Mark Gluck

..Third, previous psychological models that capture important behavioral principles of memory provide an important top-down constraint for developing computational models of the neural bases of these behaviors...

..In particular, we are working now to reconcile these kinds of incremental associative learning models with other models of the hippocampal region that account for the rapid formation of declarative memories...

..This variability in how subjects approach this task may have important implications for interpreting how different brain regions are involved in probabilistic category learning...

..A new mouse version of one of our tasks shows promise for translating these paradigms into rodents, allowing for future studies of therapeutic interventions in transgenic mouse models of AD...

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..basal forebrain, and that these differences may be most visible in non-declarative tasks such as eyeblink classical conditioning and simple associative learning...

..These findings fit other recent empirical findings and theoretical predictions that some classical conditioning tasks previously thought to depend on the hippocampus depend, rather, on the entorhinal cortex...

..Our findings point to distinct and dissociable contributions of medial temporal lobe and basal ganglia structures to learning and memory...

..This finding has implications for understanding the distinct contributions of the medial temporal lobe and basal ganglia to learning and memory...

..These preliminary results suggest that these behavioral tasks may be useful tools in predicting short-term cognitive outcome in nondemented elderly...

..These results highlight a difference in feedback-based learning in 2 amnesic etiologies, despite similar levels of declarative memory impairment...

..This finding demonstrates that the selective removal of the medial septum retards delay eyeblink conditioning in a manner similar to the disruption seen after systemic administration of scopolamine...

..This last result raises questions regarding the mechanisms by which midbrain dopamine modulates learning in Parkinson's disease, and how L-dopa affects these processes...

..In addition, the newer model is able to address some new phenomena including the effect of the number of training trials on blocking and overshadowing...

..The model provides a computational, neurally based synthesis of prior learning theories that predicts changes in medial septal activity based on the novelty of stimulus events...

..1998) lend support to the theory that blocking, at least in rabbit eyeblink conditioning, seems to be due to an error correction mechanism rather than a learned inattention mechanism...

..These preliminary results suggest that even very mild degrees of hippocampal atrophy may be associated with subtle behavioral impairments...

..Overall, future work involving testing the neural substrates of pre-exposure effects may benefit from the use of LIRR rather than LI...

..This asymmetry was consistent with similarities in cortical representations of the sounds, demonstrating that perceptual sensitivities to complex sounds can be predicted from the cortical responses they evoke...

..The purpose of this study was to examine stimulus-response (S-R) learning in active cocaine users...

..While cognitive functions have been widely studied, much less is known about implicit learning in depression...

..g. anterior cingulate cortex). These data support the notion that the OFC play a role in normal discrimination learning, and suggest qualitative similarities in learning performance of patients with OFC damage and medicated PD patients...

..These results suggest that the enduring negative symptoms of deficit patients may be related to decreased response to cognitive feedback and deficient basal ganglia functioning...

..These results indicate that the deficit syndrome is associated with prominently impaired stimulus-response reinforcement learning, which may indicate abnormal functioning of basal ganglia circuits...

..In contrast, MTL dysfunctions may result in a non-sequential learning of associations, which may indicate a loss of contextual information...

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..High-dose first generation antipsychotics may disrupt BG-dependent learning by blocking dopaminergic neurotransmission in the nigro-striatal system...

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..It appears that although selective hippocampal lesions do not eliminate blocking in eyeblink conditioning, they do disrupt novelty detection and may facilitate learning to a previously blocked cue...

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..High-dose first generation antipsychotics may disrupt BG-dependent learning by blocking dopaminergic neurotransmission in the nigro-stiratal system...

..We conclude that fMRI can have high long-term test-retest reliability, making it suitable as a biomarker for brain development and neurodegeneration...

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..The meeting will be broadly advertised, and open to all who wish to attend, subject only to physical space limitations at the meeting venue. ..

..This will allow doctors to identify optimal dosing and medication combinations for each individual patient that lead to enhanced motor and cognitive functioning. ..

..This meeting is the second in a series of international neuroscience and neurology meetings organized by Mark Gluck, of Rutgers University, in collaboration with Hebrew University and the Al Quds Palestinian Medical School...

..This will allow doctors to identify optimal dosing and medication combinations for each individual patient that lead to enhanced motor and cognitive functioning. ..