  • Sarah Scarselletta
  • Xiaohong Zhao
  • Michael M Kessels
  • Evan Eisenberg
  • Dennis Koch
  • Regina Dahlhaus
  • Lois E Greene
  • Britta Qualmann
  • Roser Pinyol
  • Chih Jen Huang
  • Ehud Goldin
  • Sarah Knuth
  • Susan A Slaugenhaupt
  • Nadia Ameen
  • Neil A Bradbury

Detail Information

Publications26

  1. pmc The regulation of endocytosis by kinases: cell biology meets genomics
    Zita Balklava
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Genome Biol 6:245. 2005
    ..A new genome-wide analysis of human kinases using RNA interference shows an unexpected depth and complexity to the interactions between these processes...
  2. ncbi request reprint The ins and outs of endocytic transport
    Barth D Grant
    Department of Molecular Biology and Biochemistry, Rutgers University, 604 Allison Road, Nelson Biological Laboratories Room A307, Piscataway, NJ 08854, USA
    Nat Cell Biol 7:1151-4. 2005
    ..Organized by Margaret Robinson (Cambridge, UK) and Howard Riezman (Geneva, Switzerland), the meeting covered diverse topics that highlighted essential roles for endocytosis during cell growth, development and parasitic invasion...
  3. ncbi request reprint Functional genomic maps in Caenorhabditis elegans
    Barth D Grant
    Rutgers, State University of New Jersey, Department of Molecular Biology and Biochemistry, 604 Allison Road, Nelson Biological Laboratories, room A307, Piscataway, NJ 08854, USA
    Curr Opin Cell Biol 15:206-12. 2003
    ..These studies combined genomic approaches to probe complex biological pathways on an unprecedented scale...
  4. pmc Mechanisms of EHD/RME-1 protein function in endocytic transport
    Barth D Grant
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Traffic 9:2043-52. 2008
    ....
  5. pmc Pathways and mechanisms of endocytic recycling
    Barth D Grant
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Nat Rev Mol Cell Biol 10:597-608. 2009
    ..Recent work emphasizes the importance of regulated recycling in processes as diverse as cytokinesis, cell adhesion, morphogenesis, cell fusion, learning and memory...
  6. pmc A novel requirement for C. elegans Alix/ALX-1 in RME-1-mediated membrane transport
    Anbing Shi
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Biol 17:1913-24. 2007
    ..In addition, Alix is associated with the actin cytoskeleton and might regulate cytoskeletal dynamics...
  7. pmc Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit
    Miyuki Sato
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Nat Cell Biol 7:559-69. 2005
    ..These results suggest a mechanism for the activation of Rab5 in clathrin-coated pits or clathrin-coated vesicles that is essential for the delivery of endocytic cargo to early endosomes...
  8. pmc Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein
    Miyuki Sato
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA
    EMBO J 27:1183-96. 2008
    ..We propose that RME-4 functions on coated pits and/or vesicles to recruit RAB-35, which in turn functions in the endosome to promote receptor recycling...
  9. pmc Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8
    Anbing Shi
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA
    EMBO J 28:3290-302. 2009
    ..Our results indicate a mechanism, whereby retromer can regulate endosomal clathrin dynamics through RME-8 and Hsc70, promoting the sorting of recycling cargo into the retrograde pathway...
  10. ncbi request reprint Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic
    Zita Balklava
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Nat Cell Biol 9:1066-73. 2007
    ..Consistent with these results, we found that tagged CDC-42/Cdc42 is enriched on recycling endosomes in C. elegans and mammalian cells, suggesting a direct function in the regulation of transport...
  11. pmc Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans
    Ken Sato
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Mol Biol Cell 17:3085-94. 2006
    ..Our results demonstrate that the distribution of CAV-1 is highly dynamic during development and provides new insights into the sorting mechanisms that regulate CAV-1 localization...
  12. pmc AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling
    Saumya Pant
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Nat Cell Biol 11:1399-410. 2009
    ..Our results indicate that AMPH-1 and RME-1 cooperatively regulate endocytic recycling, probably through functions required for the production of cargo carriers that exit the recycling endosome for the cell surface...
  13. pmc RAB-10 is required for endocytic recycling in the Caenorhabditis elegans intestine
    Carlos Chih Hsiung Chen
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Mol Biol Cell 17:1286-97. 2006
    ..We found that a functional GFP-RAB-10 reporter protein is localized to endosomes and Golgi in wild-type intestinal cells consistent with a direct role for RAB-10 in this transport pathway...
  14. doi request reprint Meiotic maturation: receptor trafficking is the key
    Julie S Hang
    Waksman Institute and Department of Genetics, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Curr Biol 18:R416-8. 2008
