Donald R Gerecke

Summary

Affiliation: Rutgers University
Country: USA

Publications

  1. pmc Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect
    Donald R Gerecke
    Environmental and Occupational Health Sciences Institute EOHSI, a joint institute of UMDNJ RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 234:156-65. 2009
  2. pmc Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 249:178-87. 2010
  3. doi request reprint The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard
    Ruijin Zheng
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 272:345-55. 2013
  4. pmc Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model
    Yoke Chen Chang
    Rutgers University, Pharmacology and Toxicology, 170 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 268:178-87. 2013
  5. pmc Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 253:112-20. 2011
  6. pmc Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 245:352-60. 2010
  7. ncbi request reprint Preferential expression of matrix metalloproteinase-9 in mouse skin after sulfur mustard exposure
    Michael P Shakarjian
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    J Appl Toxicol 26:239-46. 2006
  8. doi request reprint Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model
    Yoke Chen Chang
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, EOHSI, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    J Biochem Mol Toxicol 23:172-84. 2009
  9. pmc Doxycycline hydrogels as a potential therapy for ocular vesicant injury
    Marion K Gordon
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    J Ocul Pharmacol Ther 26:407-19. 2010
  10. ncbi request reprint Complete primary structure and genomic organization of the mouse Col14a1 gene
    Donald R Gerecke
    Department of Pharmacology and Toxicology, Environmental and Occupational Health Sciences Institute, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Matrix Biol 22:595-601. 2004

Research Grants

  1. Role of FACIT Collagens in Hypertension
    Donald Gerecke; Fiscal Year: 2005

Collaborators

Detail Information

Publications13

  1. pmc Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect
    Donald R Gerecke
    Environmental and Occupational Health Sciences Institute EOHSI, a joint institute of UMDNJ RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 234:156-65. 2009
    ..These results can help in understanding the molecular mechanism of SM-induced blistering, as well as to test the efficacy of different inhibitors...
  2. pmc Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 249:178-87. 2010
    ..These effects are similar to human responses to vesicants in vivo and suggest that the full thickness skin equivalent is a useful in vitro model to characterize the biological effects of mustards and to develop potential therapeutics...
  3. doi request reprint The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard
    Ruijin Zheng
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 272:345-55. 2013
    ..The sensitivity of corneal epithelial cells to oxidative stress may be an important mechanism mediating tissue injury induced by UVB or nitrogen mustard...
  4. pmc Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model
    Yoke Chen Chang
    Rutgers University, Pharmacology and Toxicology, 170 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 268:178-87. 2013
    ....
  5. pmc Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 253:112-20. 2011
    ..These data suggest that MAP kinases regulate Hsp 27 and Hsp70; moreover, caveolae-mediated regulation of heat shock protein expression may be important in the pathophysiology of vesicant-induced skin toxicity...
  6. pmc Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide
    Adrienne T Black
    Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA
    Toxicol Appl Pharmacol 245:352-60. 2010
    ..Inhibiting the capacity of keratinocytes to generate eicosanoids may be important in limiting inflammation and protecting the skin from vesicant-induced oxidative stress and injury...
  7. ncbi request reprint Preferential expression of matrix metalloproteinase-9 in mouse skin after sulfur mustard exposure
    Michael P Shakarjian
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    J Appl Toxicol 26:239-46. 2006
    ..These observations suggest the differential expression of MMP-2 and -9 during the cutaneous response to SM injury and suggest a role for MMP-9 in SM-induced injury...
  8. doi request reprint Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model
    Yoke Chen Chang
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, EOHSI, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
    J Biochem Mol Toxicol 23:172-84. 2009
    ..Protein production was in excess of the amount required to form heterotrimeric laminin-332 and was associated with the migrating epithelial sheet, suggesting a potential role in wound healing for monomeric laminin-gamma2...
  9. pmc Doxycycline hydrogels as a potential therapy for ocular vesicant injury
    Marion K Gordon
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    J Ocul Pharmacol Ther 26:407-19. 2010
    ....
  10. ncbi request reprint Complete primary structure and genomic organization of the mouse Col14a1 gene
    Donald R Gerecke
    Department of Pharmacology and Toxicology, Environmental and Occupational Health Sciences Institute, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Matrix Biol 22:595-601. 2004
    ..The entire mouse genomic structure has been determined and is made up of 48 exons. Alternatively spliced forms of mouse type XIV, collagen were not identified corresponding to the findings for the human form...
  11. ncbi request reprint Expression of FACIT collagens XII and XIV during bleomycin-induced pulmonary fibrosis in mice
    Eleni G Tzortzaki
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Anat Rec A Discov Mol Cell Evol Biol 275:1073-80. 2003
    ..These data support the hypothesis that fibrosis is a multistep process that involves both collagen accumulation and changes in the molecules that modulate the biomechanical properties of fibrils...
  12. ncbi request reprint Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators
    Carol R Gardner
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 192:119-30. 2003
    ..In contrast, increases in IL-10 were more rapid and more pronounced. These data demonstrate that signaling through TNFR1 is important in inflammatory mediator production and toxicity induced by acetaminophen...
  13. ncbi request reprint Solar ultraviolet radiation as a trigger of cell signal transduction
    Diane E Heck
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicol Appl Pharmacol 195:288-97. 2004
    ..The present review summarizes some of the mechanisms by which ultraviolet light alters signaling pathways as well as the genes important in the beneficial and toxic effects of ultraviolet light...

Research Grants3

  1. Role of FACIT Collagens in Hypertension
    Donald Gerecke; Fiscal Year: 2005
    ..We propose to examine the role of these collagens in the hypertensive rat model using a variety of biochemical and molecular biological techniques. ..