Affiliation: Rutgers University
Knowles B, Weis V, Yu S, Roland J, Williams J, Alvarado G, et al
. Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. J Cell Sci. 2015;128:1617-26 pubmed publisher
..Rab11a deficiency in enterocytes altered the apical localization of syntaxin 3. These data affirm the role of Rab11a in apical membrane trafficking and the maintenance of apical microvilli in enterocytes. ..
Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, et al
. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res. 2014;74:5480-92 pubmed publisher
Yu D, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, et al
. Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol. 2015;16:211 pubmed publisher
Yu S, Yehia G, Wang J, Stypulkowski E, Sakamori R, Jiang P, et al
. Global ablation of the mouse Rab11a gene impairs early embryogenesis and matrix metalloproteinase secretion. J Biol Chem. 2014;289:32030-43 pubmed publisher
..Rab11a(null) embryos were able to properly form normal blastocysts but died at peri-implantation stages. Our data suggest that Rab11a critically controls mouse blastocyst development and soluble matrix metalloproteinase secretion. ..
Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, et al
. Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development. 2015;142:2147-62 pubmed publisher
..Rab8a thus controls Wnt delivery in producing cells and is crucial for Paneth cell maturation. Our data highlight the profound tissue plasticity that occurs in response to stress induced by depletion of a stem cell niche signal. ..
Feng Q, Bonder E, Engevik A, Zhang L, Tyska M, Goldenring J, et al
. Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy. J Cell Sci. 2017;130:2491-2505 pubmed publisher
..These data identify a potentially important and distinct mechanism for a characteristic microvillus defect exhibited by enterocytes of patients with neonatal enteropathy. ..