    ..Recent work has provided insights into the modulation of the MSP signal by the trafficking of its receptor in oocytes...
  15. ncbi request reprint EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegans
    Rika Maruyama
    Waksman Institute, Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Biol 17:1555-60. 2007
    ..Therefore, EGG-3 plays a central role in egg activation by influencing polarized F-actin dynamics and the localization or activity of molecules that are directly involved in executing the egg-to-embryo transition...
  16. pmc RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway
    Doreen R Glodowski
    Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Mol Biol Cell 18:4387-96. 2007
    ..We propose that RAB-10 and LIN-10 recycle AMPARs from intracellular endosomal compartments to synapses along distinct pathways, each with distinct sensitivities to cholesterol and the clathrin-mediated endocytosis machinery...
  17. ncbi request reprint The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans
    Pavan Kadandale
    Waksman Institute and Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Biol 15:2222-9. 2005
    ..elegans fecundity and understanding the evolutionary differentiation of molecular function and speciation...
  18. pmc EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans
    Jean M Parry
    Waksman Institute and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Curr Biol 19:1752-7. 2009
    ..Therefore, EGG-4 and EGG-5 are not only required for critical events of the oocyte-to-embryo transition but also link the dynamics of the regulatory machinery with the advancing cell cycle...
  19. ncbi request reprint ATP binding regulates oligomerization and endosome association of RME-1 family proteins
    Dong Won Lee
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 0301, USA
    J Biol Chem 280:17213-20. 2005
    ..Taken together, these results indicate that ATP binding is required for oligomerization of mRme-1/EHD1, which in turn is required for its association with endosomes...
  20. pmc Caenorhabditis elegans num-1 negatively regulates endocytic recycling
    Lars Nilsson
    Umeå Center for Molecular Pathogenesis, Umea University, SE 901 87 Umea, Sweden
    Genetics 179:375-87. 2008
    ....
  21. pmc Genetic analysis of lysosomal trafficking in Caenorhabditis elegans
    Greg J Hermann
    Department of Biology, Lewis and Clark College, Portland, OR 97219, USA
    Mol Biol Cell 16:3273-88. 2005
    ..The glo mutants thus provide a simple model system for the analysis of lysosome-related organelle biogenesis in animal cells...
  22. pmc Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6
    Sophia Semerdjieva
    Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, England, UK
    J Cell Biol 183:499-511. 2008
    ..These data are consistent with a model in which hRME-6 and rab5 regulate AP2 uncoating in vivo by coordinately regulating mu2 dephosphorylation and PtdIns(4,5)P(2) levels in CCVs...
  23. pmc Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis
    Sebastian Treusch
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 101:4483-8. 2004
    ..Finally, we propose a model that relates the lysosome biogenesis defect in the absence of CUP-5/h-mucolipin-1 to cellular phenotypes in worms and in humans...
  24. ncbi request reprint Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator
    John A Picciano
    Cystic Fibrosis Research Center, Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Am J Physiol Cell Physiol 285:C1009-18. 2003
    ....
  25. pmc EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling
    Anne Braun
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    Mol Biol Cell 16:3642-58. 2005
    ..Our data thus reveal that, in addition to a crucial role in endocytic internalization, syndapin protein complexes play an important role in endocytic receptor recycling...
  26. pmc Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells
    Clifford M Babbey
    Department of Medicine, Division of Nephrology, Indiana University Medical Center, Indianapolis, IN 46202, USA
    Mol Biol Cell 17:3156-75. 2006
    ..These results suggest that Rab10 mediates transport from basolateral sorting endosomes to common endosomes...

Research Grants10

  1. Endocytosis and Recycling in C. elegans and Mammals
    Barth Grant; Fiscal Year: 2010
    ..A better understanding of how endocytic recycling functions will be profoundly important in identifying therapeutic targets to combat this and other diseases. ..
  2. Endocytic Trafficking in C. elegans and Mammals
    Barth Grant; Fiscal Year: 2007
    ..elegans. By combining the power of C. elegans genetics and mamalian cell biology this work will significantly advance our understanding of .the mechanisms determining a key metazoan membrane transport process. ..
  3. Endocytosis and Recycling in C. elegans and Mammals
    Barth Grant; Fiscal Year: 2010
    ..A better understanding of how endocytic recycling functions will be profoundly important in identifying therapeutic targets to combat this and other diseases. ..